Reduced folate carrier gene (RFCI) expression and anti-folate resistance in transfected and non-selected cell lines

International Journal of Cancer

Volumn 72, Issue 1, 1997, Pages 184-190

  Moscow, Jeffrey A ^a,c   Connolly, Tatiana ^a   Myers, Timothy G ^a   Cheng, C C ^b   Paull, Kenneth ^a   Cowan, Kenneth H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIVICIN; ANTINEOPLASTIC AGENT; FOLIC ACID; FOLIC ACID ANTAGONIST; FOLINIC ACID; MESSENGER RNA; METHOTREXATE; NSC 111119; NSC 125347; NSC 196219; NSC 644902; NSC 670036; NSC 98099; TRICIRIBINE PHOSPHATE; TRIMETREXATE; UNCLASSIFIED DRUG; VINCRISTINE;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG RESISTANCE; GENE; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENE;

ANTINEOPLASTIC AGENTS; CARRIER PROTEINS; DRUG RESISTANCE, NEOPLASM; FOLIC ACID; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; NEOPLASMS; RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0030745895     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970703)72:1<184::AID-IJC26>3.0.CO;2-I     Document Type: Article

References (29)

1. ALVAREZ, M., PAULL, K., MONKS, A., HOSE, C., LEE, J.-S., WEINSTEIN, J., GREVER, M., BATES, S. and FOJO, T., Generation of a drug resistance profile by quantitation of mdr1/P-glycoprotein in the cell lines of the National Cancer Institute anticancer drug screen. J. clin. Invest., 95, 2205-2214 (1995).
2. BOYD, M.R. and PAULL, K.D., Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen. Drug Develop. Res., 34, 91-109 (1995).
3. BUNTING, K.D., LINDHAL, R. and TOWNSEND, A.J., Oxazaphosphoorine-specific resistance in human MCF-7 breast carcinoma cell lines expressing transfected rat class 3 aldehyde dehydrogenase. J. biol. Chem., 269, 23197-23203 (1994).
4. CHUNG, K.N., SAIKAWA, Y., PAIK, T.H., DIXON, K.H., MULLIGAN, T., COWAN, K.H. and ELWOOD, P.C., Stable transfectants of human MCF-7 breast cancer cells with increased levels of human folate receptor exhibit increased sensitivity to antifolates. J. clin. Invest., 91, 1289-1294 (1993).
5. COWAN, K.H. and JOLIVET, J., A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates. J. biol. Chem., 259, 10793-10800 (1984).
6. CURT, G.A. and ALLEGRA, C.J., Methotrexate resistance: mechanisms and implications. In: D. Kessel (ed.), Resistance to antineoplastic drugs, pp. 369-384. CRC Press, Boca Raton, FL ( 1989).
7. DIXON, K., MULLIGAN, T., CHUNG, K., ELWOOD, P. and COWAN, K., Effects of folate receptor expression following stable transfection into wild type and methotrexate transport-deficient ZR-75-1 human breast cancer cells. J. biol. Chem., 267, 24140-24147 (1992).
8. DIXON, K.H., LANPHER, B.C., CHIU, J., KELLEY, K. and COWAN, K.H., A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells. J. biol. Chem., 269, 17-20 (1994).
9. DIXON, K.H., TREPEL, J.B., ENG, S.C. and COWAN, K.H., Folate transport and the modulation of antifolate sensitivity in a methotrexate-resistant human breast cancer cell line. Cancer Comm., 3, 357-365 (1991).
10. ELWOOD, P.C., Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture. J. biol. Chem., 264, 14893-14901 (1989).
11. FAIRCHILD, C.A., Moscow, J.A.. O'BRIEN, E. and COWAN, K.H., Multidrug resistance resulting from transfection of a variant mdr1 gene is unaltered by glutathione S-transferase π expression. Mol. Pharmacol., 37, 801-809 (1990).
12. HENDERSON, G.B., Separation and inhibitor specificity of a second unidirectional efflux route for methotrexate in L1210 cells. Biochim. biophys. Acta, 5, 137-143 (1992).
13. HENDERSON, G.B. and STRAUSS, B.P., Characteristics of a novel transport system for folate compounds in wild-type and methotrexate-resistant L1210 cells. Cancer Res., 50, 1709-1714 (1990).
14. LACEY, S.W., SANDERS, J.M., ROTHBERG, K.G., ANDERSON, R.G.W. and KAMEN, B.A., Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidyl inositol. J. clin. Invest., 84, 715-720 (1989).
15. MONKS, A.D., SCUDIERO, P., SKEHAN, P., SHOEMAKER, K., PAULL, K., VISTICA, D., HOSE, C., LANGLEY, J., CONISE, P. and VAIGRO-WOLFF, A., Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J. nat. Cancer Inst., 83, 757-766 (1991).
16. Moscow, J.A., GONG, M., HE, R., M.K., S., DIXON, K.D., ANZICK, S.L., MELTZER, P.S. and COWAN, K.H., Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res., 55, 3790-3794 (1995a).
17. Moscow, J. A., JOHNSTON, P.O., COLE, D., POPLACK, D.O. and COWAN, K.H., Characterization of cross-resistance to methotrexate in a human breast cancer cell line selected for resistance to melphalan. Biochem. Pharmacol., 49, 1069-1078 (1995b).
18. OHNUMA, T., Lo, R.J., SCANLON, K.J., KAMEN, B.A., OHNOSHI, T., WOLMAN, S.R. and HOLLAND, J.F., Evolution of methotrexate resistance of human lymphoblastic leukemia cells in vitro. Cancer Res., 45, 1815-1822 (1985).
19. PRASAD, P.D., RAMAMOORTHY, S., LEIBACH, F.H. and GANAPATHY, V., Molecular cloning of the human placental folate transporter. Biochem. biophys. Res. Comm., 206, 681-687 (1995).
20. RATNAM, M., MAROUARDT, H., DUHRING, J.L. and FRESHEIM, J.H., Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA. Biochemistry, 28, 8249-8254 (1989).
21. SADASIVAN, E. and ROTHENBERG, S.P., The complete amino acid sequence of a human folate binding protein from KB cells determined from the cDNA. J. biol. Chem., 264, 5806-5811 (1989).
22. SCHUETZ, J.D., MATHERLY, L.H., WESTIN, E.H. and GOLDMAN, I.D., Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line. J. biol. Chem., 263, 9840-9847 (1988).
23. SKEHAN, P., STORENG, R., SCUDIERO, D., MONKS, A., MCMAHON, J., VISTICA, D., WAREN, J.T., BOKESCH, H., KENNEY, S. and BOYD, M.R., New colorimetric cytotoxicity assay for anticancer drug screening. J. nat. Cancer Inst., 82, 1107-1112 (1990).
24. UEDA, K., CARDARELLI, C., GOTTESMAN, M.M. and PASTAN, I., Expression of a full-length cDNA for the human "MDR" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc. not. Acad. Sci. (Wash.), 84, 3004-3008 (1987).
25. UNDERHILL, T.M. and FLINTOFF, W.F., Mutant Chinese hamster ovary cells with defective methotrexate uptake are distinguishable by reversion analysis. Somat. Cell Mol. Genet., 15,49-59 (1992).
26. VAN DER VEER, L., WESTERHOF, G.R., RUKSEN, G., SCHORNAGEL, J.H. and JANSEN, G., Cytotoxicity of methotrexate and trimetrexate and its reversal by folinic acid in human leukemic CCRF-CEM cells with carrier-mediated and receptor-mediated folate uptake. Leukemia Res., 13,981-987 (1989).
27. WESTERHOF, G.R., JANSEN, G., VAN EMMERICK, N., KATHMANN, I., RIJKSEN, G., JACKMAN, A.L. and SCHORNAGEL, J.H., Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier- and receptor-mediated transport systems. Cancer Res., 51, 5507-5513 (1991).
28. WILLIAMS, F.M. and FLINTOFF, W.F., Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake. J. biol. Chem., 270, 2987-2992 (1995).
29. WONG, S.C.. PROEFKE. S.A. and MATHERLY, L.H., Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-deficient Chinese hamster ovary cells. J. biol. Chem., 270, 17468-17475 (1995).