Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer

American Journal of Human Genetics

Volumn 104, Issue 5, 2019, Pages 861-878

  Smith, Iris Nira ^a   Thacker, Stetson ^a,b   Seyfi, Marilyn ^a   Cheng, Feixiong ^a,b,c   Eng, Charis ^a,b,c,d  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d TAUSSIG CANCER INSTITUTE   (United States)

Author keywords

conformation dynamics; germline PTEN mutations; molecular dynamics simulation; network proximity analysis; PTEN; PTEN allostery; PTEN interactome

Indexed keywords

ALLOSTERISM; ARTICLE; AUTISM; CONTROLLED STUDY; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GERMLINE MUTATION; HUMAN; MALIGNANT NEOPLASM; MISSENSE MUTATION; MOLECULAR DYNAMICS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PTEN GENE; TUMOR SUPPRESSOR GENE; CHEMISTRY; COMPARATIVE STUDY; GENE REGULATORY NETWORK; GENETICS; NEOPLASM; PATHOLOGY; PROTEIN CONFORMATION; THERMODYNAMICS;

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, HUMAN;

ALLOSTERIC REGULATION; AUTISTIC DISORDER; GENE REGULATORY NETWORKS; GERM-LINE MUTATION; HUMANS; MOLECULAR DYNAMICS SIMULATION; NEOPLASMS; PHENOTYPE; PROTEIN CONFORMATION; PTEN PHOSPHOHYDROLASE; THERMODYNAMICS;

EID: 85064923801     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2019.03.009     Document Type: Article

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