Ebola virus disease: Potential use of melatonin as a treatment

Journal of Pineal Research

Volumn 57, Issue 4, 2014, Pages 381-384

  Tan, Dun Xian ^a   Korkmaz, Ahmet ^b   Reiter, Russel J ^a   Manchester, Lucien C ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

Disseminated intravascular coagulation; Ebola virus; Endothelial damage; Melatonin; Multiple organ hemorrhage; Sepsis

Indexed keywords

ALPHA INTERFERON; BLOOD CLOTTING FACTOR 8; INTERLEUKIN 6; INTERLEUKIN 8; MELATONIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PATTERN RECOGNITION RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; THROMBOPLASTIN; TIGHT JUNCTION PROTEIN; TISSUE FACTOR PATHWAY INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; ANTIOXIDANT;

ANTICOAGULATION; ARTICLE; BLEEDING; BLOOD CLOTTING; DISSEMINATED INTRAVASCULAR CLOTTING; EBOLA HEMORRHAGIC FEVER; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; FIBRINOLYSIS; HUMAN; INNATE IMMUNITY; MACROPHAGE; MULTI ORGAN HEMORRHAGE; NONHUMAN; PATHOLOGY; PROTEIN DEGRADATION; SEPTIC SHOCK; THROMBOCYTE ACTIVATION; VASCULAR ENDOTHELIUM; ANIMAL; HEMORRHAGIC FEVER, EBOLA;

ANIMALS; ANTIOXIDANTS; HEMORRHAGIC FEVER, EBOLA; HUMANS; MELATONIN;

EID: 84918822391     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12186     Document Type: Article

References (27)

1. EMOND RT, EVANS B, BOWEN ET et al. A case of Ebola virus infection. Br Med J 1977; 2:541-544.
2. AKST J. Ebola Outbreak Threatens World Security. The Scientist, 2014 (September 22).
3. TWENHAFEL NA, MATTIX ME, JOHNSON JC et al. Pathology of experimental aerosol Zaire ebolavirus infection in rhesus macaques. Vet Pathol 2013; 50:514-529.
4. HENSLEY LE, GEISBERT TW. The contribution of the endothelium to the development of coagulation disorders that characterize Ebola hemorrhagic fever in primates. Thromb Haemost 2005; 94:254-261.
5. HENSLEY LE, YOUNG HA, JAHRLING PB et al. Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily. Immunol Lett 2002; 80:169-179.
6. MARTINEZ O, VALMAS C, BASLER CF. Ebola virus-like particle-induced activation of NF-kappaB and Erk signaling in human dendritic cells requires the glycoprotein mucin domain. Virology 2007; 364:342-354.
7. GEISBERT TW, HENSLEY LE, JAHRLING PB et al. Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys. Lancet 2003; 362:1953-1958.
8. TAN DX, MANCHESTER LC, TERRON MP et al. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 2007; 42:28-42.
9. GALANO A, TAN DX, REITER RJ. On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res 2013; 54:245-257.
10. BERTUGLIA S, MARCHIAFAVA PL, COLANTUONI A. Melatonin prevents ischemia reperfusion injury in hamster cheek pouch microcirculation. Cardiovasc Res 1996; 31:947-952.
11. HUNG MW, KRAVTSOV GM, LAU CF et al. Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia. J Pineal Res 2013; 55:247-256.
12. NAKAO T, MORITA H, MAEMURA K et al. Melatonin ameliorates angiotensin II-induced vascular endothelial damage via its antioxidative properties. J Pineal Res 2013; 55:287-293.
13. ALAMILI M, BENDTZEN K, LYKKESFELDT J et al. Melatonin suppresses markers of inflammation and oxidative damage in a human daytime endotoxemia model. J Crit Care 2014; 29:184.e9-184.e13.
14. SONG J, KANG SM, LEE WT et al. The beneficial effect of melatonin in brain endothelial cells against oxygen-glucose deprivation followed by reperfusion-induced injury. Oxid Med Cell Longev 2014; 2014:639531.
15. OZDEMIR G, ERGÜN Y, BAKARIS-S et al. Melatonin prevents retinal oxidative stress and vascular changes in diabetic rats. Eye (Lond) 2014; 28:1020-1027.
16. TUNALI T, SENER G, YARAT A et al. Melatonin reduces oxidative damage to skin and normalizes blood coagulation in a rat model of thermal injury. Life Sci 2005; 76:1259-1265.
17. WIRTZ PH, SPILLMANN M, BÄRTSCHI C et al. Oral melatonin reduces blood coagulation activity: a placebo-controlled study in healthy young men. J Pineal Res 2008; 44:127-133.
18. WIRTZ PH, BÄRTSCHI C, SPILLMANN M et al. Effect of oral melatonin on the procoagulant response to acute psychosocial stress in healthy men: a randomized placebo-controlled study. J Pineal Res 2008; 44:358-365.
19. KOSTOVSKI E, DAHM AE, IVERSEN N et al. Melatonin stimulates release of tissue factor pathway inhibitor from the vascular endothelium. Blood Coagul Fibrinolysis 2011; 22:254-259.
20. BRAY M, MAHANTY S. Ebola hemorrhagic fever and septic shock. J Infect Dis 2003; 188:1613-1617.
21. PETERS CJ, ZAKI SR. Role of the endothelium in viral hemorrhagic fevers. Crit Care Med 2002; 30:S268-S273.
22. GITTO E, KARBOWNIK M, REITER RJ et al. Effects of melatonin treatment in septic newborns. Pediatr Res 2001; 50:756-760.
23. GALLEY HF, LOWES DA, ALLEN L et al. Melatonin as a potential therapy for sepsis: a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis. J Pineal Res 2014; 56:427-438.
24. BOGA JA, COTO-MONTES A, ROSALES-CORRAL SA et al. Beneficial actions of melatonin in the management of viral infections: a new use for this "molecular handyman"? Rev Med Virol 2012; 22:323-338.
25. MAESTRONI GJ, CONTI A, PIERPAOLI W. Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone. J Neuroimmunol 1986; 13:19-30.
26. CALVO JR, GONZ-ALEZ-YANES C, MALDONADO MD. The role of melatonin in the cells of the innate immunity: a review. J Pineal Res 2013; 55:103-120.
27. TAN DX, ZHENG X, KONG J et al. Fundamental issues related to the origin of melatonin and melatonin isomers during evolution: relation to their biological functions. Int J Mol Sci 2014; 15:15858-15890.