GB virus B and hepatitis C virus NS3 serine proteases share substrate specificity

Journal of Virology

Volumn 71, Issue 7, 1997, Pages 4985-4989

  Scarselli, Elisa ^a   Urbani, Andrea ^a   Sbardellati, Andrea ^a   Tomei, Licia ^a   De Francesco, Raffaele ^a   Traboni, Cinzia ^a  

^a IRBM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

SERINE PROTEINASE; VIRUS ENZYME;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ESCHERICHIA COLI; FLAVIVIRUS; HEPATITIS; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

EID: 0030985915     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.7.4985-4989.1997     Document Type: Article

References (30)

1. Abe, K., G. Inchauspe, T. Shikata, and A. M. Prince. 1992. Three different patterns of hepatitis C virus infection in chimpanzees. Hepatology 15:690-695.
2. Darke, P. L., E. Chen, D. L. Hall, K. M. Sardana, C. A. Veloski, L. R. Lafemina, J. A. Shafer, and L. C. Kuo. 1994. Purification of active herpes simplex virus-1 protease expressed in Escherichia coli. J. Biol. Chem. 269: 18708-18711.
3. De Francesco, R., A. Urbani, M. C. Nardi, L. Tomei, C. Steinkühler, and A. Tramontano. 1996. A zinc binding site in viral serine proteinases. Biochemistry 35:13282-13287.
4. Deinhardt, F., A. W. Holmes, R. B. Capps, and H. Popper. 1967. Studies on the transmission of human viral hepatitis to marmoset monkeys. Transmission of disease, serial passages, and description of liver lesion. J. Exp. Med. 125:673-687.
5. DiIanni, C. L., C. Mapelli, D. A. Drier, J. Tsao, S. Natarajan, D. Riexinger, S. M. Festin, M. Bolgar, G. Yamanaka, S. P. Weinheimer, C. A. Meyers, R. J. Colonno, and M. G. Cordingley. 1993. In vitro activity of the herpes virus type 1 protease with peptide substrates. J. Biol. Chem. 268:25449-25454.
6. Failla, C., L. Tomei, and R. De Francesco. 1994. Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. J. Virol. 68:3753-3760.
7. Failla, C., L. Tomei, and R. De Francesco. 1995. An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A. J. Virol. 69:1769-1777.
8. Failla, C. M., E. Pizzi, R. De Francesco, and A. Tramontano. 1996. Redesigning the substrate specificity of the hepatitis C virus NS3 protease. Folding Design 1:35-42.
9. Farci, P., T. W. London, D. C. Wong, J. G. Dawson, S. D. Vallari, R. Engle, and R. H. Purcell. 1992. The natural history of infection with hepatitis C virus (HCV) in chimpanzees: comparison of serologic response measured with first- and second-generation assays and relationship to HCV viremia. J. Infect. Dis. 165:1006-1011.
10. Grakoui, A., D. W. McCourt, C. Wychowski, S. M. Feinstone, and C. M. Rice. 1993. Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites. J. Virol. 67:2832-2843.
11. Kim, J. L., K. A. Morgenstern, C. Lin, T. Fox, M. D. Dwyer, J. A. Landro, S. P. Chambers, W. Markland, C. A. Lepre, E. T. O'Malley, S. L. Harbeson, C. M. Rice, M. A. Murcko, P. R. Caron, and J. A. Thomson. 1996. Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell 87:343-355.
12. Lin, C., J. A. Thomson, and C. Rice. 1995. A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro. J. Virol. 69:4373-4380.
13. Love, R. A., H. E. Parge, J. A. Wickersham, Z. Hostomsky, N. Habuka, E. W. Moomaw, T. Adachi, and Z. Hostomska. 1996. The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell 87:331-342.
14. Muerhoff, A. S., T. P. Leary, J. N. Simons, T. J. Pilot-Matias, G. J. Dawson, J. C. Erker, M. L. Chalmers, G. G. Schlauder, S. M. Desai, and I. K. Mushahwar. 1995. Genomic organization of GB viruses A and B: two new members of the Flaviviridae associated with GB agent hepatitis. J. Virol. 69:5621-5630.
15. Ohba, K., M. Mizokami, J. Y. N. Lau, E. Orito, K. Ikeo, and T. Gojobori. 1996. Evolutionary relationship of hepatitis C, pesti-, flavi-, plantiviruses, and newly discovered GB hepatitis agent. FEBS Lett. 378:232-234.
16. Pilot-Matias, T. J., A. S. Muerhoff, J. N. Simons, T. P. Leary, S. L. Buijk, M. L. Chalmers, J. C. Erker, G. J. Dawson, S. M. Desai, and I. K. Mushahwar. 1996. Identification of antigenic regions in the GB hepatitis viruses GBV-A, GBV-B, and GBV-C. J. Med Virol. 48:329-338.
17. Pizzi, E., A. Tramontano, L. Tomei, N. La Monica, C. Failla, M. Sardana, T. Wood, and R. De Francesco. 1994. Molecular model of the specificity pocket of the hepatitis C virus protease: implication for substrate recognition. Proc. Natl. Acad. Sci. USA 91:888-892.
18. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
19. Sardana, V. V., J. A. Wolfgang, C. A. Veloski, W. J. Long, K. LeGrow, B. Wolansky, E. A. Emini, and R. L. LaFemina. 1994. Peptide substrate cleavage specificity of the human cytomegalovirus protease. J. Biol. Chem. 269: 14337-14340.
20. Schlauder, G. G., G. J. Dawson, J. N. Simons, T. J. Pilot-Matias, R. A. Gutierrez, C. A. Heynen, M. F. Knigge, G. S. Kurpiewsky, S. L. Buijk, T. P. Leary, A. S. Muerhoff, S. M. Desai, and I. K. Mushahwar. 1995. Molecular and serologic analysis in the transmission of the GB hepatitis agents. J. Med. Virol. 46:81-90.
21. Schlauder, G. G., T. J. Pilot-Matias, G. S. Gabriel, J. N. Simons, A. S. Muerhoff, G. J. Dawson, and I. K. Mushahwar. 1995. Origin of GB-hepatitis viruses. Lancet 346:447-448.
22. Simons, J. N., T. P. Leary, G. J. Dawson, T. J. Pilot-Matias, A. S. Muerhoff, G. G. Schlauder, S. M. Desai, and I. K. Mushahwar. 1995. Isolation of novel virus-like sequences associated with human hepatitis. Nat. Med. 1:564-569.
23. Simons, J. N., T. J. Pilot-Matias, T. P. Leary, G. J. Dawson, S. M. Desai, G. G. Schlauder, A. Scott Muerhoff, J. C. Erker, S. L. Buijk, M. L. Chalmers, C. L. Van Sant, and I. K. Mushahwar. 1995. Identification of two flavivirus-like genomes in the GB hepatitis agent. Proc. Natl. Acad. Sci. USA 92:3401-3405.
24. Steinkühler, C., L. Tomei, and R. De Francesco. 1996. In vitro activity of hepatitis C virus protease NS3 purified from recombinant baculovirus-infected Sf9 cells. J. Biol. Chem. 271:6367-6373.
25. Steinkühler, C., A. Urbani, L. Tomei, G. Biasiol, M. Sardana, E. Bianchi, A. Pessi, and R. De Francesco. 1996. Activity of purified hepatitis C virus protease NS3 on peptide substrates. J. Virol. 70:6694-6700.
26. Stemmer, W. P. C., A. Crameri, K. D. Ha, T. M. Brennan, and H. L. Heyneker. 1995. Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides. Gene 164:49-53.
27. Tabor, S., and C. C. Richardson. 1985. A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. Proc. Natl. Acad. Sci. USA 82:1074-1078.
28. Takamizawa, A., C. Mori, I. Fuke, S. Manabe, S. Murakami, J. Fujita, E. Onishi, T. Andoh, I. Yoshida, and H. Okayama. 1991. Structure and organization of the hepatitis C virus genome isolated from human carriers. J. Virol. 65:1105-1113.
29. Tomei, L., C. Failla, E. Santolini, R. De Francesco, and N. La Monica. 1993. NS3 is a serine protease required for processing of hepatitis C virus polyprotein. J. Virol. 67:4017-4026.
30. Zuckerman, A. J. 1995. The new GB hepatitis viruses. Lancet 345:1453-1454.