Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice

Journal of Biological Chemistry

Volumn 271, Issue 16, 1996, Pages 9455-9459

  Zhang, Bei ^a,c   Graziano, Michael P ^a   Doebber, Thomas W ^a   Leibowitz, Mark D ^a   White Carrington, Sylvia ^a   Szalkowski, Deborah M ^a   Hey, Patricia J ^a   Wu, Margaret ^a   Cullinan, Catherine A ^a   Bailey, Philip ^a   Lollmann, Bettina ^b   Frederich, Robert ^b   Flier, Jeffrey S ^b   Strader, Catherine D ^a   Smith, Roy G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c P O Box 2000 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; AD 5075; ANTIDIABETIC AGENT; GLUCOSE; LEPTIN; MESSENGER RNA; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; CONTROLLED STUDY; DIABETES MELLITUS; ENERGY BALANCE; GENE EXPRESSION REGULATION; GLUCOSE HOMEOSTASIS; INSULIN SENSITIVITY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADIPOSE TISSUE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOOD GLUCOSE; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; DNA PROBES; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION; GLUCOSE; HOMEOSTASIS; HYPOGLYCEMIC AGENTS; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MOLECULAR SEQUENCE DATA; OBESITY; POLYMERASE CHAIN REACTION; PROTEIN BIOSYNTHESIS; PROTEINS; RATS; RATS, ZUCKER; REFERENCE VALUES; RNA, MESSENGER; THIAZOLES; THIAZOLIDINEDIONES; TRIGLYCERIDES;

ANIMALIA; RODENTIA;

EID: 15844415080     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.16.9455     Document Type: Article

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