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Volumn 3, Issue 2, 2004, Pages 147-148

H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity

Author keywords

Chromatin structure; Double strand breaks; Genomic instability; Histone H2AX; Translocations

Indexed keywords

DOUBLE STRANDED DNA; HISTONE H2A; HISTONE H2AX; UNCLASSIFIED DRUG;

EID: 85077949203     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.3.2.684     Document Type: Review
Times cited : (2)

References (47)
  • 1
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for historic H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. A critical role for historic H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 2000; 10:886-95.
    • (2000) Curr Biol , vol.10 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 2
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998; 273:5858-68.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 3
    • 0034737439 scopus 로고    scopus 로고
    • Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139
    • Rogakou EP, Nieves-Neira W, Boon C, Pommier Y, Bonner WM. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J Biol Chem Mar 31 2000; 275:9390-5.
    • (2000) J Biol Chem Mar 31 , vol.275 , pp. 9390-9395
    • Rogakou, E.P.1    Nieves-Neira, W.2    Boon, C.3    Pommier, Y.4    Bonner, W.M.5
  • 4
    • 0036261707 scopus 로고    scopus 로고
    • Sensing and repairing DNA double-strand breaks
    • Jackson SP. Sensing and repairing DNA double-strand breaks. Carcinogenesis 2002; 23:687-96.
    • (2002) Carcinogenesis , vol.23 , pp. 687-696
    • Jackson, S.P.1
  • 5
    • 0033590179 scopus 로고    scopus 로고
    • DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
    • Dasika GK, Lin SC, Zhao S, Sung P, Tomkinson A, Lee EY. DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis. Oncogene 1999; 18:7883-99.
    • (1999) Oncogene , vol.18 , pp. 7883-7899
    • Dasika, G.K.1    Lin, S.C.2    Zhao, S.3    Sung, P.4    Tomkinson, A.5    Lee, E.Y.6
  • 6
    • 0037660900 scopus 로고    scopus 로고
    • The role of DNA breaks in genomic instability and tumorigenesis
    • Mills KD, Ferguson DO, Alt FW. The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev Aug 2003; 194:77-95.
    • (2003) Immunol Rev Aug , vol.194 , pp. 77-95
    • Mills, K.D.1    Ferguson, D.O.2    Alt, F.W.3
  • 7
    • 0036240127 scopus 로고    scopus 로고
    • The mechanism and regulation of chromosomal V(D)J recombination
    • Bassing CH, Swat W, Alt FW. The mechanism and regulation of chromosomal V(D)J recombination. Cell 2002; 109:S45-55.
    • (2002) Cell , vol.109
    • Bassing, C.H.1    Swat, W.2    Alt, F.W.3
  • 8
    • 0036152242 scopus 로고    scopus 로고
    • Mechanism and control of class-switch recombination
    • Manis JP, Tian M, Alt FW. Mechanism and control of class-switch recombination. Trends Immunol 2002; 23:31-9.
    • (2002) Trends Immunol , vol.23 , pp. 31-39
    • Manis, J.P.1    Tian, M.2    Alt, F.W.3
  • 9
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou EP, Boon C, Redon C, Bonner WM. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 1999; 146:905-16.
    • (1999) J Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 12
    • 0344237360 scopus 로고    scopus 로고
    • DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner
    • Park EJ, Chan DW, Park JH, Oettinger MA, Kwon J. DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner. Nucleic Acids Res Dec 1 2003; 31:6819-27.
    • (2003) Nucleic Acids Res Dec 1 , vol.31 , pp. 6819-6827
    • Park, E.J.1    Chan, D.W.2    Park, J.H.3    Oettinger, M.A.4    Kwon, J.5
  • 13
    • 0035834693 scopus 로고    scopus 로고
    • ATM phosphorylates histone H2AX in response to DNA double-strand breaks
    • Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 2001; 276:42462-7.
    • (2001) J Biol Chem , vol.276 , pp. 42462-42467
    • Burma, S.1    Chen, B.P.2    Murphy, M.3    Kurimasa, A.4    Chen, D.J.5
  • 14
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
    • Ward IM, Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem 2001; 276:47759-62.
    • (2001) J Biol Chem , vol.276 , pp. 47759-47762
    • Ward, I.M.1    Chen, J.2
  • 15
    • 0037335861 scopus 로고    scopus 로고
    • Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
    • Brown EJ, Baltimore D. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev 2003; 17:615-28.
    • (2003) Genes Dev , vol.17 , pp. 615-628
    • Brown, E.J.1    Baltimore, D.2
  • 16
    • 3242881919 scopus 로고    scopus 로고
    • Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA-double-strand breaks induced by mammalian DNA topoisomerase 1 cleavage complexes
    • Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, et al. Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA-double-strand breaks induced by mammalian DNA topoisomerase 1 cleavage complexes. J Biol Chem 2003; 25:25.
    • (2003) J Biol Chem , vol.25 , pp. 25
    • Furuta, T.1    Takemura, H.2    Liao, Z.Y.3    Aune, G.J.4    Redon, C.5    Sedelnikova, O.A.6
  • 17
    • 0038613469 scopus 로고    scopus 로고
    • Checkpoint mediators: Relaying signals from DNA strand breaks
    • Jun 17
    • Canman CE. Checkpoint mediators: Relaying signals from DNA strand breaks. Curr Biol Jun 17 2003; 13:R488-90.
    • (2003) Curr Biol , vol.13
    • Canman, C.E.1
  • 24
    • 0038143321 scopus 로고    scopus 로고
    • Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX
    • Ward IM, Minn K, Jorda KG, Chen J. Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem 2003; 278:19579-82.
    • (2003) J Biol Chem , vol.278 , pp. 19579-19582
    • Ward, I.M.1    Minn, K.2    Jorda, K.G.3    Chen, J.4
  • 26
    • 0034700511 scopus 로고    scopus 로고
    • A cole for Saccharomyces cerevisiae histone H2A in DNA repair
    • Downs JA, Lowndes NF, Jackson SP. A cole for Saccharomyces cerevisiae histone H2A in DNA repair. Nature 2000; 408:1001-4.
    • (2000) Nature , vol.408 , pp. 1001-1004
    • Downs, J.A.1    Lowndes, N.F.2    Jackson, S.P.3
  • 27
    • 0042991379 scopus 로고    scopus 로고
    • Histone H2AX: A dosage-dependent suppressor of oncogenic translocationsand tumors
    • Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, et al. Histone H2AX: A dosage-dependent suppressor of oncogenic translocationsand tumors. Cell 2003; 114:359-70.
    • (2003) Cell , vol.114 , pp. 359-370
    • Bassing, C.H.1    Suh, H.2    Ferguson, D.O.3    Chua, K.F.4    Manis, J.5    Eckersdorff, M.6
  • 28
    • 0037866984 scopus 로고    scopus 로고
    • H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation
    • Reina-San-Martin B, Difilippantonio S, Hanitsch L, Masilamani RF, Nussenzweig A, Nussenzweig MC. H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J Exp Med 2003; 197:1767-78.
    • (2003) J Exp Med , vol.197 , pp. 1767-1778
    • Reina-San-Martin, B.1    Difilippantonio, S.2    Hanitsch, L.3    Masilamani, R.F.4    Nussenzweig, A.5    Nussenzweig, M.C.6
  • 29
    • 0034284341 scopus 로고    scopus 로고
    • Abnormal rearrangement within the alpha/delta T-cell receptor locus in lymphomas from Atm-deficient mice
    • Liyanage M, Weaver Z, Barlow C, Coleman A, Pankratz DG, Anderson S, et al. Abnormal rearrangement within the alpha/delta T-cell receptor locus in lymphomas from Atm-deficient mice. Blood 2000; 96:1940-6.
    • (2000) Blood , vol.96 , pp. 1940-1946
    • Liyanage, M.1    Weaver, Z.2    Barlow, C.3    Coleman, A.4    Pankratz, D.G.5    Anderson, S.6
  • 30
    • 0037136318 scopus 로고    scopus 로고
    • Evidence for replicative repair of DNA double-strand breaks leading to oncogenic tcanslocation and gene amplification
    • Difilippantonio MJ, Petersen S, Chen HT, Johnson R, Jasin M, Kanaar R, et al. Evidence for replicative repair of DNA double-strand breaks leading to oncogenic tcanslocation and gene amplification. J Exp Med 2002; 196:469-80.
    • (2002) J Exp Med , vol.196 , pp. 469-480
    • Difilippantonio, M.J.1    Petersen, S.2    Chen, H.T.3    Johnson, R.4    Jasin, M.5    Kanaar, R.6
  • 31
    • 0037824720 scopus 로고    scopus 로고
    • The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice
    • Gladdy RA, Taylor MD, Williams CJ, Grandal I, Karaskova J, Squire JA, et al. The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. Cancer Cell 2003; 3:37-50.
    • (2003) Cancer Cell , vol.3 , pp. 37-50
    • Gladdy, R.A.1    Taylor, M.D.2    Williams, C.J.3    Grandal, I.4    Karaskova, J.5    Squire, J.A.6
  • 32
    • 0037188898 scopus 로고    scopus 로고
    • Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations
    • Zhu C, Mills KD, Ferguson DO, Lee C, Manis J, Fleming J, et al. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell 2002; 109:811-21.
    • (2002) Cell , vol.109 , pp. 811-821
    • Zhu, C.1    Mills, K.D.2    Ferguson, D.O.3    Lee, C.4    Manis, J.5    Fleming, J.6
  • 33
    • 0038148400 scopus 로고    scopus 로고
    • Chromatin dynamics and locus accessibility in the immune system
    • Mostoslavsky R, Alt FW, Bassing CH. Chromatin dynamics and locus accessibility in the immune system. Nat Immunol 2003; 4:603-6.
    • (2003) Nat Immunol , vol.4 , pp. 603-606
    • Mostoslavsky, R.1    Alt, F.W.2    Bassing, C.H.3
  • 35
    • 0141780833 scopus 로고    scopus 로고
    • NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors
    • Xu X, Stern DF. NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. Faseb J 2003; 17:1842-8.
    • (2003) Faseb J , vol.17 , pp. 1842-1848
    • Xu, X.1    Stern, D.F.2
  • 36
    • 0141815630 scopus 로고    scopus 로고
    • Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA
    • Iwabuchi K, Basu BP, Kysela B, Kurihara T, Shibata M, Guan D, et al. Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. J Biol Chem 2003; 278:36487-95.
    • (2003) J Biol Chem , vol.278 , pp. 36487-36495
    • Iwabuchi, K.1    Basu, B.P.2    Kysela, B.3    Kurihara, T.4    Shibata, M.5    Guan, D.6
  • 37
    • 0142186242 scopus 로고    scopus 로고
    • The MRN complex: Coordinating and mediating the response to broken chromosomes
    • van den Bosch M, Bree RT, Lowndes NF. The MRN complex: Coordinating and mediating the response to broken chromosomes. EMBO Rep 2003; 4:844-9.
    • (2003) EMBO Rep , vol.4 , pp. 844-849
    • Van Den Bosch, M.1    Bree, R.T.2    Lowndes, N.F.3
  • 38
    • 0030498092 scopus 로고    scopus 로고
    • A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle
    • Li Z, Dordai DI, Lee J, Desiderio S. A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle. Immunity 1996; 5:575-89.
    • (1996) Immunity , vol.5 , pp. 575-589
    • Li, Z.1    Dordai, D.I.2    Lee, J.3    Desiderio, S.4
  • 39
    • 0031466618 scopus 로고    scopus 로고
    • Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart
    • Shiloh Y. Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart. Annu Rev Genet 1997; 31:635-62.
    • (1997) Annu Rev Genet , vol.31 , pp. 635-662
    • Shiloh, Y.1
  • 40
    • 0141567744 scopus 로고    scopus 로고
    • RecQ helicases: Suppressors of tumorigenesis and premature aging
    • Bachrati CZ, Hickson ID. RecQ helicases: Suppressors of tumorigenesis and premature aging. Biochem J 2003; 374:577-606.
    • (2003) Biochem J , vol.374 , pp. 577-606
    • Bachrati, C.Z.1    Hickson, I.D.2
  • 41
    • 0033544724 scopus 로고    scopus 로고
    • The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
    • Stewart GS, Maser RS, Stankovic T, Bressan DA, Kaplan MI, Jaspers NG, et al. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 1999; 99:577-87.
    • (1999) Cell , vol.99 , pp. 577-587
    • Stewart, G.S.1    Maser, R.S.2    Stankovic, T.3    Bressan, D.A.4    Kaplan, M.I.5    Jaspers, N.G.6
  • 43
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh Y. ATM and related protein kinases: Safeguarding genome integrity. Nat Rev Cancer 2003; 3:155-68.
    • (2003) Nat Rev Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 44
    • 0037115935 scopus 로고    scopus 로고
    • Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability
    • Tauchi H, Matsuura S, Kobayashi J, Sakamoto S, Komatsu K. Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability. Oncogene 2002; 21:8967-80.
    • (2002) Oncogene , vol.21 , pp. 8967-8980
    • Tauchi, H.1    Matsuura, S.2    Kobayashi, J.3    Sakamoto, S.4    Komatsu, K.5
  • 45
    • 0141864666 scopus 로고    scopus 로고
    • Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks
    • Davalos AR, Campisi J. Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J Cell Biol 2003; 162:1197-209.
    • (2003) J Cell Biol , vol.162 , pp. 1197-1209
    • Davalos, A.R.1    Campisi, J.2
  • 46
    • 0033566329 scopus 로고    scopus 로고
    • Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia
    • Schaffner C, Stilgenbauer S, Rappold GA, Dohner H, Lichter P. Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia. Blood 1999; 94:748-53.
    • (1999) Blood , vol.94 , pp. 748-753
    • Schaffner, C.1    Stilgenbauer, S.2    Rappold, G.A.3    Dohner, H.4    Lichter, P.5
  • 47
    • 0033229701 scopus 로고    scopus 로고
    • Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma
    • Stilgenbauer S, Winkler D, Ott G, Schaffner C, Leupolt E, Bentz M, et al. Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma. Blood 1999; 94:3262-4.
    • (1999) Blood , vol.94 , pp. 3262-3264
    • Stilgenbauer, S.1    Winkler, D.2    Ott, G.3    Schaffner, C.4    Leupolt, E.5    Bentz, M.6


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