Expansion of CD7low and CD7negative CD8 T-cell effector subsets in HIV-1 infection: Correlation with antigenic load and reversion by antiretroviral treatment

Blood

Volumn 104, Issue 12, 2004, Pages 3672-3678

  Aandahl, Einar M ^b   Quigley, Máire F ^b   Moretto, Walter J ^b   Moll, Markus ^b   Gonzalez, Veronica D ^b   Sönnerborg, Anders ^b   Lindbäck, Stefan ^b   Hecht, Frederick M ^b   Deeks, Steven G ^b   Rosenberg, Michael G ^b   Nixon, Douglas F ^b   Sandberg, Johan K ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD7 ANTIGEN; CD8 ANTIGEN;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CELL DEATH; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOMEGALOVIRUS; DISEASE COURSE; DOWN REGULATION; EFFECTOR CELL; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEMORY CELL; PRIORITY JOURNAL; T LYMPHOCYTE; TREATMENT OUTCOME; VIRUS LOAD;

EID: 9444295329     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-07-2540     Document Type: Article

References (55)

1. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 1994;68:6103-6110.
2. Koup RA, Safrit JT, Cao Y, et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 1994;68:4650-4655.
3. Musey L, Hughes J, Schacker T, Shea T, Corey L, McElrath MJ. Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection. N Engl J Med. 1997;337:1267-1274.
4. Johnson WE, Desrosiers RC. Viral persistence: HIVs strategies of immune system evasion. Annu Rev Med. 2002;53:499-518.
5. Gandhi RT, Walker BD. Immunologic control of HIV-1. Annu Rev Med. 2002;53:149-172.
6. + T-cell depletion in HIV disease. Nature. 2001;410:974-979.
7. + T cells go out of stock. Nat Immunol. 2000;1:285-289.
8. + T cells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002;8:379-385.
9. Champagne P, Ogg GS, King AS, et al. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature. 2001;410:106-111.
10. + T cells. J Immunol. 2002;169:5838-5843.
11. + T cells. J Immunol. 2002;168:4184-4191.
12. Hislop AD, Annels NE, Gudgeon NH, Leese AM, Rickinson AB. Epitope-specific evolution of human CD8(+) T cell responses from primary to persistent phases of Epstein-Barr virus infection. J Exp Med. 2002;195:893-905.
13. Wills MR, Okecha G, Weekes MP, Gandhi MK, Sissons PJ, Carmichael AJ. Identification of naive or antigen-experienced human CD8(+) T cells by expression of costimulation and chemokine receptors: analysis of the human cytomegalovirus-specific CD8(+) T cell response. J Immunol. 2002;168:5455-5464.
14. - memory T cells do not differ in immediate effector cell function. J Immunol. 2002;169:638-641.
15. + memory cells in humans defined by HLA and CC chemokine ligand 19 tetramers. J Immunol. 2003;170:2461-2468.
16. Zhang D, Shankar P, Xu Z, et al. Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic. Blood. 2003;101:226-235.
17. + lymphocyte percent a useful immunological marker for monitoring HIV-1-infected patients. J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14:158-152.
18. Giorgi JV, Hultin LE, McKeating JA, et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis. 1999;179:859-870.
19. + T cells. Blood. 2003;101:2711-2720.
20. + T cell changes independent of viral load. Blood. 2004;104:952-947.
21. Hazenberg MD, Otto SA, van Benthem BH, et al. Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS. 2003;17:1881-1888.
22. Gruters RA, Terpstra FG, De Goede RE, et al. Immunological and virological markers in individuals progressing from seroconversion to AIDS. AIDS. 1991;5:837-844.
23. - cells. AIDS. 1996;10:104-106.
24. Aandahl EM, Sandberg JK, Beckerman KP, Tasken K, Moretto WJ, Nixon DF. CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets. J Immunol. 2003;170:2349-2355.
25. Lobach DF, Hensley LL, Ho W, Haynes BF. Human T cell antigen expression during the early stages of fetal thymic maturation. J Immunol. 1985;135:1752-1759.
26. Sempowski GD, Lee DM, Kaufman RE, Haynes BF. Structure and function of the CD7 molecule. Grit Rev Immunol. 1999;19:331-348.
27. Lyman SD, Escobar S, Rousseau AM, Armstrong A, Fanslow WC. Identification of CD7 as a cognate of the human K12 (SECTM1) protein. J Biol Chem. 2000;275:3431-3437.
28. Stillwell R, Bierer BE. T cell signal transduction and the role of CD7 in costimulation. Immunol Res. 2001;24:31-52.
29. Ward SG, Parry R, LeFeuvre C, Sansom DM, Westwick J, Lazarovits AI. Antibody ligation of CD7 leads to association with phosphoinositide 3-kinase and phosphatidylinositol 3,4,5-trisphosphate formation in T lymphocytes. Eur J Immunol. 1995;25:502-507.
30. Lee DM, Patel DD, Pendergast AM, Haynes BF. Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif. Int Immunol. 1996;8:1195-1203.
31. Chan AS, Mobley JL, Fields GB, Shimizu Y. CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation- dependent activation of phosphatidylinositol 3-kinase. J Immunol. 1997;159:934-942.
32. Pace KE, Hahn HP, Pang M, Nguyen JT, Baum LG. CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death. J Immunol. 2000;165:2331-2334.
33. Perillo NL, Pace KE, Seilhamer JJ, Baum LG. Apoptosis of T cells mediated by galectin-1. Nature. 1995;378:736-739.
34. Perillo NL, Uittenbogaart CH, Nguyen JT, Baum LG. Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes. J Exp Med. 1997;185:1851-1858.
35. Rabinovich GA, Baum LG, Tinari N, et al. Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response? Trends Immunol. 2002;23:313-320.
36. +CD7-leukemic T cells from patients with Sezary syndrome are protected from galectin-1-triggered T cell death. Leukemia. 2002;16:840-845.
37. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401708-712.
38. + T cells. J Exp Med. 1997;186:1407-1418.
39. Wherry EJ, Ahmed R. Memory CD8 T-cell differentiation during viral infection. J Virol. 2004;78:5535-5545.
40. Sandberg JK, Fast NM, Nixon DF. Functional heterogeneity of cytokines and cytolytic effector molecules in human cd8(+) T lymphocytes. J Immunol. 2001;167:181-187.
41. Wallace DL, Matear PM, Davies DC, et al. CD7 expression distinguishes subsets of CD4(+) T cells with distinct functional properties and ability to support replication of HIV-1. Eur J Immunol. 2000;30:577-585.
42. - T cells in HIV infection add to the prognostic value of low CD4 T cell levels and HIV-1-RNA quantification. AIDS. 2001;15:2459-2460.
43. - T helper cells from normal donors and HIV-infected patients. J Immunol. 1995;154:1408-1417.
44. + T cells: a new T-lymphocyte subset expanded during human immunodeficiency virus infection. Blood. 1992;79:1746-1753.
45. - lymphocyte subset is expanded in HIV-infected patients with low CD4 cell count rescue during highly active antiretroviral therapy. AIDS. 1999;13:621-622.
46. Shearer WT, Quinn TC, LaRussa P, et al. Viral load and disease progression in infants infected with human immunodeficiency virus type 1. Women and Infants Transmission Study Group. N Engl J Med. 1997;336:1337-1342.
47. Sandberg JK, Fast NM, Jordan KA, et al. HIV-specific CD8(+) T cell function in children with vertically acquired HIV-1 infection is critically influenced by age and the state of the CD4(+) T cell compartment. J Immunol. 2003;170:4403-4410.
48. Scott ZA, Chadwick EG, Gibson LL, et al. Infrequent detection of HIV-1-specific, but not cytomegalovirus-speciftc, CD8(+) T cell responses in young HIV-1-infected infants. J Immunol. 2001;167:7134-7140.
49. Spiegel HM, Chandwani R, Sheehy ME, et al. The impact of early initiation of highly active anti-retroviral therapy on the human immunodeficiency virus type 1-specific CD8 T cell response in children. J Infect Dis. 2000;182:88-95.
50. Chandwani R, Jordan KA, Shacklett BL, et al. Limited magnitude and breadth in the HLA-A2-restricted CD8 T-cell response to Nef in children with vertically acquired HIV-1 infection. Scand J Immunol. 2004;59:109-114.
51. Appay V, Nixon DF, Donahoe SM, et al. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J Exp Med. 2000;192:63-75.
52. + T cell proliferation is coupled to perforin expression and is maintained in non-progressors. Nat Immunol. 2002;3:1061-1068.
53. Gamadia LE, Rentenaar RJ, Baars PA, et al. Differentiation of cytomegalovirus-specific CD8(+) T cells in healthy and immunosuppressed virus carriers. Blood. 2001;98:754-761.
54. Appay V, Rowland-Jones SL. Premature ageing of the immune system: the cause of AIDS? Trends Immunol. 2002;23:580-585.
55. + T cell maturation state: potential implications for therapeutic immunization. J Infect Dis. 2003;187:364-374.