The roles of pteridine reductase 1 and dihydrofolate reductase- thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major

Journal of Biological Chemistry

Volumn 272, Issue 21, 1997, Pages 13883-13891

  Nare, Bakela ^a   Hardy, Larry W ^b   Beverley, Stephen M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; PTERIDINE DERIVATIVE; PTERIDINE REDUCTASE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG RESISTANCE; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME SYNTHESIS; GENE AMPLIFICATION; GROWTH REGULATION; LEISHMANIA MAJOR; PRIORITY JOURNAL;

ANIMALS; BIOPTERIN; BLOTTING, WESTERN; CHROMATOGRAPHY, GEL; FOLIC ACID; FOLIC ACID ANTAGONISTS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; LEISHMANIA MAJOR; METHOTREXATE; MODELS, CHEMICAL; MULTIENZYME COMPLEXES; NADP; OXIDOREDUCTASES; PTERIDINES; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

LEISHMANIA MAJOR; LEISHMANIA TARENTOLAE; PROTOZOA; TRYPANOSOMATIDAE;

EID: 0030946111     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.21.13883     Document Type: Article

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