CD8+,CD38+ lymphocyte percent: A useful immunological marker for monitoring HIV-1-infected patients

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 14, Issue 2, 1997, Pages 158-162

  Mocroft, A ^a   Bofill, M ^a   Lipman, M ^a   Medina, E ^a   Borthwick, N ^a   Timms, A ^a   Batista, L ^a   Winter, M ^a   Sabin, C A ^a   Johnson, M ^a   Lee, C A ^a   Phillips, A ^a   Janossy, G ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

CD4 lymphocyte count; CD8+,CD38+ lymphocyte subset; Patient monitoring; 2 Microglobulin

Indexed keywords

CD38 ANTIGEN; CD8 ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; DIAGNOSTIC VALUE; FEMALE; FOLLOW UP; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; RISK ASSESSMENT; T LYMPHOCYTE ACTIVATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 12644311247     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199702010-00009     Document Type: Article

References (27)

1. Phillips AN, Lee CA, Elford J, et al. Serial CD4 lymphocyte counts and development of AIDS. Lancet 1991;337:389-92.
2. Phillips AN, Lee CA, Elford J, et al. The cumulative risk of AIDS as the CD4 lymphocyte count declines. J AIDS 1992;5:148-52.
3. Moss AR, Bachetti P, Osmond D, et al. Seropositivity for HIV and the development of AIDS or AIDS related condition: three year follow-up of the San Francisco General Hospital Cohort. Br Med J 1988;296:745-50.
4. Schechter MT, Craib KJP, Lo TN, et al. Progression to AIDS in seroprevalent and seroincident cohorts of homosexual men. AIDS 1989;3:347-53.
5. Stein DS, Korvick JA, Vermund SH. CD4+ lymphocyte cell enumeration for prediction of clinical course of human immunodeficiency virus disease: a review. J Infect Dis 1992;165:352-63.
6. Phillips AN, Sabin CA, Elford J, et al. Acquired immunodeficiency syndrome (AIDS) risk in recent and long-standing human immunodeficiency virus type-1 (HIV-1) infected patients with similar CD4 lymphocyte counts. Am J Epidemiol 1993;138:870-8.
7. Fahey JL, Taylor JMG, Detels R, et al. The prognostic value of cellular and serological markers in infection with human immunodeficiency virus type-1. N Engl J Med 1990;322:168-72.
8. Fernandez-Cruz E, Descoe M, Montes MG, et al. Immunological and serological markers predictive of progression to AIDS in a cohort of infected drug-users. AIDS 1990;4:987-94.
9. Hoffmann B, Wang Y, Cumberland WG, et al. Serum beta-2-microglobulin level increases in HIV-1 infection: relation to sero-conversion, CD4 T-cell fall and prognosis. AIDS 1990;4:207-14.
10. Anderson RE, Lang W, Shiboski S, et al. Use of beta-2-microglobulin and CD4 lymphocyte count to predict development of acquired immunodeficiency syndrome in persons with human immunodeficiency virus infection. Ann Intern Med 1990;150: 73-7.
11. Sabin CA, Phillips AN, Lee CA, et al. Beta-2-microglobulin levels as a predictor of prognosis in HIV-infected men with haemophilia: a proposed strategy for use in clinical care. Br J Haematol 1994; 36:366-71.
12. Giorgi JV, Liu Z, Hultin LE, et al. Elevated levels of CD38+CD8+ cells in HIV infection add to the prognostic value of low CD4+ T-cell levels: results of 6 years of follow-up. J AIDS 1993;6:1258-66.
13. Levacher M, Hulstaert F, Tallet S, et al. The significance of activation markers in CD8 lymphocytes in human immunodeficiency syndrome: staging and prognostic value. Clin Exp Immunol 1992; 90:376-82.
14. + T cells in HIV-1 infected patients. AIDS 1996;10: 827-34.
15. Prince HE, Kleiman S, Czaplicki C, et al. Interrelationships between serological markers of immune activation and T lymphocyte subsets in HIV infection. J AIDS 1990;3:525-30.
16. Bass HZ, Nishanian P, Hardy WD, et al. Immune changes in HIV-1 infection: significant correlations and differences in serum markers and lymphoid phenotypic antigens. Clin Immunol Immunopathol 1992;64:63-70.
17. Lee CA, Phillips AN, Elford J, et al. Progression of HIV disease in a haemophilic cohort followed for 11 years and the effect of treatment. Br Med J 1991;303:1093-6.
18. Center for Disease Control. Revision of the surveillance case definition for the acquired immunodeficiency syndrome. MMWR 1987;36:39-155.
19. Bofill M, Janossy G, Lee CA, et al. Laboratory control values for CD4 and CD8 t-lymphocytes. Implications for HIV-1 diagnosis. Clin Exp Immunol 1992;88:243-52.
20. Mercolino TJ, Connelly MC, Meyer EJ, et al. Immunological differentiation of absolute lymphocyte count with an integrated flow cytometric system: a new concept for absolute T cell subset determinations. Cytometry 1995;21:48-59.
21. SAS Institute. SAS users guide: statistics, version 6. 3rd ed. Cary: SAS, 1990.
22. Darbyshire J, Schoenfield DA, Weller IVD. Clinical trials in HIV infection: current problems and future directions. AIDS 1991;5 (suppl 2):S167-73.
23. Ellenberg SS, Finkelstein DM, Schoenfield DA. Statistical issues arising in clinical trials. J Am Stat Assoc 1992;87:562-9.
24. Loveday C, Hill A. Prediction of progression to AIDS with serum HIV-1 RNA and CD4 count. Lancet 1995;345:790-1.
25. Roos MTL, Miedema F, Koot M, et al. T cell function in vitro is an independent progression marker for AIDS in human immunodeficiency virus infected symptomatic subjects. J Infect Dis 1995; 171:531-6.
26. Koot M, Keet IPM, Vos AHV, et al. Prognostic value of HIV-1 syncytium inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann Intern Med 1993;118:681-8.
27. Giorgi JV. HIV pathogenesis and prognostic markers of HIV disease progression: update from the Multicentre AIDS Cohort study [Abstract S41]. Third Conference on Retroviruses and Opportunistic Infections, Washington, D.C., U.S.A., 1996:179.