Extreme obesity may be linked to markers flanking the human OB gene

Diabetes

Volumn 45, Issue 5, 1996, Pages 691-694

  Reed, Danielle R ^a   Ding, Yuan ^b   Xu, Weizhen ^a   Cather, Corinne ^c   Green, Eric D ^d   Price, R Arlen ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; PROTEIN;

ALLELE; ARTICLE; BODY MASS; CHROMOSOME MAP; GENE; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; OBESITY; PRIORITY JOURNAL;

EID: 0029938057     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.5.691     Document Type: Article

References (25)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994
2. Green ED, Maffei M, Braden VV, Proenca R, DeSilva U, Zhang Y, Chua SC, Leibel RL, Weissenbach J, Friedman JM: The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Res 5.5-12, 1995
3. Geffroy S, De Vos P, Staels B, Duban B, Auwerx J, de Martinville B: Localization of the human OB gene (OBS) to chromosome 7q32 by fluorescence in situ hybridization. Genomics 28: 603-604, 1995
4. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269 540-543, 1995
5. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546, 1995
6. Campfleld LA, Smith F, Guisez Y, Devos R, Burn P: Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269 546-540, 1995
7. Masuzaki H, Ogawa Y, Isse N, Satoh N, Okazaki T, Shigemoto M, Mori K, Tamura N, Hosoda K, Yoshimasa Y, Jingami H, Kawada T, Nakao K: Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44:855-858, 1995
8. Considine RV, Considine EL, Williams CJ, Nyee MR, Magosin SA, Bauer TL, Rosate EL, Colberg J, Caro JF: Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 95:2720-2728, 1995
9. Lönnqvist F, Arner P, Nordfors L, Schalling M: Overexpression of the obese (ob) gene in adipose tissue of human obese subjects Nature Med 1:950-953, 1995
10. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects Nature Med 1:1155-1161, 1995
11. MacDougald OA, Hwang C-S, Fan H, Lane MD. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci USA 92:9034-9037, 1995
12. Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girand J, Staels B, Auwerx J: Transient increase in obese gene expression after food intake or insulin administration. Nature 377:527-529, 1995
13. Coleman DL, Hummel KP: The influence of genetic background on the expression of the obese (ob) gene in the mouse. Diabetologia 9:287-293, 1973
14. Stirling B, Cox NJ, Bell GI, Hanis CL, Spielman RS, Concannon P: Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sibling pairs. Diabetes 44:999-1001, 1995
15. Hamilton BS, Paglia D, Kwan AYM, Deitel M: Increased obese mRNA expression in omental fat cells from masssively obese humans. Nature Med 1:953-956, 1995
16. Reed DR, Ding Y, Xu W, Cather C, Price RA: Human obesity does not segregate with the chromosomal regions of Prader-Willi, Bardet-Biedl, Cohen, Borjeson or Wilson-Turner syndromes. Int J Obesity 19:599-603, 1995
17. Fasman KH, Cuticchia AJ, Kingsbury DT: The GDB(TM) Human Genome Data Base Anno Nucleic Acids Res 22.3462-3469, 1994
18. Blackwelder WC, Elston RC: Statistical Analysis for Genetic Epidemiology, Release 2 1: computer program package available from the Department of Biometry and Genetics, LSU Medical Center, New Orleans Genet Epidemiol 2:85-97, 1985
19. Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516, 1993
20. Clement K, Gamer C, Hager J, Philippi A, LeDuc C, Carey A, Harns TJR, Jury C, Cardon LR, Basdevant A, Demenais F, Guy-Grand B, North M, Froguel P: Possible evidence for linkage of the human OB gene region with extreme obesity. Diabetes 45:687-690, 1996
21. Kuezmarski RJ: Prevalence of overweight and weight gain in the United States. Am J Clin Nutr 55 (Suppl 2):495S-502S, 1992
22. Rolland-Cachera MF, Cole TJ, Sempe M, Tichet J, Rossignol C, Charraud A: Body mass index variations: centiles from birth to 87 years. Eur J Clin Nutr 45:13-21, 1991
23. Borecki IB, Rice T, Perusse L, Bouchard C, Rao DC: An exploratory investigation of genetic linkage with body composition and fatness phenotypes: the Quebec family study. Obesity Res 2:213-219, 1994
24. Funahashi T, Shimomura I, Hiraoka H, Arai T, Takahashi M, Nakamura T, Nozaki S, Yamashita S, Takemura K, Tokunaga K, Matsuzawa Y: Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats. Biochem Biophys Res Commun 211:469-475, 1995
25. Lander E, Kruglyak L: Genetic dissection of complex traits: guidelines for interpreting and reporting linkage findings. Nature Genet 11:241-247, 1995