The dynamics of CD4+ T-cell depletion in HIV disease

Nature

Volumn 410, Issue 6831, 2001, Pages 974-979

  McCune, J M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; IMMUNOLOGY; PHYSIOLOGY; VIRUSES;

HUMAN IMMUNODEFICIENCY VIRUS (HIV);

DISEASES;

CD4 ANTIGEN;

CELL DEATH; HOMEOSTASIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; LYMPHOCYTE DEPLETION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROLYMPHOCYTE; REVIEW; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DEATH; DISEASE PROGRESSION; HIV; HIV INFECTIONS; HUMANS; LEUKOPOIESIS; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; MODELS, BIOLOGICAL;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0035912232     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35073648     Document Type: Review

References (81)

1. Pathogenesis of human immunodeficiency virus infection
2. Are HIV-specific CTL responses salutary or pathogenic?
3. Differential representations of memory T cell subsets are characteristic of polarized immunity in leprosy and atopic diseases
4. Lymphocyte subsets in the blood: A diagnostic window of the lymphoid system?
5. + T cell demographics and dynamics in lymphatic tissues
6. Reduced CD4 cell counts in blood do not reflect CD4 cell depletion in tonsillar tissue in asymptomatic HIV-1 infection
7. + repertoire during antiviral therapy
8. A Th1 to Th2 switch is a critical step in the aetiology of HIV infection
9. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
10. Viral dynamics in human immunodeficiency virus type 1 infection
11. Virological mayhem
12. Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection
13. Rapid turnover of T lymphocytes in SIV-infected rhesus macaques
14. Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy
15. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans
16. Factors influencing T cell turnover in HIV-1-seropositive patients
17. Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization
18. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
19. Lymphocyte homing and homeostasis
20. Naive and memory T cells show distinct pathways of lymphocyte recirculation
21. Differential distribution of antigen-specific helper T cells and cytotoxic T cell after antigenic stimulation in vivo
22. Non-random migration of CD4 and CD8 T cells: Changes in the CD4:CD8 ratio and interleukin 2 responsiveness of efferent lymph node cells following in vivo antigen challenge
23. T-cell homeostasis in HIV infection is neither failing nor blind: Modified cell counts reflect an adaptive response of the host
24. The importance of lymphocyte trafficking in regulating blood lymphocyte levels during HIV and SIV infections
25. + lymphocytes
26. Markers of lymphocyte homing distinguish CD4 T cell subsets that turn over in response to HIV-1 infection in humans
27. Decline in the CD4+ lymphocyte population in the blood of SIV-infected macaques is not reflected in lymph nodes
28. From HIV infection to AIDS: Are the manifestations of effective immune resistance misinterpreted?
29. A novel mechanism of CD4 lymphocyte depletion involves effects of HIV on resting lymphocytes: Induction of lymph node homing and apoptosis upon secondary signaling through homing receptors
30. + cell turnover
31. + cell turnover
32. + cell turnover
33. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation
34. + lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues
35. + T cells go out of stock
36. Multiple modes of cellular activation and virus transmission in HIV infection: A role for chronically and latently infected cells in sustaining viral replication
37. Direct HIV cytopathicity cannot account for CD4 decline in AIDS in the presence of homeostasis: A worst-case dynamic analysis
38. CD95's deadly mission in the immune system
39. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1
40. Immune activation in the context of HIV infection
41. Chronic immune activation associated with intestinal helminth infections results in impaired signal transduction and anergy
42. The influence of human immunodeficiency virus-1 on hematopoiesis
43. Reversal of HIV-1-associated hematosuppression by effective antiretroviral therapy
44. + T-cell renewal in early HIV-1 infection: Effect of highly active antiretroviral therapy
45. HIV-1: The infective process in vivo
46. HIV-1 induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo
47. R5 and X4 strains of HIV-1 exhibit differential tropism and pathogenesis in vivo
48. Altered representation of naive and memory CD8 T cell subsets in HIV-infected children
49. CD8 naive T cell counts decrease progressively in HIV-infected adults
50. Changes in thymic function with age and during the treatment of HIV infection
51. Direct evidence for thymic function in adult humans
52. Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy
53. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
54. Kinetics of CD4+ T cell repopulation of lymphoid tissues after treatment of HIV-1 infection
55. Thymic size and lymphocyte restoration in HIV infected patients following 48 weeks of therapy with zidovudine, lamivudine, and ritonavir
56. Early progression of disease in HIV-infected infants with thymus dysfunction
57. Incubation periods for paediatric AIDS patients
58. Influence of age at infection on human immunodeficiency virus disease progression to different clinical endpoints: The SEROCO cohort (1988-1994)
59. Ageing of lymphocytes and lymphocytes in the aged
60. Thymic function in HIV-1 disease
61. High prevalence of thymic tissue in adults with HIV-1 infection
62. Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia
63. Role of macrophages in the pathogenesis of human immunodeficiency virus (HIV) infection
64. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
65. Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
66. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: Implications for T-cell homeostasis
67. A potential role for IL-7 in T cell homeostasis
68. + thymocytes: A critical role for tumor necrosis factor and interleukin-7
69. Sustained CD4 T cell response after virologic failure of protease inhibitor based regimens in HIV infected patients
70. CD4-cell count in HIV-1-infected individuals remaining viraemic with highly active antiretroviral therapy
71. Incomplete and complete suppression of HIV-1 replication with protease inhibitor-based regimen are associated with similar T cell dynamics and activation
72. Impaired replication of protease inhibitor-resistant HIV-1 in human thymus
73. Mechanisms of lymphocyte killing by HIV
74. + T cells by a Fas-independent mechanism
75. Immunopathogenesis of human immunodeficiency virus
76. Molecular determinants of acute single-cell lysis by human immunodeficiency virus type 1
77. Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest
78. HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor κB
79. Measurement of T-cell kinetics: Recent methodologic advances