Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses

Antiviral Research

Volumn 150, Issue , 2018, Pages 123-129

  Müller, Christin ^a,c   Schulte, Falk W ^b   Lange Grünweller, Kerstin ^b   Obermann, Wiebke ^b   Madhugiri, Ramakanth ^a   Pleschka, Stephan ^a,c   Ziebuhr, John ^a,c   Hartmann, Roland K ^b   Grünweller, Arnold ^b  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c Deutsches Zentrum für Infektions forschung DZIF   (Germany)

Author keywords

Cap dependent translation; Coronavirus; eIF4A; IRES; Picornavirus; Silvestrol

Indexed keywords

ANTIVIRUS AGENT; DEAD BOX PROTEIN; INITIATION FACTOR 4A; SILVESTROL; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ELF4 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRITERPENE;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONAVIRIDAE; CYTOTOXICITY; EBOLAVIRUS; EC50; ENTEROVIRUS; FIBROBLAST; HUH-7 CELL LINE; HUMAN; HUMAN CELL; HUMAN RHINOVIRUS A1; IMMUNOFLUORESCENCE; INTERNAL RIBOSOME ENTRY SITE; LUNG ALVEOLUS CELL; MACROPHAGE; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MRC-5 CELL LINE; PERIPHERAL BLOOD MONONUCLEAR CELL; PICORNAVIRIDAE; PRIORITY JOURNAL; SARS CORONAVIRUS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHLOROCEBUS AETHIOPS; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION; GENE EXPRESSION REGULATION; REPORTER GENE; VERO CELL LINE;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CERCOPITHECUS AETHIOPS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; GENE EXPRESSION REGULATION, VIRAL; GENES, REPORTER; HUMANS; PICORNAVIRIDAE; TRANSCRIPTION FACTORS; TRITERPENES; VERO CELLS;

EID: 85039172275     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2017.12.010     Document Type: Article

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