FDA-approved selective estrogen receptor modulators inhibit ebola virus infection

Science Translational Medicine

Volumn 5, Issue 190, 2013, Pages

  Johansen, Lisa M ^a   Brannan, Jennifer M ^b   Delos, Sue E ^c   Shoemaker, Charles J ^c   Stossel, Andrea ^b   Lear, Calli ^b   Hoffstrom, Benjamin G ^a,d   DeWald, Lisa Evans ^b   Schornberg, Kathryn L ^c   Scully, Corinne ^b   Lehár, Joseph ^a,e   Hensley, Lisa E ^b   White, Judith M ^c   Olinger, Gene G ^b  

^a Zalicus Inc   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

^e BOSTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOMIFENE CITRATE; EQUILIN; ESTROGEN RECEPTOR; HYDROXYPROGESTERONE CAPROATE; QUINESTROL; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN CITRATE; TOREMIFENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG APPROVAL; DRUG POTENCY; DRUG SCREENING; DRUG TARGETING; EBOLA HEMORRHAGIC FEVER; EBOLA VIRUS; FEMALE; FOOD AND DRUG ADMINISTRATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VIRUS CELL INTERACTION; VIRUS ENTRY; VIRUS INHIBITION;

ANIMALS; CATHEPSINS; CERCOPITHECUS AETHIOPS; CLOMIPHENE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG APPROVAL; EBOLAVIRUS; ENDOSOMES; HEMORRHAGIC FEVER, EBOLA; HEP G2 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; MICE, INBRED C57BL; RECEPTORS, ESTROGEN; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SURVIVAL ANALYSIS; TOREMIFENE; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION; VERO CELLS; VIRION; VIRUS INTERNALIZATION;

EID: 84880544466     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3005471     Document Type: Article

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