Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites

Journal of Clinical Investigation

Volumn 117, Issue 4, 2007, Pages 902-909

  Tsou, Chia Lin ^a   Peters, Wendy ^a   Si, Yue ^a   Slaymaker, Sarah ^a   Aslanian, Ara M ^a,e   Weisberg, Stuart P ^b   Mack, Matthias ^c   Charo, Israel F ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

^d GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^e NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CCR2; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; MONOCYTE CHEMOTACTIC PROTEIN 5; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CELL ACTIVATION; CELL MIGRATION; CONTROLLED STUDY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADOPTIVE TRANSFER; ANIMALS; BLOOD CELL COUNT; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CHEMOKINES; HUMANS; INFLAMMATION; MICE; MICE, KNOCKOUT; MONOCYTE CHEMOATTRACTANT PROTEINS; MONOCYTES; POLYMORPHISM, GENETIC; RECEPTORS, CHEMOKINE;

EID: 34147164049     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI29919     Document Type: Article

References (33)

1. Charo, I.F., and Ransohoff, R.M. 2006. The many roles of chemokines and chemokine receptors in inflammation. N. Engl. J. Med. 354:610-621.
2. Gerard, C., and Rollins, B.J. 2001. Chemokines and disease. Nat. Immunol. 2:108-115.
3. Charo, I.F., et al. 1994. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc. Natl. Acad. Sci. U. S. A. 91:2752-2756.
4. Boring, L., et al. 1997. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J. Clin. Invest. 100:2552-2561.
5. Izikson, L., et al. 2000. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J. Exp. Med. 192:1075-1080.
6. Peters, W., et al. 2001. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U. S. A. 98:7958-7963.
7. Boring, L., Gosling, J., Cleary, M., and Charo, I.F. 1998. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature. 394:894-897.
8. Lu, B., et al. 1998. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J. Exp. Med. 187:601-608.
9. Huang, D., Wang, J., Kivisakk, P., Rollins, B.J., and Ransohoff, R.M. 2001. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J. Exp. Med. 193:713-725.
10. Henderson, R.B., Hobbs, J.A., Mathies, M., and Hogg, N. 2003. Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood. 102:328-335.
11. Sunderkotter, C., et al. 2004. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J. Immunol. 172:4410-4417.
12. Gordon, S., and Taylor, P.R. 2005. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5:953-964.
13. Hirsch, S., and Gordon, S. 1983. Polymorphic expression of a neutrophil differentiation antigen revealed by monoclonal antibody 7/4. Immunogenetics. 18:229-239.
14. Fleming, T.J., Fleming, M.L., and Malek, T.R. 1993. Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family. J. Immunol. 151:2399-2408.
15. Drevets, D.A., et al. 2004. The Ly-6Chigh monocyte subpopulation transports Listeria monocytogenes into the brain during systemic infection of mice. J. Immunol. 172:4418-4424.
16. Lemos, M.P., Esquivel, F., Scott, P., and Laufer, T.M. 2004. MHC class II expression restricted to CD8alpha+ and CD11b+ dendritic cells is sufficient for control of Leishmania major. J. Exp. Med. 199:725-730.
17. Taylor, P.R., Brown, G.D., Geldhof, A.B., Martinez-Pomares, L., and Gordon, S. 2003. Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo. Eur. J. Immunol. 33:2090-2097.
18. Taylor, P.R., et al. 2005. Macrophage receptors and immune recognition. Annu. Rev. Immunol. 23:901-944.
19. Hume, D.A., et al. 2002. The mononuclear phagocyte system revisited. J. Leukoc. Biol. 72:621-627.
20. Byrne, P.V., Guilbert, L.J., and Stanley, E.R. 1981. Distribution of cells bearing receptors for a colonystimulating factor (CSF-1) in murine tissues. J. Cell Biol. 91:848-853.
21. Tacke, F., et al. 2006. Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery. J. Exp. Med. 203:583-597.
22. Geissmann, F., Jung, S., and Littman, D.R. 2003. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 19:71-82.
23. Steinberg, D. 2005. Hypercholesterolemia and inflammation in atherogenesis: two sides of the same coin. Mol. Nutr. Food Res. 49:995-998.
24. Aikawa, M., et al. 2002. Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma. Circulation. 106:1390-1396.
25. Takahashi, K., et al. 2003. Adiposity elevates plasma MCP-1 levels leading to the increased CD11b-positive monocytes in mice. J. Biol. Chem. 278:46654-46660.
26. Huang, Z.S., Chien, K.L., Yang, C.Y., Tsai, K.S., and Wang, C.H. 2001. Peripheral differential leukocyte counts in humans vary with hyperlipidemia, smoking, and body mass index. Lipids. 36:237-245.
27. Jagels, M.A., Chambers, J.D., Arfors, K.E., and Hugli, T.E. 1995. C5a- and tumor necrosis factor-alpha-induced leukocytosis occurs independently of beta 2 integrins and L-selectin: differential effects on neutrophil adhesion molecule expression in vivo. Blood. 85:2900-2909.
28. Terashima, T., English, D., Hogg, J.C., and van Eeden, S.F. 1998. Release of polymorphonuclear leukocytes from the bone marrow by interleukin-8. Blood. 92:1062-1069.
29. Martin, C., et al. 2003. Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence. Immunity. 19:583-593.
30. Suratt, B.T., et al. 2004. Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis. Blood. 104:565-571.
31. Daly, C., and Rollins, B.J. 2003. Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: therapeutic opportunities and controversies. Microcirculation. 10:247-257.
32. Serbina, N.V., and Pamer, E.G. 2006. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat. Immunol. 7:311-317.
33. Mack, M., et al. 2001. Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice. J. Immunol. 166:4697-4704.