메뉴 건너뛰기




Volumn 126, Issue 10, 2020, Pages 1456-1474

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2

Author keywords

cardiovascular diseases; coronavirus; dysbiosis; heart failure; renin angiotensin system

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; DIPEPTIDYL CARBOXYPEPTIDASE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; VIRUS RECEPTOR;

EID: 85083388421     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.120.317015     Document Type: Review
Times cited : (1526)

References (201)
  • 1
    • 84963808130 scopus 로고    scopus 로고
    • Role of the ACE2/Angiotensin 1-7 axis of the renin-angiotensin system in heart failure
    • Patel VB, Zhong JC, Grant MB, Oudit GY. Role of the ACE2/Angiotensin 1-7 axis of the renin-angiotensin system in heart failure. Circ Res. 2016;118:1313-1326. doi: 10.1161/CIRCRESAHA.116.307708
    • (2016) Circ Res. , vol.118 , pp. 1313-1326
    • Patel, V.B.1    Zhong, J.C.2    Grant, M.B.3    Oudit, G.Y.4
  • 2
    • 0034721906 scopus 로고    scopus 로고
    • A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase
    • Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem. 2000;275:33238-33243. doi: 10.1074/jbc.M002615200
    • (2000) J Biol Chem. , vol.275 , pp. 33238-33243
    • Tipnis, S.R.1    Hooper, N.M.2    Hyde, R.3    Karran, E.4    Christie, G.5    Turner, A.J.6
  • 4
    • 85084535521 scopus 로고    scopus 로고
    • Angiotensin converting enzyme 2: a double-edged sword
    • Wang K, Gheblawi M, Oudit GY. Angiotensin converting enzyme 2: a double-edged sword. Circulation. 2020. doi:10.1161/CIRCULATIONAHA.120.047049
    • (2020) Circulation
    • Wang, K.1    Gheblawi, M.2    Oudit, G.Y.3
  • 6
    • 2542473313 scopus 로고    scopus 로고
    • ACE2: from vasopeptidase to SARS virus receptor
    • Turner AJ, Hiscox JA, Hooper NM. ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci. 2004;25:291-294. doi: 10.1016/j.tips.2004.04.001
    • (2004) Trends Pharmacol Sci. , vol.25 , pp. 291-294
    • Turner, A.J.1    Hiscox, J.A.2    Hooper, N.M.3
  • 7
    • 84859871006 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2: the first decade
    • Clarke NE, Turner AJ. Angiotensin-converting enzyme 2: the first decade. Int J Hypertens. 2012;2012:307315. doi: 10.1155/2012/307315
    • (2012) Int J Hypertens. , vol.2012 , pp. 307315
    • Clarke, N.E.1    Turner, A.J.2
  • 9
    • 85019683403 scopus 로고    scopus 로고
    • Gut microbiota: potential for a unifying hypothesis for prevention and treatment of hypertension
    • Qi Y, Kim S, Richards EM, Raizada MK, Pepine CJ. Gut microbiota: potential for a unifying hypothesis for prevention and treatment of hypertension. Circ Res. 2017;120:1724-1726. doi: 10.1161/CIRCRESAHA.117.310734
    • (2017) Circ Res. , vol.120 , pp. 1724-1726
    • Qi, Y.1    Kim, S.2    Richards, E.M.3    Raizada, M.K.4    Pepine, C.J.5
  • 11
    • 85074676636 scopus 로고    scopus 로고
    • Bone marrow-derived cells restore functional integrity of the gut epithelial and vascular barriers in a model of diabetes and ACE2 deficiency
    • Duan Y, Prasad R, Feng D, Beli E, Li Calzi S, Longhini ALF, Lamendella R, Floyd JL, Dupont M, Noothi SK, et al. Bone marrow-derived cells restore functional integrity of the gut epithelial and vascular barriers in a model of diabetes and ACE2 deficiency. Circ Res. 2019;125:969-988. doi: 10.1161/CIRCRESAHA.119.315743
    • (2019) Circ Res. , vol.125 , pp. 969-988
    • Duan, Y.1    Prasad, R.2    Feng, D.3    Beli, E.4    Li Calzi, S.5    Longhini, A.L.F.6    Lamendella, R.7    Floyd, J.L.8    Dupont, M.9    Noothi, S.K.10
  • 12
    • 84927796509 scopus 로고    scopus 로고
    • Oral delivery of Angiotensin-converting enzyme 2 and Angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension
    • Shenoy V, Kwon KC, Rathinasabapathy A, Lin S, Jin G, Song C, Shil P, Nair A, Qi Y, Li Q, et al. Oral delivery of Angiotensin-converting enzyme 2 and Angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension. Hypertension. 2014;64:1248-1259. doi: 10.1161/HYPERTENSIONAHA.114.03871
    • (2014) Hypertension , vol.64 , pp. 1248-1259
    • Shenoy, V.1    Kwon, K.C.2    Rathinasabapathy, A.3    Lin, S.4    Jin, G.5    Song, C.6    Shil, P.7    Nair, A.8    Qi, Y.9    Li, Q.10
  • 14
    • 85073125544 scopus 로고    scopus 로고
    • ACE2 and ADAM17 interaction regulates the activity of presympathetic neurons
    • Mukerjee S, Gao H, Xu J, Sato R, Zsombok A, Lazartigues E. ACE2 and ADAM17 interaction regulates the activity of presympathetic neurons. Hypertension. 2019;74:1181-1191. doi: 10.1161/HYPERTENSIONAHA.119.13133
    • (2019) Hypertension , vol.74 , pp. 1181-1191
    • Mukerjee, S.1    Gao, H.2    Xu, J.3    Sato, R.4    Zsombok, A.5    Lazartigues, E.6
  • 15
    • 85081283286 scopus 로고    scopus 로고
    • Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein
    • Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell. 2020;181:281-292. doi: 10.1016/j.cell.2020.02.058
    • (2020) Cell , vol.181 , pp. 281-292
    • Walls, A.C.1    Park, Y.J.2    Tortorici, M.A.3    Wall, A.4    McGuire, A.T.5    Veesler, D.6
  • 16
    • 85082184064 scopus 로고    scopus 로고
    • Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
    • Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science. 2020;367:1444-1448. doi: 10.1126/science.abb2762
    • (2020) Science , vol.367 , pp. 1444-1448
    • Yan, R.1    Zhang, Y.2    Li, Y.3    Xia, L.4    Guo, Y.5    Zhou, Q.6
  • 18
    • 23844463115 scopus 로고    scopus 로고
    • A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury
    • Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 2005;11:875-879. doi: 10.1038/nm1267
    • (2005) Nat Med. , vol.11 , pp. 875-879
    • Kuba, K.1    Imai, Y.2    Rao, S.3    Gao, H.4    Guo, F.5    Guan, B.6    Huan, Y.7    Yang, P.8    Zhang, Y.9    Deng, W.10
  • 23
    • 20444439901 scopus 로고    scopus 로고
    • Six truisms concerning ACE and the renin-angiotensin system educed from the genetic analysis of mice
    • Bernstein KE, Xiao HD, Frenzel K, Li P, Shen XZ, Adams JW, Fuchs S. Six truisms concerning ACE and the renin-angiotensin system educed from the genetic analysis of mice. Circ Res. 2005;96:1135-1144. doi: 10.1161/01.RES.0000169536.73576.66
    • (2005) Circ Res. , vol.96 , pp. 1135-1144
    • Bernstein, K.E.1    Xiao, H.D.2    Frenzel, K.3    Li, P.4    Shen, X.Z.5    Adams, J.W.6    Fuchs, S.7
  • 24
    • 0000884783 scopus 로고
    • Angiotonin-activator, renin- and angiotonin-inhibitor, and the mechanism of angiotonin tachyphylaxis in normal, hypertensive, and nephrectomized animalS
    • Page IH, Helmer OM. Angiotonin-activator, renin- and angiotonin-inhibitor, and the mechanism of angiotonin tachyphylaxis in normal, hypertensive, and nephrectomized animalS. J Exp Med. 1940;71:495-519. doi: 10.1084/jem.71.4.495
    • (1940) J Exp Med. , vol.71 , pp. 495-519
    • Page, I.H.1    Helmer, O.M.2
  • 26
    • 0038163054 scopus 로고
    • The preparation and function of the hypertensin-converting enzyme
    • Skeggs LT Jr, Kahn JR, Shumway NP. The preparation and function of the hypertensin-converting enzyme. J Exp Med. 1956;103:295-299. doi: 10.1084/jem.103.3.295
    • (1956) J Exp Med. , vol.103 , pp. 295-299
    • Skeggs, L.T.1    Kahn, J.R.2    Shumway, N.P.3
  • 27
    • 85024286205 scopus 로고
    • Studies on experimental hypertension: I. The production of persistent elevation of systolic blood pressure by means of renal ischemia
    • Goldblatt H, Lynch J, Hanzal RF, Summerville WW. Studies on experimental hypertension: I. The production of persistent elevation of systolic blood pressure by means of renal ischemia. J Exp Med. 1934;59:347-379. doi: 10.1084/jem.59.3.347
    • (1934) J Exp Med. , vol.59 , pp. 347-379
    • Goldblatt, H.1    Lynch, J.2    Hanzal, R.F.3    Summerville, W.W.4
  • 28
    • 6344246036 scopus 로고    scopus 로고
    • Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
    • Rice GI, Thomas DA, Grant PJ, Turner AJ, Hooper NM. Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem J. 2004;383:45-51. doi: 10.1042/BJ20040634
    • (2004) Biochem J. , vol.383 , pp. 45-51
    • Rice, G.I.1    Thomas, D.A.2    Grant, P.J.3    Turner, A.J.4    Hooper, N.M.5
  • 30
    • 85081901579 scopus 로고    scopus 로고
    • Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
    • Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054-1062. doi: 10.1016/S0140-6736(20)30566-3
    • (2020) Lancet , vol.395 , pp. 1054-1062
    • Zhou, F.1    Yu, T.2    Du, R.3    Fan, G.4    Liu, Y.5    Liu, Z.6    Xiang, J.7    Wang, Y.8    Song, B.9    Gu, X.10
  • 31
    • 24944498409 scopus 로고    scopus 로고
    • Structure of SARS coronavirus spike receptor-binding domain complexed with receptor
    • Li F, Li W, Farzan M, Harrison SC. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science. 2005;309:1864-1868. doi: 10.1126/science.1116480
    • (2005) Science , vol.309 , pp. 1864-1868
    • Li, F.1    Li, W.2    Farzan, M.3    Harrison, S.C.4
  • 33
    • 67349158649 scopus 로고    scopus 로고
    • Coronaviruses post-SARS: update on replication and pathogenesis
    • Perlman S, Netland J. Coronaviruses post-SARS: update on replication and pathogenesis. Nat Rev Microbiol. 2009;7:439-450. doi: 10.1038/nrmicro2147
    • (2009) Nat Rev Microbiol. , vol.7 , pp. 439-450
    • Perlman, S.1    Netland, J.2
  • 34
    • 0027239987 scopus 로고
    • Structural and functional analysis of the surface protein of human coronavirus OC43
    • Künkel F, Herrler G. Structural and functional analysis of the surface protein of human coronavirus OC43. Virology. 1993;195:195-202. doi: 10.1006/viro.1993.1360
    • (1993) Virology , vol.195 , pp. 195-202
    • Künkel, F.1    Herrler, G.2
  • 35
    • 0014077175 scopus 로고
    • Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease
    • McIntosh K, Dees JH, Becker WB, Kapikian AZ, Chanock RM. Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease. Proc Natl Acad Sci USA. 1967;57:933-940. doi: 10.1073/pnas.57.4.933
    • (1967) Proc Natl Acad Sci USA , vol.57 , pp. 933-940
    • McIntosh, K.1    Dees, J.H.2    Becker, W.B.3    Kapikian, A.Z.4    Chanock, R.M.5
  • 36
    • 85078761741 scopus 로고    scopus 로고
    • Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
    • Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507-513. doi: 10.1016/S0140-6736(20)30211-7
    • (2020) Lancet , vol.395 , pp. 507-513
    • Chen, N.1    Zhou, M.2    Dong, X.3    Qu, J.4    Gong, F.5    Han, Y.6    Qiu, Y.7    Wang, J.8    Liu, Y.9    Wei, Y.10
  • 37
    • 85079242706 scopus 로고    scopus 로고
    • Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China
    • Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323:1061-1069. doi: 10.1001/jama.2020.1585
    • (2020) JAMA , vol.323 , pp. 1061-1069
    • Wang, D.1    Hu, B.2    Hu, C.3    Zhu, F.4    Liu, X.5    Zhang, J.6    Wang, B.7    Xiang, H.8    Cheng, Z.9    Xiong, Y.10
  • 38
    • 85078262578 scopus 로고    scopus 로고
    • Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
    • Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497-506. doi: 10.1016/S0140-6736(20)30183-5
    • (2020) Lancet , vol.395 , pp. 497-506
    • Huang, C.1    Wang, Y.2    Li, X.3    Ren, L.4    Zhao, J.5    Hu, Y.6    Zhang, L.7    Fan, G.8    Xu, J.9    Gu, X.10
  • 39
    • 2642544842 scopus 로고    scopus 로고
    • Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways
    • Ding Y, He L, Zhang Q, Huang Z, Che X, Hou J, Wang H, Shen H, Qiu L, Li Z, et al. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways. J Pathol. 2004;203:622-630. doi: 10.1002/path.1560
    • (2004) J Pathol. , vol.203 , pp. 622-630
    • Ding, Y.1    He, L.2    Zhang, Q.3    Huang, Z.4    Che, X.5    Hou, J.6    Wang, H.7    Shen, H.8    Qiu, L.9    Li, Z.10
  • 41
    • 85079051459 scopus 로고    scopus 로고
    • Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China
    • Wu A, Peng Y, Huang B, Ding X, Wang X, Niu P, Meng J, Zhu Z, Zhang Z, Wang J, et al. Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China. Cell Host Microbe. 2020;27:325-328. doi: 10.1016/j.chom.2020.02.001
    • (2020) Cell Host Microbe. , vol.27 , pp. 325-328
    • Wu, A.1    Peng, Y.2    Huang, B.3    Ding, X.4    Wang, X.5    Niu, P.6    Meng, J.7    Zhu, Z.8    Zhang, Z.9    Wang, J.10
  • 42
    • 85083343318 scopus 로고    scopus 로고
    • Structural basis of receptor recognition by SARS-CoV-2
    • [published online March 30, 2020]
    • Shang J, Ye G, Shi K, Wan Y, Luo C, Aihara H, Geng Q, Auerbach A, Li F. Structural basis of receptor recognition by SARS-CoV-2 [published online March 30, 2020]. Nature. doi: 10.1038/s41586-020-2179-y. Available at nature.com/articles/s41586-020-2179-y.
    • Nature
    • Shang, J.1    Ye, G.2    Shi, K.3    Wan, Y.4    Luo, C.5    Aihara, H.6    Geng, Q.7    Auerbach, A.8    Li, F.9
  • 43
    • 84930047858 scopus 로고    scopus 로고
    • Host cell proteases: critical determinants of coronavirus tropism and pathogenesis
    • Millet JK, Whittaker GR. Host cell proteases: critical determinants of coronavirus tropism and pathogenesis. Virus Res. 2015;202:120-134. doi: 10.1016/j.virusres.2014.11.021
    • (2015) Virus Res. , vol.202 , pp. 120-134
    • Millet, J.K.1    Whittaker, G.R.2
  • 45
    • 85079455708 scopus 로고    scopus 로고
    • Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury
    • Liu Y, Yang Y, Zhang C, Huang F, Wang F, Yuan J, Wang Z, Li J, Li J, Feng C, et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Sci China Life Sci. 2020;63:364-374. doi: 10.1007/s11427-020-1643-8
    • (2020) Sci China Life Sci. , vol.63 , pp. 364-374
    • Liu, Y.1    Yang, Y.2    Zhang, C.3    Huang, F.4    Wang, F.5    Yuan, J.6    Wang, Z.7    Li, J.8    Li, J.9    Feng, C.10
  • 46
    • 66849134954 scopus 로고    scopus 로고
    • SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS
    • Oudit GY, Kassiri Z, Jiang C, Liu PP, Poutanen SM, Penninger JM, Butany J. SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS. Eur J Clin Invest. 2009;39:618-625. doi: 10.1111/j.1365-2362.2009.02153.x
    • (2009) Eur J Clin Invest. , vol.39 , pp. 618-625
    • Oudit, G.Y.1    Kassiri, Z.2    Jiang, C.3    Liu, P.P.4    Poutanen, S.M.5    Penninger, J.M.6    Butany, J.7
  • 47
    • 85083241171 scopus 로고    scopus 로고
    • Clinical characteristics of coronavirus disease 2019 in China
    • [published online February 28, 2020]
    • Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, et al; China Medical Treatment Expert Group for Covid-19. Clinical characteristics of coronavirus disease 2019 in China [published online February 28, 2020]. N Engl J Med. doi: 10.1056/NEJMoa2002032. Available at nejm.org/doi/full/10.1056/NEJMoa2002032.
    • N Engl J Med.
    • Guan, W.J.1    Ni, Z.Y.2    Hu, Y.3    Liang, W.H.4    Ou, C.Q.5    He, J.X.6    Liu, L.7    Shan, H.8    Lei, C.L.9    Hui, D.S.C.10
  • 48
    • 85083064516 scopus 로고    scopus 로고
    • SARS-CoV2: should inhibitors of the renin-angiotensin system be withdrawn in patients with covid-19?
    • [published online March 20, 2020]
    • Kuster GM, Pfister O, Burkard T, Zhou Q, Twerenbold R, Haaf P, Widmer AF, Osswald S. SARS-CoV2: should inhibitors of the renin-angiotensin system be withdrawn in patients with covid-19? [published online March 20, 2020]. Eur Heart J. doi: 10.1093/eurheartj/ehaa235. Available at academic.oup.com/eurheartj/article/doi/10.1093/eurheartj.ehaa235/5810479.
    • Eur Heart J.
    • Kuster, G.M.1    Pfister, O.2    Burkard, T.3    Zhou, Q.4    Twerenbold, R.5    Haaf, P.6    Widmer, A.F.7    Osswald, S.8
  • 49
  • 50
    • 85082439582 scopus 로고    scopus 로고
    • Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China
    • [published online March 25, 2020]
    • Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, Gong W, Liu X, Liang J, Zhao Q, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China [published online March 25, 2020]. JAMA Cardiol. doi: 10.1001/jamacardio.2020.0950. Available at jamanetwork.com/journals/jamacardiology/fullarticle/2763524.
    • JAMA Cardiol.
    • Shi, S.1    Qin, M.2    Shen, B.3    Cai, Y.4    Liu, T.5    Yang, F.6    Gong, W.7    Liu, X.8    Liang, J.9    Zhao, Q.10
  • 52
    • 85082441674 scopus 로고    scopus 로고
    • Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19)
    • [published online March 27, 2020]
    • Guo T, Fan Y, Chen M, Wu X, Zhang L, He T, Wang H, Wan J, Wang X, Lu Z. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19) [published online March 27, 2020]. JAMA Cardiol. doi: 10.1001/jamacardio.2020.1017. Available at jamanetwork.com/journals/jamacardiology/fullarticle/2763845.
    • JAMA Cardiol.
    • Guo, T.1    Fan, Y.2    Chen, M.3    Wu, X.4    Zhang, L.5    He, T.6    Wang, H.7    Wan, J.8    Wang, X.9    Lu, Z.10
  • 53
    • 85078241697 scopus 로고    scopus 로고
    • A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster
    • Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395:514-523. doi: 10.1016/S0140-6736(20)30154-9
    • (2020) Lancet , vol.395 , pp. 514-523
    • Chan, J.F.1    Yuan, S.2    Kok, K.H.3    To, K.K.4    Chu, H.5    Yang, J.6    Xing, F.7    Liu, J.8    Yip, C.C.9    Poon, R.W.10
  • 54
    • 2442676278 scopus 로고    scopus 로고
    • Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome
    • Cheng PK, Wong DA, Tong LK, Ip SM, Lo AC, Lau CS, Yeung EY, Lim WW. Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome. Lancet. 2004;363:1699-1700. doi: 10.1016/S0140-6736(04)16255-7
    • (2004) Lancet , vol.363 , pp. 1699-1700
    • Cheng, P.K.1    Wong, D.A.2    Tong, L.K.3    Ip, S.M.4    Lo, A.C.5    Lau, C.S.6    Yeung, E.Y.7    Lim, W.W.8
  • 55
    • 0141483076 scopus 로고    scopus 로고
    • Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection
    • Leung WK, To KF, Chan PK, Chan HL, Wu AK, Lee N, Yuen KY, Sung JJ. Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. Gastroenterology. 2003;125:1011-1017. doi: 10.1016/s0016-5085(03)01215-0
    • (2003) Gastroenterology , vol.125 , pp. 1011-1017
    • Leung, W.K.1    To, K.F.2    Chan, P.K.3    Chan, H.L.4    Wu, A.K.5    Lee, N.6    Yuen, K.Y.7    Sung, J.J.8
  • 56
    • 85037354690 scopus 로고    scopus 로고
    • Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus
    • Zhou J, Li C, Zhao G, Chu H, Wang D, Yan HH, Poon VK, Wen L, Wong BH, Zhao X, et al. Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus. Sci Adv. 2017;3:eaao4966. doi: 10.1126/sciadv.aao4966
    • (2017) Sci Adv. , vol.3 , pp. eaao4966
    • Zhou, J.1    Li, C.2    Zhao, G.3    Chu, H.4    Wang, D.5    Yan, H.H.6    Poon, V.K.7    Wen, L.8    Wong, B.H.9    Zhao, X.10
  • 57
    • 84963838320 scopus 로고    scopus 로고
    • Brain-gut-bone marrow axis: implications for hypertension and related therapeutics
    • Santisteban MM, Kim S, Pepine CJ, Raizada MK. Brain-gut-bone marrow axis: implications for hypertension and related therapeutics. Circ Res. 2016;118:1327-1336. doi: 10.1161/CIRCRESAHA.116.307709
    • (2016) Circ Res. , vol.118 , pp. 1327-1336
    • Santisteban, M.M.1    Kim, S.2    Pepine, C.J.3    Raizada, M.K.4
  • 59
    • 85080982309 scopus 로고    scopus 로고
    • Enteric involvement of coronaviruses: is faecal-oral transmission of SARS-CoV-2 possible?
    • Yeoa C, Kaushala S, Yeoa D. Enteric involvement of coronaviruses: is faecal-oral transmission of SARS-CoV-2 possible? Lancet Gastroenterol Hepatol. 2020;5:335-337.
    • (2020) Lancet Gastroenterol Hepatol. , vol.5 , pp. 335-337
    • Yeoa, C.1    Kaushala, S.2    Yeoa, D.3
  • 60
    • 2642539225 scopus 로고    scopus 로고
    • Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis
    • Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004;203:631-637. doi: 10.1002/path.1570
    • (2004) J Pathol. , vol.203 , pp. 631-637
    • Hamming, I.1    Timens, W.2    Bulthuis, M.L.3    Lely, A.T.4    Navis, G.5    Van Goor, H.6
  • 61
    • 85048382899 scopus 로고    scopus 로고
    • Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db mice
    • Beli E, Yan Y, Moldovan L, Vieira CP, Gao R, Duan Y, Prasad R, Bhatwadekar A, White FA, Townsend SD, et al. Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db mice. Diabetes. 2018;67:1867-1879. doi: 10.2337/db18-0158
    • (2018) Diabetes , vol.67 , pp. 1867-1879
    • Beli, E.1    Yan, Y.2    Moldovan, L.3    Vieira, C.P.4    Gao, R.5    Duan, Y.6    Prasad, R.7    Bhatwadekar, A.8    White, F.A.9    Townsend, S.D.10
  • 64
    • 0029793010 scopus 로고    scopus 로고
    • Chronic control of high blood pressure in the spontaneously hypertensive rat by delivery of angiotensin type 1 receptor antisense
    • Iyer SN, Lu D, Katovich MJ, Raizada MK. Chronic control of high blood pressure in the spontaneously hypertensive rat by delivery of angiotensin type 1 receptor antisense. Proc Natl Acad Sci USA. 1996;93:9960-9965. doi: 10.1073/pnas.93.18.9960
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9960-9965
    • Iyer, S.N.1    Lu, D.2    Katovich, M.J.3    Raizada, M.K.4
  • 68
    • 85075140449 scopus 로고    scopus 로고
    • Pulmonary hypertension: pathophysiology beyond the lung
    • Oliveira AC, Richards EM, Raizada MK. Pulmonary hypertension: pathophysiology beyond the lung. Pharmacol Res. 2020;151:104518. doi: 10.1016/j.phrs.2019.104518
    • (2020) Pharmacol Res. , vol.151 , pp. 104518
    • Oliveira, A.C.1    Richards, E.M.2    Raizada, M.K.3
  • 69
    • 0038730473 scopus 로고    scopus 로고
    • Churning out safer microbes for drug delivery
    • Syvanen M. Churning out safer microbes for drug delivery. Nat Biotechnol. 2003;21:758-759. doi: 10.1038/nbt0703-758
    • (2003) Nat Biotechnol. , vol.21 , pp. 758-759
    • Syvanen, M.1
  • 70
    • 0346723082 scopus 로고    scopus 로고
    • Genetically engineered probiotics
    • Steidler L. Genetically engineered probiotics. Best Pract Res Clin Gastroenterol. 2003;17:861-876. doi: 10.1016/s1521-6918(03)00072-6
    • (2003) Best Pract Res Clin Gastroenterol. , vol.17 , pp. 861-876
    • Steidler, L.1
  • 71
    • 85051080506 scopus 로고    scopus 로고
    • Lactic acid bacteria for delivery of endogenous or engineered therapeutic molecules
    • Bron PA, Kleerebezem M. Lactic acid bacteria for delivery of endogenous or engineered therapeutic molecules. Front Microbiol. 2018;9:1821. doi: 10.3389/fmicb.2018.01821
    • (2018) Front Microbiol. , vol.9 , pp. 1821
    • Bron, P.A.1    Kleerebezem, M.2
  • 74
    • 0031698581 scopus 로고    scopus 로고
    • ADAMs: focus on the protease domain
    • Black RA, White JM. ADAMs: focus on the protease domain. Curr Opin Cell Biol. 1998;10:654-659. doi: 10.1016/s0955-0674(98)80042-2
    • (1998) Curr Opin Cell Biol. , vol.10 , pp. 654-659
    • Black, R.A.1    White, J.M.2
  • 75
    • 77949558495 scopus 로고    scopus 로고
    • ADAM-17: the enzyme that does it all
    • Gooz M. ADAM-17: the enzyme that does it all. Crit Rev Biochem Mol Biol. 2010;45:146-169. doi: 10.3109/10409231003628015
    • (2010) Crit Rev Biochem Mol Biol. , vol.45 , pp. 146-169
    • Gooz, M.1
  • 76
    • 84953344999 scopus 로고    scopus 로고
    • Cardiomyocyte a disintegrin and metalloproteinase 17 (adam17) is essential in post-myocardial infarction repair by regulating angiogenesis
    • Fan D, Takawale A, Shen M, Wang W, Wang X, Basu R, Oudit GY, Kassiri Z. Cardiomyocyte a disintegrin and metalloproteinase 17 (adam17) is essential in post-myocardial infarction repair by regulating angiogenesis. Circ Heart Fail. 2015;8:970-979. doi: 10.1161/CIRCHEARTFAILURE.114.002029
    • (2015) Circ Heart Fail , vol.8 , pp. 970-979
    • Fan, D.1    Takawale, A.2    Shen, M.3    Wang, W.4    Wang, X.5    Basu, R.6    Oudit, G.Y.7    Kassiri, Z.8
  • 77
    • 84891683755 scopus 로고    scopus 로고
    • Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS
    • Patel VB, Clarke N, Wang Z, Fan D, Parajuli N, Basu R, Putko B, Kassiri Z, Turner AJ, Oudit GY. Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS. J Mol Cell Cardiol. 2014;66:167-176. doi: 10.1016/j.yjmcc.2013.11.017
    • (2014) J Mol Cell Cardiol. , vol.66 , pp. 167-176
    • Patel, V.B.1    Clarke, N.2    Wang, Z.3    Fan, D.4    Parajuli, N.5    Basu, R.6    Putko, B.7    Kassiri, Z.8    Turner, A.J.9    Oudit, G.Y.10
  • 78
    • 85063256195 scopus 로고    scopus 로고
    • Cell-specific functions of ADAM17 regulate the progression of thoracic aortic aneurysm
    • Shen M, Hu M, Fedak PWM, Oudit GY, Kassiri Z. Cell-specific functions of ADAM17 regulate the progression of thoracic aortic aneurysm. Circ Res. 2018;123:372-388. doi: 10.1161/CIRCRESAHA.118.313181
    • (2018) Circ Res. , vol.123 , pp. 372-388
    • Shen, M.1    Hu, M.2    Fedak, P.W.M.3    Oudit, G.Y.4    Kassiri, Z.5
  • 79
    • 49349093061 scopus 로고    scopus 로고
    • Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system
    • Epelman S, Tang WH, Chen SY, Van Lente F, Francis GS, Sen S. Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system. J Am Coll Cardiol. 2008;52:750-754. doi: 10.1016/j.jacc.2008.02.088
    • (2008) J Am Coll Cardiol. , vol.52 , pp. 750-754
    • Epelman, S.1    Tang, W.H.2    Chen, S.Y.3    Van Lente, F.4    Francis, G.S.5    Sen, S.6
  • 80
    • 80053927932 scopus 로고    scopus 로고
    • Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor α-converting enzyme (TACE/ADAM-17) activation in primary human monocytes
    • Scott AJ, O'Dea KP, O'Callaghan D, Williams L, Dokpesi JO, Tatton L, Handy JM, Hogg PJ, Takata M. Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor α-converting enzyme (TACE/ADAM-17) activation in primary human monocytes. J Biol Chem. 2011;286:35466-35476. doi: 10.1074/jbc.M111.277434
    • (2011) J Biol Chem. , vol.286 , pp. 35466-35476
    • Scott, A.J.1    O'Dea, K.P.2    O'Callaghan, D.3    Williams, L.4    Dokpesi, J.O.5    Tatton, L.6    Handy, J.M.7    Hogg, P.J.8    Takata, M.9
  • 81
    • 76849107016 scopus 로고    scopus 로고
    • Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation
    • Xu P, Derynck R. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Mol Cell. 2010;37:551-566. doi: 10.1016/j.molcel.2010.01.034
    • (2010) Mol Cell. , vol.37 , pp. 551-566
    • Xu, P.1    Derynck, R.2
  • 82
    • 85019871485 scopus 로고    scopus 로고
    • Clinical relevance and role of neuronal AT1 receptors in ADAM17-mediated ACE2 shedding in neurogenic hypertension
    • Xu J, Sriramula S, Xia H, Moreno-Walton L, Culicchia F, Domenig O, Poglitsch M, Lazartigues E. Clinical relevance and role of neuronal AT1 receptors in ADAM17-mediated ACE2 shedding in neurogenic hypertension. Circ Res. 2017;121:43-55. doi: 10.1161/CIRCRESAHA.116.310509
    • (2017) Circ Res. , vol.121 , pp. 43-55
    • Xu, J.1    Sriramula, S.2    Xia, H.3    Moreno-Walton, L.4    Culicchia, F.5    Domenig, O.6    Poglitsch, M.7    Lazartigues, E.8
  • 83
    • 38849114449 scopus 로고    scopus 로고
    • SARS coronavirus entry into host cells through a novel clathrin- and caveolaeindependent endocytic pathway
    • Wang H, Yang P, Liu K, Guo F, Zhang Y, Zhang G, Jiang C. SARS coronavirus entry into host cells through a novel clathrin- and caveolaeindependent endocytic pathway. Cell Res. 2008;18:290-301. doi: 10.1038/cr.2008.15
    • (2008) Cell Res. , vol.18 , pp. 290-301
    • Wang, H.1    Yang, P.2    Liu, K.3    Guo, F.4    Zhang, Y.5    Zhang, G.6    Jiang, C.7
  • 84
    • 45549097784 scopus 로고    scopus 로고
    • Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNFalpha production and facilitates viral entry
    • Haga S, Yamamoto N, Nakai-Murakami C, Osawa Y, Tokunaga K, Sata T, Yamamoto N, Sasazuki T, Ishizaka Y. Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNFalpha production and facilitates viral entry. Proc Natl Acad Sci USA. 2008;105:7809-7814. doi: 10.1073/pnas.0711241105
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7809-7814
    • Haga, S.1    Yamamoto, N.2    Nakai-Murakami, C.3    Osawa, Y.4    Tokunaga, K.5    Sata, T.6    Yamamoto, N.7    Sasazuki, T.8    Ishizaka, Y.9
  • 85
    • 20344383258 scopus 로고    scopus 로고
    • Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry
    • Hofmann H, Pyrc K, van der Hoek L, Geier M, Berkhout B, Pöhlmann S. Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. Proc Natl Acad Sci USA. 2005;102:7988-7993. doi: 10.1073/pnas.0409465102
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 7988-7993
    • Hofmann, H.1    Pyrc, K.2    Van Der Hoek, L.3    Geier, M.4    Berkhout, B.5    Pöhlmann, S.6
  • 86
    • 85079372059 scopus 로고    scopus 로고
    • Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS
    • Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS. J Virol. 2020;94:e00127-20. doi: 10.1128/JVI.00127-20
    • (2020) J Virol. , vol.94 , pp. e00127-e00220
    • Wan, Y.1    Shang, J.2    Graham, R.3    Baric, R.S.4    Li, F.5
  • 87
    • 77956612123 scopus 로고    scopus 로고
    • Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters
    • Kuba K, Imai Y, Ohto-Nakanishi T, Penninger JM. Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacol Ther. 2010;128:119-128. doi: 10.1016/j.pharmthera.2010.06.003
    • (2010) Pharmacol Ther. , vol.128 , pp. 119-128
    • Kuba, K.1    Imai, Y.2    Ohto-Nakanishi, T.3    Penninger, J.M.4
  • 88
    • 84963585271 scopus 로고    scopus 로고
    • Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and inflammatory lung disease
    • Jia H. Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and inflammatory lung disease. Shock. 2016;46:239-248. doi: 10.1097/SHK.0000000000000633
    • (2016) Shock , vol.46 , pp. 239-248
    • Jia, H.1
  • 89
    • 85077751162 scopus 로고    scopus 로고
    • ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway
    • Ye R, Liu Z. ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway. Exp Mol Pathol. 2020;113:104350. doi: 10.1016/j.yexmp.2019.104350
    • (2020) Exp Mol Pathol. , vol.113 , pp. 104350
    • Ye, R.1    Liu, Z.2
  • 90
    • 77955981900 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction
    • 18 p following 728
    • Zhong J, Basu R, Guo D, Chow FL, Byrns S, Schuster M, Loibner H, Wang XH, Penninger JM, Kassiri Z, et al. Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation. 2010;122:717-728, 18 p following 728. doi: 10.1161/CIRCULATIONAHA.110.955369
    • (2010) Circulation , vol.122 , pp. 717-728
    • Zhong, J.1    Basu, R.2    Guo, D.3    Chow, F.L.4    Byrns, S.5    Schuster, M.6    Loibner, H.7    Wang, X.H.8    Penninger, J.M.9    Kassiri, Z.10
  • 93
    • 80055049289 scopus 로고    scopus 로고
    • Recombinant human angiotensin-converting enzyme 2 as a new renin-angiotensin system peptidase for heart failure therapy
    • Oudit GY, Penninger JM. Recombinant human angiotensin-converting enzyme 2 as a new renin-angiotensin system peptidase for heart failure therapy. Curr Heart Fail Rep. 2011;8:176-183. doi: 10.1007/s11897-011-0063-7
    • (2011) Curr Heart Fail Rep. , vol.8 , pp. 176-183
    • Oudit, G.Y.1    Penninger, J.M.2
  • 94
    • 42649141954 scopus 로고    scopus 로고
    • Genetically altered animal models for Mas and angiotensin-(1-7)
    • Alenina N, Xu P, Rentzsch B, Patkin EL, Bader M. Genetically altered animal models for Mas and angiotensin-(1-7). Exp Physiol. 2008;93:528-537. doi: 10.1113/expphysiol.2007.040345
    • (2008) Exp Physiol. , vol.93 , pp. 528-537
    • Alenina, N.1    Xu, P.2    Rentzsch, B.3    Patkin, E.L.4    Bader, M.5
  • 95
    • 84873033171 scopus 로고    scopus 로고
    • ACE2, angiotensin-(1-7), and Mas: the other side of the coin
    • Bader M. ACE2, angiotensin-(1-7), and Mas: the other side of the coin. Pflugers Arch. 2013;465:79-85. doi: 10.1007/s00424-012-1120-0
    • (2013) Pflugers Arch. , vol.465 , pp. 79-85
    • Bader, M.1
  • 97
    • 34548851716 scopus 로고    scopus 로고
    • Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS receptor axis: more than regulation of blood pressure?
    • Chappell MC. Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS receptor axis: more than regulation of blood pressure? Hypertension. 2007;50:596-599. doi: 10.1161/HYPERTENSIONAHA.106.076216
    • (2007) Hypertension , vol.50 , pp. 596-599
    • Chappell, M.C.1
  • 98
    • 0031601350 scopus 로고    scopus 로고
    • Angiotensin-(1-7) contributes to the antihypertensive effects of blockade of the renin-angiotensin system
    • Iyer SN, Ferrario CM, Chappell MC. Angiotensin-(1-7) contributes to the antihypertensive effects of blockade of the renin-angiotensin system. Hypertension. 1998;31:356-361. doi: 10.1161/01.hyp.31.1.356
    • (1998) Hypertension , vol.31 , pp. 356-361
    • Iyer, S.N.1    Ferrario, C.M.2    Chappell, M.C.3
  • 99
    • 85047744051 scopus 로고    scopus 로고
    • Multifunctional role of chymase in acute and chronic tissue injury and remodeling
    • Dell'Italia LJ, Collawn JF, Ferrario CM. Multifunctional role of chymase in acute and chronic tissue injury and remodeling. Circ Res. 2018;122:319-336. doi: 10.1161/CIRCRESAHA.117.310978
    • (2018) Circ Res. , vol.122 , pp. 319-336
    • Dell'Italia, L.J.1    Collawn, J.F.2    Ferrario, C.M.3
  • 100
    • 33847018997 scopus 로고    scopus 로고
    • Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways
    • Sampaio WO, Souza dos Santos RA, Faria-Silva R, da Mata Machado LT, Schiffrin EL, Touyz RM. Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways. Hypertension. 2007;49:185-192. doi: 10.1161/01.HYP.0000251865.35728.2f
    • (2007) Hypertension , vol.49 , pp. 185-192
    • Sampaio, W.O.1    Souza Dos Santos, R.A.2    Faria-Silva, R.3    Da Mata MacHado, L.T.4    Schiffrin, E.L.5    Touyz, R.M.6
  • 102
    • 25444473110 scopus 로고    scopus 로고
    • Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor
    • Tallant EA, Ferrario CM, Gallagher PE. Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor. Am J Physiol Heart Circ Physiol. 2005;289:H1560-H1566. doi: 10.1152/ajpheart.00941.2004
    • (2005) Am J Physiol Heart Circ Physiol. , vol.289 , pp. H1560-H1566
    • Tallant, E.A.1    Ferrario, C.M.2    Gallagher, P.E.3
  • 103
    • 84922259071 scopus 로고    scopus 로고
    • Alteration of cardiac ACE2/Mas expression and cardiac remodelling in rats with aortic constriction
    • Zhang Y, Li B, Wang B, Zhang J, Wu J, Morgan T. Alteration of cardiac ACE2/Mas expression and cardiac remodelling in rats with aortic constriction. Chin J Physiol. 2014;57:335-342. doi: 10.4077/CJP.2014.BAD268
    • (2014) Chin J Physiol. , vol.57 , pp. 335-342
    • Zhang, Y.1    Li, B.2    Wang, B.3    Zhang, J.4    Wu, J.5    Morgan, T.6
  • 104
    • 84866697003 scopus 로고    scopus 로고
    • Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin type 2 receptor
    • Flores-Muñoz M, Godinho BM, Almalik A, Nicklin SA. Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin type 2 receptor. PLoS One. 2012;7:e45564. doi: 10.1371/journal.pone.0045564
    • (2012) PLoS One , vol.7
    • Flores-Muñoz, M.1    Godinho, B.M.2    Almalik, A.3    Nicklin, S.A.4
  • 105
    • 84856257062 scopus 로고    scopus 로고
    • Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor
    • Flores-Munoz M, Work LM, Douglas K, Denby L, Dominiczak AF, Graham D, Nicklin SA. Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor. Hypertension. 2012;59:300-307. doi: 10.1161/HYPERTENSIONAHA.111.177485
    • (2012) Hypertension , vol.59 , pp. 300-307
    • Flores-Munoz, M.1    Work, L.M.2    Douglas, K.3    Denby, L.4    Dominiczak, A.F.5    Graham, D.6    Nicklin, S.A.7
  • 107
    • 79952755311 scopus 로고    scopus 로고
    • Rho kinase inhibition activates the homologous angiotensinconverting enzyme-angiotensin-(1-9) axis in experimental hypertension
    • Ocaranza MP, Rivera P, Novoa U, Pinto M, González L, Chiong M, Lavandero S, Jalil JE. Rho kinase inhibition activates the homologous angiotensinconverting enzyme-angiotensin-(1-9) axis in experimental hypertension. J Hypertens. 2011;29:706-715. doi: 10.1097/HJH.0b013e3283440665
    • (2011) J Hypertens. , vol.29 , pp. 706-715
    • Ocaranza, M.P.1    Rivera, P.2    Novoa, U.3    Pinto, M.4    González, L.5    Chiong, M.6    Lavandero, S.7    Jalil, J.E.8
  • 109
    • 84872178401 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats
    • Lo J, Patel VB, Wang Z, Levasseur J, Kaufman S, Penninger JM, Oudit GY. Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats. Exp Physiol. 2013;98:109-122. doi: 10.1113/expphysiol.2012.067165
    • (2013) Exp Physiol. , vol.98 , pp. 109-122
    • Lo, J.1    Patel, V.B.2    Wang, Z.3    Levasseur, J.4    Kaufman, S.5    Penninger, J.M.6    Oudit, G.Y.7
  • 111
    • 84861528870 scopus 로고    scopus 로고
    • Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1-7 in experimental heart failure in angiotensinconverting enzyme 2-null mice
    • Patel VB, Bodiga S, Fan D, Das SK, Wang Z, Wang W, Basu R, Zhong J, Kassiri Z, Oudit GY. Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1-7 in experimental heart failure in angiotensinconverting enzyme 2-null mice. Hypertension. 2012;59:1195-1203. doi: 10.1161/HYPERTENSIONAHA.112.191650
    • (2012) Hypertension , vol.59 , pp. 1195-1203
    • Patel, V.B.1    Bodiga, S.2    Fan, D.3    Das, S.K.4    Wang, Z.5    Wang, W.6    Basu, R.7    Zhong, J.8    Kassiri, Z.9    Oudit, G.Y.10
  • 112
    • 33645299090 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme II in the heart and the kidney
    • Danilczyk U, Penninger JM. Angiotensin-converting enzyme II in the heart and the kidney. Circ Res. 2006;98:463-471. doi: 10.1161/01.RES.0000205761.22353.5f
    • (2006) Circ Res. , vol.98 , pp. 463-471
    • Danilczyk, U.1    Penninger, J.M.2
  • 115
    • 77954323444 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXIV. Apelin receptor nomenclature, distribution, pharmacology, and function
    • Pitkin SL, Maguire JJ, Bonner TI, Davenport AP. International Union of Basic and Clinical Pharmacology. LXXIV. Apelin receptor nomenclature, distribution, pharmacology, and function. Pharmacol Rev. 2010;62:331-342. doi: 10.1124/pr.110.002949
    • (2010) Pharmacol Rev. , vol.62 , pp. 331-342
    • Pitkin, S.L.1    Maguire, J.J.2    Bonner, T.I.3    Davenport, A.P.4
  • 116
    • 33744816839 scopus 로고    scopus 로고
    • Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure
    • Chong KS, Gardner RS, Morton JJ, Ashley EA, McDonagh TA. Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure. Eur J Heart Fail. 2006;8:355-360. doi: 10.1016/j.ejheart.2005.10.007
    • (2006) Eur J Heart Fail , vol.8 , pp. 355-360
    • Chong, K.S.1    Gardner, R.S.2    Morton, J.J.3    Ashley, E.A.4    McDonagh, T.A.5
  • 118
    • 79954792483 scopus 로고    scopus 로고
    • Reduced circulating apelin in essential hypertension and its association with cardiac dysfunction
    • Przewlocka-Kosmala M, Kotwica T, Mysiak A, Kosmala W. Reduced circulating apelin in essential hypertension and its association with cardiac dysfunction. J Hypertens. 2011;29:971-979. doi: 10.1097/HJH.0b013e328344da76
    • (2011) J Hypertens. , vol.29 , pp. 971-979
    • Przewlocka-Kosmala, M.1    Kotwica, T.2    Mysiak, A.3    Kosmala, W.4
  • 120
    • 84887527968 scopus 로고    scopus 로고
    • Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues
    • Wang W, McKinnie SM, Patel VB, Haddad G, Wang Z, Zhabyeyev P, Das SK, Basu R, McLean B, Kandalam V, et al. Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. J Am Heart Assoc. 2013;2:e000249. doi: 10.1161/JAHA.113.000249
    • (2013) J Am Heart Assoc. , vol.2 , pp. e000249
    • Wang, W.1    McKinnie, S.M.2    Patel, V.B.3    Haddad, G.4    Wang, Z.5    Zhabyeyev, P.6    Das, S.K.7    Basu, R.8    McLean, B.9    Kandalam, V.10
  • 122
    • 84874232168 scopus 로고    scopus 로고
    • The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans-inhibition
    • Siddiquee K, Hampton J, McAnally D, May L, Smith L. The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans-inhibition. Br J Pharmacol. 2013;168:1104-1117. doi: 10.1111/j.1476-5381.2012.02192.x
    • (2013) Br J Pharmacol. , vol.168 , pp. 1104-1117
    • Siddiquee, K.1    Hampton, J.2    McAnally, D.3    May, L.4    Smith, L.5
  • 124
    • 85068123827 scopus 로고    scopus 로고
    • Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs
    • Wang W, Shen M, Fischer C, Basu R, Hazra S, Couvineau P, Paul M, Wang F, Toth S, Mix DS, et al. Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs. Proc Natl Acad Sci USA. 2019;116:13006-13015. doi: 10.1073/pnas.1900152116
    • (2019) Proc Natl Acad Sci USA , vol.116 , pp. 13006-13015
    • Wang, W.1    Shen, M.2    Fischer, C.3    Basu, R.4    Hazra, S.5    Couvineau, P.6    Paul, M.7    Wang, F.8    Toth, S.9    Mix, D.S.10
  • 125
    • 84970024448 scopus 로고    scopus 로고
    • Angiotensinconverting enzyme 2 metabolizes and partially inactivates Pyr-Apelin-13 and Apelin-17: physiological effects in the cardiovascular system
    • Wang W, McKinnie SM, Farhan M, Paul M, McDonald T, McLean B, Llorens-Cortes C, Hazra S, Murray AG, Vederas JC, et al. Angiotensinconverting enzyme 2 metabolizes and partially inactivates Pyr-Apelin-13 and Apelin-17: physiological effects in the cardiovascular system. Hypertension. 2016;68:365-377. doi: 10.1161/HYPERTENSIONAHA.115.06892
    • (2016) Hypertension , vol.68 , pp. 365-377
    • Wang, W.1    McKinnie, S.M.2    Farhan, M.3    Paul, M.4    McDonald, T.5    McLean, B.6    Llorens-Cortes, C.7    Hazra, S.8    Murray, A.G.9    Vederas, J.C.10
  • 127
    • 84902532919 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 is a critical determinant of angiotensin II-induced loss of vascular smooth muscle cells and adverse vascular remodeling
    • Patel VB, Zhong JC, Fan D, Basu R, Morton JS, Parajuli N, McMurtry MS, Davidge ST, Kassiri Z, Oudit GY. Angiotensin-converting enzyme 2 is a critical determinant of angiotensin II-induced loss of vascular smooth muscle cells and adverse vascular remodeling. Hypertension. 2014;64:157-164. doi: 10.1161/HYPERTENSIONAHA.114.03388
    • (2014) Hypertension , vol.64 , pp. 157-164
    • Patel, V.B.1    Zhong, J.C.2    Fan, D.3    Basu, R.4    Morton, J.S.5    Parajuli, N.6    McMurtry, M.S.7    Davidge, S.T.8    Kassiri, Z.9    Oudit, G.Y.10
  • 130
    • 36448975192 scopus 로고    scopus 로고
    • Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells
    • Sampaio WO, Henrique de Castro C, Santos RA, Schiffrin EL, Touyz RM. Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells. Hypertension. 2007;50:1093-1098. doi: 10.1161/HYPERTENSIONAHA.106.084848
    • (2007) Hypertension , vol.50 , pp. 1093-1098
    • Sampaio, W.O.1    Henrique De Castro, C.2    Santos, R.A.3    Schiffrin, E.L.4    Touyz, R.M.5
  • 131
    • 28144432331 scopus 로고    scopus 로고
    • Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects
    • Iwata M, Cowling RT, Gurantz D, Moore C, Zhang S, Yuan JX, Greenberg BH. Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects. Am J Physiol Heart Circ Physiol. 2005;289:H2356-H2363. doi: 10.1152/ajpheart.00317.2005
    • (2005) Am J Physiol Heart Circ Physiol. , vol.289 , pp. H2356-H2363
    • Iwata, M.1    Cowling, R.T.2    Gurantz, D.3    Moore, C.4    Zhang, S.5    Yuan, J.X.6    Greenberg, B.H.7
  • 132
    • 84904431923 scopus 로고    scopus 로고
    • From gene to protein-experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension
    • Patel SK, Velkoska E, Freeman M, Wai B, Lancefield TF, Burrell LM. From gene to protein-experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Front Physiol. 2014;5:227. doi: 10.3389/fphys.2014.00227
    • (2014) Front Physiol. , vol.5 , pp. 227
    • Patel, S.K.1    Velkoska, E.2    Freeman, M.3    Wai, B.4    Lancefield, T.F.5    Burrell, L.M.6
  • 135
    • 70350457666 scopus 로고    scopus 로고
    • Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction
    • Kassiri Z, Zhong J, Guo D, Basu R, Wang X, Liu PP, Scholey JW, Penninger JM, Oudit GY. Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ Heart Fail. 2009;2:446-455. doi: 10.1161/CIRCHEARTFAILURE.108.840124
    • (2009) Circ Heart Fail , vol.2 , pp. 446-455
    • Kassiri, Z.1    Zhong, J.2    Guo, D.3    Basu, R.4    Wang, X.5    Liu, P.P.6    Scholey, J.W.7    Penninger, J.M.8    Oudit, G.Y.9
  • 136
    • 84953637407 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 inhibits high-mobility group box 1 and attenuates cardiac dysfunction post-myocardial ischemia
    • Qi YF, Zhang J, Wang L, Shenoy V, Krause E, Oh SP, Pepine CJ, Katovich MJ, Raizada MK. Angiotensin-converting enzyme 2 inhibits high-mobility group box 1 and attenuates cardiac dysfunction post-myocardial ischemia. J Mol Med. 2016;94:37-49.
    • (2016) J Mol Med. , vol.94 , pp. 37-49
    • Qi, Y.F.1    Zhang, J.2    Wang, L.3    Shenoy, V.4    Krause, E.5    Oh, S.P.6    Pepine, C.J.7    Katovich, M.J.8    Raizada, M.K.9
  • 139
    • 85026508106 scopus 로고    scopus 로고
    • Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease
    • Patel VB, Shah S, Verma S, Oudit GY. Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease. Heart Fail Rev. 2017;22:889-902. doi: 10.1007/s10741-017-9644-1
    • (2017) Heart Fail Rev. , vol.22 , pp. 889-902
    • Patel, V.B.1    Shah, S.2    Verma, S.3    Oudit, G.Y.4
  • 140
    • 85050821660 scopus 로고    scopus 로고
    • Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium
    • Packer M. Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium. J Am Coll Cardiol. 2018;71:2360-2372. doi: 10.1016/j.jacc.2018.03.509
    • (2018) J Am Coll Cardiol. , vol.71 , pp. 2360-2372
    • Packer, M.1
  • 141
    • 85031689841 scopus 로고    scopus 로고
    • ACE2/Ang 1-7 axis: A critical regulator of epicardial adipose tissue inflammation and cardiac dysfunction in obesity
    • Patel VB, Basu R, Oudit GY. ACE2/Ang 1-7 axis: A critical regulator of epicardial adipose tissue inflammation and cardiac dysfunction in obesity. Adipocyte. 2016;5:306-311. doi: 10.1080/21623945.2015.1131881
    • (2016) Adipocyte , vol.5 , pp. 306-311
    • Patel, V.B.1    Basu, R.2    Oudit, G.Y.3
  • 147
    • 55949126600 scopus 로고    scopus 로고
    • Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function
    • Rentzsch B, Todiras M, Iliescu R, Popova E, Campos LA, Oliveira ML, Baltatu OC, Santos RA, Bader M. Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function. Hypertension. 2008;52:967-973. doi: 10.1161/HYPERTENSIONAHA.108.114322
    • (2008) Hypertension , vol.52 , pp. 967-973
    • Rentzsch, B.1    Todiras, M.2    Iliescu, R.3    Popova, E.4    Campos, L.A.5    Oliveira, M.L.6    Baltatu, O.C.7    Santos, R.A.8    Bader, M.9
  • 149
    • 24044444558 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)
    • Lambert DW, Yarski M, Warner FJ, Thornhill P, Parkin ET, Smith AI, Hooper NM, Turner AJ. Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J Biol Chem. 2005;280:30113-30119. doi: 10.1074/jbc.M505111200
    • (2005) J Biol Chem. , vol.280 , pp. 30113-30119
    • Lambert, D.W.1    Yarski, M.2    Warner, F.J.3    Thornhill, P.4    Parkin, E.T.5    Smith, A.I.6    Hooper, N.M.7    Turner, A.J.8
  • 150
    • 84886089553 scopus 로고    scopus 로고
    • Brain angiotensinconverting enzyme type 2 shedding contributes to the development of neurogenic hypertension
    • Xia H, Sriramula S, Chhabra KH, Lazartigues E. Brain angiotensinconverting enzyme type 2 shedding contributes to the development of neurogenic hypertension. Circ Res. 2013;113:1087-1096. doi: 10.1161/CIRCRESAHA.113.301811
    • (2013) Circ Res. , vol.113 , pp. 1087-1096
    • Xia, H.1    Sriramula, S.2    Chhabra, K.H.3    Lazartigues, E.4
  • 152
    • 85059869675 scopus 로고    scopus 로고
    • Decreased circulating catestatin levels are associated with coronary artery disease: the emerging anti-inflammatory role
    • Chen Y, Wang X, Yang C, Su X, Yang W, Dai Y, Han H, Jiang J, Lu L, Wang H, et al. Decreased circulating catestatin levels are associated with coronary artery disease: the emerging anti-inflammatory role. Atherosclerosis. 2019;281:78-88. doi: 10.1016/j.atherosclerosis.2018.12.025
    • (2019) Atherosclerosis , vol.281 , pp. 78-88
    • Chen, Y.1    Wang, X.2    Yang, C.3    Su, X.4    Yang, W.5    Dai, Y.6    Han, H.7    Jiang, J.8    Lu, L.9    Wang, H.10
  • 154
    • 84861099242 scopus 로고    scopus 로고
    • Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis
    • Patel VB, Bodiga S, Basu R, Das SK, Wang W, Wang Z, Lo J, Grant MB, Zhong J, Kassiri Z, et al. Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis. Circ Res. 2012;110:1322-1335. doi: 10.1161/CIRCRESAHA.112.268029
    • (2012) Circ Res. , vol.110 , pp. 1322-1335
    • Patel, V.B.1    Bodiga, S.2    Basu, R.3    Das, S.K.4    Wang, W.5    Wang, Z.6    Lo, J.7    Grant, M.B.8    Zhong, J.9    Kassiri, Z.10
  • 156
    • 84891420160 scopus 로고    scopus 로고
    • Role of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications
    • Patel VB, Parajuli N, Oudit GY. Role of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications. Clin Sci (Lond). 2014;126:471-482. doi: 10.1042/CS20130344
    • (2014) Clin Sci (Lond) , vol.126 , pp. 471-482
    • Patel, V.B.1    Parajuli, N.2    Oudit, G.Y.3
  • 157
    • 0034725353 scopus 로고    scopus 로고
    • Optimizing treatment of hypertension in patients with diabetes
    • Cooper ME, Johnston CI. Optimizing treatment of hypertension in patients with diabetes. JAMA. 2000;283:3177-3179. doi: 10.1001/jama.283.24.3177
    • (2000) JAMA , vol.283 , pp. 3177-3179
    • Cooper, M.E.1    Johnston, C.I.2
  • 159
  • 163
    • 84969822642 scopus 로고    scopus 로고
    • Adeno-associated virus overexpression of angiotensin-converting enzyme-2 reverses diabetic retinopathy in Type 1 diabetes in mice
    • Dominguez JM II, Hu P, Caballero S, Moldovan L, Verma A, Oudit GY, Li Q, Grant MB. Adeno-associated virus overexpression of angiotensin-converting enzyme-2 reverses diabetic retinopathy in Type 1 diabetes in mice. Am J Pathol. 2016;186:1688-1700. doi: 10.1016/j.ajpath.2016.01.023
    • (2016) Am J Pathol. , vol.186 , pp. 1688-1700
    • Dominguez, J.M.1    Hu, P.2    Caballero, S.3    Moldovan, L.4    Verma, A.5    Oudit, G.Y.6    Li, Q.7    Grant, M.B.8
  • 165
    • 84875523863 scopus 로고    scopus 로고
    • Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model
    • Hazra S, Jarajapu YP, Stepps V, Caballero S, Thinschmidt JS, Sautina L, Bengtsson N, Licalzi S, Dominguez J, Kern TS, et al. Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model. Diabetologia. 2013;56:644-653. doi: 10.1007/s00125-012-2781-0
    • (2013) Diabetologia , vol.56 , pp. 644-653
    • Hazra, S.1    Jarajapu, Y.P.2    Stepps, V.3    Caballero, S.4    Thinschmidt, J.S.5    Sautina, L.6    Bengtsson, N.7    Licalzi, S.8    Dominguez, J.9    Kern, T.S.10
  • 168
    • 77649273140 scopus 로고    scopus 로고
    • Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks
    • Semple BD, Kossmann T, Morganti-Kossmann MC. Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks. J Cereb Blood Flow Metab. 2010;30:459-473. doi: 10.1038/jcbfm.2009.240
    • (2010) J Cereb Blood Flow Metab. , vol.30 , pp. 459-473
    • Semple, B.D.1    Kossmann, T.2    Morganti-Kossmann, M.C.3
  • 169
    • 34147164049 scopus 로고    scopus 로고
    • Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites
    • Tsou CL, Peters W, Si Y, Slaymaker S, Aslanian AM, Weisberg SP, Mack M, Charo IF. Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest. 2007;117:902-909. doi: 10.1172/JCI29919
    • (2007) J Clin Invest. , vol.117 , pp. 902-909
    • Tsou, C.L.1    Peters, W.2    Si, Y.3    Slaymaker, S.4    Aslanian, A.M.5    Weisberg, S.P.6    Mack, M.7    Charo, I.F.8
  • 170
    • 20944435318 scopus 로고    scopus 로고
    • Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice
    • Huang D, Wujek J, Kidd G, He TT, Cardona A, Sasse ME, Stein EJ, Kish J, Tani M, Charo IF, et al. Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice. FASEB J. 2005;19:761-772. doi: 10.1096/fj.04-3104com
    • (2005) FASEB J. , vol.19 , pp. 761-772
    • Huang, D.1    Wujek, J.2    Kidd, G.3    He, T.T.4    Cardona, A.5    Sasse, M.E.6    Stein, E.J.7    Kish, J.8    Tani, M.9    Charo, I.F.10
  • 171
    • 68649107955 scopus 로고    scopus 로고
    • The role of CC chemokine receptor 2 on microglia activation and blood-borne cell recruitment after transient focal cerebral ischemia in mice
    • Schilling M, Strecker JK, Ringelstein EB, Schäbitz WR, Kiefer R. The role of CC chemokine receptor 2 on microglia activation and blood-borne cell recruitment after transient focal cerebral ischemia in mice. Brain Res. 2009;1289:79-84. doi: 10.1016/j.brainres.2009.06.054
    • (2009) Brain Res. , vol.1289 , pp. 79-84
    • Schilling, M.1    Strecker, J.K.2    Ringelstein, E.B.3    Schäbitz, W.R.4    Kiefer, R.5
  • 172
    • 84875464297 scopus 로고    scopus 로고
    • Activation of the ACE2/angiotensin-(1-7)/Mas receptor axis enhances the reparative function of dysfunctional diabetic endothelial progenitors
    • Jarajapu YP, Bhatwadekar AD, Caballero S, Hazra S, Shenoy V, Medina R, Kent D, Stitt AW, Thut C, Finney EM, et al. Activation of the ACE2/angiotensin-(1-7)/Mas receptor axis enhances the reparative function of dysfunctional diabetic endothelial progenitors. Diabetes. 2013;62:1258-1269. doi: 10.2337/db12-0808
    • (2013) Diabetes , vol.62 , pp. 1258-1269
    • Jarajapu, Y.P.1    Bhatwadekar, A.D.2    Caballero, S.3    Hazra, S.4    Shenoy, V.5    Medina, R.6    Kent, D.7    Stitt, A.W.8    Thut, C.9    Finney, E.M.10
  • 173
    • 57049086924 scopus 로고    scopus 로고
    • Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease
    • Reich HN, Oudit GY, Penninger JM, Scholey JW, Herzenberg AM. Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease. Kidney Int. 2008;74:1610-1616. doi: 10.1038/ki.2008.497
    • (2008) Kidney Int. , vol.74 , pp. 1610-1616
    • Reich, H.N.1    Oudit, G.Y.2    Penninger, J.M.3    Scholey, J.W.4    Herzenberg, A.M.5
  • 175
    • 84945445209 scopus 로고    scopus 로고
    • Role of angiotensin-converting enzyme (ACE) and ACE2 in a rat model of smoke inhalation induced acute respiratory distress syndrome
    • Yilin Z, Yandong N, Faguang J. Role of angiotensin-converting enzyme (ACE) and ACE2 in a rat model of smoke inhalation induced acute respiratory distress syndrome. Burns. 2015;41:1468-1477. doi: 10.1016/j.burns.2015.04.010
    • (2015) Burns , vol.41 , pp. 1468-1477
    • Yilin, Z.1    Yandong, N.2    Faguang, J.3
  • 176
    • 74949134345 scopus 로고    scopus 로고
    • Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets
    • Treml B, Neu N, Kleinsasser A, Gritsch C, Finsterwalder T, Geiger R, Schuster M, Janzek E, Loibner H, Penninger J, et al. Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets. Crit Care Med. 2010;38:596-601. doi: 10.1097/CCM.0b013e3181c03009
    • (2010) Crit Care Med. , vol.38 , pp. 596-601
    • Treml, B.1    Neu, N.2    Kleinsasser, A.3    Gritsch, C.4    Finsterwalder, T.5    Geiger, R.6    Schuster, M.7    Janzek, E.8    Loibner, H.9    Penninger, J.10
  • 177
    • 84878293904 scopus 로고    scopus 로고
    • Diminazene aceturate improves autonomic modulation in pulmonary hypertension
    • Rigatto K, Casali KR, Shenoy V, Katovich MJ, Raizada MK. Diminazene aceturate improves autonomic modulation in pulmonary hypertension. Eur J Pharmacol. 2013;713:89-93. doi: 10.1016/j.ejphar.2013.04.017
    • (2013) Eur J Pharmacol. , vol.713 , pp. 89-93
    • Rigatto, K.1    Casali, K.R.2    Shenoy, V.3    Katovich, M.J.4    Raizada, M.K.5
  • 178
    • 2342620869 scopus 로고    scopus 로고
    • Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors
    • Ishiyama Y, Gallagher PE, Averill DB, Tallant EA, Brosnihan KB, Ferrario CM. Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors. Hypertension. 2004;43:970-976. doi: 10.1161/01.HYP.0000124667.34652.1a
    • (2004) Hypertension , vol.43 , pp. 970-976
    • Ishiyama, Y.1    Gallagher, P.E.2    Averill, D.B.3    Tallant, E.A.4    Brosnihan, K.B.5    Ferrario, C.M.6
  • 179
    • 19644384705 scopus 로고    scopus 로고
    • Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2
    • Ferrario CM, Jessup J, Chappell MC, Averill DB, Brosnihan KB, Tallant EA, Diz DI, Gallagher PE. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005;111:2605-2610. doi: 10.1161/CIRCULATIONAHA.104.510461
    • (2005) Circulation , vol.111 , pp. 2605-2610
    • Ferrario, C.M.1    Jessup, J.2    Chappell, M.C.3    Averill, D.B.4    Brosnihan, K.B.5    Tallant, E.A.6    Diz, D.I.7    Gallagher, P.E.8
  • 181
    • 23944472129 scopus 로고    scopus 로고
    • Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in the aorta of spontaneously hypertensive rats
    • Igase M, Strawn WB, Gallagher PE, Geary RL, Ferrario CM. Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1-7) expression in the aorta of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2005;289:H1013-H1019. doi: 10.1152/ajpheart.00068.2005
    • (2005) Am J Physiol Heart Circ Physiol. , vol.289 , pp. H1013-H1019
    • Igase, M.1    Strawn, W.B.2    Gallagher, P.E.3    Geary, R.L.4    Ferrario, C.M.5
  • 183
    • 33750589885 scopus 로고    scopus 로고
    • Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat
    • Ocaranza MP, Godoy I, Jalil JE, Varas M, Collantes P, Pinto M, Roman M, Ramirez C, Copaja M, Diaz-Araya G, et al. Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat. Hypertension. 2006;48:572-578. doi: 10.1161/01.HYP.0000237862.94083.45
    • (2006) Hypertension , vol.48 , pp. 572-578
    • Ocaranza, M.P.1    Godoy, I.2    Jalil, J.E.3    Varas, M.4    Collantes, P.5    Pinto, M.6    Roman, M.7    Ramirez, C.8    Copaja, M.9    Diaz-Araya, G.10
  • 184
    • 60549095157 scopus 로고    scopus 로고
    • Localization of ACE2 in the renal vasculature: amplification by angiotensin II type 1 receptor blockade using telmisartan
    • Soler MJ, Ye M, Wysocki J, William J, Lloveras J, Batlle D. Localization of ACE2 in the renal vasculature: amplification by angiotensin II type 1 receptor blockade using telmisartan. Am J Physiol Renal Physiol. 2009;296:F398-F405. doi: 10.1152/ajprenal.90488.2008
    • (2009) Am J Physiol Renal Physiol. , vol.296 , pp. F398-F405
    • Soler, M.J.1    Ye, M.2    Wysocki, J.3    William, J.4    Lloveras, J.5    Batlle, D.6
  • 185
    • 84861893417 scopus 로고    scopus 로고
    • ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production
    • Jin HY, Song B, Oudit GY, Davidge ST, Yu HM, Jiang YY, Gao PJ, Zhu DL, Ning G, Kassiri Z, et al. ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production. PLoS One. 2012;7:e38502. doi: 10.1371/journal.pone.0038502
    • (2012) PLoS One , vol.7
    • Jin, H.Y.1    Song, B.2    Oudit, G.Y.3    Davidge, S.T.4    Yu, H.M.5    Jiang, Y.Y.6    Gao, P.J.7    Zhu, D.L.8    Ning, G.9    Kassiri, Z.10
  • 187
    • 84859476274 scopus 로고    scopus 로고
    • Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice
    • Lo CS, Liu F, Shi Y, Maachi H, Chenier I, Godin N, Filep JG, Ingelfinger JR, Zhang SL, Chan JS. Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice. Am J Physiol Renal Physiol. 2012;302:F840-F852. doi: 10.1152/ajprenal.00340.2011
    • (2012) Am J Physiol Renal Physiol. , vol.302 , pp. F840-F852
    • Lo, C.S.1    Liu, F.2    Shi, Y.3    Maachi, H.4    Chenier, I.5    Godin, N.6    Filep, J.G.7    Ingelfinger, J.R.8    Zhang, S.L.9    Chan, J.S.10
  • 188
    • 27644585370 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients
    • Keidar S, Gamliel-Lazarovich A, Kaplan M, Pavlotzky E, Hamoud S, Hayek T, Karry R, Abassi Z. Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients. Circ Res. 2005;97:946-953. doi: 10.1161/01.RES.0000187500.24964.7A
    • (2005) Circ Res. , vol.97 , pp. 946-953
    • Keidar, S.1    Gamliel-Lazarovich, A.2    Kaplan, M.3    Pavlotzky, E.4    Hamoud, S.5    Hayek, T.6    Karry, R.7    Abassi, Z.8
  • 189
    • 48749108107 scopus 로고    scopus 로고
    • Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes
    • Yamamuro M, Yoshimura M, Nakayama M, Abe K, Sumida H, Sugiyama S, Saito Y, Nakao K, Yasue H, Ogawa H. Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes. Circ J. 2008;72:1346-1350. doi: 10.1253/circj.72.1346
    • (2008) Circ J. , vol.72 , pp. 1346-1350
    • Yamamuro, M.1    Yoshimura, M.2    Nakayama, M.3    Abe, K.4    Sumida, H.5    Sugiyama, S.6    Saito, Y.7    Nakao, K.8    Yasue, H.9    Ogawa, H.10
  • 190
    • 34548822986 scopus 로고    scopus 로고
    • Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl saltsensitive hypertensive rats
    • Takeda Y, Zhu A, Yoneda T, Usukura M, Takata H, Yamagishi M. Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl saltsensitive hypertensive rats. Am J Hypertens. 2007;20:1119-1124. doi: 10.1016/j.amjhyper.2007.05.008
    • (2007) Am J Hypertens. , vol.20 , pp. 1119-1124
    • Takeda, Y.1    Zhu, A.2    Yoneda, T.3    Usukura, M.4    Takata, H.5    Yamagishi, M.6
  • 191
    • 43449084360 scopus 로고    scopus 로고
    • Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway
    • Koka V, Huang XR, Chung AC, Wang W, Truong LD, Lan HY. Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway. Am J Pathol. 2008;172:1174-1183. doi: 10.2353/ajpath.2008.070762
    • (2008) Am J Pathol. , vol.172 , pp. 1174-1183
    • Koka, V.1    Huang, X.R.2    Chung, A.C.3    Wang, W.4    Truong, L.D.5    Lan, H.Y.6
  • 193
    • 0032588244 scopus 로고    scopus 로고
    • Angiotensin AT1 receptor subtype as a cardiac target of aldosterone: role in aldosterone-salt-induced fibrosis
    • Robert V, Heymes C, Silvestre JS, Sabri A, Swynghedauw B, Delcayre C. Angiotensin AT1 receptor subtype as a cardiac target of aldosterone: role in aldosterone-salt-induced fibrosis. Hypertension. 1999;33:981-986. doi: 10.1161/01.hyp.33.4.981
    • (1999) Hypertension , vol.33 , pp. 981-986
    • Robert, V.1    Heymes, C.2    Silvestre, J.S.3    Sabri, A.4    Swynghedauw, B.5    Delcayre, C.6
  • 194
    • 84878246840 scopus 로고    scopus 로고
    • Aldosterone-induced osteopontin expression in vascular smooth muscle cells involves MR, ERK, and p38 MAPK
    • Fu GX, Xu CC, Zhong Y, Zhu DL, Gao PJ. Aldosterone-induced osteopontin expression in vascular smooth muscle cells involves MR, ERK, and p38 MAPK. Endocrine. 2012;42:676-683. doi: 10.1007/s12020-012-9675-2
    • (2012) Endocrine , vol.42 , pp. 676-683
    • Fu, G.X.1    Xu, C.C.2    Zhong, Y.3    Zhu, D.L.4    Gao, P.J.5
  • 195
    • 82555165003 scopus 로고    scopus 로고
    • Aldosterone increases VEGF-A production in human neutrophils through PI3K, ERK1/2 and p38 pathways
    • Walczak C, Gaignier F, Gilet A, Zou F, Thornton SN, Ropars A. Aldosterone increases VEGF-A production in human neutrophils through PI3K, ERK1/2 and p38 pathways. Biochim Biophys Acta. 2011;1813:2125-2132. doi: 10.1016/j.bbamcr.2011.07.010
    • (2011) Biochim Biophys Acta. , vol.1813 , pp. 2125-2132
    • Walczak, C.1    Gaignier, F.2    Gilet, A.3    Zou, F.4    Thornton, S.N.5    Ropars, A.6
  • 196
    • 85081557718 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target
    • Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med. 2020;46:586-590. doi: 10.1007/s00134-020-05985-9
    • (2020) Intensive Care Med. , vol.46 , pp. 586-590
    • Zhang, H.1    Penninger, J.M.2    Li, Y.3    Zhong, N.4    Slutsky, A.S.5
  • 197
    • 85083061613 scopus 로고    scopus 로고
    • Renin-angiotensin-aldosterone system inhibitors in patients with COVID-19
    • [published online March 30, 2020]
    • Vaduganathan M, Vardeny O, Michel T, McMurray JJV, Pfeffer MA, Solomon SD. Renin-angiotensin-aldosterone system inhibitors in patients with COVID-19 [published online March 30, 2020]. N Engl J Med. doi: 10.1056/NEJMsr2005760. Available at nejm.org/doi/full/10.1056/NEJMsr2005760.
    • N Engl J Med.
    • Vaduganathan, M.1    Vardeny, O.2    Michel, T.3    McMurray, J.J.V.4    Pfeffer, M.A.5    Solomon, S.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.