Drug Repurposing: New Treatments for Zika Virus Infection?

Trends in Molecular Medicine

Volumn 22, Issue 11, 2016, Pages 919-921

  Cheng, Feixiong ^a,b   Murray, James L ^c   Rubin, Donald H ^d,e  

^a NORTHEASTERN UNIVERSITY   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c GeneTAG Technology Inc   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

antiviral; drug repurposing; mechanism of action; Zika virus

Indexed keywords

ANTIVIRUS AGENT;

ANTIVIRAL ACTIVITY; ANTIVIRAL THERAPY; DRUG EFFICACY; DRUG INDICATION; DRUG REPOSITIONING; DRUG SCREENING; FOOD AND DRUG ADMINISTRATION; HUMAN; NONHUMAN; SHORT SURVEY; ZIKA FEVER; DRUG EFFECTS; METABOLISM; PROCEDURES; SIGNAL TRANSDUCTION; ZIKA VIRUS; ZIKA VIRUS INFECTION;

ANTIVIRAL AGENTS; DRUG REPOSITIONING; HUMANS; SIGNAL TRANSDUCTION; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 84992707516     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2016.09.006     Document Type: Short Survey

References (9)

1. 1 Tabata, T., et al. Zika virus targets different primary human placental cells, suggesting two routes for vertical transmission. Cell Host Microbe 20 (2016), 155–166.
2. 2 Laxminarayan, R., et al. Achieving global targets for antimicrobial resistance. Science 353 (2016), 874–875.
3. 3 Nosengo, N., Can you teach old drugs new tricks?. Nature 534 (2016), 314–316.
4. 4 He, S., et al. Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection. Sci. Transl. Med., 7, 2015, 282ra249.
5. 5 Sakurai, Y., et al. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science 347 (2015), 995–998.
6. 6 Cheng, F., et al. Systems biology-based investigation of cellular antiviral drug targets identified by gene-trap insertional mutagenesis. PLoS Comput. Biol., 12, 2016, e1005074.
7. 7 Barrows, N.J., et al. A screen of FDA-approved drugs for inhibitors of Zika virus infection. Cell Host Microbe 20 (2016), 259–270.
8. 8 Xu, M., et al. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat. Med., 2016, 10.1038/nm.4184 Published online August 29, 2016.
9. 9 Satoh, K., et al. Identification of niclosamide as a novel anticancer agent for adrenocortical carcinoma. Clin. Cancer Res. 22 (2016), 3458–3466.