Antifolate resistance mechanisms from bacteria to cancer cells with emphasis on parasites

Advances in Experimental Medicine and Biology

Volumn 456, Issue , 1998, Pages 99-113

  Ouellette, M ^a   Leblanc, E ^a   Kundig C ^a   Papadopoulou, B ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COTRIMOXAZOLE; DIHYDROFOLATE REDUCTASE; FANSIDAR; FOLIC ACID ANTAGONIST; METHOTREXATE; PROGUANIL; PTEROPTIN; PYRIMETHAMINE; SULFONAMIDE; TRIMETHOPRIM;

ANTIBIOTIC RESISTANCE; CANCER CELL; DRUG TRANSPORT; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTOZOON; REVIEW;

PROTOZOA;

EID: 0032226554     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-4897-3_6     Document Type: Review

References (98)

1. Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variant of cultured murine cells
2. Folate receptors
3. Isolation and characterization of a mutant dihydrofolate reductase-thymidylate synthase from methotrexate-resistant Leishmania cells
4. Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells
5. Sequential amplification of dihydrofolate reductase and multidrug resistance genes in Chinese hamster ovary cells selected for stepwise resistance to the lipid-soluble antifolate trimetrexate
6. Nutritional requirements of wild-type and folate transport-deficient Leishmania donovani for pterins and folates
7. Biopterin conversion to reduced folates by Leishmania donovani promastigotes
8. PTRI: A reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major
9. Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene
10. Ode to methotrexate
11. Gene amplification in Leishmania
12. New mechanisms of drug resistance in parasitic protozoa
13. Correlation of sulfadoxine resistance with point mutations located within the bifunctional hydroxymethyldihydrobiopterin pyrophosphokinase-dihydropteroate synthase gene of the human malaria parasite Plasmodium falciparum
14. Combinations of sulphonamides with diaminopyrimidines: How, when and why?
15. Heavy metal resistance: A new role for P-glycoproteins in Leishmania
16. A member of the aldoketo reductase family confers methotrexate resistance in Leishmania
17. Polyglutamation of methotrexate. Is methotrexate a prodrug?
18. Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293
19. Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica
20. Antifolate drug selection results in duplication and rearrangement of chromosome 7 in Plasmodium chabaudi
21. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum
22. A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance
23. Cloning and characterization of a novel, plasmid-encoded trimethoprim-resistant dihydrofolate reductase from Staphylococcus haemolyticus MUR313
24. P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake
25. Genetic characterization of trimethoprim resistance in Haemophilus influenzae
26. Impaired drug uptake in methotrexate resistant Crithidia fasciculata without changes in dihydrofolate reductase activity or gene amplification
27. Stable molecular transformation of Toxoplasma gondii: A selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria
28. Biochemistry and regulation of folate and methotrexate transport in Leishmania major
29. Reductions in methotrexate and folate influx in methotrexate-resistant lines of Leishmania major are independent of R and H region amplification
30. Wild type and drug-resistant Leishhamia major hydrolyze methotrexate to N-10-methyl-4-deoxy-4-aminopteroate without accumulation of methotrexate polyglutamates
31. Sulfonamide resistance in Neisseria meningitidis as defined by site-directed mutagenesis could have its origin in other species
32. Dihydrofolate reductase-thymidylate synthetase a bifunctionnal polypeptide from Crithidia fasciculata
33. Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance
34. Multidrug resistance phenotype and P-glycoprotein overexpression in a methotrexate-resistant Leishmania infantum
35. Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure
36. Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic-leukemia and is correlated with p53 gene mutations
37. Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression
38. Intrinsic and acquired resistance to methotrexate in acute leukemia
39. Co-amplification of the γ-glutamylcysteine synthetase gene gsh I and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae
40. The mammalian dihydrofolate reductase locus
41. Structure and function of the dihydropteroate synthase from Staphylococcus aureus
42. Functional implications from the effects of 1-cholro-2.4-dinitrobenzene and ethacrynic acid on efflux routes for methotrexate and cholate in L1210 cells
43. Selective inhibitors of dihydrofolate reductase
44. In search of dihydrofolate reductase
45. Trimethoprim and sulfanamide resistance
46. Pyrimethamine resistant Plasmodium falciparum: Overproduction of dihydrofolate reductase by a gene duplication
47. Short-chain dehydrogenases/reductases (SDR)
48. Searching for magic bullets: Early approaches to chemotherapy-antifolates, methotrexate
49. Methotrexate-resistant Leishmania donovani genetically deficient in the folate-methotrexate transporter
50. Multidrug efflux in intrinsic resistance to trimethoprim and sulfamethoxazole in Pseudomonas aeruginosa
51. Amplification of ptrI and dhfr-1s in L. tarentolae selected for methotrexate resistance
52. Overexpression of btI, a novel mechanisms of methotrexate resistance in Leishmania
53. Residues involved in co-factor and substrate binding of the short chain dehydrogenase/reductase PTRI producing methotrexate resistance in Leishmania
54. Efflux systems and increased trypanothione levels in arsenite resistant Leishmania species
55. Multidrug resistance pumps provide broad defense
56. Gamma-glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias
57. Acquired versus intrinsic resistance to methotrexate: Diversity of the drug-resistant phenotype in mammalian cells
58. Pteridine transport and recurrent amplification of extrachromosomal DNAs in Leishmania
59. Reduced folate carrier gene (RFCI) expression and anti-folate resistance in transfected and non-selected cell lines
60. An amplified DNA element in Leishmania encodes potential integral membrane and nucleotide-binding proteins
61. New approaches to Leishmania chemotherapy: Pteridine reductase I (PTRI) as a target and modulator of antifolate sensitivity
62. The roles of pterine reductase I and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major
63. Microbial multidrug resistance
64. Mechanisms of drug resistance in Leishmania
65. The amplified H circle of methotrexate-resistant Leishmania tarentolae contains a novel P-glycoprotein gene
66. Transport of antimonials and antifolates in drug resistant Leishmania
67. A novel antifolate resistance gene on the amplified H circle of Leishmania
68. Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania
69. Contribution of the Leishmania P-glycoprotein related gene hpgpA to oxyanion resistance
70. Changes in folate and pterin metabolism after disruption of the Leishmania H locus short-chain dehydrogenase gene
71. Isolation and molecular characterization of the bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase gene from Toxoplasma gondii
72. Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum
73. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria
74. In vito activity of sulfonamides and sulfones against Leishmania major promastigotes
75. Acquisition of resistance to antifolates caused by enhanced g-glutamyl hydrolase activity
76. A pteridine reductase gene ptrI contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi
77. Trimethoprim resistance transposon Tn4003 from Staphylococus aureus encodes genes for a dihydrofolate reductase and thymidylate synthetase flnaked by three copies of IS257
78. Posttranscriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of the enzyme
79. Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania
80. Decreased expression of the human folate receptor mediates transport-defective methotrexate resistance in KB cells
81. Folylpolyglutamates in Leishmania major
82. Energy-dependent efflux of methotrexate in L1210 leukemia cells. Evidence for the role of an ATPase obtained with inside-out plasma membrane vesicles
83. Dihydrofolate reductase as a therapeutic target
84. LD1 amplification in Leishmania
85. Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase
86. Mutations in the gene for human dihydrofolate reductase: An unlikely cause of clinical relapse in pediatric leukemia after therapy with methotrexate
87. The form of folate affects the mechanisms of methotrexate resistance in Enterococcus faecium
88. Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum
89. Stable transfection of malaria parasite blood stages
90. Potential antifolate resistance determinants and genotypic variation in the bifunctional dihydrofolate reductase-thymidylate synthase gene from human and bovine isolates of Cryptosporidium parvum
91. The multifunctional folic acid synthesis fas gene of Pneumocystis carinii encodes dihydroneopterin aldolase, hydroxymethyldihydropterin pyrophosphokinase and dihydropteroate synthase
92. Resistance to antifolates in plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins
93. Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization
94. Folate and pterin reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTRI
95. Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake
96. Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine
97. Human gamma-glutamylhydrolase:cloning and characterization of the enzyme expressed in vitro
98. Impact of overexpression of the reduced folate carrier (RFCI), an anion exchanger, on concentrative transport in murine L1210 leukemia cells