(Latent) transforming growth factor β in liver parenchymal cells, its injury-dependent release, and paracrine effects on rat hepatic stellate cells

Hepatology

Volumn 27, Issue 4, 1998, Pages 1003-1012

  Roth, Sylke ^a   Michel, Kristin ^a   Gressner, Axel M ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CHRONIC LIVER DISEASE; CONTROLLED STUDY; LIVER CELL DAMAGE; LIVER FIBROSIS; LIVER PARENCHYMA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; STELLATE CELL;

EID: 0031948431     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510270416     Document Type: Article

References (13)

1. Border WA, Noble NA. Mechanisms of disease: transforming growth factor-beta in tissue fibrosis. N Engl J Med 1994;331:1286-1292.
2. Bedossa P, Paradis V. Transforming growth factor-beta (TGF-beta): a key-role in liver fibrogenesis. J Hepatol 1995;22:37-42.
3. Pinzani M. Novel insights into the biology and physiology of the Ito cell. Pharmacol Ther 1995;66:387-412.
4. Bachem MG, Sell KM, Melchior R, Kropf J, Eller T, Gressner AM. Tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-betal (TGF-betal) stimulate fibronectin synthesis and the transdifferentiation of fat storing cells in the rat liver into myofibroblasts. Virchows Arch B Cell Pathol 1993;63:123-130.
5. Matsuoka M, Tsukamoto H. Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor-beta: implication of a pathogenetic role in alcoholic liver fibrogenesis. HEPATOLOGY 1990;11:599-605.
6. Meyer DH, Bachem MG, Gressner AM. Modulation of hepatic lipocyte proteoglycan synthesis and proliferation by Kupffer cell-derived transforming growth factors type-betal and type-alpha. Biochem Biophys Res Commun 1990;171:1122-1129.
7. Bachem MG, Riess U, Melchior R, Sell KM, Gressner AM. Transforming growth factors (TGF-alpha and TGF-betal) stimulate chondroitin sulfate and hyaluronate synthesis in cultured rat liver fat storing cells. FEBS Lett 1989;257:134-137.
8. Lawrence DA. Transforming growth factor-beta: a general review. Eur Cytokine Netw 1996;7:363-374.
9. Braun L, Mead JE, Panzica M, Mikumo R, Bell GI, Fausto N. Transforming growth factor-beta mRNA increases during liver regeneration. A possible paracrine mechanism of growth regulation. Proc Natl Acad Sci U S A 1988;85:1539-1543.
10. Bursch W, Oberhammer F, Jirtle RL, Askari M, Sedivy R, Grasl-Kraupp B, Purchio AF, et al. Transforming growth factor-betal as a signal for induction of cell death by apoptosis. Br J Cancer 1993;67:531-536.
11. Oberhammer FA, Pavelka M, Sharma S, Tiefenbacher R, Purchio AF, Bursch W, Schulte-Hermann R. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor-betal. Proc Natl Acad Sci U S A 1992;89:5408-5412.
12. Gressner AM, Polzar B, Lahme B, Mannherz HG. Induction of rat liver parenchymal cell apoptosis by hepatic myofibroblasts via transforming growth factor beta. HEPATOLOGY 1996;23:571-581.
13. Castilla A, Prieto J, Fausto N. Transforming growth factors-betal and alfa in chronic liver disease: effects of interferon alfa therapy. N Engl J Med 1991;324:933-940.