Galectins and their ligands: Amplifiers, silencers or tuners of the inflammatory response?

Trends in Immunology

Volumn 23, Issue 6, 2002, Pages 313-320

  Rabinovich, Gabriel A ^a   Baum, Linda G ^b   Tinari, Nicola ^c   Paganelli, Roberto ^c   Natoli, Clara ^c   Liu, Fu Tong ^d   Iacobelli, Stefano ^c  

^a HOSPITAL DE CLÍNICAS JOSÉ DE SAN MARTÍN   (Argentina)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CHIETI   (Italy)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CARBOHYDRATE BINDING PROTEIN; CYTOKINE; GALECTIN;

AMINO ACID SEQUENCE; BINDING AFFINITY; CELL GROWTH; CELL SURVIVAL; CHEMOTAXIS; CYTOKINE RELEASE; HOMEOSTASIS; HUMAN; IMMUNITY; IMMUNOCOMPETENT CELL; INFLAMMATION; METASTASIS; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TUMOR GROWTH;

AMINO SUGARS; ANIMALS; APOPTOSIS; AUTOIMMUNE DISEASES; CATTLE; CELL COMMUNICATION; CELL SURVIVAL; CHAGAS DISEASE; EXTRACELLULAR MATRIX; GALECTINS; HEMAGGLUTININS; HOMEOSTASIS; HUMANS; INFECTION; INFLAMMATION; LIGANDS; MAMMALS; MICE; MICE, INBRED DBA; MODELS, MOLECULAR; NEOPLASMS; POLYSACCHARIDES; PROTEIN CONFORMATION; PROTEIN ISOFORMS; T-LYMPHOCYTE SUBSETS;

EID: 0036606914     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(02)02232-9     Document Type: Review

References (82)

1. Selectins, T-cell rolling and inflammation
2. God must love galectins; He made so many of them
3. Galectins: An evolutionarily conserved family of animal lectins with multifunctional properties; A trip from the gene to clinical therapy
4. Galectins: A new family of regulators of inflammation
5. Isolation and characterization of a novel eosinophil-specific galectin released into the lungs in response to allergen challenge
6. The family of metazoan metal-independent β-galactoside-binding lectins: Structure, function and molecular evolution
7. Galectin-8: A complex sub-family of galectins
8. Galectin-1: Secretion and modulation of cell interactions with laminin
9. Plasma membrane targetting, vesicular budding and release of galectin-3 from the cytoplasm of mammalian cells during secretion
10. New alternatively spliced form of galectin-3, a member of beta-galactoside-binding animal lectin family, contains predicted transmembrane spanning domain and leucine zipper motif
11. Galectin-1: Oligomeric structure and interactions with polylactosamine
12. Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction
13. Identification of galectin-3 as a factor in pre-mRNA splicing
14. Expression of galectin-3 modulates T-cell growth and apoptosis
15. Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from mitochondria: A role for synexin in galectin-3 translocation
16. Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release
17. Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells
18. β-galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells
19. Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: Biochemical and functional characterization
20. Regulated expression of galectin-1 during B-cell activation and implications for T-cell apoptosis
21. Specific inhibition of lymphocyte proliferation and induction of apoptosis by CLL-I, a β-galactoside-binding lectin
22. Negative cell cycle control of human T cells by β-galactoside-binding protein (β GBP): Induction of programmed cell death in leukaemia cells
23. Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes
24. Apoptosis of T cells mediated by galectin-1
25. Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation
26. Molecular mechanisms implicated in galectin-1-induced apoptosis: Activation of the AP-1 transcription factor and downregulation of Bcl-2
27. Expression of a specific glycosyltransferase enzyme regulates T-cell death mediated by galectin-1
28. CD45 modulates galectin-1-induced T-cell death: Regulation by expression of core 2 O-glycans
29. Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1
30. CD7, delivers a pro-apoptotic signal during galectin-1-induced T-cell death
31. Regulation of CD45-signaling by galectin-1 in Burkitt lymphoma B cells
32. Involvement of CD2 and CD3 in galectin-1-induced signaling in human Jurkat T cells
33. Probing the cons and pros of lectin-induced immunomodulation: Case studies for the mistletoe lectin and galectin-1
34. Galectin-1 induces partial TCR ζ-chain phosphorylation and antagonizes processive TCR signal transduction
35. Stimulation of vascular cell proliferation by β-galactoside-binding lectins
36. Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells
37. Galectin-3 protects human breast carcinoma cells against nitric-oxide-induced apoptosis: Implication of galectin-3 function during metastasis
38. Galectin-3, anti-apoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family
39. Galectin-3 overexpression protects from cell damage and death by influencing mitochondrial homeostasis
40. Galectin-3 stimulates cell proliferation
41. Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses
42. Expression and function of galectin-3, a beta-galactoside-binding protein in activated T lymphocytes
43. Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
44. Glycosylation, immunity and autoimmunity
45. Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinotyes
46. Developmental regulated expression and apoptotic potential of galectin-9, a β-galactoside-binding lectin
47. Cell cycle regulation by galectin-12, a new member of the galectin superfamily
48. Specific inhibition of T-cell adhesion to extracellular matrix and pro-inflammatory cytokine secretion by human recombinant galectin-1
49. Galectin-3 promotes adhesion of human neutrophils to laminin
50. Lymphocyte triggering via L-selectin leads to enhanced galectin-3-mediated binding to dendritic cells
51. Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis
52. Phosphorylation of the beta-galactoside-binding protein galectin-3 modulates binding to its ligands
53. Galectin-3 phosphorylation is required for its anti-apoptotic function and cell cycle arrest
54. Recombinant human β-galactoside-binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis
55. Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T-cell apoptosis
56. Prevention and therapy with electrolectin of experimental autoimmune myasthenia gravis in rabbits
57. Galectin-1 exerts immunomodulatory and protective effects on concanavalin-A-induced hepatitis in mice
58. Expression of galectins-1 and -3 correlates with defective mononuclear cell apoptosis in patients with juvenile rheumatoid arthritis
59. Efficacy of galectins in the amelioration of nephrotoxic serum nephritis in Wistar Kyoto rats
60. Normal development of mice carrying a null mutation in the gene encoding the L-14 S-type lectin
61. Galectin-3 down-regulates IL-5 gene expression on different cell types
62. Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes
63. Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). Similarities to the Ig E binding protein and the S-type animal lectin superfamily
64. Evidence of a role for galectin-1 in acute inflammation
65. Galectin-3 activates the NADPH oxidase in exudated but not peripheral-blood neutrophils
66. A human lectin, galectin-3 (ε-BP/Mac-2) stimulates superoxide production by neutrophils
67. An endogenous lectin, galectin-3 (ε-BP/Mac-2) potentiates IL-1 production by human monocytes
68. Human galectin-3 is a novel chemoattractant for monocytes and macrophages
69. Maintenance of granulocyte numbers during acute peritonitis is defective in galectin-3-null mutant mice
70. The animal lectin galectin-3 interacts with bacterial lipopolysaccharides via two independent sites
71. LPS-dependent interaction of Mac-2-binding protein with immobilized CD14
72. Regulated expression and effect of galectin-1 on Trypanosoma-cruzi-infected macrophages: Modulation of microbicidal activity and survival
73. Anti-galectin-1 autoantibodies in human Trypanosoma cruzi infection: Differential expression of this β-galactoside-binding protein in cardiac Chagas' disease
74. Human T lymphotropic virus-I infection of human T lymphocytes induces expression of the β-galactoside-binding lectin, galectin-3
75. Human milk 90K (Mac-2 BP): Possible protective effects against acute respiratory infections
76. The role of galectin-3 in tumor metastasis
77. Laminin-binding lectins during invasion and metastasis
78. Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion
79. Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation
80. Effects of Thomsen-Friedenreich antigen-specific peptide P-30 on β-galactoside-mediated homotypic aggregation and adhesion to the endothelium of MDA-MB-435 human breast carcinoma cells
81. Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures
82. Concentrations of galectin-3 in the sera of normal controls and cancer patients