Viral load and disease progression in infants infected with human immunodeficiency virus type 1

New England Journal of Medicine

Volumn 336, Issue 19, 1997, Pages 1337-1342

  Shearer, William T ^a,l   Quinn, Thomas C ^b,c   Larussa, Philip ^d   Lew, Judy F ^c   Mofenson, Lynne ^e   Almy, Susan ^f   Rich, Kenneth ^g   Handelsman, Edward ^h   Diaz, Clemente ⁱ   Pagano, Marcello ^j   Smeriglio, Vincent ^k   Kalish, Leslie A ^f  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d New York State Psychiat Inst and New York Presbyterian Hospital Columbia University Medical Center   (United States)

^e EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^f NEW ENGLAND RESEARCH INSTITUTES   (United States)

^g UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^h SUNY DOWNSTATE MEDICAL CENTER   (United States)

ⁱ UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^j HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^k NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^l TEXAS CHILDREN S HOSPITAL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; VIRUS RNA; ZIDOVUDINE;

ARTICLE; DISEASE COURSE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; INTRAUTERINE INFECTION; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; PERINATAL INFECTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PUERPERAL INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; VIRUS CULTURE; VIRUS REPLICATION;

CHILD, PRESCHOOL; DISEASE PROGRESSION; DISEASE TRANSMISSION, VERTICAL; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INFANT; INFANT, NEWBORN; LONGITUDINAL STUDIES; MALE; RNA, VIRAL; VIRAL LOAD;

EID: 2442670578     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199705083361901     Document Type: Article

References (25)

1. De Rossi A, Masiero S, Giaquinto C, et al. Dynamics of viral replication in infants with vertically acquired human immunodeficiency virus type 1 infection. J Clin Invest 1996;97:323-30.
2. Palumbo PE, Kwok S, Waters S, et al. Viral measurement by polymerase chain react ion-based assays in human immunodeficiency virus-infected infants. J Pediatr 1995;126:592-5.
3. O'Brien TR, Blattner WA, Waters D, et al. Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study. JAMA 1996;276;105-10.
4. McIntosh K, Shevitz A, Zaknun D, et al. Age- and time-related changes in extracellular viral load in children vertically infected by human immunodeficiency virus. Pediatr Infect Dis J 1996;15:1087-91.
5. Mofenson LM, Korelitz J, Meyer WA III, et al. The relationship between serum HIV-1 RNA levels, CD4 lymphocyte percent, and long-term mortality risk in HIV-1-infected children. J Infect Dis (in press).
6. Dickover R, Kwok S, Wei L, Christoph erson C, Bryson Y. HFV RNA peak during primary viremia is a major determinant of clinical course in perinatally infected infants. In: Program and abstracts of the 3rd Conference on Retroviruses and Opportunistic Infections, Washington, D.C., January 28-February 1, 1996. Alexandria, Va.: Infectious Diseases Society of America, 1996:93. abstract.
7. Tetali S, Romano J, Than S, et al. Virus load as marker of disease progression in HlV-infected children. In: Program and abstracts of the 3rd Conference on Retroviruses and Opportunistic Infections, Washington, D.C., January 28-February 1, 1996. Alexandria, Va.: Infectious Diseases Society of America, 1996:99. abstract.
8. Abrams EJ, Weedon JC, Lambert G, Steketee R. HIV viral load early in life as a predictor of disease progression in HIV-infected infants. In: Vol. 2. Abstracts. XI International Conference on AIDS, Vancouver, B.C., July 7-12, 1996:25. abstract.
9. Mellors JW, Rinaldo CR Jr, Gupta P, White RM, Todd JA, Kingsley LA. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 1996;272:1167-70.
10. Mellors JW, Kingsley LA, Rinaldo CR Jr, et al. Quantitation of HfV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med 1995;122:573-9.
11. Jurriaans S, Van Gemen B, Weverling GJ, et al. The natural history of HIV-1 infection: virus load and virus phenotype independent determinants of clinical course? Virology 1994;204:223-33.
12. Henrard DR, Phillips JF, Muenz LR, et al. Natural history of HIV-1 cell-free viremia. JAMA 1995;274:554-8.
13. Ho DD. Viral counts in HIV infection. Science 1996;272:1124-5.
14. Hollinger FB, Bremer JW, Myers LE, Gold JWM, McQuay L, NIH/NIAID/DAIDS/ACTG Virology Laboratories. Standardization of sensitive human immunodeficiency virus coculture procedures and establishment of a multicenter quality assurance program for the AIDS Clinical Trials Group. J Clin Microbiol 1992;30:1787-94.
15. Landesman SH, Kalish LA, Burns DN, et al. Obstetrical factors and the transmission of human immunodeficiency virus type 1 from mother to child. N Engl J Med 1996;334:1617-23.
16. Bryson YJ, Luzuriaga K, Sullivan JL, Wara DW. Proposed definitions for in utero versus intrapartum transmission of HIV-1, N Engl J Med 1992;327:1246-7.
17. 1994 Revised classification system for human immunodeficiency virus infection in children less than 13 years of age. MMWR Morb Mortal Wkly Rep 1994;43(RR-12):1-10.1
18. McIntosh K, Pitt J, Brambilla D, et al. Blood culture in the first 6 months of life for the diagnosis of vertically transmitted human immunodeficiency virus infection. J Infect Dis 1994;170:996-1000.
19. Boom R, Sol CJ, Salimans MM, Jansen CL, Wertheim-van Dillen PM, van der Noordaa J. Rapid and simple method for purification of nucleic acids. J Clin Microbiol 1990;28:495-503.
20. Dickover RE, Garratty EM, Herman SA, et al. Identification of levels of maternal HIV-1 RNA associated with risk of perinatal transmission: effect of maternal zidovudine treatment on viral load. JAMA 1996;275:599-605.
21. Zar JH. Biostatistical analysis. 2nd ed. Englewood Cliffs, N.J.: Prentice-Hall, 1974:390.
22. Rosner B. Fundamentals of biostatistics. 3rd ed. Boston: PWS-Kent Publishing, 1990:304-9.
23. Kaplan E, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
24. Peto R, Peto J. Asymptotically efficient rank invariant test procedures. J R Stat Soc [A] 1972;135:185-206.
25. Conway B, Alien U, Lapointe N, et al. HIV viremia in relation to clinical and laboratory correlates among HIV-infected children. In: Program and abstracts of the 3rd Conference on Retroviruses and Opportunistic Infections, Washington, D.C., January 28-February 1, 1996. Alexandria, Va.: Infectious Diseases Society of America, 1996:102. abstract.