Upregulation of adipocyte metabolism by agouti protein: Possible paracrine actions in yellow mouse obesity

American Journal of Physiology - Endocrinology and Metabolism

Volumn 270, Issue 1 33-1, 1996, Pages

  Jones, Brynn H ^b   Kim, Jung H ^b   Zemel, Michael B ^b   Woychik, Richard P ^b   Michaud, Edward J ^b   Wilkison, William O ^b   Moustaid, Naima ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b NONE

Author keywords

3T3 L1 adipocytes; fatty acid synthase; gene expression; intracellular calcium; lipogenesis; nitrendipine; stearoyl coenzyme A desaturase; triglycerides

Indexed keywords

ACYL COENZYME A DESATURASE; FATTY ACID SYNTHASE; MESSENGER RNA;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL STRAIN 3T3; DRUG EFFECT; ENZYME ACTIVITY; FATTY ACID DESATURATION; FATTY ACID SYNTHESIS; GENE EXPRESSION REGULATION; GENE MUTATION; LIPOGENESIS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL;

EID: 0030062529     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.270.1.e192     Document Type: Article

References (30)

1. Bradford, M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
2. Buffey, J. A., M. Edfecombe, and S. MacNeil. Calcium plays a complex role in the regulation of melanogenesis in murine B16 melanoma cells. Pigm. Cell Res. 6: 385-393, 1993.
3. Enser, M. The role of insulin in the regulation of stearic acid desaturase activity in liver and adipose tissue from obesehyperglycaemic (ob/ob) and lean mice. Biochem. J. 180: 551-558, 1979.
4. Fenton, P. F., and H. B. Chase. Effect of diet on obesity of yellow mice in inbred lines. Proc. Soc. Exp. Biol. Med. 77: 420-422, 1951.
5. 4a. Guichard, C., I. Dugail, X. Le-Liepvre, and M. Lavau. Genetic regulation of fatty acid synthetase expression in adipose tissue: overtranscription of gene in genetically obese rats. J. Lipid Res. 33: 679-687, 1992.
6. Halaas, J. L., K. S. Gajiwala, M. Maffei, S. L. Cohen, B. T. Chait, D. Robinowitz, R. Lallone, S. K. Burley, and J. M. Friedman. Weight-reducing effects of the plasma protein encoded by the obese gene. Science Wash. DC 269: 543-546, 1995.
7. Hillgartner, F. B., L. M. Salati, and A. G. Goodridge. Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis. Physiol. Rev. 75: 47-76, 1995.
8. 2+ in corticotropin-stimulated white adipocytes. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E418-E426, 1994.
9. Johnson, P. R., and J. Hirsch. Cellularity of adipose depots in six strains of genetically obese mice. J. Lipid Res. 13: 2-11, 1972.
10. Jones, B. H., W. J. Banz, M. A. Abel, M. B. Zemel, and N. Monstaïd. Dietary polyunsaturated fatty acids suppress stearoyl-CoA desaturase gene expression in adipose tissue (Abstract). FASEB J. 9: A1331, 1995.
11. Klebig, M. L., J. E. Wilkinson, J. G. Geisler, and R. P. Woychik. Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. Proc. Natl. Acad. Sci. USA 92: 4728-4732, 1995.
12. Klebig, M. L., J. E. Wilkinson, and R. P. Woychik. Molecular analysis of the mouse agouti gene and the role of dominant agouti-locus mutations in obesity and insulin resistance. In: Molecular and Genetic Aspects of Obesity. Baton Rouge: Louisiana State Univ. Press, 1994.
13. Konda, Y., I. Gantz, J. DelValle, Y. Shimoto, H. Miwa, and T. Yamada. Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor. J. Biol. Chem. 269: 13162-13166, 1994.
14. Kwon, H. Y., S. J. Bultman, C. Loffeler, W. Chen, P. J. Furdon, J. G. Powell, A. L. Usala, W. O. Wilkison, I. Hansmann, and R. P. Woychick. Molecular structure and chromosomal mapping of the human homolog of the agouti gene. Proc. Natl. Acad. Sci. USA 91: 9760-9764, 1994.
15. Landschulz, K. Y., D. B. Jump, O. A. MacDougald, and M. D. Lane. Transcriptional control of the stearoyl-CoA desaturase-1 gene by polyunsaturated fatty acids. Biochim. Biophys. Res. Commun. 200: 763-768, 1994.
16. Lu, D., D. Willard, I. R. Patel, S. Radwell, L. Overton, T. Kost, M. Luther, W. Chen, R. P. Woychik, W. O. Wilkison, and R. D. Cone. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature Lond. 371: 799-802, 1994.
17. Manne, J., A. C. Argeson, and L. D. Siracusa. Mechanisms for the pleitropic effects of the agouti gene. Proc. Natl. Acad. Sci. USA 92: 4721-4724, 1995.
18. Moustaïd, N., R. S. Beyer, and H. S. Sul. Identification of an insulin response element in the fatty acid synthase promoter. J. Biol. Chem. 269: 5629-5634, 1994.
19. Moustaïd, N., B. Hainque, and A. Quignard-Boulange. Dexamethasone regulation of terminal differentiation in 3T3-F442A preadipocyte cell line. Cytotechnology 1: 285-293, 1988.
20. Moustaïd, N., and H. S. Sul. Regulation of expression of the fatty acid synthase gene in 3T3-L1 cells by differentiation and triiodothyronine. J. Biol. Chem. 266: 18550-18554, 1991.
21. Ntambi, J. M. Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver. J. Biol. Chem. 267: 10925-10930, 1992.
22. Rolland, V., I. Dugail, X. Le Liepvre, and M. Lavau. Evidence of increased glyceraldehyde-3-phosphate dehydrogenase and fatty acid synthetase promoter activities in transiently transfected adipocytes from genetically obese rats. J. Biol. Chem. 270: 1102-1106, 1995.
23. Shillabeer, G., J. Hornford, J. M. Forden, N. C. Wong, J. C. Russell, and D. C. W. Lau. Fatty acid synthase and adipsin mRNA levels in obese and lean JCR:LA-cp rats: effect of diet. J. Lipid Res. 33: 31-39, 1992.
24. Silvers, W. K., and E. S. Russell. An experimental approach to action of genes at the agouti locus in the mouse. J. Exp. Zool. 130: 199-220, 1955.
25. y/a) and non-yellow (α/α) mice in parabiosis. Genetics 48: 1041-1058, 1963.
26. vy/α mice. Biochim. Biophys. Acta 441: 213-220, 1976.
27. i) results in stimulation of fatty acid synthase (Abstract). Obesity Res. 3: 338s, 1995.
28. Zemel, M. B., J. H. Kim, R. P. Woychik, E. J. Michaud, S. Kadwell, I. R. Patel, and W. O. Wilkison. Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice. Proc. Natl. Acad. Sci. USA 92: 2441-2445, 1995.
29. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. Positional cloning of the mouse obese gene and its human homologue. Nature Lond. 372: 425-432, 1994.
30. Zomely, C., and J. Mayer. Fat metabolism in experimental obesities. Am. J. Physiol. 196: 611-613, 1959.