Antipyretic role of endogenous melanocortins mediated by central melanocortin receptors during endotoxin-induced fever

Journal of Neuroscience

Volumn 17, Issue 9, 1997, Pages 3343-3351

  Huang, Qin Heng ^a   Entwistle, Margaret L ^a   Alvaro, John D ^b   Duman, Ronald S ^b   Hruby, Victor J ^c   Tatro, Jeffrey B ^a,d  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c University of Arizona   (United States)

^d TUFTS MEDICAL CENTER   (United States)

Author keywords

endotoxin; fever; melanocortin receptor; neuroimmunomodulation; pituitary adrenal axis; SHU 9119; MSH

Indexed keywords

ALPHA INTERMEDIN; CYCLIC AMP; ENDOTOXIN; HORMONE RECEPTOR; INTERMEDIN; INTERMEDIN DERIVATIVE; MELANOCORTIN; NEUROPEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPYRETIC ACTIVITY; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; FEVER; HOST RESISTANCE; HYPOPHYSIS ADRENAL SYSTEM; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030953605     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-09-03343.1997     Document Type: Article

References (20)

1. Alvaro JD, Tatro JB, Quillan JM, Fogliano M, Eisenhard M, Lerner MR, Nestler EJ, Duman RS (1996) Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction. Mol Pharmacol 50:583-591.
2. Bell RC, Lipton JM (1987) Pulsatile release of antipyretic neuropeptide α-MSH from septum of rabbit during fever. Am J Physiol 252:R1152-R1157.
3. Bock M, Roth J, Kluger MJ, Zeisberger E (1994) Antipyresis caused by stimulation of vasopressinergic neurons and intraseptal or systemic infusions of γ-MSH. Am J Physiol 266:R614-R621.
4. Bull DF, King MG, Pfister HP, Singer G (1990) Alpha-melanocytestimulating hormone conditioned suppression of a lipopolysaccharide-induced fever. Peptides 11:1027-1031.
5. Cannon JG, Tatro JB, Reichlin SR, Dinarcllo CA (1986) α-Melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin-1 . J Immunol 137:2232-2236.
6. Catania A, Lipton JM (1993) α-Melanocyte stimulating hormone in the modulation of host reactions. Endocr Rev 14:564-576.
7. Coelho MM, Souza GE, Pela IR (1992) Endotoxin-induced fever is modulated by endogenous glucocorticoids in rats. Am J Physiol 263:R423-R427.
8. Doré B, Entwistle ML, Tatro JB, Drouin J, Roselli-Rehfuss L (1996) Mutations in three amino acids of the rat melanocortin 3 receptor result in altered receptor activity. Proceedings of the 10th International Congress of Endocrinology, San Francisco, CA, June 1996, p 794.
9. Gantz I, Kondaf Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T (1993a) Molecular cloning of a novel melanocortin receptor. J Biol Chem 268:8248-8250.
10. Gantz I, Miwa H, Konda Y, Shimoto Y, Tashiro T, Watson SJ, DelValle J, Yamada T (1993b) Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J Biol Chem 268:15174-15179.
11. Glyn-Ballinger JR, Bernardini GL, Lipton JM (1983) α-MSH injected into the septal region reduces fever in rabbits. Peptides 4:199-203.
12. Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz J, Sokoloff P (1994) Molecular cloning and characterization of the rat fifth melanocortin receptor. Biochem Biophys Res Commun 200:1007-1014.
13. Haskell-Leuvano C, Miwa H, Dickinson C, Hadley ME, Hruby VJ, Yamada T, Gantz I (1996) Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R. J Med Chem 39:432-435.
14. Hiltz ME, Lipton JM (1990) Alpha-MSH peptides inhibit acute inflammation and contact sensitivity. Peptides 11:979-982.
15. Holdeman M, Khorram O, Samson WK, Lipton JM (1985) Fever-specific changes in central MSH and CRF concentrations. Am J Physiol 248:R125-R129.
16. 2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J Med Chem 38:3454-3461.
17. 125I to high specific activity. Biochim Biophys Acta 251:363-369.
18. Villar M, Perassi N, Cellis ME (1991) Central and peripheral actions of alpha-MSH in the thermoregulation of rats. Peptides 12:1441-1443.
19. Vriend CA, Janz L, Jansen A, Murray L, Greenberg AH, Nance DM (1994) Alpha-MSH activates the splenic nerve and is depleted from the arcuate nucleus following IL-1β injections. Soc Neurosci Abstr 20:950.
20. Wilson JF (1988) Low permeability of the blood-brain barrier to nanomolar concentrations of immunoreactive alpha-melanotropin. Psychopharmacology (Berl) 96:262-266.