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Volumn 221, Issue 1, 1996, Pages 54-66

In vitro studies on the activation of the hepatitis C virus NS3 proteinase by the NS4A cofactor

Author keywords

[No Author keywords available]

Indexed keywords

PLASMID DNA; PROTEINASE; SYNTHETIC PEPTIDE; VIRUS ENZYME;

EID: 0030198933     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1996.0352     Document Type: Article
Times cited : (57)

References (42)
  • 1
    • 0001311689 scopus 로고
    • Peptide synthesis. 10. Use of pentafluorophenyl esters of fluoreny-methoxycarbonylamino acids in solid phase synthesis
    • Atherton, R., Cameron, L. R., and Sheppard, R. C. (1988). Peptide synthesis. 10. Use of pentafluorophenyl esters of fluoreny-methoxycarbonylamino acids in solid phase synthesis. Tetrahedron 44, 843-857.
    • (1988) Tetrahedron , vol.44 , pp. 843-857
    • Atherton, R.1    Cameron, L.R.2    Sheppard, R.C.3
  • 2
    • 0026516061 scopus 로고
    • Expression of the P-protein of the human hepatitis B virus in a vaccinia virus system and detection of the nucleocapsid-associated P-gene product by radiolabelling at newly introduced phosphorylation sites
    • Bartenschlager, R., Kuhn, C., and Schaller, H. (1992). Expression of the P-protein of the human hepatitis B virus in a vaccinia virus system and detection of the nucleocapsid-associated P-gene product by radiolabelling at newly introduced phosphorylation sites. Nucl. Acids Res. 20, 195-202.
    • (1992) Nucl. Acids Res. , vol.20 , pp. 195-202
    • Bartenschlager, R.1    Kuhn, C.2    Schaller, H.3
  • 3
    • 0027287798 scopus 로고
    • Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions
    • Bartenschlager, R., Ahlborn-Laake, L., Mous, J., and Jacobsen, H. (1993). Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J. Virol. 67, 3835-3844.
    • (1993) J. Virol. , vol.67 , pp. 3835-3844
    • Bartenschlager, R.1    Ahlborn-Laake, L.2    Mous, J.3    Jacobsen, H.4
  • 4
    • 0028241489 scopus 로고
    • Kinetic and structural analyses of hepatitis C virus polyprotein processing
    • Bartenschlager, R., Ahlborn-Laake, L., Mous, J., and Jacobsen, H. (1994). Kinetic and structural analyses of hepatitis C virus polyprotein processing. J. Virol. 68, 5045-5055.
    • (1994) J. Virol. , vol.68 , pp. 5045-5055
    • Bartenschlager, R.1    Ahlborn-Laake, L.2    Mous, J.3    Jacobsen, H.4
  • 5
    • 0028820118 scopus 로고
    • Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation
    • Bartenschlager, R., Lohmann, V., Wilkinson, T., and Koch, J. O. (1995a). Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation. J. Virol. 69, 7519-7528.
    • (1995) J. Virol. , vol.69 , pp. 7519-7528
    • Bartenschlager, R.1    Lohmann, V.2    Wilkinson, T.3    Koch, J.O.4
  • 6
    • 0028908783 scopus 로고
    • Substrate determinants for cleavage in cis and in trans by the hepatitis C virus NS3 proteinase
    • Bartenschlager, R., Ahlborn-Laake, L., Yasargil, K., Mous, J., and Jacobsen, H. (1995b). Substrate determinants for cleavage in cis and in trans by the hepatitis C virus NS3 proteinase. J. Virol. 69, 198-205.
    • (1995) J. Virol. , vol.69 , pp. 198-205
    • Bartenschlager, R.1    Ahlborn-Laake, L.2    Yasargil, K.3    Mous, J.4    Jacobsen, H.5
  • 7
    • 0026632752 scopus 로고
    • The Taiwanese Hepatitis C virus genome: Sequence determination and mapping the 5′ termini of viral genomic and antigenomic RNA
    • Chen, P.-J., Lin, M.-H., Tai, K.-F., Liu, P.-C., Lin, C.-J., and Chen, D.-S. (1992). The Taiwanese Hepatitis C virus genome: Sequence determination and mapping the 5′ termini of viral genomic and antigenomic RNA. Virology 188, 102-113.
    • (1992) Virology , vol.188 , pp. 102-113
    • Chen, P.-J.1    Lin, M.-H.2    Tai, K.-F.3    Liu, P.-C.4    Lin, C.-J.5    Chen, D.-S.6
  • 9
    • 0018110116 scopus 로고
    • Prediction of the secondary structure of proteins from their amino acid sequence
    • Chou, P. Y., and Fasman, G. D. (1978). Prediction of the secondary structure of proteins from their amino acid sequence. Adv. Enzymol. Relat. Areas Mol. Biol. 47, 45-148.
    • (1978) Adv. Enzymol. Relat. Areas Mol. Biol. , vol.47 , pp. 45-148
    • Chou, P.Y.1    Fasman, G.D.2
  • 10
    • 0027942956 scopus 로고
    • Hepatitis C: Progress and problems
    • Cuthbert, J. A. (1994). Hepatitis C: Progress and problems. Clin. Microbiol. Rev. 7, 505-532.
    • (1994) Clin. Microbiol. Rev. , vol.7 , pp. 505-532
    • Cuthbert, J.A.1
  • 11
    • 0027170423 scopus 로고
    • The hepatitis C virus encodes a serine proteinase involved in processing of the putative nonstructural proteins from the viral polyprotein precursor
    • Eckart, M. R., Selby, M., Masiarz, F., Lee, C., Berger, K., Crawford, K., Kuo, C., Kuo, G., Houghton, M., and Choo, Q.-L. (1993). The hepatitis C virus encodes a serine proteinase involved in processing of the putative nonstructural proteins from the viral polyprotein precursor. Biochem. Biophys. Res. Commun. 192, 399-406.
    • (1993) Biochem. Biophys. Res. Commun. , vol.192 , pp. 399-406
    • Eckart, M.R.1    Selby, M.2    Masiarz, F.3    Lee, C.4    Berger, K.5    Crawford, K.6    Kuo, C.7    Kuo, G.8    Houghton, M.9    Choo, Q.-L.10
  • 12
    • 0039797301 scopus 로고
    • Cap-independent translation of mRNA conferred by encephalomyocarditis virus 5′ sequence improves the performance of the vaccinia virus/bacteriophage T7 hybrid expression system
    • Elroy-Stein, O., Fuerst, T. R., and Moss, B. (1989). Cap-independent translation of mRNA conferred by encephalomyocarditis virus 5′ sequence improves the performance of the vaccinia virus/bacteriophage T7 hybrid expression system. Proc. Natl. Acad. Sci. USA 86, 6126-6130.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 6126-6130
    • Elroy-Stein, O.1    Fuerst, T.R.2    Moss, B.3
  • 13
    • 0028851296 scopus 로고
    • An Amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A
    • Failla, C., Tomei, L., and DeFrancesco, R. (1995). An Amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A. J. Virol. 69, 1769-1777.
    • (1995) J. Virol. , vol.69 , pp. 1769-1777
    • Failla, C.1    Tomei, L.2    Defrancesco, R.3
  • 14
    • 0028290579 scopus 로고
    • Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins
    • Failla, C., Tomei, L., and DeFrancesco, R. (1994). Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. J. Virol. 68, 3753-3760.
    • (1994) J. Virol. , vol.68 , pp. 3753-3760
    • Failla, C.1    Tomei, L.2    Defrancesco, R.3
  • 15
    • 0000233999 scopus 로고
    • Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase
    • Fuerst, T. R., Niles, E. G., Studier, F. W., and Moss, B. (1986). Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 83, 8122-8126.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 8122-8126
    • Fuerst, T.R.1    Niles, E.G.2    Studier, F.W.3    Moss, B.4
  • 17
    • 0027414062 scopus 로고
    • Characterization of the hepatitis C virus-encoded serine proteinase: Determination of proteinase-dependent polyprotein cleavage sites
    • Grakoui, A., McCourt, D. W., Wychowski, C., Feinstone, S. M., and Rice, C. M. (1993b). Characterization of the hepatitis C virus-encoded serine proteinase: Determination of proteinase-dependent polyprotein cleavage sites. J. Virol. 67, 2832-2843.
    • (1993) J. Virol. , vol.67 , pp. 2832-2843
    • Grakoui, A.1    McCourt, D.W.2    Wychowski, C.3    Feinstone, S.M.4    Rice, C.M.5
  • 18
    • 0025991559 scopus 로고
    • Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis
    • Hijikata, M., Kato, N., Ootsuyama, Y., and Nakagawa, M. (1991). Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc. Natl. Acad. Sci. USA 88, 5547-5551.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5547-5551
    • Hijikata, M.1    Kato, N.2    Ootsuyama, Y.3    Nakagawa, M.4
  • 19
    • 0027163740 scopus 로고
    • Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus
    • Hijikata, M., Mizushima, H., Akagi, T., Mori, S., Kakiuchi, N., Kato, N., Tanaka, T., Kimura, K., and Shimotohno, K. (1993a). Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J. Virol. 67, 4665-4675.
    • (1993) J. Virol. , vol.67 , pp. 4665-4675
    • Hijikata, M.1    Mizushima, H.2    Akagi, T.3    Mori, S.4    Kakiuchi, N.5    Kato, N.6    Tanaka, T.7    Kimura, K.8    Shimotohno, K.9
  • 22
    • 0025787597 scopus 로고
    • Genomic structure of the human prototype strain H of hepatitis C virus: Comparison with american and japanese isolates
    • Inchauspe, G., Yebedee, S., Lee, D.-H., Sugitani, M., Nasoff, M., and Prince, A. (1991). Genomic structure of the human prototype strain H of hepatitis C virus: Comparison with american and japanese isolates. Proc. Natl. Acad. Sci. USA 88, 10292-10296.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 10292-10296
    • Inchauspe, G.1    Yebedee, S.2    Lee, D.-H.3    Sugitani, M.4    Nasoff, M.5    Prince, A.6
  • 24
    • 0028817781 scopus 로고
    • C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity
    • Kim, D. W., Gwack, Y., Han, J. H., and Choe, J. (1995). C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity. Biochem. Biophys. Res. Commun. 215, 160-166.
    • (1995) Biochem. Biophys. Res. Commun. , vol.215 , pp. 160-166
    • Kim, D.W.1    Gwack, Y.2    Han, J.H.3    Choe, J.4
  • 25
    • 0020475449 scopus 로고
    • A method for displaying the hydropathic character of a protein
    • Kyte, J., and Doolittle, R. F. (1982). A method for displaying the hydropathic character of a protein. J. Mol. Biol. 157, 105-132.
    • (1982) J. Mol. Biol. , vol.157 , pp. 105-132
    • Kyte, J.1    Doolittle, R.F.2
  • 26
    • 0028290389 scopus 로고
    • Processing in the hepatitis C virus E2-NS2 region: Identification of p7 and two distinct E2-specific products with different C termini
    • Lin, C., Lindenbach, B. D., Pragai, B. M., McCourt, D. W., and Rice, C. M. (1994a). Processing in the hepatitis C virus E2-NS2 region: Identification of p7 and two distinct E2-specific products with different C termini. J. Virol. 68, 5063-5073.
    • (1994) J. Virol. , vol.68 , pp. 5063-5073
    • Lin, C.1    Lindenbach, B.D.2    Pragai, B.M.3    McCourt, D.W.4    Rice, C.M.5
  • 27
    • 0028089739 scopus 로고
    • Hepatitis C virus NS3 serine proteinase: Trans-cleavage requirements and processing kinetics
    • Lin, C., Pragai, B. M., Grakoui, A., Xu, J., and Rice, C. M. (1994b). Hepatitis C virus NS3 serine proteinase: Trans-cleavage requirements and processing kinetics. J. Virol. 68, 8147-8157.
    • (1994) J. Virol. , vol.68 , pp. 8147-8157
    • Lin, C.1    Pragai, B.M.2    Grakoui, A.3    Xu, J.4    Rice, C.M.5
  • 28
    • 0029074519 scopus 로고
    • A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro
    • Lin, C., Thomson, J. A., and Rice, C. M. (1995a). A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro. J. Virol. 69, 4373-4380.
    • (1995) J. Virol. , vol.69 , pp. 4373-4380
    • Lin, C.1    Thomson, J.A.2    Rice, C.M.3
  • 29
    • 0029094449 scopus 로고
    • The hepatitis C virus NS3 serine proteinase and NS4A cofactor: Establishment of a cell-free transprocessing assay
    • Lin, C., and Rice, C. M. (1995b). The hepatitis C virus NS3 serine proteinase and NS4A cofactor: establishment of a cell-free transprocessing assay. Proc. Natl. Acad. Sci. USA 92, 7622-7626.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7622-7626
    • Lin, C.1    Rice, C.M.2
  • 31
    • 0000407708 scopus 로고
    • The molecular biology of hepatitis C virus
    • Matsuura, Y., and Miyamura, T. (1993). The molecular biology of hepatitis C virus. Semin. Virol. 4, 297-304.
    • (1993) Semin. Virol. , vol.4 , pp. 297-304
    • Matsuura, Y.1    Miyamura, T.2
  • 35
    • 0028233530 scopus 로고
    • Biosynthesis and biochemical properties of the hepatitis C virus core protein
    • Santolini, E., Migliaccio, G., and La Monica, N. (1994). Biosynthesis and biochemical properties of the hepatitis C virus core protein. J. Virol. 68, 3631-3641.
    • (1994) J. Virol. , vol.68 , pp. 3631-3641
    • Santolini, E.1    Migliaccio, G.2    La Monica, N.3
  • 36
    • 0029076837 scopus 로고
    • The N-terminal region of hepatitis C virus nonstructural protein 3 (NS3) is essential for stable complex formation with NS4A
    • Satoh, S., Tanji, Y., Hijikata, M., Kimura, K., and Shimotohno, K. (1995). The N-terminal region of hepatitis C virus nonstructural protein 3 (NS3) is essential for stable complex formation with NS4A. J. Virol. 69, 4255-4260.
    • (1995) J. Virol. , vol.69 , pp. 4255-4260
    • Satoh, S.1    Tanji, Y.2    Hijikata, M.3    Kimura, K.4    Shimotohno, K.5
  • 37
    • 0027225699 scopus 로고
    • Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome
    • Selby, M. J., Choo, Q.-L., Berger, K., Kuo, G., Glazer, E., Eckart, M., Lee, C., Chien, D., Kuo, C., and Houghton, M. (1993). Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome. J. Gen. Virol. 74, 1103-1113.
    • (1993) J. Gen. Virol. , vol.74 , pp. 1103-1113
    • Selby, M.J.1    Choo, Q.-L.2    Berger, K.3    Kuo, G.4    Glazer, E.5    Eckart, M.6    Lee, C.7    Chien, D.8    Kuo, C.9    Houghton, M.10
  • 38
    • 0029655995 scopus 로고    scopus 로고
    • Identification of the sequence on NS4A required for enhanced cleavage of the NS5A/5B site by hepatitis C virus NS3 protease
    • Shimizu, Y., Yamaji, K., Masuho, Y., Yokota, T., Inoue, H., Sudo, K., Satoh, S., and Shimotohno, K. (1996). Identification of the sequence on NS4A required for enhanced cleavage of the NS5A/5B site by hepatitis C virus NS3 protease. J. Virol. 70, 127-132.
    • (1996) J. Virol. , vol.70 , pp. 127-132
    • Shimizu, Y.1    Yamaji, K.2    Masuho, Y.3    Yokota, T.4    Inoue, H.5    Sudo, K.6    Satoh, S.7    Shimotohno, K.8
  • 39
    • 0026513786 scopus 로고
    • A PCR method for introducing mutations into cloned DNA by joining an internal primer to tagged flanking primer
    • Stappert, J., Wirsching, J., and Kemler, R. (1992). A PCR method for introducing mutations into cloned DNA by joining an internal primer to tagged flanking primer. Nucleic Acids Res. 20, 624.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 624
    • Stappert, J.1    Wirsching, J.2    Kemler, R.3
  • 41
    • 0028831056 scopus 로고
    • Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing
    • Tanji, Y., Hijikata, M., Satoh, S., Kaneko, T., and Shimotohno, K. (1995). Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing. J. Virol. 69, 1575-1581.
    • (1995) J. Virol. , vol.69 , pp. 1575-1581
    • Tanji, Y.1    Hijikata, M.2    Satoh, S.3    Kaneko, T.4    Shimotohno, K.5
  • 42
    • 0027176287 scopus 로고
    • NS3 is a serine protease required for processing of hepatitis C virus polyprotein
    • Tomei, L., Failla, C., Santolini, E., De Francesco, R., and La Monica, N. (1993). NS3 is a serine protease required for processing of hepatitis C virus polyprotein. J. Virol. 67, 4017-4026.
    • (1993) J. Virol. , vol.67 , pp. 4017-4026
    • Tomei, L.1    Failla, C.2    Santolini, E.3    De Francesco, R.4    La Monica, N.5


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