메뉴 건너뛰기




Volumn 6, Issue 1, 2020, Pages

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; DACTINOMYCIN; EMODIN; IMMUNOSUPPRESSIVE AGENT; MELATONIN; MERCAPTOPURINE; NUCLEOCAPSID PROTEIN; RAPAMYCIN; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TOREMIFENE; VIRUS ENVELOPE PROTEIN;

EID: 85082021457     PISSN: 20565968     EISSN: 20565968     Source Type: Journal    
DOI: 10.1038/s41421-020-0153-3     Document Type: Article
Times cited : (1220)

References (97)
  • 1
    • 84957818744 scopus 로고    scopus 로고
    • Coronaviruses—drug discovery and therapeutic options
    • COI: 1:CAS:528:DC%2BC28XisVyru70%3D, PID: 26868298
    • Zumla, A., Chan, J. F., Azhar, E. I., Hui, D. S. & Yuen, K. Y. Coronaviruses—drug discovery and therapeutic options. Nat. Rev. Drug Discov. 15, 327–347 (2016).
    • (2016) Nat. Rev. Drug Discov. , vol.15 , pp. 327-347
    • Zumla, A.1    Chan, J.F.2    Azhar, E.I.3    Hui, D.S.4    Yuen, K.Y.5
  • 2
    • 85078468946 scopus 로고    scopus 로고
    • Coronavirus infections—more than just the common cold
    • Paules, C. I., Marston, H. D. & Fauci, A. S. Coronavirus infections—more than just the common cold. JAMA 323, 707–708 (2020).
    • (2020) JAMA , vol.323 , pp. 707-708
    • Paules, C.I.1    Marston, H.D.2    Fauci, A.S.3
  • 3
    • 84976271703 scopus 로고    scopus 로고
    • SARS and MERS: recent insights into emerging coronaviruses
    • PID: 27344959, COI: 1:CAS:528:DC%2BC28XhtVGiur7L
    • de Wit, E., van Doremalen, N., Falzarano, D. & Munster, V. J. SARS and MERS: recent insights into emerging coronaviruses. Nat. Rev. Microbiol. 14, 523–534 (2016).
    • (2016) Nat. Rev. Microbiol. , vol.14 , pp. 523-534
    • de Wit, E.1    van Doremalen, N.2    Falzarano, D.3    Munster, V.J.4
  • 5
    • 85078761741 scopus 로고    scopus 로고
    • Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
    • COI: 1:CAS:528:DC%2BB3cXhvFOmsb8%3D, PID: 32007143
    • Chen, N. et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 395, 507–513 (2020).
    • (2020) Lancet , vol.395 , pp. 507-513
    • Chen, N.1
  • 6
    • 85082296756 scopus 로고    scopus 로고
    • Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia
    • https://doi.org/10.1056/NEJMoa2001316, (,) (, press
    • Li, Q. et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N. Engl. J. Med. 10.1056/NEJMoa2001316 (2020) (in press).
    • (2020) N. Engl. J. Med.
    • Li, Q.1
  • 7
    • 85039795795 scopus 로고    scopus 로고
    • Putting the patient back together—social medicine, network medicine, and the limits of reductionism
    • PID: 29262277
    • Greene, J. A. & Loscalzo, J. Putting the patient back together—social medicine, network medicine, and the limits of reductionism. N. Engl. J. Med. 377, 2493–2499 (2017).
    • (2017) N. Engl. J. Med. , vol.377 , pp. 2493-2499
    • Greene, J.A.1    Loscalzo, J.2
  • 8
    • 84929359137 scopus 로고    scopus 로고
    • The $2.6 billion pill-methodologic and policy considerations
    • COI: 1:CAS:528:DC%2BC2MXhtlehs73J, PID: 25970049
    • Avorn, J. The $2.6 billion pill-methodologic and policy considerations. N. Engl. J. Med. 372, 1877–1879 (2015).
    • (2015) N. Engl. J. Med. , vol.372 , pp. 1877-1879
    • Avorn, J.1
  • 9
    • 85055633239 scopus 로고    scopus 로고
    • In silico oncology drug repositioning and polypharmacology
    • COI: 1:CAS:528:DC%2BC1MXhvFSmu77J, PID: 30378081
    • Cheng, F. In silico oncology drug repositioning and polypharmacology. Methods Mol. Biol. 1878, 243–261 (2019).
    • (2019) Methods Mol. Biol. , vol.1878 , pp. 243-261
    • Cheng, F.1
  • 10
    • 85027108338 scopus 로고    scopus 로고
    • Individualized network-based drug repositioning infrastructure for precision oncology in the panomics era
    • COI: 1:CAS:528:DC%2BC1MXjsVyqsLY%3D, PID: 27296652
    • Cheng, F., Hong, H., Yang, S. & Wei, Y. Individualized network-based drug repositioning infrastructure for precision oncology in the panomics era. Brief Bioinformatics 18, 682–697 (2017).
    • (2017) Brief Bioinformatics , vol.18 , pp. 682-697
    • Cheng, F.1    Hong, H.2    Yang, S.3    Wei, Y.4
  • 11
    • 84992707516 scopus 로고    scopus 로고
    • Drug repurposing: new treatments for Zika virus infection?
    • PID: 27692879
    • Cheng, F., Murray, J. L. & Rubin, D. H. Drug repurposing: new treatments for Zika virus infection? Trends Mol. Med. 22, 919–921 (2016).
    • (2016) Trends Mol. Med. , vol.22 , pp. 919-921
    • Cheng, F.1    Murray, J.L.2    Rubin, D.H.3
  • 12
    • 85000936652 scopus 로고    scopus 로고
    • A comprehensive map of molecular drug targets
    • COI: 1:CAS:528:DC%2BC28XitVSms7rK, PID: 27910877
    • Santos, R. et al. A comprehensive map of molecular drug targets. Nat. Rev. Drug Discov. 16, 19–34 (2017).
    • (2017) Nat. Rev. Drug Discov. , vol.16 , pp. 19-34
    • Santos, R.1
  • 13
    • 85050009917 scopus 로고    scopus 로고
    • Network-based approach to prediction and population-based validation of in silico drug repurposing
    • PID: 30002366, COI: 1:CAS:528:DC%2BC1cXhtlajsLvM
    • Cheng, F. et al. Network-based approach to prediction and population-based validation of in silico drug repurposing. Nat. Commun. 9, 2691 (2018).
    • (2018) Nat. Commun. , vol.9
    • Cheng, F.1
  • 14
    • 84989355048 scopus 로고    scopus 로고
    • Systems biology-based investigation of cellular antiviral drug targets identified by gene-trap insertional mutagenesis
    • PID: 27632082, COI: 1:CAS:528:DC%2BC28XhvFaktbrK
    • Cheng, F. et al. Systems biology-based investigation of cellular antiviral drug targets identified by gene-trap insertional mutagenesis. PLoS Comput. Biol. 12, e1005074 (2016).
    • (2016) PLoS Comput. Biol. , vol.12
    • Cheng, F.1
  • 15
    • 85070903661 scopus 로고    scopus 로고
    • Understanding human-virus protein-protein interactions using a human protein complex-based analysis framework
    • COI: 1:CAS:528:DC%2BC1MXisVensbzO, PID: 30984872
    • Yang, S., Fu, C., Lian, X., Dong, X. & Zhang, Z. Understanding human-virus protein-protein interactions using a human protein complex-based analysis framework. mSystems 4, e00303 (2019).
    • (2019) mSystems , vol.4
    • Yang, S.1    Fu, C.2    Lian, X.3    Dong, X.4    Zhang, Z.5
  • 17
    • 84902176510 scopus 로고    scopus 로고
    • Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection
    • PID: 24841273, COI: 1:CAS:528:DC%2BC2cXhs1art73L
    • Dyall, J. et al. Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob. Agents Chemother. 58, 4885–4893 (2014).
    • (2014) Antimicrob. Agents Chemother. , vol.58 , pp. 4885-4893
    • Dyall, J.1
  • 18
    • 84880544466 scopus 로고    scopus 로고
    • FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection
    • COI: 1:CAS:528:DC%2BC3sXhtFGqsb3O
    • Johansen, L. M. et al. FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection. Sci. Transl. Med. 5, 190ra179 (2013).
    • (2013) Sci. Transl. Med. , vol.5 , pp. 190ra179
    • Johansen, L.M.1
  • 19
    • 84927644630 scopus 로고    scopus 로고
    • Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection
    • COI: 1:CAS:528:DC%2BC2MXnvVars74%3D
    • He, S. et al. Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection. Sci. Transl. Med. 7, 282ra249 (2015).
    • (2015) Sci. Transl. Med. , vol.7 , pp. 282ra249
    • He, S.1
  • 20
    • 84979738780 scopus 로고    scopus 로고
    • A screen of FDA-approved drugs for inhibitors of Zika virus infection
    • COI: 1:CAS:528:DC%2BC28Xht1Ghu7nM, PID: 27476412
    • Barrows, N. J. et al. A screen of FDA-approved drugs for inhibitors of Zika virus infection. Cell Host. Microbe 20, 259–270 (2016).
    • (2016) Cell Host. Microbe , vol.20 , pp. 259-270
    • Barrows, N.J.1
  • 21
    • 84984662505 scopus 로고    scopus 로고
    • Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
    • COI: 1:CAS:528:DC%2BC28XhsVWks7%2FF, PID: 27571349
    • Xu, M. et al. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat. Med. 22, 1101–1107 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 1101-1107
    • Xu, M.1
  • 22
    • 84863695210 scopus 로고    scopus 로고
    • Prediction of drug-target interactions and drug repositioning via network-based inference
    • COI: 1:CAS:528:DC%2BC38Xns1GntbY%3D, PID: 22589709
    • Cheng, F. et al. Prediction of drug-target interactions and drug repositioning via network-based inference. PLoS Comput. Biol. 8, e1002503 (2012).
    • (2012) PLoS Comput. Biol. , vol.8
    • Cheng, F.1
  • 23
    • 85071178752 scopus 로고    scopus 로고
    • A genome-wide positioning systems network algorithm for in silico drug repurposing
    • PID: 31375661, COI: 1:CAS:528:DC%2BC1MXhsFCitbfM
    • Cheng, F. et al. A genome-wide positioning systems network algorithm for in silico drug repurposing. Nat. Commun. 10, 3476 (2019).
    • (2019) Nat. Commun. , vol.10
    • Cheng, F.1
  • 24
    • 85075386392 scopus 로고    scopus 로고
    • deepDR: a network-based deep learning approach to in silico drug repositioning
    • PID: 31116390
    • Zeng, X. et al. deepDR: a network-based deep learning approach to in silico drug repositioning. Bioinformatics 35, 5191–5198 (2019).
    • (2019) Bioinformatics , vol.35 , pp. 5191-5198
    • Zeng, X.1
  • 25
    • 85080031447 scopus 로고    scopus 로고
    • Target identification among known drugs by deep learning from heterogeneous networks
    • COI: 1:CAS:528:DC%2BB3cXht1yit70%3D
    • Zeng, X. et al. Target identification among known drugs by deep learning from heterogeneous networks. Chem. Sci. 11, 1775–1797 (2020).
    • (2020) Chem. Sci. , vol.11 , pp. 1775-1797
    • Zeng, X.1
  • 26
    • 85082017701 scopus 로고    scopus 로고
    • Network-based prediction of drug-target interactions using an arbitrary-order proximity embedded deep forest
    • https://doi.org/10.1093/bioinformatics/btaa010, (,) (, press
    • Zeng, X. et al. Network-based prediction of drug-target interactions using an arbitrary-order proximity embedded deep forest. Bioinformatics 10.1093/bioinformatics/btaa010 (2020) (in press).
    • (2020) Bioinformatics
    • Zeng, X.1
  • 28
    • 85062852393 scopus 로고    scopus 로고
    • Network-based prediction of drug combinations
    • PID: 30867426, COI: 1:CAS:528:DC%2BC1MXnvF2iu78%3D
    • Cheng, F., Kovacs, I. A. & Barabasi, A. L. Network-based prediction of drug combinations. Nat. Commun. 10, 1197 (2019).
    • (2019) Nat. Commun. , vol.10
    • Cheng, F.1    Kovacs, I.A.2    Barabasi, A.L.3
  • 29
    • 85002250257 scopus 로고    scopus 로고
    • Molecular evolution of human coronavirus genomes
    • COI: 1:CAS:528:DC%2BC28XhsFamtb%2FO, PID: 27743750
    • Forni, D., Cagliani, R., Clerici, M. & Sironi, M. Molecular evolution of human coronavirus genomes. Trends Microbiol. 25, 35–48 (2017).
    • (2017) Trends Microbiol. , vol.25 , pp. 35-48
    • Forni, D.1    Cagliani, R.2    Clerici, M.3    Sironi, M.4
  • 30
    • 85066329882 scopus 로고    scopus 로고
    • Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
    • PID: 31138817, COI: 1:CAS:528:DC%2BC1MXhtVGhu73J
    • Kirchdoerfer, R. N. & Ward, A. B. Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors. Nat. Commun. 10, 2342 (2019).
    • (2019) Nat. Commun. , vol.10
    • Kirchdoerfer, R.N.1    Ward, A.B.2
  • 31
    • 24944498409 scopus 로고    scopus 로고
    • Structure of SARS coronavirus spike receptor-binding domain complexed with receptor
    • COI: 1:CAS:528:DC%2BD2MXpvFCisLw%3D, PID: 16166518
    • Li, F., Li, W., Farzan, M. & Harrison, S. C. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science 309, 1864–1868 (2005).
    • (2005) Science , vol.309 , pp. 1864-1868
    • Li, F.1    Li, W.2    Farzan, M.3    Harrison, S.C.4
  • 32
    • 85078741591 scopus 로고    scopus 로고
    • Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
    • PID: 32007145
    • Lu, R. et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 395, 565–574 (2020).
    • (2020) Lancet , vol.395 , pp. 565-574
    • Lu, R.1
  • 35
    • 84878124420 scopus 로고    scopus 로고
    • Transient oligomerization of the SARS-CoV N protein-implication for virus ribonucleoprotein packaging
    • COI: 1:CAS:528:DC%2BC3sXpt12qs7w%3D, PID: 23717688
    • Chang, C. K., Chen, C. M., Chiang, M. H., Hsu, Y. L. & Huang, T. H. Transient oligomerization of the SARS-CoV N protein-implication for virus ribonucleoprotein packaging. PLoS ONE 8, e65045 (2013).
    • (2013) PLoS ONE , vol.8
    • Chang, C.K.1    Chen, C.M.2    Chiang, M.H.3    Hsu, Y.L.4    Huang, T.H.5
  • 36
    • 33749335282 scopus 로고    scopus 로고
    • The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
    • COI: 1:CAS:528:DC%2BD28XhtVSnsrbN, PID: 17008526
    • Lamb, J. et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313, 1929–1935 (2006).
    • (2006) Science , vol.313 , pp. 1929-1935
    • Lamb, J.1
  • 37
    • 85071636563 scopus 로고    scopus 로고
    • A structure-informed atlas of human-virus interactions
    • COI: 1:CAS:528:DC%2BC1MXhslSqur7M, PID: 31474372
    • Lasso, G. et al. A structure-informed atlas of human-virus interactions. Cell 178, 1526–1541.e1516 (2019).
    • (2019) Cell , vol.178 , pp. 1526-1541.e1516
    • Lasso, G.1
  • 38
    • 84905386648 scopus 로고    scopus 로고
    • Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture
    • PID: 24841269, COI: 1:CAS:528:DC%2BC2cXhs1artrfJ
    • de Wilde, A. H. et al. Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture. Antimicrob. Agents Chemother. 58, 4875–4884 (2014).
    • (2014) Antimicrob. Agents Chemother. , vol.58 , pp. 4875-4884
    • de Wilde, A.H.1
  • 39
    • 84978437369 scopus 로고    scopus 로고
    • Toremifene interacts with and destabilizes the Ebola virus glycoprotein
    • COI: 1:CAS:528:DC%2BC28XhtVOns7nF, PID: 27362232
    • Zhao, Y. et al. Toremifene interacts with and destabilizes the Ebola virus glycoprotein. Nature 535, 169–172 (2016).
    • (2016) Nature , vol.535 , pp. 169-172
    • Zhao, Y.1
  • 40
    • 84883292729 scopus 로고    scopus 로고
    • The cellular interactome of the coronavirus infectious bronchitis virus nucleocapsid protein and functional implications for virus biology
    • COI: 1:CAS:528:DC%2BC3sXhtlCmurnI, PID: 23637410
    • Emmott, E. et al. The cellular interactome of the coronavirus infectious bronchitis virus nucleocapsid protein and functional implications for virus biology. J. Virol. 87, 9486–9500 (2013).
    • (2013) J. Virol. , vol.87 , pp. 9486-9500
    • Emmott, E.1
  • 41
    • 85061393814 scopus 로고    scopus 로고
    • Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling
    • PID: 30632963
    • V’Kovski, P. et al. Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling. Elife 8, e42037 (2019).
    • (2019) Elife , vol.8
    • V’Kovski, P.1
  • 42
    • 4544369788 scopus 로고    scopus 로고
    • The central role of angiotensin I-converting enzyme in vertebrate pathophysiology
    • COI: 1:CAS:528:DC%2BD2cXnslCms7Y%3D, PID: 15379656
    • Moskowitz, D. W. & Johnson, F. E. The central role of angiotensin I-converting enzyme in vertebrate pathophysiology. Curr. Top. Med. Chem. 4, 1433–1454 (2004).
    • (2004) Curr. Top. Med. Chem. , vol.4 , pp. 1433-1454
    • Moskowitz, D.W.1    Johnson, F.E.2
  • 43
    • 33644779680 scopus 로고    scopus 로고
    • Effect of the angiotensin II receptor blocker olmesartan on the development of murine acute myocarditis caused by coxsackievirus B3
    • COI: 1:CAS:528:DC%2BD28XivV2mur8%3D, PID: 16336207
    • Seko, Y. Effect of the angiotensin II receptor blocker olmesartan on the development of murine acute myocarditis caused by coxsackievirus B3. Clin. Sci. 110, 379–386 (2006).
    • (2006) Clin. Sci. , vol.110 , pp. 379-386
    • Seko, Y.1
  • 44
    • 85040041467 scopus 로고    scopus 로고
    • The impact of statin and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker therapy on cognitive function in adults with human immunodeficiency virus infection
    • COI: 1:CAS:528:DC%2BC1cXisV2kurfE, PID: 29020174
    • Erlandson, K. M. et al. The impact of statin and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker therapy on cognitive function in adults with human immunodeficiency virus infection. Clin. Infect. Dis. 65, 2042–2049 (2017).
    • (2017) Clin. Infect. Dis. , vol.65 , pp. 2042-2049
    • Erlandson, K.M.1
  • 45
    • 84934938919 scopus 로고    scopus 로고
    • Irbesartan, an FDA approved drug for hypertension and diabetic nephropathy, is a potent inhibitor for hepatitis B virus entry by disturbing Na(+)-dependent taurocholate cotransporting polypeptide activity
    • COI: 1:CAS:528:DC%2BC2MXhtVWqs7zO, PID: 26086883
    • Wang, X. J. et al. Irbesartan, an FDA approved drug for hypertension and diabetic nephropathy, is a potent inhibitor for hepatitis B virus entry by disturbing Na(+)-dependent taurocholate cotransporting polypeptide activity. Antivir. Res. 120, 140–146 (2015).
    • (2015) Antivir. Res. , vol.120 , pp. 140-146
    • Wang, X.J.1
  • 46
    • 84975139885 scopus 로고    scopus 로고
    • The FDA-approved drug irbesartan inhibits HBV-infection in HepG2 cells stably expressing sodium taurocholate co-transporting polypeptide
    • COI: 1:CAS:528:DC%2BC28XhtlWhs7vM, PID: 25929767
    • Ko, C. et al. The FDA-approved drug irbesartan inhibits HBV-infection in HepG2 cells stably expressing sodium taurocholate co-transporting polypeptide. Antivir. Ther. 20, 835–842 (2015).
    • (2015) Antivir. Ther. , vol.20 , pp. 835-842
    • Ko, C.1
  • 47
    • 45749135827 scopus 로고    scopus 로고
    • Identification of a novel transcriptional repressor (HEPIS) that interacts with nsp-10 of SARS coronavirus
    • COI: 1:CAS:528:DC%2BD1cXnsVCms7o%3D, PID: 18433331
    • Hong, M. et al. Identification of a novel transcriptional repressor (HEPIS) that interacts with nsp-10 of SARS coronavirus. Viral Immunol. 21, 153–162 (2008).
    • (2008) Viral Immunol. , vol.21 , pp. 153-162
    • Hong, M.1
  • 48
    • 84871987961 scopus 로고    scopus 로고
    • Host mTORC1 signaling regulates andes virus replication
    • COI: 1:CAS:528:DC%2BC3sXltV2jtbc%3D, PID: 23135723
    • McNulty, S., Flint, M., Nichol, S. T. & Spiropoulou, C. F. Host mTORC1 signaling regulates andes virus replication. J. Virol. 87, 912–922 (2013).
    • (2013) J. Virol. , vol.87 , pp. 912-922
    • McNulty, S.1    Flint, M.2    Nichol, S.T.3    Spiropoulou, C.F.4
  • 49
    • 84940202073 scopus 로고    scopus 로고
    • Host cell mTORC1 is required for HCV RNA replication
    • PID: 26276683, COI: 1:CAS:528:DC%2BC1cXpslKrsg%3D%3D
    • Stohr, S. et al. Host cell mTORC1 is required for HCV RNA replication. Gut 65, 2017–2028 (2016).
    • (2016) Gut , vol.65 , pp. 2017-2028
    • Stohr, S.1
  • 50
    • 84893289257 scopus 로고    scopus 로고
    • Adjuvant treatment with a mammalian target of rapamycin inhibitor, sirolimus, and steroids improves outcomes in patients with severe H1N1 pneumonia and acute respiratory failure
    • COI: 1:CAS:528:DC%2BC2cXhtFyht7c%3D, PID: 24105455
    • Wang, C. H. et al. Adjuvant treatment with a mammalian target of rapamycin inhibitor, sirolimus, and steroids improves outcomes in patients with severe H1N1 pneumonia and acute respiratory failure. Crit. Care Med. 42, 313–321 (2014).
    • (2014) Crit. Care Med. , vol.42 , pp. 313-321
    • Wang, C.H.1
  • 51
    • 85034083736 scopus 로고    scopus 로고
    • Middle East respiratory syndrome and severe acute respiratory syndrome: current therapeutic options and potential targets for novel therapies
    • PID: 29143192
    • Dyall, J. et al. Middle East respiratory syndrome and severe acute respiratory syndrome: current therapeutic options and potential targets for novel therapies. Drugs 77, 1935–1966 (2017).
    • (2017) Drugs , vol.77 , pp. 1935-1966
    • Dyall, J.1
  • 52
    • 37549024231 scopus 로고    scopus 로고
    • Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer
    • COI: 1:CAS:528:DC%2BD2sXhsVKku73I, PID: 18097462
    • Karran, P. & Attard, N. Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer. Nat. Rev. Cancer 8, 24–36 (2008).
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 24-36
    • Karran, P.1    Attard, N.2
  • 53
    • 65549141218 scopus 로고    scopus 로고
    • Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme
    • PID: 19374142
    • Chen, X., Chou, C. Y. & Chang, G. G. Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme. Antivir. Chem. Chemother. 19, 151–156 (2009).
    • (2009) Antivir. Chem. Chemother. , vol.19 , pp. 151-156
    • Chen, X.1    Chou, C.Y.2    Chang, G.G.3
  • 54
    • 84920260798 scopus 로고    scopus 로고
    • Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus
    • COI: 1:CAS:528:DC%2BC2MXlvFOmsA%3D%3D, PID: 25542975
    • Cheng, K. W. et al. Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus. Antivir. Res. 115, 9–16 (2015).
    • (2015) Antivir. Res. , vol.115 , pp. 9-16
    • Cheng, K.W.1
  • 55
    • 0036238652 scopus 로고    scopus 로고
    • Interaction of the coronavirus nucleoprotein with nucleolar antigens and the host cell
    • COI: 1:CAS:528:DC%2BD38XjtleqsLs%3D, PID: 11967337
    • Chen, H., Wurm, T., Britton, P., Brooks, G. & Hiscox, J. A. Interaction of the coronavirus nucleoprotein with nucleolar antigens and the host cell. J. Virol. 76, 5233–5250 (2002).
    • (2002) J. Virol. , vol.76 , pp. 5233-5250
    • Chen, H.1    Wurm, T.2    Britton, P.3    Brooks, G.4    Hiscox, J.A.5
  • 56
    • 33646252267 scopus 로고    scopus 로고
    • Influenza (“Bird Flu”), inflammation and anti-inflammatory/analgesic drugs
    • COI: 1:CAS:528:DC%2BD28XkvF2ltLw%3D, PID: 16835706
    • Rainsford, K. D. Influenza (“Bird Flu”), inflammation and anti-inflammatory/analgesic drugs. Inflammopharmacology 14, 2–9 (2006).
    • (2006) Inflammopharmacology , vol.14 , pp. 2-9
    • Rainsford, K.D.1
  • 57
    • 79955649371 scopus 로고    scopus 로고
    • The development of anti-inflammatory drugs for infectious diseases
    • PID: 21189219
    • Garcia, C. C., Guabiraba, R., Soriani, F. M. & Teixeira, M. M. The development of anti-inflammatory drugs for infectious diseases. Discov. Med. 10, 479–488 (2010).
    • (2010) Discov. Med. , vol.10 , pp. 479-488
    • Garcia, C.C.1    Guabiraba, R.2    Soriani, F.M.3    Teixeira, M.M.4
  • 58
    • 84884878172 scopus 로고    scopus 로고
    • Melatonin: its possible role in the management of viral infections-a brief review
    • PID: 24090288, COI: 1:CAS:528:DC%2BC2cXisFGhsr8%3D
    • Silvestri, M. & Rossi, G. A. Melatonin: its possible role in the management of viral infections-a brief review. Ital. J. Pediatr. 39, 61 (2013).
    • (2013) Ital. J. Pediatr. , vol.39 , pp. 61
    • Silvestri, M.1    Rossi, G.A.2
  • 59
    • 84856559047 scopus 로고    scopus 로고
    • Melatonin in bacterial and viral infections with focus on sepsis: a review
    • COI: 1:CAS:528:DC%2BC38XitVeltr4%3D, PID: 22264213
    • Srinivasan, V., Mohamed, M. & Kato, H. Melatonin in bacterial and viral infections with focus on sepsis: a review. Recent Pat. Endocr. Metab. Immune Drug Discov. 6, 30–39 (2012).
    • (2012) Recent Pat. Endocr. Metab. Immune Drug Discov. , vol.6 , pp. 30-39
    • Srinivasan, V.1    Mohamed, M.2    Kato, H.3
  • 60
    • 84918822391 scopus 로고    scopus 로고
    • Ebola virus disease: potential use of melatonin as a treatment
    • COI: 1:CAS:528:DC%2BC2cXhslKgtbjI, PID: 25262626
    • Tan, D. X., Korkmaz, A., Reiter, R. J. & Manchester, L. C. Ebola virus disease: potential use of melatonin as a treatment. J. Pineal Res. 57, 381–384 (2014).
    • (2014) J. Pineal Res. , vol.57 , pp. 381-384
    • Tan, D.X.1    Korkmaz, A.2    Reiter, R.J.3    Manchester, L.C.4
  • 61
    • 33845536018 scopus 로고    scopus 로고
    • One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?
    • COI: 1:CAS:528:DC%2BD2sXhtlKksb8%3D, PID: 17198536
    • Tan, D. X., Manchester, L. C., Terron, M. P., Flores, L. J. & Reiter, R. J. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J. Pineal Res. 42, 28–42 (2007).
    • (2007) J. Pineal Res. , vol.42 , pp. 28-42
    • Tan, D.X.1    Manchester, L.C.2    Terron, M.P.3    Flores, L.J.4    Reiter, R.J.5
  • 62
    • 84874949228 scopus 로고    scopus 로고
    • On the free radical scavenging activities of melatonin’s metabolites, AFMK and AMK
    • COI: 1:CAS:528:DC%2BC3sXkslSks7g%3D, PID: 22998574
    • Galano, A., Tan, D. X. & Reiter, R. J. On the free radical scavenging activities of melatonin’s metabolites, AFMK and AMK. J. Pineal Res. 54, 245–257 (2013).
    • (2013) J. Pineal Res. , vol.54 , pp. 245-257
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 63
    • 66249117976 scopus 로고    scopus 로고
    • Anti-inflammatory effects of eplerenone on viral myocarditis
    • COI: 1:CAS:528:DC%2BD1MXlvFSjtrc%3D, PID: 19213804
    • Xiao, J., Shimada, M., Liu, W., Hu, D. & Matsumori, A. Anti-inflammatory effects of eplerenone on viral myocarditis. Eur. J. Heart Fail. 11, 349–353 (2009).
    • (2009) Eur. J. Heart Fail. , vol.11 , pp. 349-353
    • Xiao, J.1    Shimada, M.2    Liu, W.3    Hu, D.4    Matsumori, A.5
  • 65
    • 84869423899 scopus 로고    scopus 로고
    • Systematic identification of synergistic drug pairs targeting HIV
    • COI: 1:CAS:528:DC%2BC38XhsV2rsLbN, PID: 23064238
    • Tan, X. et al. Systematic identification of synergistic drug pairs targeting HIV. Nat. Biotechnol. 30, 1125–1130 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , pp. 1125-1130
    • Tan, X.1
  • 66
    • 84921899175 scopus 로고    scopus 로고
    • Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis
    • PID: 25487801, COI: 1:CAS:528:DC%2BC2MXisVagsbw%3D
    • Kindrachuk, J. et al. Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis. Antimicrob. Agents Chemother. 59, 1088–1099 (2015).
    • (2015) Antimicrob. Agents Chemother. , vol.59 , pp. 1088-1099
    • Kindrachuk, J.1
  • 67
    • 0027065549 scopus 로고
    • Differential in vitro inhibition of feline enteric coronavirus and feline infectious peritonitis virus by actinomycin D
    • COI: 1:CAS:528:DyaK3sXntlWqtQ%3D%3D, PID: 1335030
    • Lewis, E. L., Harbour, D. A., Beringer, J. E. & Grinsted, J. Differential in vitro inhibition of feline enteric coronavirus and feline infectious peritonitis virus by actinomycin D. J. Gen. Virol. 73, 3285–3288 (1992).
    • (1992) J. Gen. Virol. , vol.73 , pp. 3285-3288
    • Lewis, E.L.1    Harbour, D.A.2    Beringer, J.E.3    Grinsted, J.4
  • 68
    • 79960842378 scopus 로고    scopus 로고
    • Toremifene is an effective and safe alternative to tamoxifen in adjuvant endocrine therapy for breast cancer: results of four randomized trials
    • COI: 1:CAS:528:DC%2BC3MXoslahurg%3D, PID: 21553116
    • Zhou, W. B., Ding, Q., Chen, L., Liu, X. A. & Wang, S. Toremifene is an effective and safe alternative to tamoxifen in adjuvant endocrine therapy for breast cancer: results of four randomized trials. Breast Cancer Res. Treat. 128, 625–631 (2011).
    • (2011) Breast Cancer Res. Treat. , vol.128 , pp. 625-631
    • Zhou, W.B.1    Ding, Q.2    Chen, L.3    Liu, X.A.4    Wang, S.5
  • 69
    • 85044284357 scopus 로고    scopus 로고
    • MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells
    • PID: 29566060, COI: 1:CAS:528:DC%2BC1cXhslenurvF
    • Cong, Y. et al. MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells. PLoS ONE 13, e0194868 (2018).
    • (2018) PLoS ONE , vol.13
    • Cong, Y.1
  • 70
    • 79953685440 scopus 로고    scopus 로고
    • Emodin inhibits current through SARS-associated coronavirus 3a protein
    • COI: 1:CAS:528:DC%2BC3MXksFaqu7g%3D, PID: 21356245
    • Schwarz, S., Wang, K., Yu, W., Sun, B. & Schwarz, W. Emodin inhibits current through SARS-associated coronavirus 3a protein. Antivir. Res. 90, 64–69 (2011).
    • (2011) Antivir. Res. , vol.90 , pp. 64-69
    • Schwarz, S.1    Wang, K.2    Yu, W.3    Sun, B.4    Schwarz, W.5
  • 71
    • 33947221383 scopus 로고    scopus 로고
    • Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction
    • COI: 1:CAS:528:DC%2BD2sXjsVegtLk%3D, PID: 16730806
    • Ho, T. Y., Wu, S. L., Chen, J. C., Li, C. C. & Hsiang, C. Y. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antivir. Res. 74, 92–101 (2007).
    • (2007) Antivir. Res. , vol.74 , pp. 92-101
    • Ho, T.Y.1    Wu, S.L.2    Chen, J.C.3    Li, C.C.4    Hsiang, C.Y.5
  • 72
    • 38049005632 scopus 로고    scopus 로고
    • Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain
    • COI: 1:CAS:528:DC%2BD1cXpsF2ltg%3D%3D, PID: 18070603
    • Lambert, D. W., Clarke, N. E., Hooper, N. M. & Turner, A. J. Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain. FEBS Lett. 582, 385–390 (2008).
    • (2008) FEBS Lett. , vol.582 , pp. 385-390
    • Lambert, D.W.1    Clarke, N.E.2    Hooper, N.M.3    Turner, A.J.4
  • 73
    • 0036219437 scopus 로고    scopus 로고
    • Modulation of intracellular calcium and calmodulin by melatonin in MCF-7 human breast cancer cells
    • COI: 1:CAS:528:DC%2BD38Xis1OltLs%3D, PID: 12071468
    • Dai, J., Inscho, E. W., Yuan, L. & Hill, S. M. Modulation of intracellular calcium and calmodulin by melatonin in MCF-7 human breast cancer cells. J. Pineal Res. 32, 112–119 (2002).
    • (2002) J. Pineal Res. , vol.32 , pp. 112-119
    • Dai, J.1    Inscho, E.W.2    Yuan, L.3    Hill, S.M.4
  • 74
    • 85038413595 scopus 로고    scopus 로고
    • Activation of the c-Jun NH2-terminal kinase pathway by coronavirus infectious bronchitis virus promotes apoptosis independently of c-Jun
    • PID: 29238080, COI: 1:CAS:528:DC%2BC1cXhtVSks7rM
    • Fung, T. S. & Liu, D. X. Activation of the c-Jun NH2-terminal kinase pathway by coronavirus infectious bronchitis virus promotes apoptosis independently of c-Jun. Cell Death Dis. 8, 3215 (2017).
    • (2017) Cell Death Dis. , vol.8
    • Fung, T.S.1    Liu, D.X.2
  • 75
    • 84997336158 scopus 로고    scopus 로고
    • The natural compound silvestrol is a potent inhibitor of Ebola virus replication
    • COI: 1:CAS:528:DC%2BC28XhvFWnsLnL, PID: 27864075
    • Biedenkopf, N. et al. The natural compound silvestrol is a potent inhibitor of Ebola virus replication. Antivir. Res. 137, 76–81 (2017).
    • (2017) Antivir. Res. , vol.137 , pp. 76-81
    • Biedenkopf, N.1
  • 76
    • 85039172275 scopus 로고    scopus 로고
    • Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses
    • PID: 29258862, COI: 1:CAS:528:DC%2BC2sXitVCmtLvN
    • Muller, C. et al. Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses. Antivir. Res. 150, 123–129 (2018).
    • (2018) Antivir. Res. , vol.150 , pp. 123-129
    • Muller, C.1
  • 77
    • 85057203765 scopus 로고    scopus 로고
    • Review of computational methods for virus-host protein interaction prediction: a case study on novel Ebola-human interactions
    • COI: 1:CAS:528:DC%2BC1MXhslaiu7vK, PID: 29028879
    • Halder, A. K., Dutta, P., Kundu, M., Basu, S. & Nasipuri, M. Review of computational methods for virus-host protein interaction prediction: a case study on novel Ebola-human interactions. Brief. Funct. Genomics 17, 381–391 (2018).
    • (2018) Brief. Funct. Genomics , vol.17 , pp. 381-391
    • Halder, A.K.1    Dutta, P.2    Kundu, M.3    Basu, S.4    Nasipuri, M.5
  • 78
    • 84966290897 scopus 로고    scopus 로고
    • Pleiotropic effects of statins: new therapeutic targets in drug design
    • COI: 1:CAS:528:DC%2BC28Xntlymu7Y%3D, PID: 27146293
    • Bedi, O., Dhawan, V., Sharma, P. L. & Kumar, P. Pleiotropic effects of statins: new therapeutic targets in drug design. Naunyn Schmiedebergs Arch. Pharmacol. 389, 695–712 (2016).
    • (2016) Naunyn Schmiedebergs Arch. Pharmacol. , vol.389 , pp. 695-712
    • Bedi, O.1    Dhawan, V.2    Sharma, P.L.3    Kumar, P.4
  • 79
    • 84901688047 scopus 로고    scopus 로고
    • Integrative functional genomics of hepatitis C virus infection identifies host dependencies in complete viral replication cycle
    • PID: 24852294, COI: 1:CAS:528:DC%2BC2cXhsVGkurzN
    • Li, Q. et al. Integrative functional genomics of hepatitis C virus infection identifies host dependencies in complete viral replication cycle. PLoS Pathog. 10, e1004163 (2014).
    • (2014) PLoS Pathog. , vol.10
    • Li, Q.1
  • 80
    • 85041411422 scopus 로고    scopus 로고
    • CRISPR-Cas9 genetic analysis of virus-host interactions
    • Gebre, M., Nomburg, J. L. & Gewurz, B. E. CRISPR-Cas9 genetic analysis of virus-host interactions. Viruses 10, 55 (2018).
    • (2018) Viruses , vol.10 , pp. 55
    • Gebre, M.1    Nomburg, J.L.2    Gewurz, B.E.3
  • 81
    • 84897508325 scopus 로고    scopus 로고
    • Acute eosinophilic pneumonia related to a mesalazine suppository
    • PID: 23667838
    • Kim, J. H. et al. Acute eosinophilic pneumonia related to a mesalazine suppository. Asia Pac. Allergy 3, 136–139 (2013).
    • (2013) Asia Pac. Allergy , vol.3 , pp. 136-139
    • Kim, J.H.1
  • 82
    • 85017422451 scopus 로고    scopus 로고
    • Mesalamine induced eosinophilic pneumonia
    • PID: 28458997
    • Gupta, A. & Gulati, S. Mesalamine induced eosinophilic pneumonia. Respir. Med. Case Rep. 21, 116–117 (2017).
    • (2017) Respir. Med. Case Rep. , vol.21 , pp. 116-117
    • Gupta, A.1    Gulati, S.2
  • 83
    • 85040227147 scopus 로고    scopus 로고
    • Translational high-dimensional drug interaction discovery and validation using health record databases and pharmacokinetics models
    • COI: 1:CAS:528:DC%2BC1cXnt1SltQ%3D%3D, PID: 29052226
    • Chiang, C. W. et al. Translational high-dimensional drug interaction discovery and validation using health record databases and pharmacokinetics models. Clin. Pharmacol. Ther. 103, 287–295 (2018).
    • (2018) Clin. Pharmacol. Ther. , vol.103 , pp. 287-295
    • Chiang, C.W.1
  • 84
    • 85050137432 scopus 로고    scopus 로고
    • MEGA X: molecular evolutionary genetics analysis across computing platforms
    • COI: 1:CAS:528:DC%2BC1MXis1Ontrc%3D, PID: 29722887
    • Kumar, S., Stecher, G., Li, M., Knyaz, C. & Tamura, K. MEGA X: molecular evolutionary genetics analysis across computing platforms. Mol. Biol. Evol. 35, 1547–1549 (2018).
    • (2018) Mol. Biol. Evol. , vol.35 , pp. 1547-1549
    • Kumar, S.1    Stecher, G.2    Li, M.3    Knyaz, C.4    Tamura, K.5
  • 85
    • 84987663170 scopus 로고    scopus 로고
    • Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
    • COI: 1:CAS:528:DC%2BC2sXhtV2itrfF, PID: 27141961
    • Kuleshov, M. V. et al. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res. 44, W90–W97 (2016).
    • (2016) Nucleic Acids Res. , vol.44 , pp. W90-W97
    • Kuleshov, M.V.1
  • 86
    • 84891767304 scopus 로고    scopus 로고
    • DrugBank 4.0: shedding new light on drug metabolism
    • COI: 1:CAS:528:DC%2BC2cXos1Kh, PID: 24203711
    • Law, V. et al. DrugBank 4.0: shedding new light on drug metabolism. Nucleic Acids Res. 42, D1091–D1097 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. D1091-D1097
    • Law, V.1
  • 87
    • 84976885067 scopus 로고    scopus 로고
    • Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information
    • COI: 1:CAS:528:DC%2BC2sXhtV2nsrzP, PID: 26578601
    • Yang, H. et al. Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information. Nucleic Acids Res. 44, D1069–D1074 (2016).
    • (2016) Nucleic Acids Res. , vol.44 , pp. D1069-D1074
    • Yang, H.1
  • 88
    • 84862192766 scopus 로고    scopus 로고
    • ChEMBL: a large-scale bioactivity database for drug discovery
    • COI: 1:CAS:528:DC%2BC3MXhs12htbjN, PID: 21948594
    • Gaulton, A. et al. ChEMBL: a large-scale bioactivity database for drug discovery. Nucleic Acids Res. 40, D1100–D1107 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. D1100-D1107
    • Gaulton, A.1
  • 89
    • 33846108633 scopus 로고    scopus 로고
    • BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities
    • COI: 1:CAS:528:DC%2BD2sXivFKktg%3D%3D, PID: 17145705
    • Liu, T. Q., Lin, Y. M., Wen, X., Jorissen, R. N. & Gilson, M. K. BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities. Nucleic Acids Res. 35, D198–D201 (2007).
    • (2007) Nucleic Acids Res. , vol.35 , pp. D198-D201
    • Liu, T.Q.1    Lin, Y.M.2    Wen, X.3    Jorissen, R.N.4    Gilson, M.K.5
  • 90
    • 84891791940 scopus 로고    scopus 로고
    • The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands
    • COI: 1:CAS:528:DC%2BC2cXosF2i, PID: 24234439
    • Pawson, A. J. et al. The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucleic Acids Res. 42, D1098–D1106 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. D1098-D1106
    • Pawson, A.J.1
  • 91
    • 9144232912 scopus 로고    scopus 로고
    • UniProt: the Universal Protein knowledgebase
    • COI: 1:CAS:528:DC%2BD3sXhtVSru7vK, PID: 14681372
    • Apweiler, R. et al. UniProt: the Universal Protein knowledgebase. Nucleic Acids Res. 32, D115–D119 (2004).
    • (2004) Nucleic Acids Res. , vol.32 , pp. D115-D119
    • Apweiler, R.1
  • 92
    • 84976897928 scopus 로고    scopus 로고
    • Database resources of the National Center for Biotechnology Information
    • COI: 1:CAS:528:DC%2BC2sXhtV2nsrbM
    • Coordinators, N. R. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 44, D7–D19 (2016).
    • (2016) Nucleic Acids Res. , vol.44 , pp. D7-D19
    • Coordinators, N.R.1
  • 93
    • 85064923801 scopus 로고    scopus 로고
    • Conformational dynamics and allosteric regulation landscapes of germline PTEN
    • COI: 1:CAS:528:DC%2BC1MXnslOrurw%3D, PID: 31006514
    • Smith, I. N., Thacker, S., Seyfi, M., Cheng, F. & Eng, C. Conformational dynamics and allosteric regulation landscapes of germline PTEN mutations associated with autism compared to those associated with cancer. Am. J. Hum. Genet. 104, 861–878 (2019).
    • (2019) Am. J. Hum. Genet. , vol.104 , pp. 861-878
    • Smith, I.N.1    Thacker, S.2    Seyfi, M.3    Cheng, F.4    Eng, C.5
  • 94
    • 19944419885 scopus 로고    scopus 로고
    • Expression profile of immune response genes in patients with severe acute respiratory syndrome
    • PID: 15655079, COI: 1:CAS:528:DC%2BD2MXhsVert78%3D
    • Reghunathan, R. et al. Expression profile of immune response genes in patients with severe acute respiratory syndrome. BMC Immunol. 6, 2 (2005).
    • (2005) BMC Immunol. , vol.6 , pp. 2
    • Reghunathan, R.1
  • 95
    • 84879571351 scopus 로고    scopus 로고
    • Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus
    • COI: 1:CAS:528:DC%2BC3sXhtFKktr7L, PID: 23631916
    • Josset, L. et al. Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. mBio 4, e00165–00113 (2013).
    • (2013) mBio , vol.4 , pp. e00165-00113
    • Josset, L.1
  • 96
    • 85059829725 scopus 로고    scopus 로고
    • SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
    • PID: 30631056, COI: 1:CAS:528:DC%2BC1MXmvFWisr0%3D
    • Yuan, S. et al. SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target. Nat. Commun. 10, 120 (2019).
    • (2019) Nat. Commun. , vol.10
    • Yuan, S.1
  • 97
    • 84867338003 scopus 로고    scopus 로고
    • Discovery and preclinical validation of drug indications using compendia of public gene expression data
    • COI: 1:CAS:528:DC%2BC3MXhtFOisL3K, PID: 21849665
    • Sirota, M. et al. Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci. Transl. Med. 3, 96ra77 (2011).
    • (2011) Sci. Transl. Med. , vol.3 , pp. 96ra77
    • Sirota, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.