Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery

Gene Therapy

Volumn 5, Issue 7, 1998, Pages 930-937

  Li, S ^a   Rizzo, M A ^a   Bhattacharya, S ^a   Huang, L ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cationic liposomes; Gene therapy; Gene transfer; Polymer

Indexed keywords

ALBUMIN; CATION; CHOLESTEROL; LIPID; LIPOSOME; PHOSPHATIDYLETHANOLAMINE; PLASMID DNA; PROTAMINE SULFATE;

ANIMAL CELL; ARTICLE; DNA PROTEIN COMPLEX; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; HEART; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; LIVER; LUNG; MOUSE; NONHUMAN; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; SERUM; SPLEEN;

ANIMALIA;

EID: 0031851486     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300683     Document Type: Article

References (28)

1. Gao X, Huang L. Cationic liposome-mediated gene transfer. Gene Therapy 1995; 2: 710-722.
2. Ledley FD. Nonviral gene therapy: the promise of genes as pharmaceutical products. Hum Gene Ther 1995; 6: 1129-1144.
3. Felgner PL. Improvements in cationic liposomes for in vivo gene transfer. Hum Gene Ther 1996; 7: 1791-1793.
4. Caplen NJ et al Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nature Med 1995; 1: 39-46.
5. Mclaclan G et al. Laboratory and clinical studies in support of cystic fibrosis gene therapy using pCMV-CFTR-DOTAP. Gene Ther 1996; 3: 1113-1123.
6. Lee ER et al. Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung. Hum Gene Ther 1996; 7: 1701-1717.
7. Stephan DJ et al. A new cationic liposome DNA complex enhances the efficiency of arterial gene transfer in vivo. Hum Gene Ther 1996; 7: 1803-1812.
8. Wheeler CJ et al. A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung. Proc Natl Acad Sci USA 1996; 93: 11454-11459.
9. Gao X, Huang L. Potentiation of cationic liposome-mediated gene delivery by polycations. Biochemistry 1996; 35: 1027-1036.
10. Hofland HEJ, Shephard L, Sullivan SM. Formation of stable cationic lipid/DNA complexes for gene transfer. Proc Natl Acad Sci USA 1996; 93: 7305-7309.
11. Liu F, Yang J-P, Huang L, Liu D. New cationic lipid formulations for gene transfer. Pharm Res 1996; 13: 1856-1860.
12. Felgner PL et al. Nomenclature for synthetic gene delivery systems. Hum Gene Ther 1997; 8: 511-512.
13. Zhu N, Liggitt D, Liu Y, Debs R. Systemic gene expression after intravenous DNA delivery into adult mice. Science 1993; 261: 209-211.
14. Huang L, Li S. Liposomal gene delivery: a complex package. Nature Biotechnol 1997; 15: 620-621.
15. Liu F, Qi H, Huang L, Liu D. Factors controlling efficiency of cationic lipid-mediated transfection in vivo via intravenous administration. Gene Therapy 1997; 4: 517-523.
16. Li S, Huang L. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes. Gene Therapy 1997; 4: 891-900.
17. Liu Y et al. Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery. Nature Biotechnol 1997; 15: 167-173.
18. Hong KL, Zheng WW, Baker A, Papahadjopoulos D. Stabilization of cationic liposome-plasmid DNA complexes by polyamines and poly (ethylene glycol)-phospholipid conjugates for efficient in vivo gene delivery. FEBS Lett 1997; 400: 233-237.
19. Templeton NS et al. Improved DNA: liposome complexes for increased systemic delivery and gene expression. Nature Biotechnol. 1997; 15: 647-652
20. McLean JW, Fox EA, Baluk P et al. Organ-specific endothelial cell uptake of cationic liposome-DNA complexes in mice. Am J Physiol 1997; 273: H387-H404.
21. Holland HEJ et al. In vivo gene transfer by intravenous administration of stable cationic lipid/DNA complexes. Pharm Res 1997; 14: 742-749.
22. Litzinger DC, Huang L. Phosphatidylethanolamine liposomes: drug delivery, gene transfer and immunodiagnostic applications. Biochim Biophys Acta 1992; 1113: 201-227.
23. Oja CD, Semple SC, Chonn A, Cullis PR. Influence of dose on liposome clearance: critical role of blood proteins. Biochim Biophys Acta 1996; 1281: 31-37.
24. Semple SC, Chonn A, Cullis PR. Influence of cholesterol on the association of plasma proteins with liposomes. Biochemistry 1996; 35: 2521-2525.
25. Dash PR, Toncheva V, Schacht E, Seymour LW. Synthetic polymers for vectorial delivery of DNA: characterization of polymer-DNA complexes by photon correlation spectroscopy and stability to nuclease degradation and disruption by polyanions in vitro. J Control Release 1997; 48: 269-276.
26. Sambrook, J, Fritsch EF, Maniatis, T. Molecular Cloning: A Laboratory Manual (2nd edn). Cold Spring Harbor Laboratory Press: New York, 1989, pp 1.21-1.52.
27. Prensky W. The radioiodination of RNA and DMA to high specific activities. Cell Biol 1976; 13: 121-152.
28. Wessel D, Flugge UI. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal Biochem 1984; 138: 141-143.