Antioxidants and Inflammation in Obesity

Bioactive Food as Dietary Interventions for Diabetes: Bioactive Foods in Chronic Disease States

Volumn , Issue , 2012, Pages 413-434

  Peairs, A D ^a   Abbey, E L ^b  

^a UNIVERSITY OF CINCINNATI   (United States)

^b WHITWORTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85136253092     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-397153-1.00031-7     Document Type: Chapter

References (165)

1. Anderson R.A., Evans L.M., Ellis G.R., et al. Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in type 2 diabetes. Diabetic Medicine 2006, 23:258-264.
2. Asehnoune K., Strassheim D., Mitra S., Kim J.Y., Abraham E. Involvement of reactive oxygen species in toll-like receptor 4-dependent activation of NF-?B. Journal of Immunology 2004, 172:2522-2529.
3. Bae J.H., Schwemmer M., Lee I.K., et al. Postprandial hypertriglyceridemia-induced endothelial dysfunction in healthy subjects is independent of lipid oxidation. International Journal of Cardiology 2003, 87:259-267.
4. Bajnok L., Seres I., Varga Z., et al. Relationship of endogenous hyperleptinemia to serum paraoxonase 1, cholesteryl ester transfer protein, and lecithin cholesterol acyltransferase in obese individuals. Metabolism, Clinical and Experimental 2007, 56:1542-1549.
5. Bakker G.C., van Erk M.J., Pellis L., et al. An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach. American Journal of Clinical Nutrition 2010, 91:1044-1059.
6. Basu A., Wilkinson M., Penugonda K., et al. Freeze-dried strawberry powder improves lipid profile and lipid peroxidation in women with metabolic syndrome: baseline and post intervention effects. Nutrition Journal 2009, 8:43.
7. Basu A., Du M., Leyva M.J., et al. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. Journal of Nutrition 2010, 140:1582-1587.
8. Blanco-Colio L.M., Valderrama M., Alvarez-Sala L.A., et al. Red wine intake prevents nuclear factor-kappaB activation in peripheral blood mononuclear cells of healthy volunteers during postprandial lipemia. Circulation 2000, 102:1020-1026.
9. Ble-Castillo J.L., Cleva-Villanueva G., Diaz-Zagoya J.C., et al. Effects of alpha-tocopherol on oxidative status and metabolic profile in overweight women. International Journal of Environmental Research and Public Health 2007, 4:260-267.
10. Block G., Mangels A.R., Patterson B.H., et al. Body weight and prior depletion affect plasma ascorbate levels attained on identical vitamin C intake: a controlled-diet study. Journal of the American College of Nutrition 1999, 18:628-637.
11. Block G., Jensen C.D., Morrow J.D., et al. The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline level. Free Radical Biology and Medicine 2008, 45:377-384.
12. Block G., Jensen C.D., Dalvi T.B., et al. Vitamin C treatment reduces elevated C-reactive protein. Free Radical Biology and Medicine 2009, 46:70-77.
13. Bloomer R.J., Fisher-Wellman K.H. Systemic oxidative stress is increased to a greater degree in young, obese women following consumption of a high fat meal. Oxidative Medicine and Cellular Longevity 2009, 2:19-25.
14. Blumberg J.B., Frei B. Why clinical trials of vitamin E and cardiovascular diseases may be fatally flawed. Commentary on "the relationship between dose of vitamin E and suppression of oxidative stress in humans". Free Radical Biology and Medicine 2007, 43:1374-1376.
15. Bose M., Lambert J.D., Ju J. The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice. The Journal of Nutrition 2008, 138:1677-1683.
16. Brady W.E., Mares-Perlman J.A., Bowen P., Stacewicz-Sapuntzakis M. Human serum carotenoid concentrations are related to physiologic and lifestyle factors. Journal of Nutrition 1996, 126:129-137.
17. Brown L.A., Kerr C.J., Whiting P., et al. Oxidant stress in healthy normal-weight, overweight, and obese individuals. Obesity 2009, 17:460-466.
18. Burns J., Yokota T., Ashihara H., et al. Plant foods and herbal sources of resveratrol. Journal of Agricultural and Food Chemistry 2002, 50:3337-3340.
19. Burton-Freeman B., Linares A., Hyson D., Kappagoda T. Strawberry modulates LDL oxidation and postprandial lipemia in response to high-fat meal in overweight hyperlipidemic men and women. Journal of the American College of Nutrition 2010, 29:46-54.
20. Cai D. NFkappaB-mediated metabolic inflammation in peripheral tissues versus central nervous system. Cell Cycle 2009, 8:2542-2548.
21. Canoy D., Wareham N., Welch A., et al. Plasma ascorbic acid concentrations and fat distribution in 19,068 British men and women in the European prospective investigation into cancer and nutrition Norfolk cohort study. American Journal of Clinical Nutrition 2005, 82:1203-1209.
22. Carcamo J.M., Pedraza A., Borquez-Ojeda O., Golde D.W. Vitamin C suppresses TNF alpha-induced NF kappa B activation by inhibiting I kappa B alpha phosphorylation. Biochemistry 2002, 41:12995-13002.
23. Carcamo J.M., Pedraza A., Borquez-Ojeda O., et al. Vitamin C is a kinase inhibitor: dehydroascorbic acid inhibits IkappaBalpha kinase beta. Molecular and Cellular Biology 2004, 24:6645-6652.
24. Cardona F., Tunez I., Tasset I., et al. Circulating antioxidant defences are decreased in healthy people after a high-fat meal. British Journal of Nutrition 2008, 100:312-316.
25. Carroll M.F., Schade D.S. Timing of antioxidant vitamin ingestion alters postprandial proatherogenic serum markers. Circulation 2003, 108:24-31.
26. Caruso F., Tanski J., Villegas-Estrada A., Rossi M. Structural basis for antioxidant activity of trans-resveratrol: ab initio calculations and crystal and molecular structure. Journal of Agricultural and Food Chemistry 2004, 52:7279-7285.
27. Cassis L.A., Police S.B., Yiannikouris F., Thatcher S.E. Local adipose tissue renin-angiotensin system. Current Hypertension Reports 2008, 10:93-98.
28. Chachay V.S., Kirkpatrick C.M.J., Hickman I.J., et al. Resveratrol - pills to replace a healthy diet?. British Journal of Clinical Pharmacology 2011, 72:27-38.
29. Codoner-Franch P., Lopez-Jaen A.B., de la Mano-Hernandez A., et al. Oxidative markers in children with severe obesity following low-calorie diets supplemented with mandarin juice. Acta Paediatrica 2010, 99:1841-1846.
30. Codoner-Franch P., Pons-Morales S., Boix-Garcia L., Valls-Belles V. Oxidant/antioxidant status in obese children compared to pediatric patients with type 1 diabetes mellitus. Pediatric Diabetes 2010, 11:251-257.
31. Cullinan S.B., Diehl J.A. Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway. The International Journal of Biochemistry and Cell Biology 2006, 38:317-332.
32. Dandona P., Mohanty P., Ghanim H., et al. The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. Journal of Clinical Endocrinology and Metabolism 2001, 86:355-362.
33. de Ferranti S., Mozaffarian D. The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clinical Chemistry 2008, 54:945-955.
34. de Nigris F., Balestrieri M.L., Williams-Ignarro S., et al. The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. Nitric Oxide 2007, 17:50-54.
35. Decsi T., Molnar D., Koletzko B. Reduced plasma concentrations of alpha-tocopherol and beta-carotene in obese boys. Journal of Pediatrics 1997, 130:653-655.
36. Degasperi G.R., Denis R.G., Morari J., et al. Reactive oxygen species production is increased in the peripheral blood monocytes of obese patients. Metabolism, Clinical and Experimental 2009, 58:1087-1095.
37. Depalo A., Carpagnano G.E., Spanevello A., et al. Exhaled NO and iNOS expression in sputum cells of healthy, obese and OSA subjects. Journal of Internal Medicine 2008, 263:70-78.
38. Devaraj S., Leonard S., Traber M.G., Jialal I. Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome. Free Radical Biology and Medicine 2008, 44:1203-1208.
39. Devaraj S., Mathur S., Basu A., et al. A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress. Journal of the American College of Nutrition 2008, 27:267-273.
40. Di Renzo L., Galvano F., Orlandi C., et al. Oxidative stress in normal-weight obese syndrome. Obesity 2010, 18:2125-2130.
41. Dragsted L.O. Antioxidant actions of polyphenols in humans. International Journal for Vitamin and Nutrition Research 2003, 73:112-119. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition.
42. Drewnowski A., Rock C.L., Henderson S.A., et al. Serum beta-carotene and vitamin C as biomarkers of vegetable and fruit intakes in a community-based sample of French adults. American Journal of Clinical Nutrition 1997, 65:1796-1802.
43. Dugee O., Khor G.L., Lye M.S., et al. Association of major dietary patterns with obesity risk among Mongolian men and women. Asia Pacific Journal of Clinical Nutrition 2009, 18:433-440.
44. Egert S., Bosy-Westphal A., Seiberl J., et al. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. British Journal of Nutrition 2009, 102:1065-1074.
45. Fernandez-Real J.M., Garcia-Fuentes E., Moreno-Navarrete J.M., et al. Fat overload induces changes in circulating lactoferrin that are associated with postprandial lipemia and oxidative stress in severely obese subjects. Obesity 2010, 18:482-488.
46. Ferretti G., Bacchetti T., Moroni C., et al. Paraoxonase activity in high-density lipoproteins: a comparison between healthy and obese females. Journal of Clinical Endocrinology and Metabolism 2005, 90:1728-1733.
47. Flegal K.M., Graubard B.I., Williamson D.F., Gail M.H. Cause-specific excess deaths associated with underweight, overweight, and obesity. The Journal of the American Medical Association 2007, 298:2028-2037.
48. Frankel E.N., Waterhouse A.L., Kinsella J.E. Inhibition of human LDL oxidation by resveratrol. Lancet 1993, 341:1103-1104.
49. Furukawa S., Fujita T., Shimabukuro M., et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. Journal of Clinical Investigation 2004, 114:1752-1761.
50. Gao Y., Gauvreau D., Cianflone K. Hormone and pharmaceutical regulation of ASP production in 3T3-L1 adipocytes. Journal of Cellular Biochemistry 2010, 109:896-905.
51. Gao D., Nong S., Huang X., et al. The effects of palmitate on hepatic insulin resistance are mediated by NADPH oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways. Journal of Biological Chemistry 2010, 285:29965-29973.
52. Garcia-Diaz D., Campion J., Milagro F.I., Martinez J.A. Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markers. Molecular and Cellular Biochemistry 2007, 305:87-94.
53. Garcia-Diaz D.F., Campion J., Milagro F.I., et al. Vitamin C inhibits leptin secretion and some glucose/lipid metabolic pathways in primary rat adipocytes. Journal of Molecular Endocrinology 2010, 45:33-43.
54. Garcia-Fuentes E., Murri M., Garrido-Sanchez L., et al. PPARgamma expression after a high-fat meal is associated with plasma superoxide dismutase activity in morbidly obese persons. Obesity 2010, 18:952-958.
55. Ge X., Liu Z., Qi W., Shi X., Zhai Q. Chromium (VI) induces insulin resistance in 3T3-L1 adipocytes through elevated reactive oxygen species generation. Free Radical Research 2008, 42:554-563.
56. Ghanim H., Aljada A., Hofmeyer D., et al. Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation 2004, 110:1564-1571.
57. Ghanim H., Mohanty P., Pathak R., et al. Orange juice or fructose intake does not induce oxidative and inflammatory response. Diabetes Care 2007, 30:1406-1411.
58. Ghanim H., Sia C.L., Upadhyay M., et al. Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and toll-like receptor expression. American Journal of Clinical Nutrition 2010, 91:940-949.
59. Gregor M.G., Hotamisligil G.S. Adipocyte stress: the endoplasmic reticulum and metabolic disease. Journal of Lipid Research 2007, 48:1905-1914.
60. Gresele P., Pignatelli P., Guglielmini G., et al. Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production. Journal of Nutrition 2008, 138:1602-1608.
61. Gutierrez A.D., de Serna D.G., Robinson I., Schade D.S. The response of gamma vitamin E to varying dosages of alpha vitamin E plus vitamin C. Metabolism, Clinical and Experimental 2009, 58:469-478.
62. Hartel C., Strunk T., Bucsky P., Schultz C. Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes. Cytokine 2004, 27:101-106.
63. Heber D., Seeram N.P., Wyatt H., et al. Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size. Journal of Agricultural and Food Chemistry 2007, 55:10050-10054.
64. Hennig B., Toborek M., McClain C.J. High-energy diets, fatty acids and endothelial cell function: implications for atherosclerosis. Journal of the American College of Nutrition 2001, 20:97-105.
65. Hirosumi J., Tuncman G., Chang L., et al. A central role for JNK in obesity and insulin resistance. Nature 2002, 420:333-336.
66. Holt E.M., Steffen L.M., Moran A., et al. Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents. Journal of the American Dietetic Association 2009, 109:414-421.
67. Holvoet P. Relations between metabolic syndrome, oxidative stress and inflammation and cardiovascular disease. Verhandelingen - Koninklijke Academie Voor Geneeskunde Van Belgie 2008, 70:193-219.
68. Houstis N., Rosen E.D., Lander E.S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006, 440:944-948.
69. Hozawa A., Jacobs D.R., Steffes M.W., et al. Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the coronary artery risk development in young adults (CARDIA)/young adult longitudinal trends in antioxidants (YALTA) study. Clinical Chemistry 2007, 53:447-455.
70. Jacob R.A., Burri B.J. Oxidative damage and defense. American Journal of Clinical Nutrition 1996, 63:985S-990S.
71. Jacob K., Periago M.J., Bohm V., Berruezo G.R. Influence of lycopene and vitamin C from tomato juice on biomarkers of oxidative stress and inflammation. British Journal of Nutrition 2008, 99:137-146.
72. Jagla A., Schrezenmeir J. Postprandial triglycerides and endothelial function. Experimental and Clinical Endocrinology and Diabetes 2001, 109:S533-S547.
73. Kamata H., Honda S., Maeda S., et al. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005, 120:649-661.
74. Kaneto H., Nakatani Y., Kawamori D., Miyatsuka T., Matsuoka T.A. Involvement of oxidative stress and the JNK pathway in glucose toxicity. Review of Diabetic Studies 2004, 1:165-174.
75. Kang J.H., Kim C.S., Han I.S., Kawada T., Yu R. Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages. FEBS Letters 2007, 581:4389-4396.
76. Kar P., Laight D., Rooprai H.K., Shaw K.M., Cummings M. Effects of grape seed extract in type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabetic Medicine 2009, 26:526-531.
77. Karalis K.P., Giannogonas P., Kodela E., et al. Mechanisms of obesity and related pathology: linking immune responses to metabolic stress. FEBS Journal 2009, 276:5747-5754.
78. Kaul D., Baba M.I. Genomic effect of vitamin 'C' and statins within human mononuclear cells involved in atherogenic process. European Journal of Clinical Nutrition 2005, 59:978-981.
79. Kay C.D., Holub B.J. The effect of wild blueberry (vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects. British Journal of Nutrition 2002, 88:389-398.
80. Keaney J.F., Larson M.G., Vasan R.S., et al. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham study. Arteriosclerosis, Thrombosis, and Vascular Biology 2003, 23:434-439.
81. Kimmons J.E., Blanck H.M., Tohill B.C., Zhang J., Khan L.K. Associations between body mass index and the prevalence of low micronutrient levels among US adults. Medscape General Medicine 2006, 8:59.
82. Koncsos P., Seres I., Harangi M., et al. Human paraoxonase-1 activity in childhood obesity and its relation to leptin and adiponectin levels. Pediatric Research 2010, 67:309-313.
83. Kritchevsky S.B. Beta-carotene, carotenoids and the prevention of coronary heart disease. Journal of Nutrition 1999, 129:5-8.
84. Kuno T., Hozumi M., Morinobu T., et al. Antioxidant vitamin levels in plasma and low density lipoprotein of obese girls. Free Radical Research 1998, 28:81-86.
85. Li N., Karin M. Is NF-?B the sensor of oxidative stress?. The FASEB Journal 1999, 13:1137-1143.
86. Ling L., Zhao S.P., Gao M., et al. Vitamin C preserves endothelial function in patients with coronary heart disease after a high-fat meal. Clinical Cardiology 2002, 25:219-224.
87. Lionetti L., Mollica M.P., Lombardi A., et al. From chronic overnutrition to insulin resistance: the role of fat-storing capacity and inflammation. Nutrition, Metabolism, and Cardiovascular Diseases 2009, 19:146-152.
88. Lopes H.F., Martin K.L., Nashar K., et al. DASH diet lowers blood pressure and lipid-induced oxidative stress in obesity. Hypertension 2003, 41:422-430.
89. Malhotra J.D., Miao H., Zhang K., et al. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:18525-18530.
90. Manning P.J., Sutherland W.H., McGrath M.M., et al. Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity 2008, 16:2046-2052.
91. Markovits N., Ben Amotz A., Levy Y. The effect of tomato-derived lycopene on low carotenoids and enhanced systemic inflammation and oxidation in severe obesity. The Israel Medical Association Journal 2009, 11:598-601.
92. Meijer K., de Vries M., Al-Lahham S., et al. Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages. PLoS One 2011, 6:e17154.
93. Mohn A., Catino M., Capanna R., et al. Increased oxidative stress in prepubertal severely obese children: effect of a dietary restriction-weight loss program. Journal of Clinical Endocrinology and Metabolism 2005, 90:2653-2658.
94. Molnar D., Decsi T., Koletzko B. Reduced antioxidant status in obese children with multimetabolic syndrome. International Journal of Obesity and Related Metabolic Disorders 2004, 28:1197-1202.
95. Moor de Burgos A., Wartanowicz M., Ziemlanski S. Blood vitamin and lipid levels in overweight and obese women. European Journal of Clinical Nutrition 1992, 46:803-808.
96. Motton D.D., Keim N.L., Tenorio F.A., Horn W.F., Rutledge J.C. Postprandial monocyte activation in response to meals with high and low glycemic loads in overweight women. American Journal of Clinical Nutrition 2007, 85:60-65.
97. Munzel T., Gori T., Bruno R.M., Taddei S. Is oxidative stress a therapeutic target in cardiovascular disease?. European Heart Journal 2010, 31:2741-2748.
98. Nanri H., Nakamura K., Hara M., et al. Association between dietary pattern and serum C-reactive protein in Japanese men and women. Journal of Epidemiology 2011, 21:122-131.
99. Nappo F., Esposito K., CioffiM., et al. Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. Journal of the American College of Cardiology 2002, 39:1145-1150.
100. Natsume Y., Ito S., Satsu H., Shimizu M. Protective effect of quercetin on ER stress caused by calcium dynamics dysregulation in intestinal epithelial cells. Toxicology 2009, 258:164-175.
101. Neri S., Calvagno S., Mauceri B., et al. Effects of antioxidants on postprandial oxidative stress and endothelial dysfunction in subjects with impaired glucose tolerance and type 2 diabetes. European Journal of Nutrition 2010, 49:409-416.
102. Neuhouser M.L., Rock C.L., Eldridge A.L., et al. Serum concentrations of retinol, alpha-tocopherol and the carotenoids are influenced by diet, race and obesity in a sample of healthy adolescents. Journal of Nutrition 2001, 131:2184-2191.
103. Newsom S.A., Paxton R.J., Rynn G.M., Bell C. Influence of ascorbic acid on the thermic effect of feeding in overweight and obese adult humans. Obesity 2008, 16:1749-1754.
104. Olas B., Wachowicz B. Resveratrol and vitamin C as antioxidants in blood platelets. Thrombosis Research 2002, 106:143-148.
105. Olusi S.O. Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans. International Journal of Obesity and Related Metabolic Disorders 2002, 26:1159-1164.
106. Osganian S.K., Stampfer M.J., Rimm E., et al. Dietary carotenoids and risk of coronary artery disease in women. American Journal of Clinical Nutrition 2003, 77:1390-1399.
107. Palmas W. Effects of short-term supplementation with ascorbate, folate, and vitamins B6 and B12 on inflammatory factors and estrogen levels in obese postmenopausal women. International Journal for Vitamin and Nutrition Research 2006, 76:34-38. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition.
108. Palmieri V.O., Grattagliano I., Portincasa P., Palasciano G. Systemic oxidative alterations are associated with visceral adiposity and liver steatosis in patients with metabolic syndrome. Journal of Nutrition 2006, 136:3022-3026.
109. Patel C., Ghanim H., Ravishankar S., et al. Prolonged reactive oxygen species generation and nuclear factor-kappaB activation after a high-fat, high-carbohydrate meal in the obese. Journal of Clinical Endocrinology and Metabolism 2007, 92:4476-4479.
110. Peairs A.T., Rankin J.W. Inflammatory response to a high-fat, low-carbohydrate weight loss diet: effect of antioxidants. Obesity 2008, 16:1573-1578.
111. Pearson T.A., Mensah G.A., Alexander R.W., et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the centers for disease control and prevention and the American heart association. Circulation 2003, 107:499-511.
112. Pierce G.L., Lesniewski L.A., Lawson B.R., Beske S.D., Seals D.R. Nuclear factor-κB activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans. Circulation 2009, 119:1284-1292.
113. Plotnick G.D., Corretti M.C., Vogel R.A. Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. The Journal of the American Medical Association 1997, 278:1682-1686.
114. Plotnick G.D., Corretti M.C., Vogel R.A., Hesslink R., Wise J.A. Effect of supplemental phytonutrients on impairment of the flow-mediated brachial artery vasoactivity after a single high-fat meal. Journal of the American College of Cardiology 2003, 41:1744-1749.
115. Puglisi M.J., Vaishnav U., Shrestha S., et al. Raisins and additional walking have distinct effects on plasma lipids and inflammatory cytokines. Lipids in Health and Disease 2008, 7:14.
116. Rankin J.W., Andreae M.C., Oliver Chen C.Y., O'Keefe S.F. Effect of raisin consumption on oxidative stress and inflammation in obesity. Diabetes, Obesity and Metabolism 2008, 10:1086-1096.
117. Reitman A., Friedrich I., Ben-Amotz A., Levy Y. Low plasma antioxidants and normal plasma B vitamins and homocysteine in patients with severe obesity. The Israel Medical Association Journal 2002, 4:590-593.
118. Retsky K.L., Freeman M.W., Frei B. Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions. Journal of Biological Chemistry 1993, 268:1304-1309.
119. Ricciarelli R., Zingg J.M., Azzi A. Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cells. Circulation 2000, 102:82-87.
120. Rimbach G., Minihane A.M., Majewicz J., et al. Regulation of cell signalling by vitamin E. Proceedings of the Nutrition Society 2002, 61:415-425.
121. Rivera L., Moron R., Zarzuelo A., Galisteo M. Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochemical Pharmacology 2009, 77:1053-1063.
122. Rizzo M.R., Abbatecola A.M., Barbieri M., et al. Evidence for anti-inflammatory effects of combined administration of vitamin E and C in older persons with impaired fasting glucose: impact on insulin action. Journal of the American College of Nutrition 2008, 27:505-511.
123. Rock C.L., Saxe G.A., Ruffin M.T., August D.A., Schottenfeld D. Carotenoids, vitamin A, and estrogen receptor status in breast cancer. Nutrition and Cancer 1996, 25:281-296.
124. Rock C.L., Thornquist M.D., Kristal A.R., et al. Demographic, dietary and lifestyle factors differentially explain variability in serum carotenoids and fat-soluble vitamins: baseline results from the sentinel site of the olestra post-marketing surveillance study. Journal of Nutrition 1999, 129:855-864.
125. Roussel A.M., Hininger I., Benaraba R., Ziegenfuss T.N., Anderson R.A. Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese. Journal of the American College of Nutrition 2009, 28:16-21.
126. Rytter E., Johansson C., Vessby B., et al. Biomarkers of oxidative stress in overweight men are not influenced by a combination of antioxidants. Free Radical Research 2010, 44:522-528.
127. Sacanella E., Vazquez-Agell M., Mena M.P., et al. Down-regulation of adhesion molecules and other inflammatory biomarkers after moderate wine consumption in healthy women: a randomized trial. American Journal of Clinical Nutrition 2007, 86:1463-1469.
128. Sanders T.A. Dietary fat and postprandial lipids. Current Atherosclerosis Reports 2003, 5:445-451.
129. Shen X.H., Tang Q.Y., Huang J., Cai W. Vitamin E regulates adipocytokine expression in a rat model of dietary-induced obesity. Experimental Biology and Medicine 2010, 235:47-51.
130. Shih C.K., Chang J.H., Yang S.H., Chou T.W., Cheng H.H. Beta-carotene and canthaxanthin alter the pro-oxidation and antioxidation balance in rats fed a high-cholesterol and high-fat diet. British Journal of Nutrition 2008, 99:59-66.
131. Shinozaki K., Kashiwagi A., Masada M., Okamura T. Stress and vascular responses: oxidative stress and endothelial dysfunction in the insulin-resistant state. Journal of Pharmacological Sciences 2003, 91:187-191.
132. Sies H., Stahl W. Vitamins E and C, beta-carotene, and other carotenoids as antioxidants. American Journal of Clinical Nutrition 1995, 62:1315S-1321S.
133. Solinas G., Karin M. JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. JFASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 2010, 24:2596-2611.
134. Soory M. Relevance of nutritional antioxidants in metabolic syndrome, ageing and cancer: potential for therapeutic targeting. Infectious Disorders Drug Targets 2009, 9:400-414.
135. Stewart L.K., Soileau J.L., Ribnicky D., et al. Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet. Metabolism, Clinical and Experimental 2008, 57:S39-S46.
136. Strauss R.S. Comparison of serum concentrations of alpha-tocopherol and beta-carotene in a cross-sectional sample of obese and nonobese children (NHANES III). National health and nutrition examination survey. Journal of Pediatrics 1999, 134:160-165.
137. Sutherland W.H., Manning P.J., Walker R.J., et al. Vitamin E supplementation and plasma 8-isoprostane and adiponectin in overweight subjects. Obesity 2007, 15:386-391.
138. Suzuki Y.J., Packer L. Inhibition of NF-kappa B DNA binding activity by alpha-tocopheryl succinate. Biochemistry and Molecular Biology International 1993, 31:693-700.
139. Suzuki K., Ito Y., Ochiai J., et al. Relationship between obesity and serum markers of oxidative stress and inflammation in Japanese. Asian Pacific Journal of Cancer Prevention 2003, 4:259-266.
140. Suzuki K., Inoue T., Hashimoto S., et al. Association of serum carotenoids with high molecular weight adiponectin and inflammation markers among Japanese subjects. Clinica Chimica Acta 2010, 411:1330-1334.
141. Tabur S., Torun A.N., Sabuncu T., et al. Non-diabetic metabolic syndrome and obesity do not affect serum paraoxonase and arylesterase activities but do affect oxidative stress and inflammation. European Journal of Endocrinology 2010, 162:535-541.
142. Tapiero H., Townsend D.M., Tew K.D. The role of carotenoids in the prevention of human pathologies. Biomedicine and Pharmacotherapy 2004, 58:100-110.
143. Terra X., Pallares V., Ardevol A., et al. Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats. The Journal of Nutritional Biochemistry 2011, 22:380-387.
144. Tousoulis D., Ntarladimas I., Antoniades C., et al. Acute effects of different alcoholic beverages on vascular endothelium, inflammatory markers and thrombosis fibrinolysis system. Clinical Nutrition 2008, 27:594-600.
145. Udani J.K., Singh B.B., Barrett M.L., Singh V.J. Evaluation of mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot, dose finding study. Nutrition Journal 2009, 8:48.
146. Upritchard J.E., Sutherland W.H., Mann J.I. Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care 2000, 23:733-738.
147. Van Gaal L.F., Mertens I.L., De Block C.E. Mechanisms linking obesity with cardiovascular disease. Nature 2006, 444:875-880.
148. Vincent H.K., Bourguignon C.M., Vincent K.R., et al. Antioxidant supplementation lowers exercise-induced oxidative stress in young overweight adults. Obesity 2006, 14:2224-2235.
149. Vincent H.K., Innes K.E., Vincent K.R. Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes, Obesity and Metabolism 2007, 9:813-839.
150. Vincent H.K., Bourguignon C.M., Weltman A.L., et al. Effects of antioxidant supplementation on insulin sensitivity, endothelial adhesion molecules, and oxidative stress in normal-weight and overweight young adults. Metabolism, Clinical and Experimental 2009, 58:254-262.
151. Vincent H.K., Bourguignon C.M., Taylor A.G. Relationship of the dietary phytochemical index to weight gain, oxidative stress and inflammation in overweight young adults. Journal of Human Nutrition and Dietetics 2010, 23:20-29.
152. Vioque J., Weinbrenner T., Asensio L., et al. Plasma concentrations of carotenoids and vitamin C are better correlated with dietary intake in normal weight than overweight and obese elderly subjects. British Journal of Nutrition 2007, 97:977-986.
153. Viroonudomphol D., Pongpaew P., Tungtrongchitr R., et al. Erythrocyte antioxidant enzymes and blood pressure in relation to overweight and obese Thai in Bangkok. The Southeast Asian Journal of Tropical Medicine and Public Health 2000, 31:325-334.
154. Vogel S., Contois J.H., Tucker K.L., et al. Plasma retinol and plasma and lipoprotein tocopherol and carotenoid concentrations in healthy elderly participants of the Framingham heart study. American Journal of Clinical Nutrition 1997, 66:950-958.
155. Wallstrom P., Wirfalt E., Lahmann P.H., et al. Serum concentrations of beta-carotene and alpha-tocopherol are associated with diet, smoking, and general and central adiposity. American Journal of Clinical Nutrition 2001, 73:777-785.
156. Wannamethee S.G., Lowe G.D., Rumley A., Bruckdorfer K.R., Whincup P.H. Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis. American Journal of Clinical Nutrition 2006, 83:567-574. quiz 726-7.
157. Watzl B., Kulling S.E., Moseneder J., Barth S.W., Bub A. A 4-wk intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy, nonsmoking men. American Journal of Clinical Nutrition 2005, 82:1052-1058.
158. Wei Y., Wang D., Topczewski F., Pagliassotti M.J. Fructose-mediated stress signaling in the liver: implications for hepatic insulin resistance. The Journal of Nutritional Biochemistry 2007, 18:1-9.
159. Weisberg S.P., McCann D., Desai M., et al. Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation 2003, 112:1796-1808.
160. Weisberg S.P., Leibel R., Tortoriello D.V. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 2008, 149:3549-3558.
161. White E., Kristal A.R., Shikany J.M., et al. Correlates of serum alpha- and gamma-tocopherol in the women's health initiative. Annals of Epidemiology 2001, 11:136-144.
162. Wong R.H., Howe P.R., Buckley J.D., et al. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutrition, Metabolism, and Cardiovascular Diseases 2010, 21:851-856.
163. Wu D., Hayek M.G., Meydani S. Vitamin E and macrophage cyclooxygenase regulation in the aged. Journal of Nutrition 2001, 131:382S-388S.
164. Yun J.M., Jialal I., Devaraj S. Effects of epigallocatechin gallate on regulatory T cell number and function in obese v. lean volunteers. British Journal of Nutrition 2010, 103:1771-1777.
165. Zhu J., Yong W., Wu X., et al. Anti-inflammatory effect of resveratrol on TNF-alpha-induced MCP-1 expression in adipocytes. Biochemical and Biophysical Research Communications 2008, 369:471-477.