Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes

Journal of Experimental Medicine

Volumn 185, Issue 10, 1997, Pages 1851-1858

  Perillo, Nancy L ^a   Uittenbogaart, Christel H ^a   Nguyen, Julie T ^a   Baum, Linda G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GALECTIN; LECTIN;

APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA CONTENT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DITHIOTHREITOL; DNA; EPITHELIUM; FLOW CYTOMETRY; GALECTIN 1; HEMAGGLUTININS; HUMANS; LECTINS; MODELS, IMMUNOLOGICAL; RECOMBINANT PROTEINS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0030940913     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.10.1851     Document Type: Article

References (47)

1. von Boehmer, H. 1994. Positive selection of lymphocytes. Cell. 76:219-228.
2. Jenkinson, E.J., G. Anderson, and J.J.T. Owen. 1992. Studies on T cell maturation on defined thymic stromal cell populations in vitro. J. Exp. Med. 176:845-853.
3. Yamashita, I., T. Nagata, T. Tada, T. Nakayama. 1993. CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection. Int. Immunol. 5:1139-1150.
4. Surh, C.D., and J. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature (Lond.). 372:100-103.
5. Kersh, G.J., and S.M. Hedrick. 1995. Role of TCR specificity in CD4 versus CD8 lineage commitment. J. Immunol. 154:1057-1068.
6. + thymocytes. J. Immunol. 151:1868-1880.
7. Hiramine, C., K. Hojo, M. Koseto, T. Nakagawa, and A. Mukasa. 1990. Establishment of a murine thymic epithelial cell line capable of inducing both thymic nurse cell formation and thymocyte apoptosis. Lab. Invest. 62:41-54.
8. + thymocyte in vitro. J. Exp. Med. 179:2027-2031.
9. Anderson, G., N.C. Moore, J.J.T. Owen, and E.J. Jenkinson. 1996. Cellular interactions in thymocyte development. Annu. Rev. Immunol. 14:73-99.
10. + cells in the human thymus are defined by expression of CD34. Delineation of early events in human thymic development. J. Exp. Med. 178:391-401.
11. Baum, L.G., M. Pang, N.L. Perillo, T. Wu, A. Delegeane, C. Uittenbogaart, M. Fukuda, and J.J. Seilhamer. 1995. Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells. J. Exp. Med. 181:877-887.
12. Perillo, N.L., K.E. Pace, J.J. Seilhamer, and L.G. Baum. 1995. Apoptosis of T lymphoid cells mediated by galectin-1. Nature (Lond.). 378:736-739.
13. Barondes, W.H., D.N.W. Cooper, M.A. Gitt, and H. Leffler. 1994. Galectins: structure and function of a large family of animal lectins. J. Biol. Chem. 269:20807-20810.
14. Leffler, H., and S.H. Barondes. 1986. Specificity of binding of three soluble rat lung lectins to substituted and unsubstituted mammalian β-galactosides. J. Biol. Chem. 261:10119-10126.
15. Zhou, Q. and R.D. Cummings. 1990. The S-type lectin from calf heart tissue binds selectively to the carbohydrate chains of laminin. Arch. Biochem. Biophys. 281:27-35.
16. Ozeki, Y., T. Matsui, Y. Yamamoto, M. Funahashi, J. Hamako, and K. Titani. 1995. Tissue fibronectin is an endogenous ligand for galectin-1. Glycobiology. 5:255-261.
17. Do, K.-Y., D.F. Smith, and R.D. Cummings. 1990. Lamp-1 in CHO cells is a primary carrier of poly-N-acetyllactosamine chains and is bound preferentially by a mammalian S-type lectin. Biochem. Biophys. Res. Comm. 173:1123-1128.
18. Pace, K., and L. Baum. 1996. Identification and characterization of T cell surface counter-receptors for galectin-1. Glycobiology. 6:745. (Abstr.)
19. Wells, V., and L. Mallucci. 1991. Identification of an autocrine negative growth factor: mouse β-galactoside-binding protein is a cytostatic factor and cell growth regulator. Cell. 64:91-97.
20. Yamaoka, L., S. Ohno, H. Kawasaki, and K. Suzuki. 1991. Overexpression of a β-galactoside binding protein causes transformation of BALB3T3 fibroblast cells. Biochem. Biophys. Res. Comm. 179:272-279.
21. Levi, G., R. Tarrab-Hazdai, and V.I. Teichberg. 1983. Prevention and therapy with electrolectin of experimental autoimmune myasthenia gravis in rabbits. Eur. J. Immunol. 13: 500-507.
22. Offner, H., B. Celnik, T.S. Bringman, D. Casentini-Borocz, G.E. Nedwin, and A.A. Vandenbark. 1990. Recombinant human β-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 28:177-184.
23. Couraud, P.-O., D. Casentini-Borocz, T.S. Bringman, J. Griffith, M. McGrogan, and G.E. Nedwin. 1989. Molecular cloning, characterization and expression of a human 14 kDa lectin. J. Biol. Chem. 264:1310-1316.
24. Vollger, L.W., and C.H. Uittenbogaart. 1993. Interleukin-7 promotes the generation of phenotypically mature CD45RA positive human thymocytes in vitro. Cytokine. 5:157-168.
25. Gorczyca, W., J. Gong, B. Ardelt, F. Traganos, and Z. Darzynkiewicz. 1993. The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res. 53:3186-3192.
26. Zacharchuk, C.M., M. Mercep, P. Chakraborti, S.S. Simons, Jr., and J.D. Ashwell. 1990. Programmed T lymphocyte death: cell activation and steroid-induced pathways are mutually antagonistic. J. Immunol. 145:4037-4045.
27. Iwata, M., S. Hanaoka, and K. Sato. 1991. Rescue of thymocytes and T cell hybridomas from glucocorticoid-induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possible in vitro model for positive selection of the T cell repertoire. Eur. J. Immunol. 21:643-648.
28. Cotter, P.G., S.V. Lennon, J.G. Glynn, and S.J. Martin. 1990. Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cells. Cancer Res. 10:1153-1160.
29. Dou, Q.P., B. An, and P.L. Will. 1995. Induction of a retino-blastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis. Proc. Natl. Acad. Sci. USA. 92:9019-9023.
30. Linette, G.P., Y. Li, K. Roth, and S.J. Korsmeyer. 1996. Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation. Proc. Natl. Acad. Sci. USA. 93:9545-9552.
31. + stage of thymocyte differentiation in the absence of T cell receptor rearrangement. J. Exp. Med. 183:1923-1928.
32. Shinkai, Y., L. Koyasu, K.-I. Nakayama, K.M. Murphy, D.Y. Loh, E.L. Reinherz, and F.W. Alt. 1993. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science (Wash. DC). 259:822-825.
33. Veis, D.J., C.L. Sentman, E.A. Bach, and S.J. Korsmeyer. 1993. Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J. Immunol. 151:2546-2554.
34. Ma, A., J.C. Pena, B. Chang, E. Margosian, L. Davidson, F.W. Alt, and C.B. Thompson. 1995. Bclx regulates the survival of double-positive thymocytes. Proc. Natl. Acad. Sci. USA. 92:4763-4767.
35. Ramiro, A.R., C. Trigueros, C. Marquez, J.L. San Millan, and M.L. Toribio. 1996. Regulation of pre-T cell receptor (pTα-TCRβ) gene expression during human thymic development. J. Exp. Med. 184:519-530.
36. Page, D.M., L.P. Kane, T.M. Onami, and S.M. Hedrick. 1996. Cellular and biochemical requirements for thymocyte negative selection. Semin. Immunol. 8:69-82.
37. + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J. Exp. Med. 179:709-713.
38. Brown, K.M., S. Spirito, and R.A. Basch. 1991. Thymic stromal cells in culture: Establishment and characterization of a line which is cytotoxic for normal thymocytes and produces hematopoietic growth factor(s). Cell. Immunol. 134:442-457.
39. + thymocytes in vitro does not require dedicated antigen-presenting cells. Eur. J. Immunol. 23:669-674.
40. Robey, E., and B.J. Fowlkes. 1994. Selective events in T cell development. Annu. Rev. Immunol. 12:675-705.
41. Lane, D.P. 1993. A death in the life of p53. Nature (Lond.). 362:786-787.
42. Lowe, S.W., S.M. Schmitt, S.W. Smith, B.A. Osborne, and T. Jacks. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.). 362:847-849.
43. Clarke, A.R., D.A. Purdie, D.J. Harrison, R.G. Morris, C.C. Bird, M.L. Hooper, and A.H. Wyllie. 1993. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature (Lond.). 362:849-852.
44. Pilarski, L.M. 1993. Adhesive interaction in thymic development: does selective expression of CD45 isoforms promote stage-specific microclustering in the assembly of functional adhesive complexes on differentiating T lineage lymphocytes? Immunol. Cell Biol. 71:59-69.
45. Scollay, R., and D.I. Godfrey. 1995. Thymic emigration: conveyor belts or lucky dips? Immunol. Today. 16:268-273.
46. Alvarez-Vallina, L., A. Gonzalez, R. Gambon, M. Kreisler, and R. Diaz-Espada. 1993. Delimitation of the proliferative stages in the human thymus indicates that cell expansion occurs before the expression of CD3 (T cell receptor). J. Immunol. 150:8-16.
47. Poirier, F. and E.J. Robertson. 1993. Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectin. Development. 119:1229-1236.