Cationic poly(ethyleneglycol) lipids incorporated into pre-formed vesicles enhance binding and uptake to BHK cells

Biochimica et Biophysica Acta - Biomembranes

Volumn 1512, Issue 2, 2001, Pages 259-272

  Fenske, David B ^a   Palmer, Lorne R ^a   Chen, Tao ^a   Wong, Kim F ^a   Cullis, Pieter R ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Inex Pharmaceuticals Corporation   (Canada)

Author keywords

Cationic lipids; Cationic PEG lipids; Durg delivery; Large unilamellar vesicles; Liposome cell binding

Indexed keywords

CALCIUM ION; DANSYL CHLORIDE; DISTEAROYLPHOSPHATIDYLETHANOLAMINE; ETHANOLAMINE DERIVATIVE; LIPOSOME; LYSINE DERIVATIVE; MACROGOL DERIVATIVE; POLYMER; PROTEIN; RHODAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CELL STRAIN BHK; CELL VACUOLE; CONJUGATE; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; INCUBATION TIME; LIPID COMPOSITION; LIPID TRANSPORT; LIPID VESICLE; MEMBRANE STRUCTURE; MICELLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; SURFACE CHARGE; TEMPERATURE DEPENDENCE;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; CRICETINAE; GLYCEROPHOSPHOLIPIDS; KIDNEY; KINETICS; LIPOSOMES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; QUATERNARY AMMONIUM COMPOUNDS;

EID: 0035815985     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2736(01)00327-3     Document Type: Article

References (38)

1. Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles
2. Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice
3. Comparison of free and liposome encapsulated doxorubicin tumor drug uptake and antitumor efficacy in the SC115 murine mammary tumor
4. Optimization of the retention properties of vincristine in liposomal systems
5. Liposomal vincristine which exhibits increased drug retention and increased circulation longevity cures mice bearing P388 tumors
6. Vincristine-induced dermal toxicity is significantly reduced when the drug is given in liposomes
7. Cationic liposome-mediated transfection
8. Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure
9. Stabilized plasmid-lipid particles: Construction and characterization
10. Stabilized plasmid-lipid particles: Factors influencing plasmid entrapment and transfection properties
11. Cationic liposomes coated with polyethylene glycol as carriers for oligonucleotides
12. Use of targeted cationic liposomes in enhanced DNA delivery to cancer cells
13. Attachment of antibodies to sterically-stabilized liposomes: Evaluation, comparison and optimization of coupling procedures
14. Targeting folate receptor with folate linked to extremities of poly(ethylene glycol)-grafted liposomes: In vitro studies
15. Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis
16. Folate-mediated targeting of therapeutic and imaging agents to cancers
17. Low, Riboflavin-mediated delivery of a macromolecule into cultured human cells
18. Folate-mediated targeting of antineoplastic drugs, imaging agents, and nucleic acids to cancer cells
19. Peptide attachment to extremities of liposomal surface grafted PEG chains: Preparation of the long-circulating form of laminin pentapeptide, YIGSR
20. Poly(ethylene glycol)-grafted liposomes with oligopeptide or oligosaccharide ligands appended to the termini of the polymer chains
21. Liposome-cell interactions in vitro: Effect of liposome surface charge on the binding and endocytosis of conventional and sterically-stabilized liposomes
22. Tunable pH-sensitive liposomes composed of mixtures of cationic and anionic lipids
23. Fluorescent-labeled poly(ethylene glycol) lipid conjugates with distal cationic headgroups
24. Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential
25. Vesicles of variable sizes produced by a rapid extrusion procedure
26. The colorimetric determination of phosphorus
27. A rapid method of total lipid extraction and purification
28. Spontaneous interbilayer transfer of phospholipids: Dependence on acyl chain composition
29. Interbilayer transfer of phospholipid-anchored macromolecules via monomer diffusion
30. Insertion of poly(ethylene glycol) derivatized phospholipid into pre-formed liposomes results in prolonged in vivo circulation time
31. Uptake of liposomes by cultured mouse bone marrow macrophages: Influence of liposome composition and size
32. Quantitative analysis of liposome-cell interactions in vitro: Rate constants of binding and endocytosis with suspension and adherent J774 cells and human monocytes
33. Recognition of liposomes by cells: In vitro binding and endocytosis mediated by specific lipid headgroups and surface charge density
34. Improved cationic lipid formulations for in vivo gene therapy
35. Cationic lipid-mediated transfection of liver cells in primary culture
36. Poly(ethylene glycol)-modification of the phospholipid vesicles by using the spontaneous incorporation of poly(ethylene glycol)-lipid into the vesicles
37. Comparison of different hydrophobic anchors conjugated to poly(ethylene glycol) - Effects on the pharmacokinetics of liposomal vincristine
38. Stabilized plasmid-lipid particles: Pharmacokinetics and plasmid delivery to distal tumors following intravenous injection