Absence of mutations in the human OB gene in obese/diabetic subjects

Diabetes

Volumn 45, Issue 5, 1996, Pages 679-682

  Maffei, Margherita ^a   Stoffel, Markus ^a   Barone, Marisa ^a,b   Moon, Byoung ^a,b   Dammerman, Marilyn ^a   Ravussin, Eric ^d   Bogardus, Clifton ^d   Ludwig, David S ^e   Flier, Jeffrey S ^e   Talley, Matchugo ^f   Auerbach, Stephen ^c   Friedman, Jeffrey M ^a,b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c US Public Health Service Region I   (United States)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^f Federated States of Micronesia   (Federated States of Micronesia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; DNA; LEPTIN; PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; BODY MASS; BODY WEIGHT; CHROMOSOME MAP; DIABETES MELLITUS; DNA POLYMORPHISM; DNA SEQUENCE; FEMALE; GENE; GENE MUTATION; HAMSTER; HUMAN; HYBRID CELL; MAJOR CLINICAL STUDY; MALE; NONHUMAN; OBESITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 15844373886     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.5.679     Document Type: Article

References (14)

1. Mann, GV: The influence of obesity on health. N Engl J Med 291:226-235, 1974
2. Bleicher SJ, Brodoff BN: Diabetes mellitus and obesity. In Energy metabolism and obesity. Baltimore, MD, Williams & Wilkins, 1981
3. Friedman JM, Leibel RL: Tackling a weighty problem. Cell 69.217-220, 1992
4. Coleman, DL: Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14:141-148, 1978
5. Friedman JM, Leibel RL, Bahary N, Siegel DA, Truett G: Genetic analysis of complex disorders: molecular mapping of obesity genes in mice and humans. Ann NY Acad Sci 630:100-115, 1991
6. Friedman JM, Leibel RL, Siegel D, Walsh J, Bahary N: Molecular mapping of the mouse ob mutation. Genomics 11:1054-1002, 1991
7. Zhang Y, Proenca P, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994
8. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene Science 269.543-546, 1995
9. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543, 1995
10. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1989
11. Bennett PH, Burch TA, Miller M: Diabetes mellitus in Pima Indians. Lancet ii:488-489, 1971
12. Grompe M: The rapid detection of unknown mutations in nucleic acids. Nature Genet 5:111-123, 1993
13. Green ED, Maffei M, Braden VV, Proenca R, DeSilva U, Zhang Y, Chua SC, Leibel RL, Weissenbach J, Friedman JM. The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Res 5:5-12, 1995
14. Considine RV, Considine EL, Williams CJ, Nyce MR, Magosin SA, Bauer TL, Rosato EL, Colberg J, Caro JF: Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 95:2986-2988, 1995