New basic membrane-destabilizing peptides for plasmid-based gene delivery in vitro and in vivo

Molecular Therapy

Volumn 5, Issue 2, 2002, Pages 104-114

  Rittner, Karola ^a   Benavente, Annie ^a   Bompard Sorlet, Albine ^a   Heitz, Frédéric ^b   Divita, Gilles ^b   Brasseur, Robert ^c   Jacobs, Eric ^a  

^a TRANSGENE S A   (France)

^b CNRS   (France)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Gene transfer; Membrane destabilizing peptides; Synthetic vector; helix

Indexed keywords

2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; AMPHOPHILE; CATION; CHOLESTEROL; DENDRIMER; GLYCYLLEUCYLPHENYLALANYLARGINYLALANYLLEUCYLLEUCYLARGINYLLEUCYLLEUCYLARGINYLSERYLLEUCYLTRYPTOPHYLARGINYLLEUCYLLEUCYLLEUCYLARGINYLALANINE; GLYCYLLEUCYLPHENYLALANYLLYSYLALANYLLEUCYLLEUCYLLYSYLLEUCYLLEUCYLLYSYLSERINYLLEUCYLTRYPTOPHYLLYSYLLEUCYLLEUCYLLEUCYLLYSYLALANINE; LIPOFECTIN; LIPOSOME; LUCIFERASE; MEMBRANE PROTEIN; NUCLEIC ACID; PEPTIDE DERIVATIVE; PLASMID DNA; POLYETHYLENEIMINE; POLYMER; SYNTHETIC PEPTIDE; TRYPTOPYLGLUTAMYLALANYLLYSYLLEUCYLALANYLLYSYLALANYLLEUCYLALANYLLYSYLALANYLLEUCYLALANYLLYSYLHISTIDYLLEUCYLALANYLLYSYLALANYLLEUCYLALANYLLYSYLALANYLLEUCYLALANYLLYSYLALANYLLEUCYLLYSYLALANYLCYSTINYLGLUTAMYLALANINE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; GENE DOSAGE; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE STABILIZATION; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PH; PLASMID; PROTEIN CONFORMATION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

ANIMALIA; MURINAE;

EID: 0036169073     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2002.0523     Document Type: Article

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