Checkpoint mediators: Relaying signals from DNA strand breaks

Current Biology

Volumn 13, Issue 12, 2003, Pages

  Canman, Christine E ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0038613469     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(03)00410-X     Document Type: Short Survey

References (18)

1. Stewart, G.S., Wang, B., Bignell, C.R., Taylor, A.M.R. and Elledge, S.J. (2003). MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421, 961-966.
2. Goldberg, M., Stucki, M., Falck, J., D'Amours, D., Rahman, D., Pappin, D., Bartek, J. and Jackson, S.P. (2003). MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 421, 952-956.
3. Lou, Z., Minter-Dykhouse, K., Wu, X. and Chen, J. (2003). MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 421, 957-961.
4. Xu, X. and Stern, D.F. (2003). NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways. J. Biol. Chem. 278, 8795-8803.
5. Shang, Y.L., Bodero, A.J. and Chen, P.-L. (2003). NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response. J. Biol. Chem. 278, 6323-6329.
6. Shiloh, Y. (2003). ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 3, 155-168.
7. Osborn, A.J., Elledge, S.J. and Zou, L. (2002). Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol. 12, 509-516.
8. D'Andrea, A.D. and Grompe, M. (2003). The Fanconi Anaemia/BRCA pathway. Nat. Rev. Cancer 3, 23-34.
9. Falck, J., Petrini, J.H.J., Willeams, B.R., Lukas, J. and Bartek, J. (2002). The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat. Genet. 30, 290-294.
10. Bakkenist, C.J. and Kastan, M.B. (2003). DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506.
11. Paull, T.T., Rogakou, E.P., Yamazaki, V., Kirchgessner, C.U., Gellert, M. and Bonner, W.M. (2000). A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10, 886-895.
12. Burma, S., Chen, B.P., Murphy, M., Kurimasa, A. and Chen, D.J. (2001). ATM phosphorylates Histone H2AX in response to DNA double-strand breaks. J. Biol. Chem. 276, 42462-42467.
13. Celeste, A., Petersen, S., Romanienko, P.J., Fernandex-Capetillo, O., Chen, H.-T., Sedelnikova, O.A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M.J. et al. (2002). Genomic instability in Mice lacking histone H2AX. Science 296, 922-927.
14. Lou, Z., Chini, C.C.S., Minter-Dykhouse, K. and Chen, J. (2003). Mediator of DNA Damage Checkpoint 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. J. Biol. Chem. 278, 13599-13602.
15. Fernandex-Capetillo, O., Chen, H.-T., Celeste, A., Ward, I., Romanienko, P.J., Morales, J.C., Naka, K., Xia, Z., Camerini-Otero, R.D., Motoyama, N., et al. (2002). DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat. Cell Biol. 4, 993-997.
16. Wang, B., Matsuoka, S., Carpenter, P.B. and Elledge, S.J. (2002). 53BP1, a mediator of the DNA damage checkpoint. Science 298, 1435-1438.
17. DiTullio, R.A. Jr., Mochan, T.A., Venere, M., Bartkova, J., Sehested, M., Bartek, J. and Halazonetis, T.D. (2002.) 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat. Cell Biol. 4, 998-1002.
18. Ward, I.M., Minn, K., van Deursen, J. and Chen, J. (2003). p53 binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol. Cell. Biol. 23, 2556-2563.