Immunolocalization of putative human liver progenitor cells in livers from patients with end-stage primary biliary cirrhosis and sclerosing cholangitis using the monoclonal antibody OV-6

American Journal of Pathology

Volumn 152, Issue 3, 1998, Pages 771-779

  Crosby, Heather A ^a   Hubscher, Stefan ^a   Fabris, Luca ^a   Joplin, Ruth ^a   Sell, Stewart ^a   Kelly, Deirdre ^b   Strain, Alastair J ^a,c  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b ALBANY MEDICAL COLLEGE   (United States)

^c QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 19; EPITHELIAL MEMBRANE ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY OV 6; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; CELL SHAPE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER TRANSPLANTATION; NONHUMAN; PRIMARY BILIARY CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; STEM CELL;

ADOLESCENT; ADULT; ANTIBODIES, MONOCLONAL; ANTIGENS, SURFACE; BIOLOGICAL MARKERS; CA-125 ANTIGEN; CHILD; CHILD, PRESCHOOL; CHOLANGITIS, SCLEROSING; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOHISTOCHEMISTRY; INFANT; KERATINS; LIVER; LIVER CIRRHOSIS, BILIARY; MICROSCOPY, CONFOCAL; MIDDLE AGED; STEM CELLS;

EID: 0031888109     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Sell S, Leffert HL: An evaluation of cellular lineages in the pathogenesis of experimental hepatocellular carcinomas. Hepatology 1982, 2:27-86
2. Lombardi B: On the nature, properties and significance of oval cells. Recent Trends Chem Carcinogen 1982, 1:37-56
3. Sell S: Is there a liver stem cell? Cancer Res 1990, 50:3811-3815
4. Grisham JM: Cell types in long-term propagable cultures of rat liver. Ann NY Acad Sci 1980, 349:128-137
5. Coleman W, Grisham J: Epithelial stem-like cells of the rodent liver. Liver Growth and Repair. Edited by Strain AJ, DiehL AM. London, Chapman & Hall, 1998, pp 50-99
6. Fausto N, Lemire JM, Shiojiri N: Cell lineages in hepatic development and the identification of progenitor cells in normal and injured liver. Proc Soc Exp Biol Med 1993, 204:237-241
7. Thorgeirsson SS, Evarts RP, Bisgaard HC, Fujio K, Hu Z: Hepatic stem cell compartment: activation and lineage commitment. Proc Soc Exp Biol Med 1993, 204:253-260
8. Dabeva MA, Shafritz DA: Activation, proliferation and differentiation of progenitor cells into hepatocytes in the D-galactosamine model of liver regeneration. Am J Pathol 1993, 143:1606-1620
9. Sell S, Ilic Z: Liver Stem Cells. Landes, Austin, TX, Bioscience, 1997, 346 pp
10. Farber E: Similarities in the sequence of early histologic changes induced in the livers of rats by ethionine, 2-acetylaminoazobenzene and 3′-methyl-4-dimethylaminoazobenzene. Cancer Res 1956, 16: 142-148
11. Dunsford HA, Maset R, Salman J, Sell S: Connection of ductlike structures induced by a chemical hepatocarcinogen to portal bile ducts in the rat liver detected by injection of bile ducts with a pigmented barium gelatin medium. Am J Pathol 1985, 118:218-224
12. Everts RP, Nagy P, Hakatsukasa H, Marsden ER, Thorgeirsson SS: In vivo differentiation of rat liver oval cells into hepatocytes. Cancer Res 1989, 49:1541-1547
13. Elmore LW, Sirica AE: Phenotypic characterization of metaplastic intestinal glands and ductular hepatocytes in cholangiofibrotic lesions rapidly induced in the caudate liver lobe of rats treated with furan. Cancer Res 1991, 51:5752-5759
14. Novikoff PM, Yam A, Oikawa I: Blast-like cell compartment in carcinogenesis-induced proliferating bile ductules. Am J Pathol 1996, 148:1473-1492
15. Golding M, Sarraf CE, Lalani E, Anilkumar TV, Edwards RJ, Nagy P, Thorgeirsson SS, Alison MR: Oval cell differentiation into hepatocytes in the acetylaminofluorene-treated regenerating rat liver. Hepatology 1995, 22:1243-1253
16. Alterman K: The stem cells ot the liver: a selective review. J Cancer Res Clin Oncol 1992, 118:87-115
17. Lai Y, Thung SN, Gerber MA, Chen M, Schaffner F: Expression of cytokeratins in normal and diseased livers and in primary liver carcinomas. Arch Pathol Lab Med 1989, 113:134-138
18. Van Eyken P, Sciot R, Callea F, Van Der Steen K, Moerman P, Desmet VJ: The development of the intrahepatic bile ducts in man: a keratin-immunohistochemical study. Hepatology 1988, 8:1586-1595
19. Roskams T, Van Eyken P, Desmet V: Human Liver Growth and Development. Edited by Strain AJ, DiehL AM. London, Chapman & Hall, 1998, pp 541-557
20. Thung SN: The development of proliferating ductular structures in liver disease. Arch Pathol Lab Med 1990, 114:407-411
21. Shah KD, Gerber MA: Development of intrahepatic bile ducts in humans: possible role of laminin. Arch Pathol Lab Med 1990, 114: 597-600
22. De Vos R, Desmet V: Ultrastructural characteristics of novel epithelial cell types identified in human pathologic liver specimens with chronic ductular reaction. Am J Pathol 1992, 140:1441-1450
23. Ruck P, Xiao J, Kaiserling E: Small epithelial cells and the histogenesis of hepatoblastoma: electron microscopic, immunoelectron microscopic, and immunohistochemical findings. Am J Pathol 1996, 148:321-329
24. Dunsford HA, Sell S: Production of monoclonal antibodies to preneoplastic liver cell populations induced by chemical carcinogens in rats and to transplantable Morris hepatomas. Cancer Res 1989, 49:4887-4893
25. Dunsford HA, Karnasuta C, Hunt JM, Sell S: Monoclonal antibodies identify different lineages of chemically induced hepatocellular carcinoma in rats. Cancer Res 1989, 49:4894-4900
26. Sell S, Dunsford HA: Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma. Am J Pathol 1989, 134: 1347-1363
27. Bisgaard HC, Parmelee DC, Dunsford HA, Sechi S, Thorgerisson SS: Keratin 14 protein in cultured nonparenchymal rat hepatic epithelial cells: characterization of keratin 14 and keratin 19 as antigens for the commonly used mouse monoclonal antibody OV-6. Mol Carcinogen 1993, 7:60-66
28. Blakolmer K, Jaskiewicz K, Dunsford HA, Robson SC: Hematopoietic stem cell markers are expressed by ductal plate and bile duct cells in developing human liver. Hepatology 1995, 21:1510-1516
29. Roskams T, De Vos R, Desmet V: 'Undifferentiated progenitor cells' in focal nodular hyperplasia of the liver, Histopathology 1996, 28:291-299
30. r 34,000 human epithelium-specific glycoprotein in normal and malignant tissues. Cancer Res 1987, 47:2883-2891
31. r 34,000 is a widely distributed human carcinoma marker. Br J Cancer 1987, 56:714-721
32. Moll R, Franke WW, Schiller DL, Geiger B, Krepler R: The catalogue of human cytokeratins: patterns of expression in normal epithelia, tumours and cultured cells. Cell 1982, 31:11-24
33. Van Eyken P, Sciot R, van der Steen K, Moerman P, Desmet VJ: Keratin immunohistochemistry in normal human liver. Cytokeratin pattern of hepatocytes, bile ducts and acinar gradient. Virchows Arch A Pathol Anat Histopathol 1987, 412:63-72
34. Johnson GD, Walker L: Reversed sequential double immunostaining: an indirect (antiglobulin) method for identifying cellular subsets using monoclonal antibodies of the same isotype. J Immunol Methods 1986, 95:149-152
35. Yavorkovsky L, Lai E, Ilic Z, Sell S: Participation of small intraportal stem cells in the restitutive response of the liver to periportal necrosis induced by allyl alcohol. Hepatology 1995, 21:1702-1712
36. Sell S: Electron microscopic identification of putative liver stem cells and intermediate hepatocytes following periportal necrosis induced in rats by allyl alcohol. Stem Cell 1997, 15:378-385
37. Yang Li, Faris R, Hixson DC: Phenotypic heterogeneity within clonogenic ductal cell populations isolated from normal adult rat liver. Proc Soc Exp Biol Med 1993, 204:280-288
38. Denk H, Franke WW, Dragosics B, Zeiler I: Pathology of the cytoskeleton of liver cells: demonstration of Mallory bodies (alcoholic hyalin) in murine and human hepatocytes by immunofluorescence microscopy using antibodies to cytokeratin polypeptides from hepatocytes. Hepatology 1981, 1:9-20
39. LeBrun DP, Warnke RA, Cleary ML: Expression of bcl-2 in fetal tissues suggests a role in morphogenesis. Am J Pathol 1993, 142:743-753
40. Charlotte F, L'Hermine A, Martin N, Geleyn Y, Nollet M, Gaulard P, Zafrani ES: Immunohistochemical detection of bcl-2 protein in normal and pathological human liver. Am J Pathol 1994, 144: 460-465
41. Park YN, Brody RI, Nalesnik M, Thung SN, Theise ND: OV-6 positive, HEPPAR 1 negative oval-like cells in human livers with hepatitis C cirrhosis or with acetaminophen toxicity. Hepatology 1995, 22:230A
42. Lee J-H, Rim H-J, Sell S: Heterogeneity of the "oval-cell" response in the hamster liver during cholangiocarcinogenesis following Clonorchis sinensis infection and dimethylnitrosamine treatment. J Hepatol 1997, 26:1313-1323
43. Hsia CC, Evarts RP, Nakatsukasa H, Marsden ER, Thorgeirsson SS: Occurrence of oval-type cells in hepatitis B virus-associated human hepatocarcinogenesis. Hepatology 1992, 16:1327-1333