메뉴 건너뛰기




Volumn 13, Issue 2, 1998, Pages 79-96

The role of apoptosis in neurodegenerative diseases

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 PHENYLTETRAHYDROPYRIDINE; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; CALCIUM ION; COPPER ZINC SUPEROXIDE DISMUTASE; DNA; GLUTAMINE; HUNTINGTIN; INTERLEUKIN 1BETA CONVERTING ENZYME; NEUROTOXIN; OXIDOPAMINE; PROTEIN BCL 2; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; UNCLASSIFIED DRUG;

EID: 0031826405     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020605112755     Document Type: Review
Times cited : (22)

References (136)
  • 2
    • 0029133850 scopus 로고
    • Differential induction of IEGs in response to Aβ peptides in cultured neurons: Association between c-Jun immunoreactivity and Aβ-mediated apoptosis
    • Anderson, A.J., Pike, C.J., and Cotman, C.W. (1995). Differential induction of IEGs in response to Aβ peptides in cultured neurons: association between c-Jun immunoreactivity and Aβ-mediated apoptosis. J. Neurochem. 65:1487-1498.
    • (1995) J. Neurochem. , vol.65 , pp. 1487-1498
    • Anderson, A.J.1    Pike, C.J.2    Cotman, C.W.3
  • 3
    • 0029976253 scopus 로고    scopus 로고
    • DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-jun immunoreactivity, relationship to brain area, and effect of postmortem delay
    • Anderson, A.J., Su, J.H., and Cotman, C.W. (1996). DNA damage and apoptosis in Alzheimer's disease: colocalization with c-jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J. Neurosci. 16:1710-1719.
    • (1996) J. Neurosci. , vol.16 , pp. 1710-1719
    • Anderson, A.J.1    Su, J.H.2    Cotman, C.W.3
  • 5
    • 0019781601 scopus 로고
    • A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and Alzheimer disease
    • Appel, S.H. (1981). A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and Alzheimer disease. Ann. Neurol 10:499-505.
    • (1981) Ann. Neurol , vol.10 , pp. 499-505
    • Appel, S.H.1
  • 6
    • 0027129818 scopus 로고
    • Vitamin E protects nerve cells from amyloid β protein toxicity
    • Behl, C., Davis, J., Cole, G., and Schubert, D. (1992). Vitamin E protects nerve cells from amyloid β protein toxicity. Biochem. Biophy. Res. Commun. 186:944-950.
    • (1992) Biochem. Biophy. Res. Commun. , vol.186 , pp. 944-950
    • Behl, C.1    Davis, J.2    Cole, G.3    Schubert, D.4
  • 7
    • 0028207907 scopus 로고
    • Amyloid β peptide induces necrosis rather than apoptosis
    • Behl, C., Davis, J.B., Klier, F.G., and Schubert, D. (1994a). Amyloid β peptide induces necrosis rather than apoptosis. Brain Res. 645:253-264.
    • (1994) Brain Res. , vol.645 , pp. 253-264
    • Behl, C.1    Davis, J.B.2    Klier, F.G.3    Schubert, D.4
  • 8
    • 0028233494 scopus 로고
    • Hydrogen peroxide mediates amyloid β protein toxicity
    • Behl, C., Davis, J., Lesley, R., and Schubert, D. (1994b). Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77:817-827.
    • (1994) Cell , vol.77 , pp. 817-827
    • Behl, C.1    Davis, J.2    Lesley, R.3    Schubert, D.4
  • 9
    • 0030956532 scopus 로고    scopus 로고
    • P53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells
    • Blum, D., Wu, Y., Nissou, M.F., Arnaud, S., Benabid, A.L., and Verna, J.M. (1997). p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells. Brain Res. 751:139-142.
    • (1997) Brain Res. , vol.751 , pp. 139-142
    • Blum, D.1    Wu, Y.2    Nissou, M.F.3    Arnaud, S.4    Benabid, A.L.5    Verna, J.M.6
  • 10
    • 0029153913 scopus 로고
    • Apoptosis and necrosis: Two distincts events induced, respectively by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
    • Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P., and Lipton, A.S. (1995). Apoptosis and necrosis: two distincts events induced, respectively by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. USA 92:7162-7166.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7162-7166
    • Bonfoco, E.1    Krainc, D.2    Ankarcrona, M.3    Nicotera, P.4    Lipton, A.S.5
  • 11
    • 0029910952 scopus 로고    scopus 로고
    • Programmed cell death in the developing nervous system
    • Burek, M.J., and Oppenheim, R.W. (1996). Programmed cell death in the developing nervous system Brain Pathol. 6:427-446.
    • (1996) Brain Pathol. , vol.6 , pp. 427-446
    • Burek, M.J.1    Oppenheim, R.W.2
  • 13
    • 0029549426 scopus 로고
    • A cautionary note on the use of the TUNEL stain to determine apoptosis
    • Charriaut-Marlangue, C., and Ben-Ari, Y. (1995). A cautionary note on the use of the TUNEL stain to determine apoptosis. NeuroReport 7:61-64.
    • (1995) NeuroReport , vol.7 , pp. 61-64
    • Charriaut-Marlangue, C.1    Ben-Ari, Y.2
  • 14
    • 0026497926 scopus 로고
    • Excitotoxic cell death
    • Choi, D.W. (1992). Excitotoxic cell death. J. Neurobiol. 23:1261-1276.
    • (1992) J. Neurobiol. , vol.23 , pp. 1261-1276
    • Choi, D.W.1
  • 15
    • 0022971142 scopus 로고
    • Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation
    • Cleary, M.L., Smith, S.D., and Sklar, J. (1986). Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47:19-28.
    • (1986) Cell , vol.47 , pp. 19-28
    • Cleary, M.L.1    Smith, S.D.2    Sklar, J.3
  • 16
    • 7344261216 scopus 로고
    • Irreversible inhibition of mitochondrial complex I by 1-methyl-4-pyridinium: Evidence for free radical involvement
    • Cleeter, M.W.J., Cooper, J.M., and Schapira, A.H.V. (1992). Irreversible inhibition of mitochondrial complex I by 1-methyl-4-pyridinium: evidence for free radical involvement. J. Neurochem. 58:186-189.
    • (1992) J. Neurochem. , vol.58 , pp. 186-189
    • Cleeter, M.W.J.1    Cooper, J.M.2    Schapira, A.H.V.3
  • 17
    • 0028302961 scopus 로고
    • Use of genetic and physical mapping to locate the spinal muscular atrophy locus between two new highly polymorphic DNA markers
    • Clermont, O., Burlet, P., Burglen, L., Lefebvre, S., Pascal, F., McPherson, J. et al. (1994). Use of genetic and physical mapping to locate the spinal muscular atrophy locus between two new highly polymorphic DNA markers. Am. J. Hum. Genet. 54:687-694.
    • (1994) Am. J. Hum. Genet. , vol.54 , pp. 687-694
    • Clermont, O.1    Burlet, P.2    Burglen, L.3    Lefebvre, S.4    Pascal, F.5    McPherson, J.6
  • 18
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • Coyle, J.T., and Puttfarcken, P. (1993). Oxidative stress, glutamate, and neurodegenerative disorders. Science 262:689-695.
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.2
  • 20
    • 0027426169 scopus 로고
    • Amyotrophic lateral sclerosis and structural defects in Cu, Zn Superoxide dismutase
    • Deng, H.-X., Hentati, A., Tainer, J.A., Iqbal, Z., Cayabyab, A., Hung ,W.-Y. et al. (1993). Amyotrophic lateral sclerosis and structural defects in Cu, Zn Superoxide dismutase. Science 261:1047-1051.
    • (1993) Science , vol.261 , pp. 1047-1051
    • Deng, H.-X.1    Hentati, A.2    Tainer, J.A.3    Iqbal, Z.4    Cayabyab, A.5    Hung, W.-Y.6
  • 21
    • 0030580281 scopus 로고    scopus 로고
    • Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells
    • Deng, G., Pike, C.J., and Cotman, C.W. (1996). Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. FEBS Lett. 397:50-54.
    • (1996) FEBS Lett. , vol.397 , pp. 50-54
    • Deng, G.1    Pike, C.J.2    Cotman, C.W.3
  • 22
    • 0026758988 scopus 로고
    • Role of astrocytes in MPTP metabolism and toxicity
    • Di Monte, D., Wu, E.Y., and Langsten, W. (1992). Role of astrocytes in MPTP metabolism and toxicity. Ann. NY Acad. Sci. 648:219-228.
    • (1992) Ann. NY Acad. Sci. , vol.648 , pp. 219-228
    • Di Monte, D.1    Wu, E.Y.2    Langsten, W.3
  • 23
    • 0029040355 scopus 로고
    • In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes
    • Dragunow, M., Faull, R.L.M., Lawlor, P., Beilharz, E.J., Singleton, K., Walker, E.B., and Mee, E. (1995). In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes. NeuroReport 6:1053-1057.
    • (1995) NeuroReport , vol.6 , pp. 1053-1057
    • Dragunow, M.1    Faull, R.L.M.2    Lawlor, P.3    Beilharz, E.J.4    Singleton, K.5    Walker, E.B.6    Mee, E.7
  • 24
    • 0030868345 scopus 로고    scopus 로고
    • Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons
    • Du, Y., Bales, K.R., Dodel, R.C., Hamilton-Byrd, E., Horn, H.W., Czilli, D.L. et al. (1997). Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons. Proc. Natl. Acad. Sci. USA 94:11,657-11,662.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 11657-11662
    • Du, Y.1    Bales, K.R.2    Dodel, R.C.3    Hamilton-Byrd, E.4    Horn, H.W.5    Czilli, D.L.6
  • 26
    • 0031888955 scopus 로고    scopus 로고
    • A caspase-activated DNase that degrades DNA during apoptosis and its inhibitor ICAD
    • Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., and Nagata, S. (1998). A caspase-activated DNase that degrades DNA during apoptosis and its inhibitor ICAD. Nature 391:43-50.
    • (1998) Nature , vol.391 , pp. 43-50
    • Enari, M.1    Sakahira, H.2    Yokoyama, H.3    Okawa, K.4    Iwamatsu, A.5    Nagata, S.6
  • 27
    • 0029146273 scopus 로고
    • Peroxynitrite-induced cytotoxicity in PC12 cells: Evidence for an apoptotic mechanism differentially modulated by neurotrophic factors
    • Estévez, A.G., Radi, R., Barbeito, L., Shin, J.T., Thompson, J.A., and Beckman, J.S. (1995). Peroxynitrite-induced cytotoxicity in PC12 cells: evidence for an apoptotic mechanism differentially modulated by neurotrophic factors. J. Neurochem. 65:1543-1550.
    • (1995) J. Neurochem. , vol.65 , pp. 1543-1550
    • Estévez, A.G.1    Radi, R.2    Barbeito, L.3    Shin, J.T.4    Thompson, J.A.5    Beckman, J.S.6
  • 28
    • 0031890108 scopus 로고    scopus 로고
    • Nitric oxide and Superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation
    • Estévez, A.G., Spear,N., Manuel, S.M., Radi, R., Henderson, C.E., Barbeito, L., and Beckman, J.S. (1998). Nitric oxide and Superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation. J. Neurosci. 18:923-931.
    • (1998) J. Neurosci. , vol.18 , pp. 923-931
    • Estévez, A.G.1    Spear, N.2    Manuel, S.M.3    Radi, R.4    Henderson, C.E.5    Barbeito, L.6    Beckman, J.S.7
  • 29
    • 0027946686 scopus 로고
    • Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
    • Estus, S., Zaks, W.J., Freeman, R.S., Gruda, M., Bravo, R., and Johnson, E.M. (1994). Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J. Cell. Biol. 126:1717-1727.
    • (1994) J. Cell. Biol. , vol.126 , pp. 1717-1727
    • Estus, S.1    Zaks, W.J.2    Freeman, R.S.3    Gruda, M.4    Bravo, R.5    Johnson, E.M.6
  • 30
    • 0023159034 scopus 로고
    • Induction and activation of tissue transglutaminase during programmed cell death
    • Fesus, L., Thomazy, V., and Falus, A. (1987). Induction and activation of tissue transglutaminase during programmed cell death. FEBS Lett. 224:104-108.
    • (1987) FEBS Lett. , vol.224 , pp. 104-108
    • Fesus, L.1    Thomazy, V.2    Falus, A.3
  • 31
    • 0024520475 scopus 로고
    • Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action
    • Fesus, L., Thomazy, V., Autuori, F., Ceru, M.P., Tarcsa, E., and Piacentini, M. (1989). Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action. FEBS Lett. 245:150-154.
    • (1989) FEBS Lett. , vol.245 , pp. 150-154
    • Fesus, L.1    Thomazy, V.2    Autuori, F.3    Ceru, M.P.4    Tarcsa, E.5    Piacentini, M.6
  • 35
    • 23444458415 scopus 로고
    • Transcriptional activation modulated by homopolymeric glutamine and proline stretches
    • Gerber, H.-P., Seipel, K., Georgiev, O., Hofferer, M., Hug, M., Rusconi, S., and Schaffner, W. (1994). Transcriptional activation modulated by homopolymeric glutamine and proline stretches. Science 263:806-811.
    • (1994) Science , vol.263 , pp. 806-811
    • Gerber, H.-P.1    Seipel, K.2    Georgiev, O.3    Hofferer, M.4    Hug, M.5    Rusconi, S.6    Schaffner, W.7
  • 36
    • 0030831352 scopus 로고    scopus 로고
    • Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis-molecular mechanisms of neuronal death and protection
    • Ghadge, G.D., Lee, J.P., Bindokas, V.P., Jordan, J., Ma, L., Miller, R.J., and Roos, R.P. (1997). Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis-molecular mechanisms of neuronal death and protection. J. Neurosci. 17:8756-8766.
    • (1997) J. Neurosci. , vol.17 , pp. 8756-8766
    • Ghadge, G.D.1    Lee, J.P.2    Bindokas, V.P.3    Jordan, J.4    Ma, L.5    Miller, R.J.6    Roos, R.P.7
  • 37
    • 9344227302 scopus 로고    scopus 로고
    • Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
    • Goldberg, Y.R., Nicholson, D.W., Rasper, D.M., Kalchman, M.A., Koide, H.B., Graham, R.K. et al. (1996). Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nature Genet. 13:442-449.
    • (1996) Nature Genet. , vol.13 , pp. 442-449
    • Goldberg, Y.R.1    Nicholson, D.W.2    Rasper, D.M.3    Kalchman, M.A.4    Koide, H.B.5    Graham, R.K.6
  • 38
    • 0029294613 scopus 로고
    • In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note
    • Grasl-Kraupp, B., Ruttkay-Nedecky, B., Koudelka, H., Bukowska, K., Bursch, W., and Schulte-Hermann, R. (1995). In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatol. 21:1465-1468.
    • (1995) Hepatol. , vol.21 , pp. 1465-1468
    • Grasl-Kraupp, B.1    Ruttkay-Nedecky, B.2    Koudelka, H.3    Bukowska, K.4    Bursch, W.5    Schulte-Hermann, R.6
  • 39
    • 0027507667 scopus 로고
    • Human genetic diseases due to codon reiteration: Relationship to an evolutionary mechanism
    • Green, H. (1993). Human genetic diseases due to codon reiteration: relationship to an evolutionary mechanism. Cell 74:955-956.
    • (1993) Cell , vol.74 , pp. 955-956
    • Green, H.1
  • 40
    • 0027160043 scopus 로고
    • Glutamate-dopamine interactions in the basal ganglia: Relationship to Parkinson's disease
    • Greenamyre, J.T. (1993). Glutamate-dopamine interactions in the basal ganglia: relationship to Parkinson's disease. J. Neurol. Transm. 91:255-269.
    • (1993) J. Neurol. Transm. , vol.91 , pp. 255-269
    • Greenamyre, J.T.1
  • 41
    • 0001360461 scopus 로고
    • Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
    • Griffin, W.S.T., Stanley, L.C., Ling, C., White, L., MacLeod, V., Perrot, L.J. et al. (1989). Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc. Natl. Acad. Sci. USA 86:7611-7615.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 7611-7615
    • Griffin, W.S.T.1    Stanley, L.C.2    Ling, C.3    White, L.4    MacLeod, V.5    Perrot, L.J.6
  • 42
    • 0029031348 scopus 로고
    • Apoptic cell death induced by β-amyloid peptide is cell type dependent
    • Gschwind, M., and Huber, G. (1995). Apoptic cell death induced by β-amyloid peptide is cell type dependent. J. Neurochem. 65:292-300.
    • (1995) J. Neurochem. , vol.65 , pp. 292-300
    • Gschwind, M.1    Huber, G.2
  • 43
    • 0030891662 scopus 로고    scopus 로고
    • Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide
    • Guo, Q., Furukawa, K., Sopher, B.L., Pham, D.G., Xie, J., Robinson et al. (1996). Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide. NeuroReport 8:379-383.
    • (1996) NeuroReport , vol.8 , pp. 379-383
    • Guo, Q.1    Furukawa, K.2    Sopher, B.L.3    Pham, D.G.4    Xie, J.5    Robinson6
  • 44
    • 0030917601 scopus 로고    scopus 로고
    • Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid b-peptide: Involvement of calcium and oxyradicals
    • Guo, Q., Sopher, B.L., Pham, D.G., Furukawa, K., Robinson, N., Martin, G.M., and Mattson, M.P. (1997). Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid b-peptide: involvement of calcium and oxyradicals. J. Neurosci. 17:4212-4222.
    • (1997) J. Neurosci. , vol.17 , pp. 4212-4222
    • Guo, Q.1    Sopher, B.L.2    Pham, D.G.3    Furukawa, K.4    Robinson, N.5    Martin, G.M.6    Mattson, M.P.7
  • 45
    • 0029318670 scopus 로고
    • A sticky business
    • Hacker, G., and Vaux ,D.L. (1995). A sticky business. Curr. Biol. 5:622-624.
    • (1995) Curr. Biol. , vol.5 , pp. 622-624
    • Hacker, G.1    Vaux, D.L.2
  • 46
    • 0026773281 scopus 로고
    • Oxygen radicals as key mediators in neurological disease: Fact or fiction
    • Halliwell, B. (1992). Oxygen radicals as key mediators in neurological disease: fact or fiction. Ann. Neurol. 32:S10-S15.
    • (1992) Ann. Neurol. , vol.32
    • Halliwell, B.1
  • 47
    • 84975751684 scopus 로고
    • Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: Relevance to Parkinson's disease
    • Hartley, A., Stone, J.M., Heron, C., Cooper, J.M., and Shapira, A.H.V. (1994). Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease. J. Neurochem. 63:1987-1990.
    • (1994) J. Neurochem. , vol.63 , pp. 1987-1990
    • Hartley, A.1    Stone, J.M.2    Heron, C.3    Cooper, J.M.4    Shapira, A.H.V.5
  • 48
    • 0028288277 scopus 로고
    • C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
    • Hengartner, M.O., and Horvitz, H.R. (1994). C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 76:665-676.
    • (1994) Cell , vol.76 , pp. 665-676
    • Hengartner, M.O.1    Horvitz, H.R.2
  • 49
    • 0031008145 scopus 로고    scopus 로고
    • Role of the mitochondrial permeability transition pore in apoptosis
    • Hirsch, T., Marzo, I., and Kroemer, G. (1997). Role of the mitochondrial permeability transition pore in apoptosis. Biosci. Rep. 17:67-76.
    • (1997) Biosci. Rep. , vol.17 , pp. 67-76
    • Hirsch, T.1    Marzo, I.2    Kroemer, G.3
  • 50
    • 0030613810 scopus 로고    scopus 로고
    • S100β induces neuronal cell death through nitric oxide release from astrocytes
    • Hu, J., Ferreira, A., and Van Eldik, L., (1997) S100β induces neuronal cell death through nitric oxide release from astrocytes. J. Neurochem. 69:2294-2301.
    • (1997) J. Neurochem. , vol.69 , pp. 2294-2301
    • Hu, J.1    Ferreira, A.2    Van Eldik, L.3
  • 51
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • Huntington's Disease Collaborative Research Group (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72:971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 52
    • 0030058208 scopus 로고    scopus 로고
    • Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo
    • Ikeda, H., Yamaguchi, M., Sugai, S., Aze, Y., Narumiya, S., and Kakizuka, A. (1996). Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo. Nature Genet. 13:196-202.
    • (1996) Nature Genet. , vol.13 , pp. 196-202
    • Ikeda, H.1    Yamaguchi, M.2    Sugai, S.3    Aze, Y.4    Narumiya, S.5    Kakizuka, A.6
  • 53
    • 0031442184 scopus 로고    scopus 로고
    • Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy
    • Iwahashi, H., Eguchi, Y., Yasuhara, N., Hanafusa, T., Matsuzawa, Y., and Tsujimoto, Y. (1997). Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy. Nature 390:413-417.
    • (1997) Nature , vol.390 , pp. 413-417
    • Iwahashi, H.1    Eguchi, Y.2    Yasuhara, N.3    Hanafusa, T.4    Matsuzawa, Y.5    Tsujimoto, Y.6
  • 54
    • 0028268215 scopus 로고
    • Programmed cell death and Bcl-2 protection in the absence of a nucleus
    • Jacobson, M.D., Burne, J.F., and Raff, M.C. (1994). Programmed cell death and Bcl-2 protection in the absence of a nucleus. EMBO J. 13:1899-1910.
    • (1994) EMBO J. , vol.13 , pp. 1899-1910
    • Jacobson, M.D.1    Burne, J.F.2    Raff, M.C.3
  • 55
    • 0000340348 scopus 로고
    • Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity
    • Javitch, J.A., D'amato, R.J., Strittmatter, S.M., and Snyder, S.H. (1985). Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc. Natl. Acad. Sci. USA 82:2173-2177.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 2173-2177
    • Javitch, J.A.1    D'Amato, R.J.2    Strittmatter, S.M.3    Snyder, S.H.4
  • 56
    • 0028143527 scopus 로고
    • CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1
    • Kawaguchi, Y., Okamoto, T., Taniwaki, M., Aizawa, M., Inoue, M., Katayama, S. et al. (1994). CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1. Nature Genet. 8:221-227.
    • (1994) Nature Genet. , vol.8 , pp. 221-227
    • Kawaguchi, Y.1    Okamoto, T.2    Taniwaki, M.3    Aizawa, M.4    Inoue, M.5    Katayama, S.6
  • 57
    • 0030741528 scopus 로고    scopus 로고
    • Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system
    • Kluck, R.M., Martin, S.J., Hoffman, B.M., Zhou, J.S., Green, D.R., and Newmeyer, D.D. (1997a). Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system. EMBO J. 16:4639-4649.
    • (1997) EMBO J. , vol.16 , pp. 4639-4649
    • Kluck, R.M.1    Martin, S.J.2    Hoffman, B.M.3    Zhou, J.S.4    Green, D.R.5    Newmeyer, D.D.6
  • 58
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • Kluck, R.M., Bossi-Wetzel, E., Green, D.R., and Newmeyer, D.D. (1997b). The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132-1136.
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossi-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 60
    • 0028981717 scopus 로고
    • The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice
    • LaFerla, F.M., Tinkle, B.T., Bieberich, C.J., Haudenschild, C.C., and Jay, G. (1995). The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nature Genet. 9:21-30.
    • (1995) Nature Genet. , vol.9 , pp. 21-30
    • LaFerla, F.M.1    Tinkle, B.T.2    Bieberich, C.J.3    Haudenschild, C.C.4    Jay, G.5
  • 62
    • 0029056516 scopus 로고
    • Cell death induced by β-amyloid 1-40 in MES 23.5 hybrid clone: The role of nitric oxide and NMDA-gated channel activation leading to apoptosis
    • Le, W.D., Colom, L.V., Wie, W.J., Smith, R.G., Alexianu, M., and Appel, S.H. (1995). Cell death induced by β-amyloid 1-40 in MES 23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosis. Brain Res. 686:49-60.
    • (1995) Brain Res. , vol.686 , pp. 49-60
    • Le, W.D.1    Colom, L.V.2    Wie, W.J.3    Smith, R.G.4    Alexianu, M.5    Appel, S.H.6
  • 63
    • 0028797783 scopus 로고
    • Identification and characterization of a spinal muscular atrophy-determining gene
    • Lefebvre, S., Burglen, L., Reboullet, S., Clermont, O., Burlet, P., Viollet, L. et al. (1995). Identification and characterization of a spinal muscular atrophy-determining gene. Cell 80:155-165.
    • (1995) Cell , vol.80 , pp. 155-165
    • Lefebvre, S.1    Burglen, L.2    Reboullet, S.3    Clermont, O.4    Burlet, P.5    Viollet, L.6
  • 64
    • 0031816414 scopus 로고    scopus 로고
    • Apoptosis, excitotoxicity, and neuropathology
    • Leist, M., and Nicotera, P. (1998). Apoptosis, excitotoxicity, and neuropathology. Exp. Cell Res. 239:183-201.
    • (1998) Exp. Cell Res. , vol.239 , pp. 183-201
    • Leist, M.1    Nicotera, P.2
  • 65
    • 16044365171 scopus 로고    scopus 로고
    • The E280A presenilin l Alzheimer mutation produces increase Aβ42 deposition and severe cerebellar pathology
    • Lemere, C.A., Lopera, F., Kosik, K.S., Lendon, C.L., Ossa, J., Saido, T.C. et al. (1996). The E280A presenilin l Alzheimer mutation produces increase Aβ42 deposition and severe cerebellar pathology. Nature Med. 2:1146-1150.
    • (1996) Nature Med. , vol.2 , pp. 1146-1150
    • Lemere, C.A.1    Lopera, F.2    Kosik, K.S.3    Lendon, C.L.4    Ossa, J.5    Saido, T.C.6
  • 66
    • 0025732732 scopus 로고
    • Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli
    • Lennon, S.V., Martin, S.J., and Cotter, T.G. (1991). Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli. Cell Prolif. 24:203-214.
    • (1991) Cell Prolif. , vol.24 , pp. 203-214
    • Lennon, S.V.1    Martin, S.J.2    Cotter, T.G.3
  • 67
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • Lipton, S.A., and Rosenberg, P.A. (1994). Excitatory amino acids as a final common pathway for neurologic disorders. New Eng. J. Med. 330:613-622.
    • (1994) New Eng. J. Med. , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 68
    • 13344278692 scopus 로고    scopus 로고
    • Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
    • Liston, P., Roy, N., Tamai, K., Lefebvre, C., Baird, S., Cherton-Horvat, G. et al. (1996). Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 379:349-353.
    • (1996) Nature , vol.379 , pp. 349-353
    • Liston, P.1    Roy, N.2    Tamai, K.3    Lefebvre, C.4    Baird, S.5    Cherton-Horvat, G.6
  • 69
    • 0000601446 scopus 로고    scopus 로고
    • Life and death decisions: The role of the IAPS in modulating programmed cell death
    • Liston, P., Young, S.S., Mackenzie, A.E., and Korneluk, R.G. (1997). Life and death decisions: the role of the IAPS in modulating programmed cell death. Apoptosis 2:423-441.
    • (1997) Apoptosis , vol.2 , pp. 423-441
    • Liston, P.1    Young, S.S.2    Mackenzie, A.E.3    Korneluk, R.G.4
  • 70
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptosis program in cell-free extracts: Requirement for dATPand cytochrome c
    • Liu, X., Kim, C.N., Yang, J., Jemmerson, R., and Wang, X. (1996). Induction of apoptosis program in cell-free extracts: requirement for dATPand cytochrome c. Cell 86:147-157.
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 72
    • 0028891783 scopus 로고
    • Apoptosis, oncosis, and necrosis. An overview of cell death
    • Majno, G., and Joris, I. (1995). Apoptosis, oncosis, and necrosis. An overview of cell death. Am. J. Pathol. 146:3-15.
    • (1995) Am. J. Pathol. , vol.146 , pp. 3-15
    • Majno, G.1    Joris, I.2
  • 73
    • 0023851503 scopus 로고
    • Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation
    • Martin, D.P., Schmidt, R.E., DiStefano, P. S., Lowry, O.H., Carter, J.G., and Johnson, E.M.Jr. (1988). Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J. Cell Biol. 106:829-844.
    • (1988) J. Cell Biol. , vol.106 , pp. 829-844
    • Martin, D.P.1    Schmidt, R.E.2    DiStefano, P.S.3    Lowry, O.H.4    Carter, J.G.5    Johnson Jr., E.M.6
  • 74
    • 0025185463 scopus 로고
    • Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis
    • Martin, S.J., Lennon, S.V., Bonham, A.M., and Cotter, T.G. (1990). Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis. J. Immunol. 145:1859-1867.
    • (1990) J. Immunol. , vol.145 , pp. 1859-1867
    • Martin, S.J.1    Lennon, S.V.2    Bonham, A.M.3    Cotter, T.G.4
  • 75
    • 0027516430 scopus 로고
    • Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts
    • Martin, S.J. (1993). Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts. Immuno. Lett. 35:125-134.
    • (1993) Immuno. Lett. , vol.35 , pp. 125-134
    • Martin, S.J.1
  • 76
    • 0029125701 scopus 로고
    • Protease activation during apoptosis: Death by a thousand cuts?
    • Martin, S.J., and Green, D.R. (1995). Protease activation during apoptosis: death by a thousand cuts? Cell 82:349-352.
    • (1995) Cell , vol.82 , pp. 349-352
    • Martin, S.J.1    Green, D.R.2
  • 77
    • 0029813177 scopus 로고    scopus 로고
    • Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F β-amyloid precursor protein and Alzheimer's disease
    • Masliah, E., Sisk, A., Mallory, M., Mucke, L., Schenk, D., and Games, D. (1996). Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F β-amyloid precursor protein and Alzheimer's disease. J. Neurosci. 16:5795-5811.
    • (1996) J. Neurosci. , vol.16 , pp. 5795-5811
    • Masliah, E.1    Sisk, A.2    Mallory, M.3    Mucke, L.4    Schenk, D.5    Games, D.6
  • 78
    • 0026570528 scopus 로고
    • β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
    • Mattson, M.P., Cheng, B., Davis, D., Bryant, K., Lieberburg, I., and Rydel, R.E. (1992). β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12:376-389.
    • (1992) J. Neurosci. , vol.12 , pp. 376-389
    • Mattson, M.P.1    Cheng, B.2    Davis, D.3    Bryant, K.4    Lieberburg, I.5    Rydel, R.E.6
  • 79
    • 0032007328 scopus 로고    scopus 로고
    • Modification of ion homeostasis by lipid peroxidation: Role in neuronal degeneration and adaptive plasticity
    • Mattson, M.P. (1998). Modification of ion homeostasis by lipid peroxidation: role in neuronal degeneration and adaptive plasticity. Trends in Neurol. Sci. 21:53-57.
    • (1998) Trends in Neurol. Sci. , vol.21 , pp. 53-57
    • Mattson, M.P.1
  • 80
    • 0031982670 scopus 로고    scopus 로고
    • Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease
    • Mattson, M.P., Guo, Q., Katsutoshi, F., and Pedersen, W.A. (1998). Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. J. Neurochem. 70:1-14.
    • (1998) J. Neurochem. , vol.70 , pp. 1-14
    • Mattson, M.P.1    Guo, Q.2    Katsutoshi, F.3    Pedersen, W.A.4
  • 81
    • 0027366138 scopus 로고
    • Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy
    • Mhatre, A.N., Trifiro, M.A., Kaufman, M., Kazemi-Esfarjani, P., Figlewicz, D., Rouleau, G., and Pinsky, L. (1993). Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy. Nature Genet.5:184-188.
    • (1993) Nature Genet. , vol.5 , pp. 184-188
    • Mhatre, A.N.1    Trifiro, M.A.2    Kaufman, M.3    Kazemi-Esfarjani, P.4    Figlewicz, D.5    Rouleau, G.6    Pinsky, L.7
  • 83
    • 0023243019 scopus 로고
    • Inhibition of ATP synthesis by 1-methyl-4-phenylpyridinium (MPP+) in isolated mitochondrial from mouse brain
    • Mizuno, Y., Suzuki, K., Sone, N., and Saitoh, T. (1987). Inhibition of ATP synthesis by 1-methyl-4-phenylpyridinium (MPP+) in isolated mitochondrial from mouse brain. Neurosci. Lett. 81:204-208.
    • (1987) Neurosci. Lett. , vol.81 , pp. 204-208
    • Mizuno, Y.1    Suzuki, K.2    Sone, N.3    Saitoh, T.4
  • 84
    • 0029942337 scopus 로고    scopus 로고
    • Histochemical detection of apoptosis in Parkinson's disease
    • Mochizuki, H., Goto, K., Mori, H., and Mizuno, Y. (1996). Histochemical detection of apoptosis in Parkinson's disease. J. Neurol. Sci. 137:120-123.
    • (1996) J. Neurol. Sci. , vol.137 , pp. 120-123
    • Mochizuki, H.1    Goto, K.2    Mori, H.3    Mizuno, Y.4
  • 85
    • 0029787513 scopus 로고    scopus 로고
    • Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons
    • Mu, X., He, J., Anderson, D.W. Trojanowski, J.Q., and Springer, J.E. (1996). Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons. Ann. Neurol. 40:379-386.
    • (1996) Ann. Neurol. , vol.40 , pp. 379-386
    • Mu, X.1    He, J.2    Anderson, D.W.3    Trojanowski, J.Q.4    Springer, J.E.5
  • 86
    • 0029055717 scopus 로고
    • Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
    • Nasir, J., Floresco, S.B., O'Kusky, J.R., Diewert, V.M., Richman, J.M., Zeisler, J. et al. (1995). Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell 81:811-823.
    • (1995) Cell , vol.81 , pp. 811-823
    • Nasir, J.1    Floresco, S.B.2    O'Kusky, J.R.3    Diewert, V.M.4    Richman, J.M.5    Zeisler, J.6
  • 88
    • 0027496238 scopus 로고
    • A radical hypothesis for neurodegeneration
    • Olanow, C.W. (1993). A radical hypothesis for neurodegeneration. Trends Neurosci. 16:439-444.
    • (1993) Trends Neurosci. , vol.16 , pp. 439-444
    • Olanow, C.W.1
  • 89
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai, Z.N., Milliman, C.L., and Korsmeyer, J.S. (1993). Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, J.S.3
  • 91
    • 0029860523 scopus 로고    scopus 로고
    • Amyloid β peptide of Alzheimer's disease downregulates Bcl-2 and upregulates Bax expression in human neurons
    • Paradis, E., Douillard, H., Koutroumanis, M., Goodyer, C., and LeBlanc, A. (1996). Amyloid β peptide of Alzheimer's disease downregulates Bcl-2 and upregulates Bax expression in human neurons. J. Neurosci. 16:7533-7539.
    • (1996) J. Neurosci. , vol.16 , pp. 7533-7539
    • Paradis, E.1    Douillard, H.2    Koutroumanis, M.3    Goodyer, C.4    LeBlanc, A.5
  • 92
    • 0030936575 scopus 로고    scopus 로고
    • Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain
    • Paulson, H.L., Das, S.S., Crino, P.B., Perez, M.K., Patel, S.C., Gotsdiner, D. et al. (1997a). Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain. Ann. Neurol. 41: 453-462.
    • (1997) Ann. Neurol. , vol.41 , pp. 453-462
    • Paulson, H.L.1    Das, S.S.2    Crino, P.B.3    Perez, M.K.4    Patel, S.C.5    Gotsdiner, D.6
  • 93
    • 0030850412 scopus 로고    scopus 로고
    • Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3
    • Paulson, H.L., Perez, M.K., Trottier, Y., Trojanowski, J.Q., Subramony, S.H., Das, S.S. et al. (1997b). Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3. Neuron 19:333-344.
    • (1997) Neuron , vol.19 , pp. 333-344
    • Paulson, H.L.1    Perez, M.K.2    Trottier, Y.3    Trojanowski, J.Q.4    Subramony, S.H.5    Das, S.S.6
  • 94
    • 0028283985 scopus 로고
    • Glutamine repeats as polar zippers: Their possible role in inherited neurodegenerative diseases
    • Perutz, M.F., Johnson, T., Suzuki, M., and Finch, J.T. (1994). Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases. Proc. Natl. Acad. Sci. USA 91:5355-5358.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5355-5358
    • Perutz, M.F.1    Johnson, T.2    Suzuki, M.3    Finch, J.T.4
  • 95
    • 0029072690 scopus 로고
    • Evidence for apoptotic cell death in Huntington disease and excitoxic animal models
    • Portera-Cailliau, C., Hedreen, J.C., Price, D.L., and Koliatsos, V.E. (1995). Evidence for apoptotic cell death in Huntington disease and excitoxic animal models. J. Neurosci. 15:3775-3787.
    • (1995) J. Neurosci. , vol.15 , pp. 3775-3787
    • Portera-Cailliau, C.1    Hedreen, J.C.2    Price, D.L.3    Koliatsos, V.E.4
  • 96
    • 0027996904 scopus 로고
    • Expression of the low-affinity nerve growth factor receptor enhances β-amyloid peptide toxicity
    • Rabizadeh, S., Bitler, C.M., Butcher, L.L., and Bredesen, D.E. (1994). Expression of the low-affinity nerve growth factor receptor enhances β-amyloid peptide toxicity. Proc. Natl. Acad. Sci. USA 91:10,703-10,706
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10703-10706
    • Rabizadeh, S.1    Bitler, C.M.2    Butcher, L.L.3    Bredesen, D.E.4
  • 97
    • 0028915976 scopus 로고
    • Mutations associated with amyotrophic lateral sclerosis convert Superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: Studies in yeast and neural cells
    • Rabizadeh, S., Gralla, E.B., Borchelt, D.R., Gwinn, R., Valentine, J.S., Sisodia, S. et al. (1995). Mutations associated with amyotrophic lateral sclerosis convert Superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proc. Natl. Acad. Sci. USA 92:3024-3028.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3024-3028
    • Rabizadeh, S.1    Gralla, E.B.2    Borchelt, D.R.3    Gwinn, R.4    Valentine, J.S.5    Sisodia, S.6
  • 98
    • 0026504147 scopus 로고
    • Social controls on cell survival and cell death
    • Raff, M.C. (1992). Social controls on cell survival and cell death. Nature 356:397-400.
    • (1992) Nature , vol.356 , pp. 397-400
    • Raff, M.C.1
  • 99
    • 0028095981 scopus 로고
    • Oxidative stress induces apoptosis in embryonic cortical neurons
    • Ratan, R.R., Murphy, T.H., and Baraban, J.M. (1994). Oxidative stress induces apoptosis in embryonic cortical neurons. J. Neurochem. 62:376-379.
    • (1994) J. Neurochem. , vol.62 , pp. 376-379
    • Ratan, R.R.1    Murphy, T.H.2    Baraban, J.M.3
  • 100
    • 0027374047 scopus 로고
    • Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
    • Rebeck, G.W., Reiter, J.S., Strickland, D.K., and Hyman, B.T. (1993). Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron 11:575-580.
    • (1993) Neuron , vol.11 , pp. 575-580
    • Rebeck, G.W.1    Reiter, J.S.2    Strickland, D.K.3    Hyman, B.T.4
  • 101
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • Rosen, D.R., Siddique, T., Patterson, D., Figlewicz, D.A., Sapp, P., Hentati, A. et al. (1993). Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362:59-62.
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1    Siddique, T.2    Patterson, D.3    Figlewicz, D.A.4    Sapp, P.5    Hentati, A.6
  • 102
    • 0029030610 scopus 로고
    • Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
    • Rothstein, J.F., Van Kammen, M., Levey, A.I., Martin, L.J., and Kuncl, R.W. (1995). Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann. Neurol. 38:73-84.
    • (1995) Ann. Neurol. , vol.38 , pp. 73-84
    • Rothstein, J.F.1    Van Kammen, M.2    Levey, A.I.3    Martin, L.J.4    Kuncl, R.W.5
  • 103
    • 0028896092 scopus 로고
    • The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy
    • Roy, N., Mahadevan, M.S., McLean, M., Shutler, G., Yaraghi, Z., Farahani, R. et al. (1995). The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell 80:167-178.
    • (1995) Cell , vol.80 , pp. 167-178
    • Roy, N.1    Mahadevan, M.S.2    McLean, M.3    Shutler, G.4    Yaraghi, Z.5    Farahani, R.6
  • 104
    • 0031889132 scopus 로고    scopus 로고
    • Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
    • Sakahira, H., Enari, M., and Nagata, S. (1998). Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391:96-99.
    • (1998) Nature , vol.391 , pp. 96-99
    • Sakahira, H.1    Enari, M.2    Nagata, S.3
  • 105
    • 0031884393 scopus 로고    scopus 로고
    • Apoptosis in neurological diseases
    • Savitz, S.I., and Rosenbaum, D.M. (1998). Apoptosis in neurological diseases. Neurosurgery 42:555-574.
    • (1998) Neurosurgery , vol.42 , pp. 555-574
    • Savitz, S.I.1    Rosenbaum, D.M.2
  • 106
    • 0027365822 scopus 로고
    • Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
    • Schmechel, D.E., Saunders, A.M., Strittmatter, W.J., Crain, B.J., Hulette, C.M., Joo, S.H. et al. (1993). Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA 90:9649-9653.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9649-9653
    • Schmechel, D.E.1    Saunders, A.M.2    Strittmatter, W.J.3    Crain, B.J.4    Hulette, C.M.5    Joo, S.H.6
  • 107
    • 0030931720 scopus 로고    scopus 로고
    • Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos
    • Schrank, B., Gotz, R., Gunnersen, J.M., Ure, J.M., Toyka, K.V., Smith, A.G., and Sendtner M. (1997). Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos. Proc. Natl. Acad. Sci. USA 94:9920-9925.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9920-9925
    • Schrank, B.1    Gotz, R.2    Gunnersen, J.M.3    Ure, J.M.4    Toyka, K.V.5    Smith, A.G.6    Sendtner, M.7
  • 109
    • 12044254746 scopus 로고
    • Binding of human apolipoprotein E to synthetic amyloid beta peptide: Isoform-specific effects and implications for late-onset Alzheimer disease
    • Strittmatter, W.J., Weisgraber, K.H., Huang, D.Y., Dong, L.M., Salvesen, G.S., Pericak-Vance, M. et al. (1993). Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA 90:8098-8102.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8098-8102
    • Strittmatter, W.J.1    Weisgraber, K.H.2    Huang, D.Y.3    Dong, L.M.4    Salvesen, G.S.5    Pericak-Vance, M.6
  • 111
    • 0028577208 scopus 로고
    • Immunohistochemical evidence for apoptosis in Alzheimer's disease
    • Su, J.H., Anderson, A.J., Cummings, B.J., and Cotman, C.W. (1994). Immunohistochemical evidence for apoptosis in Alzheimer's disease. NeuroReport 5:2529-2533.
    • (1994) NeuroReport , vol.5 , pp. 2529-2533
    • Su, J.H.1    Anderson, A.J.2    Cummings, B.J.3    Cotman, C.W.4
  • 112
    • 0030638139 scopus 로고    scopus 로고
    • Bax protein expression is increased in Alzheimer's brain: Correlations with DNA damage, Bcl-2 expression and brain pathology
    • Su, J.H., Deng, G., and Cotman, C.W. (1997). Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression and brain pathology. J. Neuropathol. Exp. Neurol. 56:86-93.
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 86-93
    • Su, J.H.1    Deng, G.2    Cotman, C.W.3
  • 113
    • 0030888286 scopus 로고    scopus 로고
    • In situ detection of apoptotic nuclei in the substantia nigra compacta of MPTP-treated mice using TdT labeling and acridine orange staining
    • Tatton, N.A., and Kish, S.J. (1997). In situ detection of apoptotic nuclei in the substantia nigra compacta of MPTP-treated mice using TdT labeling and acridine orange staining. Neurosci. 77:1037-1048.
    • (1997) Neurosci. , vol.77 , pp. 1037-1048
    • Tatton, N.A.1    Kish, S.J.2
  • 115
    • 0027339397 scopus 로고
    • Apoptosis in C3H/10T1/2 mouse embryonic cells: Evidence for internucleosomal DNA modification in the absence of double-strand cleavage
    • Tomei, L.D., Shapiro, J.P., and Cope, F.O. (1992). Apoptosis in C3H/10T1/2 mouse embryonic cells: evidence for internucleosomal DNA modification in the absence of double-strand cleavage. Proc. Natl. Acad. Sci. USA 90:853-857.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 853-857
    • Tomei, L.D.1    Shapiro, J.P.2    Cope, F.O.3
  • 116
    • 0031013141 scopus 로고    scopus 로고
    • Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons
    • Tompkins, MM., Basgall, E.J., Zamrini, E., and Hill, W.D. (1997). Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons. Am. J. Pathol. 150:119-131.
    • (1997) Am. J. Pathol. , vol.150 , pp. 119-131
    • Tompkins, M.M.1    Basgall, E.J.2    Zamrini, E.3    Hill, W.D.4
  • 117
    • 0029852587 scopus 로고    scopus 로고
    • In situ labeling of dying cortical neurons in normal aging and in Alzheimer's disease: Correlations with senile plaques and disease progression
    • Troncoso, J.C., Sukhov, R.R., Kawas, C.H., and Koliatsos, V.E. (1996). In situ labeling of dying cortical neurons in normal aging and in Alzheimer's disease: correlations with senile plaques and disease progression. J. Neuropathol. Exp. Med. 55:1134-1142.
    • (1996) J. Neuropathol. Exp. Med. , vol.55 , pp. 1134-1142
    • Troncoso, J.C.1    Sukhov, R.R.2    Kawas, C.H.3    Koliatsos, V.E.4
  • 118
    • 0027535559 scopus 로고
    • Toward an understanding of the molecular mechanisms of physiological cell death
    • Vaux, D.L. (1993). Toward an understanding of the molecular mechanisms of physiological cell death. Proc. Nad. Acad. Sci. USA 90:786-789.
    • (1993) Proc. Nad. Acad. Sci. USA , vol.90 , pp. 786-789
    • Vaux, D.L.1
  • 119
    • 0028127058 scopus 로고
    • Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis
    • Walkinshaw, G., and Waters, C.M. (1994). Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis. Neurosci. 63:975-987.
    • (1994) Neurosci. , vol.63 , pp. 975-987
    • Walkinshaw, G.1    Waters, C.M.2
  • 120
    • 0030046508 scopus 로고    scopus 로고
    • Life, death, and the pursuit of apoptosis
    • White, E. (1996). Life, death, and the pursuit of apoptosis. Genes & Dev. 10:1-15.
    • (1996) Genes & Dev. , vol.10 , pp. 1-15
    • White, E.1
  • 121
    • 0029671220 scopus 로고    scopus 로고
    • Altered reactivity of Superoxide dismutase in familial amyotrophic lateral sclerosis
    • Wiedau-Pazos, M., Goto, J.J., Rabizadeh, S., Gralla, E.B., Roe, J.A., Lee, M.K. et al. (1996). Altered reactivity of Superoxide dismutase in familial amyotrophic lateral sclerosis. Science 271:515-518.
    • (1996) Science , vol.271 , pp. 515-518
    • Wiedau-Pazos, M.1    Goto, J.J.2    Rabizadeh, S.3    Gralla, E.B.4    Roe, J.A.5    Lee, M.K.6
  • 124
    • 10544224542 scopus 로고    scopus 로고
    • Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
    • Wolozin, B., Iwasaki, K., Vito, P, Ganjei, J.K., Lacan, E., Sunderland, T. et al. (1996). Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science 274:1710-1713.
    • (1996) Science , vol.274 , pp. 1710-1713
    • Wolozin, B.1    Iwasaki, K.2    Vito, P.3    Ganjei, J.K.4    Lacan, E.5    Sunderland, T.6
  • 125
    • 0029053881 scopus 로고
    • An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
    • Won, P.C., Pardo, C.A., Borchelt, D.R., Lee, M.K., Copeland, N.G., Jenkins N.A. et al. (1995). An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria Neuron 14:1105-1116.
    • (1995) Neuron , vol.14 , pp. 1105-1116
    • Won, P.C.1    Pardo, C.A.2    Borchelt, D.R.3    Lee, M.K.4    Copeland, N.G.5    Jenkins, N.A.6
  • 126
    • 0018830636 scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
    • Wyllie, A.H. (1980). Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284:555-556 .
    • (1980) Nature , vol.284 , pp. 555-556
    • Wyllie, A.H.1
  • 127
    • 0021346318 scopus 로고
    • Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis
    • Wyllie, A.H., Morris, R.G., Smith, A.L., and Dunlop, D. (1984). Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J. Pathol. 142:67-77.
    • (1984) J. Pathol. , vol.142 , pp. 67-77
    • Wyllie, A.H.1    Morris, R.G.2    Smith, A.L.3    Dunlop, D.4
  • 128
    • 0031036872 scopus 로고    scopus 로고
    • Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
    • Yang, J., Liu, X., Bhalla, K., Kim, C.N., Ibrado, A.M., Cai, J. et al. (1997). Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275:1129-1132.
    • (1997) Science , vol.275 , pp. 1129-1132
    • Yang, J.1    Liu, X.2    Bhalla, K.3    Kim, C.N.4    Ibrado, A.M.5    Cai, J.6
  • 129
    • 0028206341 scopus 로고
    • BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
    • Yin, X.-M., Oltvai, Z.N., and Korsmeyer, S.J. (1994). BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 369:321-323.
    • (1994) Nature , vol.369 , pp. 321-323
    • Yin, X.-M.1    Oltvai, Z.N.2    Korsmeyer, S.J.3
  • 130
    • 0026448963 scopus 로고
    • The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death
    • Yuan, J., and Horvitz, H.R. (1992). The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development 116:309-320.
    • (1992) Development , vol.116 , pp. 309-320
    • Yuan, J.1    Horvitz, H.R.2
  • 131
    • 0027525104 scopus 로고
    • The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
    • Yuan, J., Shaham, S., Ledoux, S, Ellis, H.M., and Horvitz, H.R. (1993). The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75:641-652.
    • (1993) Cell , vol.75 , pp. 641-652
    • Yuan, J.1    Shaham, S.2    Ledoux, S.3    Ellis, H.M.4    Horvitz, H.R.5
  • 132
    • 0030848374 scopus 로고    scopus 로고
    • Mitochondrial implication in accidental and programmed cell death: Apoptosis and necrosis
    • Zamzami, N., Hirsch, T., Dallaporta, B., Petit, P.X., and Kroemer, G. (1997). Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis. J. Bioenerg. &Biomemb.29:185-193.
    • (1997) J. Bioenerg. &Biomemb. , vol.29 , pp. 185-193
    • Zamzami, N.1    Hirsch, T.2    Dallaporta, B.3    Petit, P.X.4    Kroemer, G.5
  • 133
    • 84993912315 scopus 로고
    • Increased apoptosis and arly embryonic lethality in mice nullizygous for the Huntington's disease gene homologue
    • Zeitlin, S., Liu, J.-P., Chapman, D.L., Papaioannou, V.E., and Efstratiadis, A. (1995). Increased apoptosis and arly embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nature Genet. 11:155-163.
    • (1995) Nature Genet. , vol.11 , pp. 155-163
    • Zeitlin, S.1    Liu, J.-P.2    Chapman, D.L.3    Papaioannou, V.E.4    Efstratiadis, A.5
  • 134
    • 0031034226 scopus 로고    scopus 로고
    • Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells
    • Zhao, B., Chrest, F.J., Horton, Jr. W.E., Sisodia, S.S., and Kusiak, J.W. (1997). Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells. J. Neurosci. Res. 47:253-263.
    • (1997) J. Neurosci. Res. , vol.47 , pp. 253-263
    • Zhao, B.1    Chrest, F.J.2    Horton Jr., W.E.3    Sisodia, S.S.4    Kusiak, J.W.5
  • 135
    • 0030612211 scopus 로고    scopus 로고
    • Modulation of control mechanisms of dopamine-induced apoptosis-a future approach to the treatment of Parkinson's disease
    • Ziv, I., Offen, D., Barzilai, A., Haviv, R., Stein, R., Zilkhafalb, R. et al. (1997). Modulation of control mechanisms of dopamine-induced apoptosis-a future approach to the treatment of Parkinson's disease. J. Neural Transm. 849:195-202.
    • (1997) J. Neural Transm. , vol.849 , pp. 195-202
    • Ziv, I.1    Offen, D.2    Barzilai, A.3    Haviv, R.4    Stein, R.5    Zilkhafalb, R.6
  • 136
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4 participates in cytochrome c-dependent activation of caspase-3
    • Zou, H., Henzel, W.J., Liu, X., Lutschg, A., and Wang, X. (1997). Apaf-1, a human protein homologous to C. elegans CED-4 participates in cytochrome c-dependent activation of caspase-3. Cell 90:405-413.
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.