Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus

Antiviral Research

Volumn 115, Issue , 2015, Pages 9-16

  Cheng, Kai Wen ^a   Cheng, Shu Chun ^b   Chen, Wei Yi ^a   Lin, Min Han ^a   Chuang, Shang Ju ^a   Cheng, I Hsin ^a   Sun, Chiao Yin ^b   Chou, Chi Yuan ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

6 Mercaptopurine; 6 Thioguanine; MERS CoV papain like protease; Mycophenolic acid; Synergistic inhibition

Indexed keywords

MERCAPTOPURINE; MYCOPHENOLIC ACID; PAPAIN; PROTEINASE; TIOGUANINE; 3C-LIKE PROTEASE, SARS CORONAVIRUS; ANTIVIRUS AGENT; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; VIRUS PROTEIN;

ARTICLE; BINDING SITE; DRUG MECHANISM; DRUG POTENTIATION; ENZYME INHIBITION; FATALITY; HUMAN; KINETICS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NONHUMAN; PROTEIN DEGRADATION; PROTEIN INDUCTION; PROTEIN PURIFICATION; SARS CORONAVIRUS; STEADY STATE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM;

CORONAVIRUS; SARS CORONAVIRUS;

6-MERCAPTOPURINE; ANTIVIRAL AGENTS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEASES; CYSTEINE PROTEINASE INHIBITORS; DRUG SYNERGISM; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MODELS, MOLECULAR; MYCOPHENOLIC ACID; SARS VIRUS; THIOGUANINE; VIRAL PROTEINS;

EID: 84920260798     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2014.12.011     Document Type: Article

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