Antioxidant actions of polyphenols in humans

International Journal for Vitamin and Nutrition Research

Volumn 73, Issue 2, 2003, Pages 112-119

  Dragsted, Lars O ^a  

^a DANISH VETERINARY AND FOOD ADMINISTRATION   (Denmark)

Author keywords

Antioxidant capacity; Biomarkers; Catechins; DNA; Flavonoids; Glutathione peroxidase; Glutathione reductase; Lipids; Oxidative damage; Protein

Indexed keywords

BIOLOGICAL MARKER; CATECHIN; DNA; LIPID; POLYPHENOL; PROCYANIDIN DERIVATIVE; PROTEIN;

ANTIOXIDANT ACTIVITY; CONFERENCE PAPER; DIETARY INTAKE; FOOD COMPOSITION; HUMAN; LIPID OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PHYTOCHEMISTRY;

EID: 0037359105     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: 10.1024/0300-9831.73.2.112     Document Type: Conference Paper

References (59)

1. Hertog, M. G. L., Feskens, E. J. M., Hollman, P. C. H., Katan, M. B. and Kromhout, D. (1993) Dietary antioxidant flavonoids and risk of comary heart disease: the Zutphen elderly study. The Lancet 342, 1007-1011.
2. Hertog, M. G. L., Feskens, E. J. M., Hollman, P. C. H., Katan, M. B. and Kromhout, D. (1994) Dietary flavonoids and cancer risk in the Zutphen elderly study. Nutrition and Cancer 22, 175-184.
3. Knekt, P., Järvinen, R., Reunanen, A. and Maatela, J. (1996) Flavonoid intake and coronary mortality in Findland: a cohort study. British Medical Journal 312, 478-481.
4. Hertog, M. G. L., Sweetman, P. M., Fehily, A. M., Elwood, P. C. and Kromhout, D. (1997) Antioxidant flavonols and ischemic heart disease in a Welsh population of men: the Caerphilly Study. American Journal of Clinical Nutrition 65, 1489-1494.
5. Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., Barnhart, S. and Hammer, S. (1996) Effects of a combination of beta-carotene and vitamin A on lung cancer and cardiovascular disease. The New England Journal of Medicine 334, 1150-1155.
6. The Alpha-Tocopherol, B. C. C. P. S. G. (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 330, 1029-1035.
7. Young, J. F., Nielsen, S. E., Haraldsdóttir, J., Daneshvar, B., Lauridsen, S. T., Knuthsen, P., Crozier, A., Sandström, B. and Dragsted, L. O. (1999) Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status. American Journal of Clinical Nutrition 69, 87-94.
8. Young, J. F., Dragsted, L. O., Haraldsdottir, J., Daneshvar, B., Kal, M. A., Loft, S., Nilsson, L., Nielsen, S. E., Mayer, B., Skibsted, L. H., Huynh-Ba, T., Hermetter, A. and Sandstrom, B. (2002) Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet. Br. J. Nutr. 87, 343-355.
9. Daneshvar, B., Frandsen, H., Autrup, H. and Dragsted, L. O. (1997) Gamma-glutamyl semialdehyde and 2-amino-adipic semialdehyde: biomarkers of oxidative damage to proteins. Biomarkers 2, 117-123.
10. Young, J. F., Dragsted, L. O., Daneshvar, B., Lauridsen, S. T., Hansen, M. and Sandström, B. (2000) The effect of grape skin extract on oxidative status. Br. J. Nutr. 84, 505-513.
11. Blostein-Fujii, A., DiSilvestro, R. A., Frid, D. and Katz, C. (1999) Short term citrus flavonoid supplementation of type II diabetic women: no effect on lipoprotein oxidation tendencies. Free Radic. Res. 30, 315-320.
12. O'Reilly, J.D., Sanders, T.A. and Wiseman, H. (2000) Flavonoids protect against oxidative damage to LDL in vitro: use in selection of a flavonoid rich diet and relevance to LDL oxidation resistance ex vivo? Free Radic. Res. 33, 419-426.
13. van het Hof, K. H., de Boer, H. S., Wiseman, S. A., Lien, N., Westrate, J. A. and Tijburg, L. B. (1997) Consumption of green or black tea does not increase resistance of low-density lipoprotein to oxidation in humans. Am. J. Clin. Nutr. 66, 1125-1132.
14. Ishikawa, T., Suzukawa, M., Ito, T., Yoshida, H., Ayaori, M., Nishiwaki, M., Yonemura, A., Hara, Y. and Nakamura, H. (1997) Effect of tea flavonoid supplementation on the susceptibility of low-density lipoprotein to oxidative modification. Am. J. Clin. Nutr. 66, 261-266.
15. Hodgson, J. M., Puddey, I. B., Croft, K. D., Burke, V., Mori, T. A., Caccetta, R. A. and Beilin, L. J. (2000) Acute effects of ingestion of black and green tea on lipoprotein oxidation. Am. J. Clin. Nutr 71, 1103-1107.
16. Caccetta, R. A., Croft, K. D., Beilin, L. J. and Puddey, I. B. (2000) Ingestion of red wine significantly increases plasma phenolic acid concentrations but does not acutely affect ex vivo lipoprotein oxidizability. Am. J. Clin. Nutr. 71, 67-74.
17. O'Reilly, J. D., Mallet, A. I., McAnlis, G. T., Young, I. S., Halliwell, B., Sanders, T. A. and Wiseman, H. (2001) Consumption of flavonoids in onions and black tea: lack of effect on F2-isoprostanes and autoantibodies to oxidized LDL in healthy humans. Am. J. Clin. Nutr. 73, 1040-1044.
18. Pawlowicz, P., Wilczynski, J., Stachowiak, G. and Hincz, P. (2000) Administration of natural anthocyanins derived from chokeberry retardation of idiopathic and preeclamptic origin. Influence on metabolism of plasma oxidized lipoproteins: the role of autoantibodies to oxidized low density lipoproteins. Ginekol. Pol. 71, 848-853.
19. Pawlowicz, P., Stachowiak, G., Bielak, A. and Wilczynski, J. (2001) Administration of natural anthocyanins derived from chokeberry (aronia melanocarpa) extract in the treatment of oligospermia in males with enhanced autoantibodies to oxidized low density lipoproteins (oLAB). The impact on fructose levels. Ginekol. Pol. 72, 983-988.
20. Wang, J. F., Schramm, D. D., Holt, R. R., Ensunsa, J. L., Fraga, C. G., Schmitz, H. H. and Keen, C. L. (2000) A doseresponse effect from chocolate consumption on plasma epicatechin and oxidative damage. J. Nutr. 130, 2115-2119.
21. Lauridsen, S. T. and Mortensen, A. (1999) Probucol selectively increases oxidation of atherogenid lipoproteins in cholesterol-fed mice and in Watanable heritable hyperlipidemic rabbits. Atherosclerosis 142, 169-178.
22. Miller, E. R., III, Appel, L. J. and Risby, T. H. (1998) Effect of dietary patterns on measures of lipid peroxidation: results from a randomized clinical trial. Circulation 98, 2390-2395.
23. Thompson, H. J., Heimendinger, J., Haegele, A., Sedlacek, S. M., Gillette, C., O'Neill, C., Wolfe, P. and Conry, C. (1999) Effect of increased vegetable and fruit consumption on markers of oxidative cellular damage. Carcinogenesis 20, 2261-2266.
24. van den Berg, R., van Vliet, T., Broekmans, W. M., Cnubben, N. H., Vaes, W. H., Roza, L., Haenen, G. R., Bast, A. and van den, B. H. (2001) A vegetable/fruit concentrate with high antioxidant capacity has no effect on biomarkers of antioxidant status in male smokers. J. Nutr. 131, 1714-1722.
25. Huang, H. Y., Appel, L. J., Croft, K. D., Miller, E. R., III, Mori, T. A. and Puddey, I. B. (2002) Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial. Am. J. Clin. Nutr. 76, 549-555.
26. Hodgson, J. M., Croft, K. D., Mori, T. A., Burke, V., Beilin, L. J. and Puddey, I. B. (2002) Regular ingestion of tea does not inhibit in vivo lipid peroxidation in humans. J. Nutr. 132, 55-58.
27. Patrignani, P., Panara, M. R., Tacconelli, S., Seta, F., Bucciarelli, T., Ciabattoni, G., Alessandrini, P., Mezzetti, A., Santini, G., Sciulli, M. G., Cipollone, F., Davi, G., Gallina, P., Bon, G. B. and Patrono, C. (2000) Effects of vitamin E supplementation on F(2)-isoprostane and thromboxane biosynthesis in healthy cigarette smokers. Circulation 102, 539-545.
28. Hodgson, J. M., Puddey, I. B., Croft, K. D., Mori, T. A., Rivera, J. and Beilin, L. J. (1999) Isoflavonoids do not inhibit in vivo lipid peroxidation in subjects with high-normal blood pressure. Atherosclerosis 145, 167-172.
29. Porkkala-Sarataho, E., Salonen, J. T., Nyyssonen, K., Kaikkonen, J., Salonen, R., Ristonmaa, U., Diczfalusy, U., Brigelius-Flohe, R., Loft, S. and Poulsen, H. E. (2000) Longterm effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydro-8-oxo-2′-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in nondepleted men. Arterioscler. Thromb. Vasc. Biol. 20, 2087-2093.
30. Salonen, J. T., Nyyssonen, K., Salonen, R., Lakka, H. M., Kaikkonen, J., Porkkala-Sarataho, E., Voutilainen, S., Lakka, T. A., Rissanen, T., Leskinen, L., Tuomainen, T. P., Valkonen, V. P., Ristonmaa, U. and Poulsen, H. E. (2000) Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J. Intern. Med. 248, 377-386.
31. Salonen, J. T., Herttuala, Y. S., Yamamoto, R., Butler, S., Korpela, H., Salonen, R., Nyyssönen, K., Palinski, W. and Witztum, J. L. (1992) Autoantibody against oxidised LDL and progression of carotid atherosclerosis. The Lancet 339, 883-887.
32. Collins, A. R., Dusinska, M., Gedik, C. M. and Stetina, R. (1996) Oxidative damage to DNA: do we have a reliable biomarker? Environ. Health Perspect. 104 Suppl 3, 465-469.
33. Vogel, U., Moller, P., Dragsted, L., Loft, S., Pedersen, A. and Sandstrom, B. (2002) Inter-individual variation, seasonal variation and close correlation of OGG1 and ERCC1 mRNA levels in full blood from healthy volunteers. Carcinogenesis 23, 1505-1509.
34. Klaunig, J. E., Xu, Y., Han, C., Kamendulis, L. M., Chen, J., Heiser, C., Gordon, M. S. and Mohler, E. R., III (1999) The effect of tea consumption on oxidative stress in smokers and nonsmokers. Proc. Soc. Exp. Biol. Med. 220, 249-254.
35. Priemé, H., Loft, S., Nyyssönen, K., Salonen, J. T. and Poulsen, H. E. (1997) No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion in smokers. American Journal of Clinical Nutrition 65, 503-507.
36. Collins, A. R., Olmedilla, B., Southon, S., Granado, F. and Duthie, S. J. (1998) Serum carotenoids and oxidative DNA damage in human lymphocytes. Carcinogenesis 19, 2159-2162.
37. Collins, B. H., Horska, A., Hotten, P. M., Riddoch, C. and Collins, A. R. (2001) Kiwifruit protects against oxidative DNA damage in human cells and in vitro. Nutr. Cancer 39, 148-153.
38. Duthie, S. J., Ma, A., Ross, M. A. and Collins, A. R. (1996) Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res. 56, 1291-1295.
39. Stevens, T. M., Boswell, G. A., Jr., Adler, R., Ackerman, N. R. and Kerr, J. S. (1988) Induction of antioxidant enzyme activities by a phenylurea derivative, EDU. Toxicol. Appl. Pharmacol. 96, 33-42.
40. Cowan, D. B., Weisel, R. D., Williams, W. G. and Mickle, D. A. (1992) The regulation of glutathione peroxidase gene expression by oxygen tension in cultured human cardiomyocytes. J. Mol. Cell Cardiol. 24, 423-433.
41. Alvarez, S. and Boveris, A. (1993) Induction of antioxidant enzymes and DT-diaphorase in human blood mononuclear cells by light stress. Arch. Biochem. Biophys. 305, 247-251.
42. Bub, A., Watzl, B., Abrahamse, L., Delincee, H., Adam, S., Wever, J., Muller, H. and Rechkemmer, G. (2000) Moderate intervention with carotenoid-rich vegetable products reduces lipid peroxidation in men. J. Nutr. 130, 2200-2206.
43. Bruce, B., Spiller, G. A., Klevay, L. M. and Gallagher, S. K. (2000) A diet high in whole and unrefined foods favorably alters lipids, antioxidant defenses, and colon function. J. Am. Coll. Nutr. 19, 61-67.
44. Rice-Evans, C. and Miller, N. J. (1994) Total antioxidant status in plasma and body fluids. 279-293.
45. Benzie, I. F. and Strain, J. J. (1996) The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal. Biochem. 239, 70-76.
46. Benzie, I. F., Szeto, Y. T., Strain, J. J. and Tomlinson, B. (1999) Consumption of green tea causes rapid increase in plasma antioxidant power in humans. Nutr. Cancer 34, 83-87.
47. Lee, A., Thurnham, D. I. and Chopra, M. (2000) Consumption of tomato products with olive oil but not sunflower oil increases the antioxidant activity of plasma. Free Radic. Biol. Med. 29, 1051-1055.
48. Duthie, G. G., Pedersen, M. W., Gardner, P. T., Morrice, P. C., Jenkinson, A. M., McPhail, D. B. and Steele, G. M. (1998) The effect of whiskey and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers. European Journal of Clinical Nutrition 52, 733-736.
49. Leenen, R., Roodenburg, A. J., Tijburg, L. B. and Wiseman, S. A. (2000) A single dose of tea with or without milk increases plasma antioxidant activity in humans. Eur. J. Clin. Nutr. 54, 87-92.
50. Castenmiller, J. J. M., Lauridsen, S. T., Dragsted, L. O., van het Hof, K. H., Linssen, J. P. H. and West, C. E. (1999) Betacarotene does not change markers of enzymatic and non-enzymatic antioxidant activity in human blood. J. Nutr. 129, 2162-2169.
51. Serafini, M., Ghiselli, A. and Ferro-Luzzi, A. (1996) In vivo antioxidant effect of green and black tea in man. European Journal of Clinical Nutrition 50, 28-32.
52. Langley-Evans, S. C. (2000) Consumption of black tea elicits an increase in plasma antioxidant potential in humans. Int. J. Food Sci. Nutr. 51, 309-315.
53. Leenen, R., Roodenburg, A. J., Tijburg, L. B. and Wiseman, S. A. (2000) A single dose of tea with or without milk increases plasma antioxidant activity in humans. Eur. J. Clin. Nutr. 54, 87-92.
54. Nuttall, S. L., Kendall, M. J., Bombardelli, E. and Morazzoni, P. (1998) An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J. Clin. Pharm. Ther. 23, 385-389.
55. Sung, H., Nah, J., Chun, S., Park, H., Yang, S. E. and Min, W. K. (2000) In vivo antioxidant effect of green tea. Eur. J. Clin. Nutr. 54, 527-529.
56. Pietta, P., Simonetti, P., Gardana, C., Brusamolino, A., Morazzoni, P. and Bombardelli, E. (1998) Relationship between rate and extent of catechin absorption and plasma antioxidant status. Biochem. Mol. Biol. Int. 46, 895-903.
57. Rein, D., Lotito, S., Holt, R. R., Keen, C. L., Schmitz, H. H. and Fraga, C. G. (2000) Epicatechin in human plasma: in vivo determination and effect of chocolate consumption on plasma oxidation status. J. Nutr. 130, 2109-2114.
58. Wan, Y., Vinson, J. A., Etherton, T. D., Proch, J., Lazarus, S. A. and Kris-Etherton, P. M. (2001) Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. Am. J. Clin. Nutr. 74, 596-602.
59. Nielsen, S. E., Young, J. F., Daneshvar, B., Lauridsen, S. T., Knuthsen, P., Sandstrom, B. and Dragsted, L. O. (1999) Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers 'for oxidative stress in human subjects. Br. J. Nutr. 81, 447-455.