메뉴 건너뛰기




Volumn 5 JUN, Issue , 2014, Pages

From gene to protein-experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension

Author keywords

Angiotensin converting enzyme; Angiotensin converting enzyme 2; Blood pressure; Hypertension; Renin angiotensin system

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2;

EID: 84904431923     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2014.00227     Document Type: Article
Times cited : (118)

References (102)
  • 1
    • 84876303353 scopus 로고    scopus 로고
    • Effects of felodipine combined with puerarin on ACE2-Ang (1-7)-Mas axis in renovascular hypertensive rat
    • doi: 10.1016/j.regpep.2013.03.005
    • Bai, S., Huang, Z. G., Chen, L., Wang, J. T., and Ding, B. P. (2013). Effects of felodipine combined with puerarin on ACE2-Ang (1-7)-Mas axis in renovascular hypertensive rat. Regul. Pept. 184, 54-61. doi: 10.1016/j.regpep.2013.03.005
    • (2013) Regul. Pept. , vol.184 , pp. 54-61
    • Bai, S.1    Huang, Z.G.2    Chen, L.3    Wang, J.T.4    Ding, B.P.5
  • 2
    • 3042596693 scopus 로고    scopus 로고
    • No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension
    • doi: 10.1016/j.amjhyper.2004.02.022
    • Benjafield, A. V., Wang, W. Y., and Morris, B. J. (2004). No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension. Am. J. Hypertens. 17, 624-628. doi: 10.1016/j.amjhyper.2004.02.022
    • (2004) Am. J. Hypertens. , vol.17 , pp. 624-628
    • Benjafield, A.V.1    Wang, W.Y.2    Morris, B.J.3
  • 3
    • 42649091118 scopus 로고    scopus 로고
    • Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression
    • doi: 10.1113/expphysiol.2007.040386
    • Burchill, L., Velkoska, E., Dean, R. G., Lew, R. A., Smith, A. I., Levidiotis, V., et al. (2008). Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression. Exp. Physiol. 93, 622-630. doi: 10.1113/expphysiol.2007.040386
    • (2008) Exp. Physiol. , vol.93 , pp. 622-630
    • Burchill, L.1    Velkoska, E.2    Dean, R.G.3    Lew, R.A.4    Smith, A.I.5    Levidiotis, V.6
  • 4
    • 70350458729 scopus 로고    scopus 로고
    • Impairment of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas axis contributes to the acceleration of two-kidney, one-clip Goldblatt hypertension
    • doi: 10.1097/HJH.0b013e32832f0d06
    • Burgelova, M., Vanourkova, Z., Thumova, M., Dvorak, P., Opocensky, M., Kramer, H. J., et al. (2009). Impairment of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas axis contributes to the acceleration of two-kidney, one-clip Goldblatt hypertension. J. Hypertens. 27, 1988-2000. doi: 10.1097/HJH.0b013e32832f0d06
    • (2009) J. Hypertens. , vol.27 , pp. 1988-2000
    • Burgelova, M.1    Vanourkova, Z.2    Thumova, M.3    Dvorak, P.4    Opocensky, M.5    Kramer, H.J.6
  • 5
    • 84859635766 scopus 로고    scopus 로고
    • Chronic kidney disease: cardiac and renal angiotensin converting enzyme (ACE) 2 expression in rats after subtotal nephrectomy and the effect of ACE inhibition
    • doi: 10.1113/expphysiol.2011.063156
    • Burrell, L. M., Burchill, L., Dean, R. G., Griggs, K., Patel, S. K., and Velkoska, E. (2012). Chronic kidney disease: cardiac and renal angiotensin converting enzyme (ACE) 2 expression in rats after subtotal nephrectomy and the effect of ACE inhibition. Exp. Physiol. 97, 477-485. doi: 10.1113/expphysiol.2011.063156
    • (2012) Exp. Physiol. , vol.97 , pp. 477-485
    • Burrell, L.M.1    Burchill, L.2    Dean, R.G.3    Griggs, K.4    Patel, S.K.5    Velkoska, E.6
  • 6
    • 84871878863 scopus 로고    scopus 로고
    • The ACE2 gene: its potential as a functional candidate for cardiovascular disease
    • doi: 10.1042/CS20120269
    • Burrell, L. M., Harrap, S. B., Velkoska, E., and Patel, S. K. (2013). The ACE2 gene: its potential as a functional candidate for cardiovascular disease. Clin. Sci. (Lond.) 124, 65-76. doi: 10.1042/CS20120269
    • (2013) Clin. Sci. (Lond. ) , vol.124 , pp. 65-76
    • Burrell, L.M.1    Harrap, S.B.2    Velkoska, E.3    Patel, S.K.4
  • 7
    • 20044377209 scopus 로고    scopus 로고
    • Myocardial infarction increases ACE2 expression in rat and humans
    • doi: 10.1093/eurheartj/ehi114
    • Burrell, L. M., Risvanis, J., Kubota, E., Dean, R. G., MacDonald, P. S., Lu, S., et al. (2005). Myocardial infarction increases ACE2 expression in rat and humans. Eur. Heart J. 26, 369-375. doi: 10.1093/eurheartj/ehi114
    • (2005) Eur. Heart J. , vol.26 , pp. 369-375
    • Burrell, L.M.1    Risvanis, J.2    Kubota, E.3    Dean, R.G.4    MacDonald, P.S.5    Lu, S.6
  • 8
    • 84859787726 scopus 로고    scopus 로고
    • N-terminal pro-brain natriuretic peptide and angiotension converting enzyme 2 levels and their association with post-operative cardiac complications after emergency orthopaedic surgery
    • doi: 10.1016/j.amjcard.2011.12.032
    • Chong, C. P., Lim, W. K., Velkoska, E., van Gaal, W. J., Ryan, J. E., Savige, J., et al. (2012). N-terminal pro-brain natriuretic peptide and angiotension converting enzyme 2 levels and their association with post-operative cardiac complications after emergency orthopaedic surgery. Am. J. Cardiol. 109, 1365-1373. doi: 10.1016/j.amjcard.2011.12.032
    • (2012) Am. J. Cardiol. , vol.109 , pp. 1365-1373
    • Chong, C.P.1    Lim, W.K.2    Velkoska, E.3    Van Gaal, W.J.4    Ryan, J.E.5    Savige, J.6
  • 9
    • 0037142101 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 is an essential regulator of heart function
    • doi: 10.1038/nature00786
    • Crackower, M. A., Sarao, R., Oudit, G. Y., Yagil, C., Kozieradzki, I., Scanga, S. E., et al. (2002). Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 417, 822-828. doi: 10.1038/nature00786
    • (2002) Nature , vol.417 , pp. 822-828
    • Crackower, M.A.1    Sarao, R.2    Oudit, G.Y.3    Yagil, C.4    Kozieradzki, I.5    Scanga, S.E.6
  • 10
    • 0037048716 scopus 로고    scopus 로고
    • Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors
    • doi: 10.1021/ja0277226
    • Dales, N. A., Gould, A. E., Brown, J. A., Calderwood, E. F., Guan, B., Minor, C. A., et al. (2002). Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. J. Am. Chem. Soc. 124, 11852-11853. doi: 10.1021/ja0277226
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 11852-11853
    • Dales, N.A.1    Gould, A.E.2    Brown, J.A.3    Calderwood, E.F.4    Guan, B.5    Minor, C.A.6
  • 11
    • 33749437743 scopus 로고    scopus 로고
    • Correa de Adjounian, M. F., Ferrari, M. F., Yuan, L., Silver, X., et al
    • doi: 10.1152/physiolgenomics.00312.2005
    • Diez-Freire, C., Vazquez, J., Correa de Adjounian, M. F., Ferrari, M. F., Yuan, L., Silver, X., et al. (2006). ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR. Physiol. Genomics 27, 12-19. doi: 10.1152/physiolgenomics.00312.2005
    • (2006) Physiol. Genomics , vol.27 , pp. 12-19
    • Diez-Freire, C.1    Vazquez, J.2
  • 12
    • 77952737389 scopus 로고    scopus 로고
    • The effect of ACE2 and angiotensin-(1-7) in a mouse model of early chronic kidney disease
    • doi: 10.1152/ajprenal.00426.2009
    • Dilauro, M., Zimpelmann, J., Robertson, S. J., Genest, D., and Burns, K. D. (2010). The effect of ACE2 and angiotensin-(1-7) in a mouse model of early chronic kidney disease. Am. J. Physiol. Renal Physiol. 298, F1523-F1532. doi: 10.1152/ajprenal.00426.2009
    • (2010) Am. J. Physiol. Renal Physiol. , vol.298
    • Dilauro, M.1    Zimpelmann, J.2    Robertson, S.J.3    Genest, D.4    Burns, K.D.5
  • 13
    • 0038053724 scopus 로고    scopus 로고
    • A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    • doi: 10.1161/01.RES.87.5.e1
    • Donoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M., Stagliano, N., et al. (2000). A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ. Res. 87, E1-E9. doi: 10.1161/01.RES.87.5.e1
    • (2000) Circ. Res. , vol.87
    • Donoghue, M.1    Hsieh, F.2    Baronas, E.3    Godbout, K.4    Gosselin, M.5    Stagliano, N.6
  • 14
    • 33846183617 scopus 로고    scopus 로고
    • Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system
    • doi: 10.1152/ajpregu.00292.2006
    • Doobay, M. F., Talman, L. S., Obr, T. D., Tian, X., Davisson, R. L., and Lazartigues, E. (2007). Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, R373-R381. doi: 10.1152/ajpregu.00292.2006
    • (2007) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.292
    • Doobay, M.F.1    Talman, L.S.2    Obr, T.D.3    Tian, X.4    Davisson, R.L.5    Lazartigues, E.6
  • 15
    • 18544369738 scopus 로고    scopus 로고
    • The cardiovascular continuum and renin-angiotensin-aldosterone system blockade
    • doi: 10.1097/01.hjh.0000165623.72310.dd
    • Dzau, V. (2005). The cardiovascular continuum and renin-angiotensin-aldosterone system blockade. J. Hypertens. Suppl. 23, S9-S17. doi: 10.1097/01.hjh.0000165623.72310.dd
    • (2005) J. Hypertens. Suppl. , vol.23
    • Dzau, V.1
  • 16
    • 34447547666 scopus 로고    scopus 로고
    • Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women
    • doi: 10.1038/sj.clpt.6100214
    • Fan, X., Wang, Y., Sun, K., Zhang, W., Yang, X., Wang, S., et al. (2007). Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women. Clin. Pharmacol. Ther. 82, 187-196. doi: 10.1038/sj.clpt.6100214
    • (2007) Clin. Pharmacol. Ther. , vol.82 , pp. 187-196
    • Fan, X.1    Wang, Y.2    Sun, K.3    Zhang, W.4    Yang, X.5    Wang, S.6
  • 17
    • 70249090728 scopus 로고    scopus 로고
    • Polymorphisms of angiotensin-converting enzyme (ACE) and ACE2 are not associated with orthostatic blood pressure dysregulation in hypertensive patients
    • doi: 10.1038/aps.2009.110
    • Fan, X. H., Wang, Y. B., Wang, H., Sun, K., Zhang, W. L., Song, X. D., et al. (2009). Polymorphisms of angiotensin-converting enzyme (ACE) and ACE2 are not associated with orthostatic blood pressure dysregulation in hypertensive patients. Acta Pharmacol. Sin. 30, 1237-1244. doi: 10.1038/aps.2009.110
    • (2009) Acta Pharmacol. Sin. , vol.30 , pp. 1237-1244
    • Fan, X.H.1    Wang, Y.B.2    Wang, H.3    Sun, K.4    Zhang, W.L.5    Song, X.D.6
  • 18
    • 79951509062 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 activation protects against hypertension-induced cardiac fibrosis involving extracellular signal-regulated kinases
    • doi: 10.1113/expphysiol.2010.055277
    • Ferreira, A. J., Shenoy, V., Qi, Y., Fraga-Silva, R. A., Santos, R. A., Katovich, M. J., et al. (2011). Angiotensin-converting enzyme 2 activation protects against hypertension-induced cardiac fibrosis involving extracellular signal-regulated kinases. Exp. Physiol. 96, 287-294. doi: 10.1113/expphysiol.2010.055277
    • (2011) Exp. Physiol. , vol.96 , pp. 287-294
    • Ferreira, A.J.1    Shenoy, V.2    Qi, Y.3    Fraga-Silva, R.A.4    Santos, R.A.5    Katovich, M.J.6
  • 20
    • 33746724157 scopus 로고    scopus 로고
    • Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice
    • doi: 10.1172/JCI16980
    • Gurley, S. B., Allred, A., Le, T. H., Griffiths, R., Mao, L., Philip, N., et al. (2006). Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J. Clin. Invest. 116, 2218-2225. doi: 10.1172/JCI16980
    • (2006) J. Clin. Invest. , vol.116 , pp. 2218-2225
    • Gurley, S.B.1    Allred, A.2    Le, T.H.3    Griffiths, R.4    Mao, L.5    Philip, N.6
  • 21
    • 84897030042 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2-independent action of presumed angiotensin-converting enzyme 2 activators: studies in vivo, ex vivo, and in vitro
    • doi: 10.1161/HYPERTENSIONAHA.113.02856
    • Haber, P. K., Ye, M., Wysocki, J., Maier, C., Haque, S. K., and Batlle, D. (2014). Angiotensin-converting enzyme 2-independent action of presumed angiotensin-converting enzyme 2 activators: studies in vivo, ex vivo, and in vitro. Hypertension 63, 774-782. doi: 10.1161/HYPERTENSIONAHA.113.02856
    • (2014) Hypertension , vol.63 , pp. 774-782
    • Haber, P.K.1    Ye, M.2    Wysocki, J.3    Maier, C.4    Haque, S.K.5    Batlle, D.6
  • 22
    • 84883202259 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects
    • doi: 10.1007/s40262-013-0072-7
    • Haschke, M., Schuster, M., Poglitsch, M., Loibner, H., Salzberg, M., Bruggisser, M., et al. (2013). Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects. Clin. Pharmacokinet. 52, 783-792. doi: 10.1007/s40262-013-0072-7
    • (2013) Clin. Pharmacokinet. , vol.52 , pp. 783-792
    • Haschke, M.1    Schuster, M.2    Poglitsch, M.3    Loibner, H.4    Salzberg, M.5    Bruggisser, M.6
  • 23
    • 42349105833 scopus 로고    scopus 로고
    • Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents
    • doi: 10.1161/HYPERTENSIONAHA.107.108944
    • Hernandez Prada, J. A., Ferreira, A. J., Katovich, M. J., Shenoy, V., Qi, Y., Santos, R. A., et al. (2008). Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension 51, 1312-1317. doi: 10.1161/HYPERTENSIONAHA.107.108944
    • (2008) Hypertension , vol.51 , pp. 1312-1317
    • Hernandez Prada, J.A.1    Ferreira, A.J.2    Katovich, M.J.3    Shenoy, V.4    Qi, Y.5    Santos, R.A.6
  • 24
    • 84864277556 scopus 로고    scopus 로고
    • Polymorphisms of ACE2 are associated with blood pressure response to cold pressor test: the GenSalt study
    • doi: 10.1038/ajh.2012.61
    • Huang, J., Chen, S., Lu, X., Zhao, Q., Rao, D. C., Jaquish, C. E., et al. (2012). Polymorphisms of ACE2 are associated with blood pressure response to cold pressor test: the GenSalt study. Am. J. Hypertens. 25, 937-942. doi: 10.1038/ajh.2012.61
    • (2012) Am. J. Hypertens. , vol.25 , pp. 937-942
    • Huang, J.1    Chen, S.2    Lu, X.3    Zhao, Q.4    Rao, D.C.5    Jaquish, C.E.6
  • 25
    • 33751251070 scopus 로고    scopus 로고
    • Association study of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms and essential hypertension in northern Han Chinese
    • doi: 10.1038/sj.jhh.1002090
    • Huang, W., Yang, W., Wang, Y., Zhao, Q., Gu, D., and Chen, R. (2006). Association study of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms and essential hypertension in northern Han Chinese. J. Hum. Hypertens. 20, 968-971. doi: 10.1038/sj.jhh.1002090
    • (2006) J. Hum. Hypertens. , vol.20 , pp. 968-971
    • Huang, W.1    Yang, W.2    Wang, Y.3    Zhao, Q.4    Gu, D.5    Chen, R.6
  • 26
    • 26044453206 scopus 로고    scopus 로고
    • Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats
    • doi: 10.1113/expphysiol.2005.031096
    • Huentelman, M. J., Grobe, J. L., Vazquez, J., Stewart, J. M., Mecca, A. P., Katovich, M. J., et al. (2005). Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. Exp. Physiol. 90, 783-790. doi: 10.1113/expphysiol.2005.031096
    • (2005) Exp. Physiol. , vol.90 , pp. 783-790
    • Huentelman, M.J.1    Grobe, J.L.2    Vazquez, J.3    Stewart, J.M.4    Mecca, A.P.5    Katovich, M.J.6
  • 27
    • 0028087183 scopus 로고
    • Tissue angiotensin converting enzyme in cardiac and vascular hypertrophy, repair, and remodeling
    • doi: 10.1161/01.HYP.23.2.258
    • Johnston, C. I. (1994). Tissue angiotensin converting enzyme in cardiac and vascular hypertrophy, repair, and remodeling. Hypertension 23, 258-268. doi: 10.1161/01.HYP.23.2.258
    • (1994) Hypertension , vol.23 , pp. 258-268
    • Johnston, C.I.1
  • 28
    • 76349088459 scopus 로고    scopus 로고
    • Renal ACE2 expression and activity is unaltered during established hypertension in adult SHRSP and TGR(mREN2)27
    • doi: 10.1038/hr.2009.191
    • Kamilic, J., Hamming, I., Kreutz, R., Bolbrinker, J., Siems, W. E., Nassar, I., et al. (2010). Renal ACE2 expression and activity is unaltered during established hypertension in adult SHRSP and TGR(mREN2)27. Hypertens. Res. 33, 123-128. doi: 10.1038/hr.2009.191
    • (2010) Hypertens. Res. , vol.33 , pp. 123-128
    • Kamilic, J.1    Hamming, I.2    Kreutz, R.3    Bolbrinker, J.4    Siems, W.E.5    Nassar, I.6
  • 29
    • 12344282783 scopus 로고    scopus 로고
    • Global burden of hypertension: analysis of worldwide data
    • doi: 10.1016/S0140-6736(05)17741-1
    • Kearney, P. M., Whelton, M., Reynolds, K., Muntner, P., Whelton, P. K., and He, J. (2005). Global burden of hypertension: analysis of worldwide data. Lancet 365, 217-223. doi: 10.1016/S0140-6736(05)17741-1
    • (2005) Lancet , vol.365 , pp. 217-223
    • Kearney, P.M.1    Whelton, M.2    Reynolds, K.3    Muntner, P.4    Whelton, P.K.5    He, J.6
  • 30
    • 33846702076 scopus 로고    scopus 로고
    • ACE2 activity is increased in monocyte-derived macrophages from prehypertensive subjects
    • doi: 10.1093/ndt/gfl632
    • Keidar, S., Strizevsky, A., Raz, A., and Gamliel-Lazarovich, A. (2007). ACE2 activity is increased in monocyte-derived macrophages from prehypertensive subjects. Nephrol. Dial. Transplant 22, 597-601. doi: 10.1093/ndt/gfl632
    • (2007) Nephrol. Dial. Transplant , vol.22 , pp. 597-601
    • Keidar, S.1    Strizevsky, A.2    Raz, A.3    Gamliel-Lazarovich, A.4
  • 31
    • 80054719529 scopus 로고    scopus 로고
    • Prediction of off-target effects on angiotensin-converting enzyme 2
    • doi: 10.1177/1087057111413919
    • Kulemina, L. V., and Ostrov, D. A. (2011). Prediction of off-target effects on angiotensin-converting enzyme 2. J. Biomol. Screen. 16, 878-885. doi: 10.1177/1087057111413919
    • (2011) J. Biomol. Screen. , vol.16 , pp. 878-885
    • Kulemina, L.V.1    Ostrov, D.A.2
  • 32
    • 38049005632 scopus 로고    scopus 로고
    • Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain
    • doi: 10.1016/j.febslet.2007.11.085
    • Lambert, D. W., Clarke, N. E., Hooper, N. M., and Turner, A. J. (2008). Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain. FEBS Lett. 582, 385-390. doi: 10.1016/j.febslet.2007.11.085
    • (2008) FEBS Lett , vol.582 , pp. 385-390
    • Lambert, D.W.1    Clarke, N.E.2    Hooper, N.M.3    Turner, A.J.4
  • 33
    • 24044444558 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)
    • doi: 10.1074/jbc.M505111200
    • Lambert, D. W., Yarski, M., Warner, F. J., Thornhill, P., Parkin, E. T., Smith, A. I., et al. (2005). Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J. Biol. Chem. 280, 30113-30119. doi: 10.1074/jbc.M505111200
    • (2005) J. Biol. Chem. , vol.280 , pp. 30113-30119
    • Lambert, D.W.1    Yarski, M.2    Warner, F.J.3    Thornhill, P.4    Parkin, E.T.5    Smith, A.I.6
  • 34
    • 42449122727 scopus 로고    scopus 로고
    • Early blood pressure-independent cardiac changes in diabetic rats
    • doi: 10.1677/JOE-08-0040
    • Landau, D., Chayat, C., Zucker, N., Golomb, E., Yagil, C., Yagil, Y., et al. (2008). Early blood pressure-independent cardiac changes in diabetic rats. J. Endocrinol. 197, 75-83. doi: 10.1677/JOE-08-0040
    • (2008) J. Endocrinol. , vol.197 , pp. 75-83
    • Landau, D.1    Chayat, C.2    Zucker, N.3    Golomb, E.4    Yagil, C.5    Yagil, Y.6
  • 35
    • 77749273905 scopus 로고    scopus 로고
    • The angiotensin II type 2 receptor in cardiovascular disease
    • doi: 10.1177/1470320309347785
    • Lemarie, C. A., and Schiffrin, E. L. (2010). The angiotensin II type 2 receptor in cardiovascular disease. J. Renin Angiotensin Aldosterone Syst. 11, 19-31. doi: 10.1177/1470320309347785
    • (2010) J. Renin Angiotensin Aldosterone Syst. , vol.11 , pp. 19-31
    • Lemarie, C.A.1    Schiffrin, E.L.2
  • 36
    • 42649095968 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor
    • doi: 10.1113/expphysiol.2007.040352
    • Lew, R. A., Warner, F. J., Hanchapola, I., Yarski, M. A., Manohar, J., Burrell, L. M., et al. (2008). Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor. Exp. Physiol. 93, 685-693. doi: 10.1113/expphysiol.2007.040352
    • (2008) Exp. Physiol. , vol.93 , pp. 685-693
    • Lew, R.A.1    Warner, F.J.2    Hanchapola, I.3    Yarski, M.A.4    Manohar, J.5    Burrell, L.M.6
  • 37
    • 30744445980 scopus 로고    scopus 로고
    • Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men Results of the MONICA Augsburg echocardiographic substudy
    • doi: 10.1007/s00109-005-0718-5
    • Lieb, W., Graf, J., Gotz, A., Konig, I. R., Mayer, B., Fischer, M., et al. (2006). Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. Results of the MONICA Augsburg echocardiographic substudy. J. Mol. Med. 84, 88-96. doi: 10.1007/s00109-005-0718-5
    • (2006) J. Mol. Med. , vol.84 , pp. 88-96
    • Lieb, W.1    Graf, J.2    Gotz, A.3    Konig, I.R.4    Mayer, B.5    Fischer, M.6
  • 38
    • 84872178401 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats
    • doi: 10.1113/expphysiol.2012.067165
    • Lo, J., Patel, V. B., Wang, Z., Levasseur, J., Kaufman, S., Penninger, J. M., et al. (2013). Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats. Exp. Physiol. 98, 109-122. doi: 10.1113/expphysiol.2012.067165
    • (2013) Exp. Physiol. , vol.98 , pp. 109-122
    • Lo, J.1    Patel, V.B.2    Wang, Z.3    Levasseur, J.4    Kaufman, S.5    Penninger, J.M.6
  • 39
    • 84864286293 scopus 로고    scopus 로고
    • ACE2 gene polymorphism and essential hypertension: an updated meta-analysis involving 11
    • doi: 10.1007/s11033-012-1487-1
    • Lu, N., Yang, Y., Wang, Y., Liu, Y., Fu, G., Chen, D., et al. (2012). ACE2 gene polymorphism and essential hypertension: an updated meta-analysis involving 11,051 subjects. Mol. Biol. Rep. 39, 6581-6589. doi: 10.1007/s11033-012-1487-1
    • (2012) 051 subjects. Mol. Biol. Rep. , vol.39 , pp. 6581-6589
    • Lu, N.1    Yang, Y.2    Wang, Y.3    Liu, Y.4    Fu, G.5    Chen, D.6
  • 40
    • 84888871824 scopus 로고    scopus 로고
    • The association between the Angiotensin-Converting Enzyme-2 gene and blood pressure in a cohort study of adolescents
    • doi: 10.1186/1471-2350-14-117
    • Malard, L., Kakinami, L., O'Loughlin, J., Roy-Gagnon, M. H., Labbe, A., Pilote, L., et al. (2013). The association between the Angiotensin-Converting Enzyme-2 gene and blood pressure in a cohort study of adolescents. BMC Med. Genet. 14:117. doi: 10.1186/1471-2350-14-117
    • (2013) BMC Med. Genet. , vol.14 , pp. 117
    • Malard, L.1    Kakinami, L.2    O'Loughlin, J.3    Roy-Gagnon, M.H.4    Labbe, A.5    Pilote, L.6
  • 41
    • 84884927395 scopus 로고    scopus 로고
    • Activation of angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis attenuates the cardiac reactivity to acute emotional stress
    • doi: 10.1152/ajpheart.00433.2013
    • Martins Lima, A., Xavier, C. H., Ferreira, A. J., Raizada, M. K., Wallukat, G., Velloso, E. P., et al. (2013). Activation of angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis attenuates the cardiac reactivity to acute emotional stress. Am. J. Physiol. Heart Circ. Physiol. 305, H1057-H1067. doi: 10.1152/ajpheart.00433.2013
    • (2013) Am. J. Physiol. Heart Circ. Physiol. , vol.305
    • Martins Lima, A.1    Xavier, C.H.2    Ferreira, A.J.3    Raizada, M.K.4    Wallukat, G.5    Velloso, E.P.6
  • 42
    • 84872610780 scopus 로고    scopus 로고
    • Update on the angiotensin AT(2) receptor
    • doi: 10.1007/s11906-012-0321-4
    • McCarthy, C. A., Widdop, R. E., Denton, K. M., and Jones, E. S. (2013). Update on the angiotensin AT(2) receptor. Curr. Hypertens. Rep. 15, 25-30. doi: 10.1007/s11906-012-0321-4
    • (2013) Curr. Hypertens. Rep. , vol.15 , pp. 2530
    • McCarthy, C.A.1    Widdop, R.E.2    Denton, K.M.3    Jones, E.S.4
  • 43
    • 84900003708 scopus 로고    scopus 로고
    • Autocrine and paracrine function of angiotensin 1-7 in tissue repair during hypertension
    • doi: 10.1093/ajh/hpt270
    • Meng, W., Zhao, W., Zhao, T., Liu, C., Chen, Y., Liu, H., et al. (2014). Autocrine and paracrine function of angiotensin 1-7 in tissue repair during hypertension. Am. J. Hypertens. 27, 775-782. doi: 10.1093/ajh/hpt270
    • (2014) Am. J. Hypertens. , vol.27 , pp. 775-782
    • Meng, W.1    Zhao, W.2    Zhao, T.3    Liu, C.4    Chen, Y.5    Liu, H.6
  • 44
    • 40849127119 scopus 로고    scopus 로고
    • Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls
    • doi: 10.1053/j.ajkd.2007.11.022
    • Mizuiri, S., Hemmi, H., Arita, M., Ohashi, Y., Tanaka, Y., Miyagi, M., et al. (2008). Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls. Am. J. Kidney Dis. 51, 613-623. doi: 10.1053/j.ajkd.2007.11.022
    • (2008) Am. J. Kidney Dis. , vol.51 , pp. 613-623
    • Mizuiri, S.1    Hemmi, H.2    Arita, M.3    Ohashi, Y.4    Tanaka, Y.5    Miyagi, M.6
  • 45
    • 36049047073 scopus 로고    scopus 로고
    • Correlation of angiotensin-converting enzyme 2 gene polymorphisms with stage 2 hypertension in Han Chinese
    • doi: 10.1016/j.trsl.2007.06.002
    • Niu, W., Qi, Y., Hou, S., Zhou, W., and Qiu, C. (2007). Correlation of angiotensin-converting enzyme 2 gene polymorphisms with stage 2 hypertension in Han Chinese. Transl. Res. 150, 374-380. doi: 10.1016/j.trsl.2007.06.002
    • (2007) Transl. Res. , vol.150 , pp. 374-380
    • Niu, W.1    Qi, Y.2    Hou, S.3    Zhou, W.4    Qiu, C.5
  • 46
    • 79952755311 scopus 로고    scopus 로고
    • Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension
    • doi: 10.1097/HJH.0b013e3283440665
    • Ocaranza, M. P., Rivera, P., Novoa, U., Pinto, M., Gonzalez, L., Chiong, M., et al. (2011). Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension. J. Hypertens. 29, 706-715. doi: 10.1097/HJH.0b013e3283440665
    • (2011) J. Hypertens. , vol.29 , pp. 706-715
    • Ocaranza, M.P.1    Rivera, P.2    Novoa, U.3    Pinto, M.4    Gonzalez, L.5    Chiong, M.6
  • 47
    • 77957326124 scopus 로고    scopus 로고
    • Angiotensin converting enzyme 2 gene expression increased compensatory for left ventricular remodeling in patients with end-stage heart failure
    • doi: 10.1016/j.ijcard.2009.11.057
    • Ohtsuki, M., Morimoto, S., Izawa, H., Ismail, T. F., Ishibashi-Ueda, H., Kato, Y., et al. (2010). Angiotensin converting enzyme 2 gene expression increased compensatory for left ventricular remodeling in patients with end-stage heart failure. Int. J. Cardiol. 145, 333-334. doi: 10.1016/j.ijcard.2009.11.057
    • (2010) Int. J. Cardiol. , vol.145 , pp. 333-334
    • Ohtsuki, M.1    Morimoto, S.2    Izawa, H.3    Ismail, T.F.4    Ishibashi-Ueda, H.5    Kato, Y.6
  • 48
    • 84876432226 scopus 로고    scopus 로고
    • Role of circulating angiotensin converting enzyme 2 in left ventricular remodeling following myocardial infarction: a prospective controlled study
    • doi: 10.1371/journal.pone.0061695
    • Ortiz-Perez, J. T., Riera, M., Bosch, X., De Caralt, T. M., Perea, R. J., Pascual, J., et al. (2013). Role of circulating angiotensin converting enzyme 2 in left ventricular remodeling following myocardial infarction: a prospective controlled study. PLoS ONE 8:e61695. doi: 10.1371/journal.pone.0061695
    • (2013) PLoS ONE , vol.8
    • Ortiz-Perez, J.T.1    Riera, M.2    Bosch, X.3    De Caralt, T.M.4    Perea, R.J.5    Pascual, J.6
  • 49
    • 77449160523 scopus 로고    scopus 로고
    • Human recombinant ACE2 reduces the progression of diabetic nephropathy
    • doi: 10.2337/db09-1218
    • Oudit, G. Y., Liu, G. C., Zhong, J., Basu, R., Chow, F. L., Zhou, J., et al. (2010). Human recombinant ACE2 reduces the progression of diabetic nephropathy. Diabetes 59, 529-538. doi: 10.2337/db09-1218
    • (2010) Diabetes , vol.59 , pp. 529-538
    • Oudit, G.Y.1    Liu, G.C.2    Zhong, J.3    Basu, R.4    Chow, F.L.5    Zhou, J.6
  • 50
    • 28144453548 scopus 로고    scopus 로고
    • Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2
    • doi: 10.1136/gut.2004.062398
    • Paizis, G., Tikellis, C., Cooper, M. E., Schembri, J. M., Lew, R. A., Smith, A. I., et al. (2005). Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2. Gut 54, 1790-1796. doi: 10.1136/gut.2004.062398
    • (2005) Gut , vol.54 , pp. 1790-1796
    • Paizis, G.1    Tikellis, C.2    Cooper, M.E.3    Schembri, J.M.4    Lew, R.A.5    Smith, A.I.6
  • 51
    • 84880990079 scopus 로고    scopus 로고
    • Emerging markers in cardiovascular disease: where does angiotensin-converting enzyme 2 fit in? Clin
    • doi: 10.1111/1440-1681.12069
    • Patel, S. K., Velkoska, E., and Burrell, L. M. (2013b). Emerging markers in cardiovascular disease: where does angiotensin-converting enzyme 2 fit in? Clin. Exp. Pharmacol. Physiol. 40, 551-559. doi: 10.1111/1440-1681.12069
    • (2013) Exp. Pharmacol. Physiol. , vol.40 , pp. 551-559
    • Patel, S.K.1    Velkoska, E.2    Burrell, L.M.3
  • 52
    • 84856042570 scopus 로고    scopus 로고
    • Association of ACE2 genetic variants with blood pressure, left ventricular mass, and cardiac function in Caucasians with type 2 diabetes
    • doi: 10.1038/ajh.2011.188
    • Patel, S. K., Wai, B., Ord, M., Macisaac, R. J., Grant, S., Velkoska, E., et al. (2012). Association of ACE2 genetic variants with blood pressure, left ventricular mass, and cardiac function in Caucasians with type 2 diabetes. Am. J. Hypertens. 25, 216-222. doi: 10.1038/ajh.2011.188
    • (2012) Am. J. Hypertens. , vol.25 , pp. 216-222
    • Patel, S.K.1    Wai, B.2    Ord, M.3    Macisaac, R.J.4    Grant, S.5    Velkoska, E.6
  • 53
    • 84891683755 scopus 로고    scopus 로고
    • Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS
    • doi: 10.1016/j.yjmcc.2013.11.017
    • Patel, V. B., Clarke, N., Wang, Z., Fan, D., Parajuli, N., Basu, R., et al. (2013a). Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS. J. Mol. Cell. Cardiol. 66, 167-176. doi: 10.1016/j.yjmcc.2013.11.017
    • (2013) J. Mol. Cell. Cardiol. , vol.66 , pp. 167-176
    • Patel, V.B.1    Clarke, N.2    Wang, Z.3    Fan, D.4    Parajuli, N.5    Basu, R.6
  • 54
    • 84893955875 scopus 로고    scopus 로고
    • Association of angiotensin-converting enzyme and angiotensin-converting enzyme-2 gene polymorphisms with essential hypertension in the population of Odisha
    • doi: 10.3109/03014460.2013.837195
    • Patnaik, M., Pati, P., Swain, S. N., Mohapatra, M. K., Dwibedi, B., Kar, S. K., et al. (2014). Association of angiotensin-converting enzyme and angiotensin-converting enzyme-2 gene polymorphisms with essential hypertension in the population of Odisha, India. Ann. Hum. Biol. 41, 143-150. doi: 10.3109/03014460.2013.837195
    • (2014) India. Ann. Hum. Biol. , vol.41 , pp. 143-150
    • Patnaik, M.1    Pati, P.2    Swain, S.N.3    Mohapatra, M.K.4    Dwibedi, B.5    Kar, S.K.6
  • 55
    • 49849106191 scopus 로고    scopus 로고
    • Sex differences in circulating and renal angiotensins of hypertensive mRen(2) Lewis but not normotensive Lewis rats
    • doi: 10.1152/ajpheart.01277.2007
    • Pendergrass, K. D., Pirro, N. T., Westwood, B. M., Ferrario, C. M., Brosnihan, K. B., and Chappell, M. C. (2008). Sex differences in circulating and renal angiotensins of hypertensive mRen(2). Lewis but not normotensive Lewis rats. Am. J. Physiol. Heart Circ. Physiol. 295, H10-H20. doi: 10.1152/ajpheart.01277.2007
    • (2008) Am. J. Physiol. Heart Circ. Physiol. , vol.295
    • Pendergrass, K.D.1    Pirro, N.T.2    Westwood, B.M.3    Ferrario, C.M.4    Brosnihan, K.B.5    Chappell, M.C.6
  • 56
    • 79954459188 scopus 로고    scopus 로고
    • Reciprocal changes in renal ACE/Ang II and ACE2/Ang 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats
    • doi: 10.1152/ajprenal.00383.2009
    • Prieto, M. C., Gonzalez-Villalobos, R. A., Botros, F. T., Martin, V. L., Pagan, J., Sato, R., et al. (2011). Reciprocal changes in renal ACE/Ang II and ACE2/Ang 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats. Am. J. Physiol. Renal Physiol. 300, F749-F755. doi: 10.1152/ajprenal.00383.2009
    • (2011) Am. J. Physiol. Renal Physiol. , vol.300
    • Prieto, M.C.1    Gonzalez-Villalobos, R.A.2    Botros, F.T.3    Martin, V.L.4    Pagan, J.5    Sato, R.6
  • 57
    • 57049086924 scopus 로고    scopus 로고
    • Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease
    • doi: 10.1038/ki.2008.497
    • Reich, H. N., Oudit, G. Y., Penninger, J. M., Scholey, J. W., and Herzenberg, A. M. (2008). Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease. Kidney Int. 74, 1610-1616. doi: 10.1038/ki.2008.497
    • (2008) Kidney Int , vol.74 , pp. 1610-1616
    • Reich, H.N.1    Oudit, G.Y.2    Penninger, J.M.3    Scholey, J.W.4    Herzenberg, A.M.5
  • 58
    • 55949126600 scopus 로고    scopus 로고
    • Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function
    • doi: 10.1161/HYPERTENSIONAHA.108.114322
    • Rentzsch, B., Todiras, M., Iliescu, R., Popova, E., Campos, L. A., Oliveira, M. L., et al. (2008). Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function. Hypertension 52, 967-973. doi: 10.1161/HYPERTENSIONAHA.108.114322
    • (2008) Hypertension , vol.52 , pp. 967-973
    • Rentzsch, B.1    Todiras, M.2    Iliescu, R.3    Popova, E.4    Campos, L.A.5    Oliveira, M.L.6
  • 59
    • 33750264733 scopus 로고    scopus 로고
    • Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study
    • doi: 10.1161/01.HYP.0000244543.91937.79
    • Rice, G. I., Jones, A. L., Grant, P. J., Carter, A. M., Turner, A. J., and Hooper, N. M. (2006). Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study. Hypertension 48, 914-920. doi: 10.1161/01.HYP.0000244543.91937.79
    • (2006) Hypertension , vol.48 , pp. 914-920
    • Rice, G.I.1    Jones, A.L.2    Grant, P.J.3    Carter, A.M.4    Turner, A.J.5    Hooper, N.M.6
  • 60
    • 84880968521 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 activity in patients with chronic kidney disease
    • doi: 10.1093/ndt/gft038
    • Roberts, M. A., Velkoska, E., Ierino, F. L., and Burrell, L. M. (2013). Angiotensin-converting enzyme 2 activity in patients with chronic kidney disease. Nephrol. Dial. Transplant 28, 2287-2294. doi: 10.1093/ndt/gft038
    • (2013) Nephrol. Dial. Transplant , vol.28 , pp. 2287-2294
    • Roberts, M.A.1    Velkoska, E.2    Ierino, F.L.3    Burrell, L.M.4
  • 61
    • 77950505611 scopus 로고    scopus 로고
    • Campagnole-Santos, MJ. Lifetime overproduction of circulating angiotensin-(1-7) attenuates deoxycorticosterone acetate-salt hypertension-induced cardiac dysfunction and remodeling
    • doi: 10.1161/HYPERTENSIONAHA.110.149815
    • Santiago, N. M., Guimaraes, P. S., Sirvente, R. A., Oliveira, L. A., Irigoyen, M. C., and Santos, R. A. (2010). Campagnole-Santos, MJ. Lifetime overproduction of circulating angiotensin-(1-7) attenuates deoxycorticosterone acetate-salt hypertension-induced cardiac dysfunction and remodeling. Hypertension 55, 889-96. doi: 10.1161/HYPERTENSIONAHA.110.149815
    • (2010) Hypertension , vol.55 , pp. 889-896
    • Santiago, N.M.1    Guimaraes, P.S.2    Sirvente, R.A.3    Oliveira, L.A.4    Irigoyen, M.C.5    Santos, R.A.6
  • 62
    • 84902291577 scopus 로고    scopus 로고
    • Angiotensin-(1-7)
    • doi: 10.1161/HYPERTENSIONAHA.113.01274
    • Santos, R. A. (2014). Angiotensin-(1-7). Hypertension 63, 1138-1147. doi: 10.1161/HYPERTENSIONAHA.113.01274
    • (2014) Hypertension , vol.63 , pp. 1138-1147
    • Santos, R.A.1
  • 63
    • 0037478671 scopus 로고    scopus 로고
    • Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
    • doi: 10.1073/pnas.1432869100
    • Santos, R. A., Simoese Silva, A. C., Maric, C., Silva, D. M., Machado, R. P., de Buhr, I., et al. (2003). Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc. Natl. Acad. Sci. U.S.A. 100, 8258-8263. doi: 10.1073/pnas.1432869100
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 8258-8263
    • Santos, R.A.1    Simoese Silva, A.C.2    Maric, C.3    Silva, D.M.4    Machado, R.P.5    De Buhr, I.6
  • 64
    • 77950466786 scopus 로고    scopus 로고
    • Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice
    • doi: 10.1038/hr.2009.231
    • Shiota, A., Yamamoto, K., Ohishi, M., Tatara, Y., Ohnishi, M., Maekawa, Y., et al. (2010). Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice. Hypertens. Res. 33, 298-307. doi: 10.1038/hr.2009.231
    • (2010) Hypertens. Res. , vol.33 , pp. 298-307
    • Shiota, A.1    Yamamoto, K.2    Ohishi, M.3    Tatara, Y.4    Ohnishi, M.5    Maekawa, Y.6
  • 65
    • 46849105087 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 (ACE2) expression and activity in human carotid atherosclerotic lesions
    • doi: 10.1002/path.2357
    • Sluimer, J. C., Gasc, J. M., Hamming, I., van Goor, H., Michaud, A., van den Akker, L. H., et al. (2008). Angiotensin-converting enzyme 2 (ACE2) expression and activity in human carotid atherosclerotic lesions. J. Pathol. 215, 273-279. doi: 10.1002/path.2357
    • (2008) J. Pathol. , vol.215 , pp. 273-279
    • Sluimer, J.C.1    Gasc, J.M.2    Hamming, I.3    Van Goor, H.4    Michaud, A.5    Van Den Akker, L.H.6
  • 66
    • 79960776952 scopus 로고    scopus 로고
    • Association between renin-angiotensin-aldosterone system-related genes and blood pressure in a Korean population
    • doi: 10.3109/08037051.2011.555074
    • Song, S. B., Jin, H. S., Hong, K. W., Lim, J. E., Moon, J. Y., Jeong, K. H., et al. (2011). Association between renin-angiotensin-aldosterone system-related genes and blood pressure in a Korean population. Blood Press. 20, 204-210. doi: 10.3109/08037051.2011.555074
    • (2011) Blood Press , vol.20 , pp. 204-210
    • Song, S.B.1    Jin, H.S.2    Hong, K.W.3    Lim, J.E.4    Moon, J.Y.5    Jeong, K.H.6
  • 67
    • 84855860581 scopus 로고    scopus 로고
    • Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications
    • doi: 10.1097/HJH.0b013e32834f04b6
    • Soro-Paavonen, A., Gordin, D., Forsblom, C., Rosengard-Barlund, M., Waden, J., Thorn, L., et al. (2012). Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications. J. Hypertens. 30, 375-383. doi: 10.1097/HJH.0b013e32834f04b6
    • (2012) J. Hypertens. , vol.30 , pp. 375-383
    • Soro-Paavonen, A.1    Gordin, D.2    Forsblom, C.3    Rosengard-Barlund, M.4    Waden, J.5    Thorn, L.6
  • 68
    • 81055133082 scopus 로고    scopus 로고
    • ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension
    • doi: 10.1093/cvr/cvr242
    • Sriramula, S., Cardinale, J. P., Lazartigues, E., and Francis, J. (2011). ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension. Cardiovasc. Res. 92, 401-408. doi: 10.1093/cvr/cvr242
    • (2011) Cardiovasc. Res. , vol.92 , pp. 401-408
    • Sriramula, S.1    Cardinale, J.P.2    Lazartigues, E.3    Francis, J.4
  • 69
    • 34548822986 scopus 로고    scopus 로고
    • Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl salt-sensitive hypertensive rats
    • doi: 10.1016/j.amjhyper.2007.05.008
    • Takeda, Y., Zhu, A., Yoneda, T., Usukura, M., Takata, H., and Yamagishi, M. (2007). Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl salt-sensitive hypertensive rats. Am. J. Hypertens. 20, 1119-1124. doi: 10.1016/j.amjhyper.2007.05.008
    • (2007) Am. J. Hypertens. , vol.20 , pp. 1119-1124
    • Takeda, Y.1    Zhu, A.2    Yoneda, T.3    Usukura, M.4    Takata, H.5    Yamagishi, M.6
  • 70
    • 0141893551 scopus 로고    scopus 로고
    • Molecular mechanisms of inhibition of vascular growth by angiotensin-(1-7)
    • doi: 10.1161/01.HYP.0000090322.55782.30
    • Tallant, E. A., and Clark, M. A. (2003). Molecular mechanisms of inhibition of vascular growth by angiotensin-(1-7). Hypertension 42, 574-579. doi: 10.1161/01.HYP.0000090322.55782.30
    • (2003) Hypertension , vol.42 , pp. 574-579
    • Tallant, E.A.1    Clark, M.A.2
  • 71
    • 83455195588 scopus 로고    scopus 로고
    • Regulation of angiotensin-converting enzyme 2 and Mas receptor by Ang-(1-7) in heart and kidney of spontaneously hypertensive rats
    • doi: 10.1177/1470320311402109
    • Tan, Z., Wu, J., and Ma, H. (2011). Regulation of angiotensin-converting enzyme 2 and Mas receptor by Ang-(1-7) in heart and kidney of spontaneously hypertensive rats. J. Renin Angiotensin Aldosterone Syst. 12, 413-419. doi: 10.1177/1470320311402109
    • (2011) J. Renin Angiotensin Aldosterone Syst. , vol.12 , pp. 413-419
    • Tan, Z.1    Wu, J.2    Ma, H.3
  • 72
    • 42449140640 scopus 로고    scopus 로고
    • ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes
    • doi: 10.2337/db07-1212
    • Tikellis, C., Bialkowski, K., Pete, J., Sheehy, K., Su, Q., Johnston, C., et al. (2008). ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes. Diabetes 57, 1018-1025. doi: 10.2337/db07-1212
    • (2008) Diabetes , vol.57 , pp. 1018-1025
    • Tikellis, C.1    Bialkowski, K.2    Pete, J.3    Sheehy, K.4    Su, Q.5    Johnston, C.6
  • 73
    • 33745725913 scopus 로고    scopus 로고
    • Developmental expression of ACE2 in the SHR kidney: a role in hypertension?
    • doi: 10.1038/sj.ki.5000428
    • Tikellis, C., Cooper, M. E., Bialkowski, K., Johnston, C. I., Burns, W. C., Lew, R. A., et al. (2006). Developmental expression of ACE2 in the SHR kidney: a role in hypertension? Kidney Int. 70, 34-41. doi: 10.1038/sj.ki.5000428
    • (2006) Kidney Int , vol.70 , pp. 34-41
    • Tikellis, C.1    Cooper, M.E.2    Bialkowski, K.3    Johnston, C.I.4    Burns, W.C.5    Lew, R.A.6
  • 74
    • 0037341501 scopus 로고    scopus 로고
    • Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy
    • doi: 10.1161/01.HYP.0000060689.38912.CB
    • Tikellis, C., Johnston, C. I., Forbes, J. M., Burns, W. C., Burrell, L. M., Risvanis, J., et al. (2003). Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy. Hypertension 41, 392-397. doi: 10.1161/01.HYP.0000060689.38912.CB
    • (2003) Hypertension , vol.41 , pp. 392-397
    • Tikellis, C.1    Johnston, C.I.2    Forbes, J.M.3    Burns, W.C.4    Burrell, L.M.5    Risvanis, J.6
  • 75
    • 84866466550 scopus 로고    scopus 로고
    • Interaction of diabetes and ACE2 in the pathogenesis of cardiovascular disease in experimental diabetes
    • doi: 10.1042/CS20110668
    • Tikellis, C., Pickering, R., Tsorotes, D., Du, X. J., Kiriazis, H., Nguyen-Huu, T. P., et al. (2012). Interaction of diabetes and ACE2 in the pathogenesis of cardiovascular disease in experimental diabetes. Clin. Sci. (Lond.) 123, 519-529. doi: 10.1042/CS20110668
    • (2012) Clin. Sci. (Lond. ) , vol.123 , pp. 519-529
    • Tikellis, C.1    Pickering, R.2    Tsorotes, D.3    Du, X.J.4    Kiriazis, H.5    Nguyen-Huu, T.P.6
  • 76
    • 0034721906 scopus 로고    scopus 로고
    • A human homolog of angiotensin-converting enzyme Cloning and functional expression as a captopril-insensitive carboxypeptidase
    • doi: 10.1074/jbc.M002615200
    • Tipnis, S. R., Hooper, N. M., Hyde, R., Karran, E., Christie, G., and Turner, A. J. (2000). A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J. Biol. Chem. 275, 33238-33243. doi: 10.1074/jbc.M002615200
    • (2000) J. Biol. Chem. , vol.275 , pp. 33238-33243
    • Tipnis, S.R.1    Hooper, N.M.2    Hyde, R.3    Karran, E.4    Christie, G.5    Turner, A.J.6
  • 77
    • 77952511816 scopus 로고    scopus 로고
    • Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats
    • doi: 10.1038/ajh.2010.51
    • Trask, A. J., Groban, L., Westwood, B. M., Varagic, J., Ganten, D., Gallagher, P. E., et al. (2010). Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am. J. Hypertens. 23, 687-693. doi: 10.1038/ajh.2010.51
    • (2010) Am. J. Hypertens. , vol.23 , pp. 687-693
    • Trask, A.J.1    Groban, L.2    Westwood, B.M.3    Varagic, J.4    Ganten, D.5    Gallagher, P.E.6
  • 78
    • 84898888351 scopus 로고    scopus 로고
    • New perspectives in the renin-angiotensin-aldosterone system (RAAS) IV: circulating ACE2 as a biomarker of systolic dysfunction in human hypertension and heart failure
    • doi: 10.1371/journal.pone.0087845
    • Uri, K., Fagyas, M., Manyine Siket, I., Kertesz, A., Csanadi, Z., Sandorfi, G., et al. (2014). New perspectives in the renin-angiotensin-aldosterone system (RAAS) IV: circulating ACE2 as a biomarker of systolic dysfunction in human hypertension and heart failure. PLoS ONE 9:e87845. doi: 10.1371/journal.pone.0087845
    • (2014) PLoS ONE , vol.9
    • Uri, K.1    Fagyas, M.2    Manyine Siket, I.3    Kertesz, A.4    Csanadi, Z.5    Sandorfi, G.6
  • 79
    • 77949891096 scopus 로고    scopus 로고
    • Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction
    • doi: 10.1177/1753944709353337
    • Varagic, J., Ahmad, S., Brosnihan, K. B., Groban, L., Chappell, M. C., Tallant, E. A., et al. (2010). Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther. Adv. Cardiovasc. Dis. 4, 17-25. doi: 10.1177/1753944709353337
    • (2010) Ther. Adv. Cardiovasc. Dis. , vol.4 , pp. 17-25
    • Varagic, J.1    Ahmad, S.2    Brosnihan, K.B.3    Groban, L.4    Chappell, M.C.5    Tallant, E.A.6
  • 80
    • 84865462583 scopus 로고    scopus 로고
    • Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats
    • doi: 10.1097/HJH.0b013e328356766f
    • Varagic, J., Ahmad, S., Voncannon, J. L., Moniwa, N., Simington, S. W. Jr., Brosnihan, B. K., et al. (2012). Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. J. Hypertens. 30, 1766-1774. doi: 10.1097/HJH.0b013e328356766f
    • (2012) J. Hypertens. , vol.30 , pp. 1766-1774
    • Varagic, J.1    Ahmad, S.2    Voncannon, J.L.3    Moniwa, N.4    Simington Jr, S.W.5    Brosnihan, B.K.6
  • 81
    • 70549098001 scopus 로고    scopus 로고
    • Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition
    • doi: 10.1042/CS20090318
    • Velkoska, E., Dean, R. G., Burchill, L., Levidiotis, V., and Burrell, L. M. (2010). Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition. Clin. Sci. (Lond.) 118, 269-279. doi: 10.1042/CS20090318
    • (2010) Clin. Sci. (Lond. ) , vol.118 , pp. 269-279
    • Velkoska, E.1    Dean, R.G.2    Burchill, L.3    Levidiotis, V.4    Burrell, L.M.5
  • 82
    • 79951779192 scopus 로고    scopus 로고
    • Angiotensin-(1-7) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy
    • doi: 10.1042/CS20100280
    • Velkoska, E., Dean, R. G., Griggs, K., Burchill, L., and Burrell, L. M. (2011). Angiotensin-(1-7) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy. Clin. Sci. (Lond.) 120, 335-345. doi: 10.1042/CS20100280
    • (2011) Clin. Sci. (Lond. ) , vol.120 , pp. 335-345
    • Velkoska, E.1    Dean, R.G.2    Griggs, K.3    Burchill, L.4    Burrell, L.M.5
  • 83
    • 18544378161 scopus 로고    scopus 로고
    • Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase
    • doi: 10.1074/jbc.M200581200
    • Vickers, C., Hales, P., Kaushik, V., Dick, L., Gavin, J., Tang, J., et al. (2002). Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J. Biol. Chem. 277, 14838-14843. doi: 10.1074/jbc.M200581200
    • (2002) J. Biol. Chem. , vol.277 , pp. 14838-14843
    • Vickers, C.1    Hales, P.2    Kaushik, V.3    Dick, L.4    Gavin, J.5    Tang, J.6
  • 84
    • 84877090805 scopus 로고    scopus 로고
    • World Health Organizati on Global Atlas on Cardiovascular Disease Prevention and Control
    • eds S. Mendis, P. Puska, and B Norrving. (Geneva: World Health Organization)
    • World Health Organization. (2011). Global Atlas on Cardiovascular Disease Prevention and Control. eds S. Mendis, P. Puska, and B. Norrving (Geneva: World Health Organization).
    • (2011)
  • 85
    • 73849101073 scopus 로고    scopus 로고
    • Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2 prevention of angiotensin II-dependent hypertension
    • doi: 10.1161/HYPERTENSIONAHA.109.138420
    • Wysocki, J., Ye, M., Rodriguez, E., Gonzalez-Pacheco, F. R., Barrios, C., Evora, K., et al. (2010). Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension. Hypertension 55, 90-98. doi: 10.1161/HYPERTENSIONAHA.109.138420
    • (2010) Hypertension , vol.55 , pp. 90-98
    • Wysocki, J.1    Ye, M.2    Rodriguez, E.3    Gonzalez-Pacheco, F.R.4    Barrios, C.5    Evora, K.6
  • 86
    • 59849099636 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice
    • doi: 10.1161/HYPERTENSIONAHA.108.123844
    • Xia, H., Feng, Y., Obr, T. D., Hickman, P. J., and Lazartigues, E. (2009). Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice. Hypertension 53, 210-216. doi: 10.1161/HYPERTENSIONAHA.108.123844
    • (2009) Hypertension , vol.53 , pp. 210-216
    • Xia, H.1    Feng, Y.2    Obr, T.D.3    Hickman, P.J.4    Lazartigues, E.5
  • 87
    • 84886089553 scopus 로고    scopus 로고
    • Brain ACE2 shedding contributes to the development of neurogenic hypertension
    • doi: 10.1161/CIRCRESAHA.113.301811
    • Xia, H., Sriramula, S., Chhabra, K. H., and Lazartigues, E. (2013). Brain ACE2 shedding contributes to the development of neurogenic hypertension. Circ. Res. 113, 1087-1096. doi: 10.1161/CIRCRESAHA.113.301811
    • (2013) Circ. Res. , vol.113 , pp. 1087-1096
    • Xia, H.1    Sriramula, S.2    Chhabra, K.H.3    Lazartigues, E.4
  • 88
    • 79954555219 scopus 로고    scopus 로고
    • ACE2/ANG-(1-7)/Mas pathway in the brain: the axis of good
    • doi: 10.1152/ajpregu.00222.2010
    • Xu, P., Sriramula, S., and Lazartigues, E. (2011). ACE2/ANG-(1-7)/Mas pathway in the brain: the axis of good. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R804-R817. doi: 10.1152/ajpregu.00222.2010
    • (2011) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.300
    • Xu, P.1    Sriramula, S.2    Lazartigues, E.3
  • 89
    • 0037386977 scopus 로고    scopus 로고
    • Hypothesis: ACE2 modulates blood pressure in the mammalian organism
    • doi: 10.1161/01.HYP.0000063886.71596.C8
    • Yagil, Y., and Yagil, C. (2003). Hypothesis: ACE2 modulates blood pressure in the mammalian organism. Hypertension 41, 871-873. doi: 10.1161/01.HYP.0000063886.71596.C8
    • (2003) Hypertension , vol.41 , pp. 871-873
    • Yagil, Y.1    Yagil, C.2
  • 90
    • 34047193877 scopus 로고    scopus 로고
    • Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats
    • doi: 10.1161/01.HYP.0000259942.38108.20
    • Yamazato, M., Yamazato, Y., Sun, C., Diez-Freire, C., and Raizada, M. K. (2007). Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats. Hypertension 49, 926-931. doi: 10.1161/01.HYP.0000259942.38108.20
    • (2007) Hypertension , vol.49 , pp. 926-931
    • Yamazato, M.1    Yamazato, Y.2    Sun, C.3    Diez-Freire, C.4    Raizada, M.K.5
  • 91
    • 84878015222 scopus 로고    scopus 로고
    • Effects of enalapril on the expression of cardiac angiotensin-converting enzyme and angiotensin-converting enzyme 2 in spontaneously hypertensive rats
    • doi: 10.1016/j.acvd.2013.01.004
    • Yang, Z., Yu, X., Cheng, L., Miao, L.-Y., Li, H.-X., Han, L.-H., et al. (2013). Effects of enalapril on the expression of cardiac angiotensin-converting enzyme and angiotensin-converting enzyme 2 in spontaneously hypertensive rats. Arch. Cardiovasc. Dis. 106, 196-201. doi: 10.1016/j.acvd.2013.01.004
    • (2013) Arch. Cardiovasc. Dis. , vol.106 , pp. 196-201
    • Yang, Z.1    Yu, X.2    Cheng, L.3    Miao, L.-Y.4    Li, H.-X.5    Han, L.-H.6
  • 92
    • 84865556205 scopus 로고    scopus 로고
    • Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2
    • doi: 10.1161/HYPERTENSIONAHA.112.198622
    • Ye, M., Wysocki, J., Gonzalez-Pacheco, F. R., Salem, M., Evora, K., Garcia-Halpin, L., et al. (2012). Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2. Hypertension 60, 730-740. doi: 10.1161/HYPERTENSIONAHA.112.198622
    • (2012) Hypertension , vol.60 , pp. 730-740
    • Ye, M.1    Wysocki, J.2    Gonzalez-Pacheco, F.R.3    Salem, M.4    Evora, K.5    Garcia-Halpin, L.6
  • 93
    • 33745967527 scopus 로고    scopus 로고
    • Association of ACE ACE2 and UTS2 polymorphisms with essential hypertension in Han and Dongxiang populations from north-western
    • doi: 10.1177/147323000603400306
    • Yi, L., Gu, Y. H., Wang, X. L., An, L. Z., Xie, X. D., Shao, W., et al. (2006). Association of ACE, ACE2 and UTS2 polymorphisms with essential hypertension in Han and Dongxiang populations from north-western China. J. Int. Med. Res. 34, 272-283. doi: 10.1177/147323000603400306
    • (2006) China. J. Int. Med. Res. , vol.34 , pp. 272-283
    • Yi, L.1    Gu, Y.H.2    Wang, X.L.3    An, L.Z.4    Xie, X.D.5    Shao, W.6
  • 94
    • 77952553208 scopus 로고    scopus 로고
    • Association of genetic variants in the apelin-APJ system and ACE2 with blood pressure responses to potassium supplementation: the GenSalt study
    • doi: 10.1038/ajh.2010.36
    • Zhao, Q., Gu, D., Kelly, T. N., Hixson, J. E., Rao, D. C., Jaquish, C. E., et al. (2010a). Association of genetic variants in the apelin-APJ system and ACE2 with blood pressure responses to potassium supplementation: the GenSalt study. Am. J. Hypertens. 23, 606-613. doi: 10.1038/ajh.2010.36
    • (2010) Am. J. Hypertens. , vol.23 , pp. 606-613
    • Zhao, Q.1    Gu, D.2    Kelly, T.N.3    Hixson, J.E.4    Rao, D.C.5    Jaquish, C.E.6
  • 95
    • 77956272281 scopus 로고    scopus 로고
    • Genetic variants in the apelin system and blood pressure responses to dietary sodium interventions: a family-based association study
    • doi: 10.1097/HJH.0b013e3283370d32
    • Zhao, Q., Hixson, J. E., Rao, D. C., Gu, D., Jaquish, C. E., Rice, T., et al. (2010b). Genetic variants in the apelin system and blood pressure responses to dietary sodium interventions: a family-based association study. J. Hypertens. 28, 756-763. doi: 10.1097/HJH.0b013e3283370d32
    • (2010) J. Hypertens. , vol.28 , pp. 756-763
    • Zhao, Q.1    Hixson, J.E.2    Rao, D.C.3    Gu, D.4    Jaquish, C.E.5    Rice, T.6
  • 96
    • 77955981900 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction
    • doi: 10.1161/CIRCULATIONAHA.110.955369
    • Zhong, J., Basu, R., Guo, D., Chow, F. L., Byrns, S., Schuster, M., et al. (2010). Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation 122, 717-728. doi: 10.1161/CIRCULATIONAHA.110.955369
    • (2010) Circulation , vol.122 , pp. 717-728
    • Zhong, J.1    Basu, R.2    Guo, D.3    Chow, F.L.4    Byrns, S.5    Schuster, M.6
  • 97
    • 79551485466 scopus 로고    scopus 로고
    • Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2
    • doi: 10.1161/HYPERTENSIONAHA.110.164244
    • Zhong, J., Guo, D., Chen, C. B., Wang, W., Schuster, M., Loibner, H., et al. (2011). Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2. Hypertension 57, 314-322. doi: 10.1161/HYPERTENSIONAHA.110.164244
    • (2011) Hypertension , vol.57 , pp. 314-322
    • Zhong, J.1    Guo, D.2    Chen, C.B.3    Wang, W.4    Schuster, M.5    Loibner, H.6
  • 98
    • 31944448010 scopus 로고    scopus 로고
    • Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome
    • doi: 10.1016/j.lab.2005.10.001
    • Zhong, J., Yan, Z., Liu, D., Ni, Y., Zhao, Z., Zhu, S., et al. (2006). Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome. J. Lab. Clin. Med. 147, 91-95. doi: 10.1016/j.lab.2005.10.001
    • (2006) J. Lab. Clin. Med. , vol.147 , pp. 91-95
    • Zhong, J.1    Yan, Z.2    Liu, D.3    Ni, Y.4    Zhao, Z.5    Zhu, S.6
  • 99
    • 9644258509 scopus 로고    scopus 로고
    • Upregulation of angiotensin-converting enzyme 2 by all-trans retinoic acid in spontaneously hypertensive rats
    • doi: 10.1161/01.HYP.0000146400.57221.74
    • Zhong, J. C., Huang, D. Y., Yang, Y. M., Li, Y. F., Liu, G. F., Song, X. H., et al. (2004). Upregulation of angiotensin-converting enzyme 2 by all-trans retinoic acid in spontaneously hypertensive rats. Hypertension 44, 907-912. doi: 10.1161/01.HYP.0000146400.57221.74
    • (2004) Hypertension , vol.44 , pp. 907-912
    • Zhong, J.C.1    Huang, D.Y.2    Yang, Y.M.3    Li, Y.F.4    Liu, G.F.5    Song, X.H.6
  • 100
    • 67650508044 scopus 로고    scopus 로고
    • Meta-analysis of association of ACE2 G8790A polymorphism with Chinese Han essential hypertension
    • doi: 10.1177/1470320309103047
    • Zhou, J. B., and Yang, J. K. (2009). Meta-analysis of association of ACE2 G8790A polymorphism with Chinese Han essential hypertension. J. Renin Angiotensin Aldosterone Syst. 10, 31-34. doi: 10.1177/1470320309103047
    • (2009) J. Renin Angiotensin Aldosterone Syst. , vol.10 , pp. 31-34
    • Zhou, J.B.1    Yang, J.K.2
  • 101
    • 48249151833 scopus 로고    scopus 로고
    • ACE2 and AT4R are present in diseased human blood vessels
    • Zulli, A., Burrell, L. M., Buxton, B. F., and Hare, D. L. (2008). ACE2 and AT4R are present in diseased human blood vessels. Eur. J. Histochem. 52, 39-44.
    • (2008) Eur. J. Histochem. , vol.52 , pp. 39-44
    • Zulli, A.1    Burrell, L.M.2    Buxton, B.F.3    Hare, D.L.4
  • 102
    • 32044440575 scopus 로고    scopus 로고
    • Immunolocalization of ACE2 and AT2 receptors in rabbit atherosclerotic plaques
    • doi: 10.1369/jhc.5C6782.2005
    • Zulli, A., Burrell, L. M., Widdop, R. E., Black, M. J., Buxton, B. F., and Hare, D. L. (2006). Immunolocalization of ACE2 and AT2 receptors in rabbit atherosclerotic plaques. J. Histochem. Cytochem. 54, 147-150. doi: 10.1369/jhc.5C6782.2005
    • (2006) J. Histochem. Cytochem. , vol.54 , pp. 147-150
    • Zulli, A.1    Burrell, L.M.2    Widdop, R.E.3    Black, M.J.4    Buxton, B.F.5    Hare, D.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.