메뉴 건너뛰기




Volumn 44, Issue , 2019, Pages 747-754

The path toward using microbial metabolites as therapies

Author keywords

Disease; Metabolites; Microbiome; Post biotics; Therapies

Indexed keywords

ARACHIDONIC ACID; AROMATIC HYDROCARBON RECEPTOR; BETAINE; BILE ACID; BUTYRIC ACID; CARNITINE; CHOLINE; CRESOL; FARNESOID X RECEPTOR; FLAVONOID; G PROTEIN COUPLED RECEPTOR; GUGGULSTERONE; HISTONE DEACETYLASE; INDOLE; INDOLEACETIC ACID; LINOLEIC ACID; LONG CHAIN FATTY ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLCHOLINE; POLYAMINE; RETINOIC ACID; SHORT CHAIN FATTY ACID; TAURINE; TRIMETHYLAMINE; TRIMETHYLAMINE OXIDE; TYROSINE; UNINDEXED DRUG; UREMIC TOXIN; FATTY ACID; METHYLAMINE; TRIMETHYLOXAMINE;

EID: 85067025173     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2019.05.063     Document Type: Review
Times cited : (80)

References (127)
  • 2
    • 85021296885 scopus 로고    scopus 로고
    • The remedy within: will the microbiome fulfill its therapeutic promise?
    • Thaiss, C.A., Elinav, E., The remedy within: will the microbiome fulfill its therapeutic promise?. J Mol Med (Berl) 95:10 (2017), 1021–1027.
    • (2017) J Mol Med (Berl) , vol.95 , Issue.10 , pp. 1021-1027
    • Thaiss, C.A.1    Elinav, E.2
  • 3
    • 84872139636 scopus 로고    scopus 로고
    • Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation
    • Bennett, B.J., de Aguiar Vallim, T.Q., Wang, Z., et al. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab 17:1 (2013), 49–60.
    • (2013) Cell Metab , vol.17 , Issue.1 , pp. 49-60
    • Bennett, B.J.1    de Aguiar Vallim, T.Q.2    Wang, Z.3
  • 4
    • 85059425019 scopus 로고    scopus 로고
    • Plasma Trimethylamine N-oxide as a novel biomarker for plaque rupture in patients with ST-segment-elevation myocardial infarction
    • Tan, Y., Sheng, Z., Zhou, P., et al. Plasma Trimethylamine N-oxide as a novel biomarker for plaque rupture in patients with ST-segment-elevation myocardial infarction. Circ Cardiovasc Interv, 12(1), 2019, e007281.
    • (2019) Circ Cardiovasc Interv , vol.12 , Issue.1
    • Tan, Y.1    Sheng, Z.2    Zhou, P.3
  • 5
    • 85062976115 scopus 로고    scopus 로고
    • Gut microbe-generated metabolite trimethylamine N-oxide and the risk of diabetes: a systematic review and dose-response meta-analysis
    • Zhuang, R., Ge, X., Han, L., et al. Gut microbe-generated metabolite trimethylamine N-oxide and the risk of diabetes: a systematic review and dose-response meta-analysis. Obes Rev 20:6 (Jun 2019), 883–894.
    • (2019) Obes Rev , vol.20 , Issue.6 , pp. 883-894
    • Zhuang, R.1    Ge, X.2    Han, L.3
  • 6
    • 85053113519 scopus 로고    scopus 로고
    • Gut microbiota-dependent Trimethylamine N-oxide predicts risk of cardiovascular events in patients with stroke and is related to Proinflammatory monocytes
    • Haghikia, A., Li, X.S., Liman, T.G., et al. Gut microbiota-dependent Trimethylamine N-oxide predicts risk of cardiovascular events in patients with stroke and is related to Proinflammatory monocytes. Arterioscler Thromb Vasc Biol 38:9 (2018), 2225–2235.
    • (2018) Arterioscler Thromb Vasc Biol , vol.38 , Issue.9 , pp. 2225-2235
    • Haghikia, A.1    Li, X.S.2    Liman, T.G.3
  • 7
    • 85062282934 scopus 로고    scopus 로고
    • Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk
    • Li, X.S., Wang, Z., Cajka, T., et al. Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk. JCI Insight, 3(6), 2018.
    • (2018) JCI Insight , vol.3 , Issue.6
    • Li, X.S.1    Wang, Z.2    Cajka, T.3
  • 8
    • 84954497042 scopus 로고    scopus 로고
    • Serum Trimethylamine-N-oxide is strongly related to renal function and predicts outcome in chronic kidney disease
    • Missailidis, C., Hallqvist, J., Qureshi, A.R., et al. Serum Trimethylamine-N-oxide is strongly related to renal function and predicts outcome in chronic kidney disease. PLoS One, 11(1), 2016, e0141738.
    • (2016) PLoS One , vol.11 , Issue.1
    • Missailidis, C.1    Hallqvist, J.2    Qureshi, A.R.3
  • 9
    • 85064212059 scopus 로고    scopus 로고
    • Trimethylamine N-oxide and cardiovascular outcomes in patients with end-stage kidney disease receiving maintenance Hemodialysis
    • (pii: CJN.06190518)
    • Stubbs, J.R., Stedman, M.R., Liu, S., et al. Trimethylamine N-oxide and cardiovascular outcomes in patients with end-stage kidney disease receiving maintenance Hemodialysis. Clin J Am Soc Nephrol, Jan 21 2019, 10.2215/CJN.06190518 (pii: CJN.06190518).
    • (2019) Clin J Am Soc Nephrol
    • Stubbs, J.R.1    Stedman, M.R.2    Liu, S.3
  • 10
    • 85058915975 scopus 로고    scopus 로고
    • The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease
    • Vogt, N.M., Romano, K.A., Darst, B.F., et al. The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease. Alzheimers Res Ther, 10(1), 2018, 124.
    • (2018) Alzheimers Res Ther , vol.10 , Issue.1 , pp. 124
    • Vogt, N.M.1    Romano, K.A.2    Darst, B.F.3
  • 11
    • 79953733693 scopus 로고    scopus 로고
    • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
    • Wang, Z., Klipfell, E., Bennett, B.J., et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472:7341 (2011), 57–63.
    • (2011) Nature , vol.472 , Issue.7341 , pp. 57-63
    • Wang, Z.1    Klipfell, E.2    Bennett, B.J.3
  • 12
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
    • Koeth, R.A., Wang, Z., Levison, B.S., et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 19:5 (2013), 576–585.
    • (2013) Nat Med , vol.19 , Issue.5 , pp. 576-585
    • Koeth, R.A.1    Wang, Z.2    Levison, B.S.3
  • 13
    • 85052752665 scopus 로고    scopus 로고
    • Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk
    • Zhu, W., Buffa, J.A., Wang, Z., et al. Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk. J Thromb Haemost 16:9 (2018), 1857–1872.
    • (2018) J Thromb Haemost , vol.16 , Issue.9 , pp. 1857-1872
    • Zhu, W.1    Buffa, J.A.2    Wang, Z.3
  • 14
    • 84921362010 scopus 로고    scopus 로고
    • The TMAO-generating enzyme Flavin Monooxygenase 3 is a central regulator of cholesterol balance
    • Warrier, M., Shih, D.M., Burrows, A.C., et al. The TMAO-generating enzyme Flavin Monooxygenase 3 is a central regulator of cholesterol balance. Cell Rep 10:3 (Jan 20 2015), 326–338.
    • (2015) Cell Rep , vol.10 , Issue.3 , pp. 326-338
    • Warrier, M.1    Shih, D.M.2    Burrows, A.C.3
  • 15
    • 85058883368 scopus 로고    scopus 로고
    • Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism
    • Ding, L., Chang, M., Guo, Y., et al. Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism. Lipids Health Dis, 17(1), 2018, 286.
    • (2018) Lipids Health Dis , vol.17 , Issue.1 , pp. 286
    • Ding, L.1    Chang, M.2    Guo, Y.3
  • 16
    • 85067017645 scopus 로고    scopus 로고
    • Guggulsterone, a farnesoid X receptor antagonist lowers plasma trimethylamine- N-oxide levels: an evidence from in vitro and in vivo studies
    • Gautam, A., Paudel, Y.N., Abidin, S., Bhandari, U., Guggulsterone, a farnesoid X receptor antagonist lowers plasma trimethylamine- N-oxide levels: an evidence from in vitro and in vivo studies. Hum Exp Toxicol, 960327118817862, 2018.
    • (2018) Hum Exp Toxicol , vol.960327118817862
    • Gautam, A.1    Paudel, Y.N.2    Abidin, S.3    Bhandari, U.4
  • 17
    • 84959922537 scopus 로고    scopus 로고
    • Gut microbial metabolite TMAO enhances platelet Hyperreactivity and thrombosis risk
    • Zhu, W., Gregory, J.C., Org, E., et al. Gut microbial metabolite TMAO enhances platelet Hyperreactivity and thrombosis risk. Cell 165:1 (2016), 111–124.
    • (2016) Cell , vol.165 , Issue.1 , pp. 111-124
    • Zhu, W.1    Gregory, J.C.2    Org, E.3
  • 18
    • 84950297830 scopus 로고    scopus 로고
    • Non-lethal inhibition of gut microbial Trimethylamine production for the treatment of atherosclerosis
    • Wang, Z., Roberts, A.B., Buffa, J.A., et al. Non-lethal inhibition of gut microbial Trimethylamine production for the treatment of atherosclerosis. Cell 163:7 (2015), 1585–1595.
    • (2015) Cell , vol.163 , Issue.7 , pp. 1585-1595
    • Wang, Z.1    Roberts, A.B.2    Buffa, J.A.3
  • 19
    • 85052313625 scopus 로고    scopus 로고
    • Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential
    • Roberts, A.B., Gu, X., Buffa, J.A., et al. Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential. Nat Med 24:9 (2018), 1407–1417.
    • (2018) Nat Med , vol.24 , Issue.9 , pp. 1407-1417
    • Roberts, A.B.1    Gu, X.2    Buffa, J.A.3
  • 20
    • 84995596508 scopus 로고    scopus 로고
    • Trimethylamine N-oxide: the good, the bad and the unknown
    • Velasquez, M.T., Ramezani, A., Manal, A., Raj, D.S., Trimethylamine N-oxide: the good, the bad and the unknown. Toxins (Basel), 8(11), 2016.
    • (2016) Toxins (Basel) , vol.8 , Issue.11
    • Velasquez, M.T.1    Ramezani, A.2    Manal, A.3    Raj, D.S.4
  • 21
    • 84971519476 scopus 로고    scopus 로고
    • From dietary Fiber to host physiology: short-chain fatty acids as key bacterial metabolites
    • Koh, A., De Vadder, F., Kovatcheva-Datchary, P., Backhed, F., From dietary Fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 165:6 (2016), 1332–1345.
    • (2016) Cell , vol.165 , Issue.6 , pp. 1332-1345
    • Koh, A.1    De Vadder, F.2    Kovatcheva-Datchary, P.3    Backhed, F.4
  • 22
    • 84893859801 scopus 로고    scopus 로고
    • The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
    • Chang, P.V., Hao, L., Offermanns, S., Medzhitov, R., The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A 111:6 (2014), 2247–2252.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.6 , pp. 2247-2252
    • Chang, P.V.1    Hao, L.2    Offermanns, S.3    Medzhitov, R.4
  • 23
    • 85060327779 scopus 로고    scopus 로고
    • The short chain fatty acid butyrate imprints an antimicrobial program in macrophages
    • Schulthess, J., Pandey, S., Capitani, M., et al. The short chain fatty acid butyrate imprints an antimicrobial program in macrophages. Immunity 50:2 (2019), 432–45 e7.
    • (2019) Immunity , vol.50 , Issue.2 , pp. 432-45 e7
    • Schulthess, J.1    Pandey, S.2    Capitani, M.3
  • 24
    • 85052632504 scopus 로고    scopus 로고
    • Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
    • Sun, M., Wu, W., Chen, L., et al. Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis. Nat Commun, 9(1), 2018, 3555.
    • (2018) Nat Commun , vol.9 , Issue.1 , pp. 3555
    • Sun, M.1    Wu, W.2    Chen, L.3
  • 25
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • Smith, P.M., Howitt, M.R., Panikov, N., et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341:6145 (2013), 569–573.
    • (2013) Science , vol.341 , Issue.6145 , pp. 569-573
    • Smith, P.M.1    Howitt, M.R.2    Panikov, N.3
  • 26
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
    • Arpaia, N., Campbell, C., Fan, X., et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504:7480 (2013), 451–455.
    • (2013) Nature , vol.504 , Issue.7480 , pp. 451-455
    • Arpaia, N.1    Campbell, C.2    Fan, X.3
  • 27
    • 85020848232 scopus 로고    scopus 로고
    • Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43
    • Wu, W., Sun, M., Chen, F., et al. Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43. Mucosal Immunol 10:4 (2017), 946–956.
    • (2017) Mucosal Immunol , vol.10 , Issue.4 , pp. 946-956
    • Wu, W.1    Sun, M.2    Chen, F.3
  • 28
    • 85047547704 scopus 로고    scopus 로고
    • Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice
    • Kim, M., Friesen, L., Park, J., Kim, H.M., Kim, C.H., Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice. Eur J Immunol 48:7 (2018), 1235–1247.
    • (2018) Eur J Immunol , vol.48 , Issue.7 , pp. 1235-1247
    • Kim, M.1    Friesen, L.2    Park, J.3    Kim, H.M.4    Kim, C.H.5
  • 29
    • 84878579044 scopus 로고    scopus 로고
    • The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
    • Kimura, I., Ozawa, K., Inoue, D., et al. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun, 4, 2013, 1829.
    • (2013) Nat Commun , vol.4 , pp. 1829
    • Kimura, I.1    Ozawa, K.2    Inoue, D.3
  • 30
    • 80555126824 scopus 로고    scopus 로고
    • Synergistic effects of sodium butyrate, a histone deacetylase inhibitor, on increase of neurogenesis induced by pyridoxine and increase of neural proliferation in the mouse dentate gyrus
    • Yoo, D.Y., Kim, W., Nam, S.M., et al. Synergistic effects of sodium butyrate, a histone deacetylase inhibitor, on increase of neurogenesis induced by pyridoxine and increase of neural proliferation in the mouse dentate gyrus. Neurochem Res 36:10 (2011), 1850–1857.
    • (2011) Neurochem Res , vol.36 , Issue.10 , pp. 1850-1857
    • Yoo, D.Y.1    Kim, W.2    Nam, S.M.3
  • 32
    • 84907228623 scopus 로고    scopus 로고
    • Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes
    • Puddu, A., Sanguineti, R., Montecucco, F., Viviani, G.L., Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes. Mediators Inflamm, 2014, 2014, 162021.
    • (2014) Mediators Inflamm , vol.2014
    • Puddu, A.1    Sanguineti, R.2    Montecucco, F.3    Viviani, G.L.4
  • 33
    • 59149103242 scopus 로고    scopus 로고
    • Butyrate modulates oxidative stress in the colonic mucosa of healthy humans
    • Hamer, H.M., Jonkers, D.M., Bast, A., et al. Butyrate modulates oxidative stress in the colonic mucosa of healthy humans. Clin Nutr 28:1 (2009), 88–93.
    • (2009) Clin Nutr , vol.28 , Issue.1 , pp. 88-93
    • Hamer, H.M.1    Jonkers, D.M.2    Bast, A.3
  • 34
    • 85014070812 scopus 로고    scopus 로고
    • Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men
    • van der Beek, C.M., Canfora, E.E., Lenaerts, K., et al. Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men. Clin Sci (Lond) 130:22 (2016), 2073–2082.
    • (2016) Clin Sci (Lond) , vol.130 , Issue.22 , pp. 2073-2082
    • van der Beek, C.M.1    Canfora, E.E.2    Lenaerts, K.3
  • 35
    • 84941879755 scopus 로고    scopus 로고
    • Short-chain fatty acids in control of body weight and insulin sensitivity
    • Canfora, E.E., Jocken, J.W., Blaak, E.E., Short-chain fatty acids in control of body weight and insulin sensitivity. Nat Rev Endocrinol 11:10 (2015), 577–591.
    • (2015) Nat Rev Endocrinol , vol.11 , Issue.10 , pp. 577-591
    • Canfora, E.E.1    Jocken, J.W.2    Blaak, E.E.3
  • 36
    • 85019847333 scopus 로고    scopus 로고
    • Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial
    • Canfora, E.E., van der Beek, C.M., Jocken, J.W.E., et al. Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial. Sci Rep, 7(1), 2017, 2360.
    • (2017) Sci Rep , vol.7 , Issue.1 , pp. 2360
    • Canfora, E.E.1    van der Beek, C.M.2    Jocken, J.W.E.3
  • 37
    • 85055258934 scopus 로고    scopus 로고
    • The microbiome: a new target for research and treatment of schizophrenia and its resistant presentations? A systematic literature search and review
    • Cuomo, A., Maina, G., Rosso, G., et al. The microbiome: a new target for research and treatment of schizophrenia and its resistant presentations? A systematic literature search and review. Front Pharmacol, 9, 2018, 1040.
    • (2018) Front Pharmacol , vol.9 , pp. 1040
    • Cuomo, A.1    Maina, G.2    Rosso, G.3
  • 38
    • 84933043202 scopus 로고    scopus 로고
    • Host microbiota constantly control maturation and function of microglia in the CNS
    • Erny, D., Hrabe de Angelis, A.L., Jaitin, D., et al. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci 18:7 (2015), 965–977.
    • (2015) Nat Neurosci , vol.18 , Issue.7 , pp. 965-977
    • Erny, D.1    Hrabe de Angelis, A.L.2    Jaitin, D.3
  • 39
    • 84975317355 scopus 로고    scopus 로고
    • Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring
    • Buffington, S.A., Di Prisco, G.V., Auchtung, T.A., Ajami, N.J., Petrosino, J.F., Costa-Mattioli, M., Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring. Cell 165:7 (2016), 1762–1775.
    • (2016) Cell , vol.165 , Issue.7 , pp. 1762-1775
    • Buffington, S.A.1    Di Prisco, G.V.2    Auchtung, T.A.3    Ajami, N.J.4    Petrosino, J.F.5    Costa-Mattioli, M.6
  • 40
    • 84958279436 scopus 로고    scopus 로고
    • Butyrate, neuroepigenetics and the gut microbiome: can a high fiber diet improve brain health?
    • Bourassa, M.W., Alim, I., Bultman, S.J., Ratan, R.R., Butyrate, neuroepigenetics and the gut microbiome: can a high fiber diet improve brain health?. Neurosci Lett 625 (2016), 56–63.
    • (2016) Neurosci Lett , vol.625 , pp. 56-63
    • Bourassa, M.W.1    Alim, I.2    Bultman, S.J.3    Ratan, R.R.4
  • 41
    • 80051984937 scopus 로고    scopus 로고
    • Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression
    • Govindarajan, N., Agis-Balboa, R.C., Walter, J., Sananbenesi, F., Fischer, A., Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression. J Alzheimers Dis 26:1 (2011), 187–197.
    • (2011) J Alzheimers Dis , vol.26 , Issue.1 , pp. 187-197
    • Govindarajan, N.1    Agis-Balboa, R.C.2    Walter, J.3    Sananbenesi, F.4    Fischer, A.5
  • 42
    • 84915811448 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors reverse manic-like behaviors and protect the rat brain from energetic metabolic alterations induced by ouabain
    • Lopes-Borges, J., Valvassori, S.S., Varela, R.B., et al. Histone deacetylase inhibitors reverse manic-like behaviors and protect the rat brain from energetic metabolic alterations induced by ouabain. Pharmacol Biochem Behav 128 (2015), 89–95.
    • (2015) Pharmacol Biochem Behav , vol.128 , pp. 89-95
    • Lopes-Borges, J.1    Valvassori, S.S.2    Varela, R.B.3
  • 43
    • 85013756511 scopus 로고    scopus 로고
    • Targeting the microbiota-gut-brain Axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice
    • Burokas, A., Arboleya, S., Moloney, R.D., et al. Targeting the microbiota-gut-brain Axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice. Biol Psychiatry 82:7 (2017), 472–487.
    • (2017) Biol Psychiatry , vol.82 , Issue.7 , pp. 472-487
    • Burokas, A.1    Arboleya, S.2    Moloney, R.D.3
  • 44
    • 85033784875 scopus 로고    scopus 로고
    • Dietary and microbial metabolites in the regulation of host immunity
    • Shibata, N., Kunisawa, J., Kiyono, H., Dietary and microbial metabolites in the regulation of host immunity. Front Microbiol, 8, 2017, 2171.
    • (2017) Front Microbiol , vol.8 , pp. 2171
    • Shibata, N.1    Kunisawa, J.2    Kiyono, H.3
  • 45
    • 85022068358 scopus 로고    scopus 로고
    • Gut microbiome, metabolome, and allergic diseases
    • Hirata, S.I., Kunisawa, J., Gut microbiome, metabolome, and allergic diseases. Allergol Int 66:4 (2017), 523–528.
    • (2017) Allergol Int , vol.66 , Issue.4 , pp. 523-528
    • Hirata, S.I.1    Kunisawa, J.2
  • 46
    • 84887122496 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition
    • Kishino, S., Takeuchi, M., Park, S.B., et al. Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. Proc Natl Acad Sci U S A 110:44 (2013), 17808–17813.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.44 , pp. 17808-17813
    • Kishino, S.1    Takeuchi, M.2    Park, S.B.3
  • 47
    • 84866613234 scopus 로고    scopus 로고
    • Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn's disease
    • Bassaganya-Riera, J., Hontecillas, R., Horne, W.T., et al. Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn's disease. Clin Nutr 31:5 (2012), 721–727.
    • (2012) Clin Nutr , vol.31 , Issue.5 , pp. 721-727
    • Bassaganya-Riera, J.1    Hontecillas, R.2    Horne, W.T.3
  • 48
    • 85018673674 scopus 로고    scopus 로고
    • Supplemental feeding of a gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, alleviates spontaneous atopic dermatitis and modulates intestinal microbiota in NC/nga mice
    • Kaikiri, H., Miyamoto, J., Kawakami, T., et al. Supplemental feeding of a gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, alleviates spontaneous atopic dermatitis and modulates intestinal microbiota in NC/nga mice. Int J Food Sci Nutr 68:8 (2017), 941–951.
    • (2017) Int J Food Sci Nutr , vol.68 , Issue.8 , pp. 941-951
    • Kaikiri, H.1    Miyamoto, J.2    Kawakami, T.3
  • 49
    • 84921841372 scopus 로고    scopus 로고
    • A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK-ERK pathway
    • Miyamoto, J., Mizukure, T., Park, S.B., et al. A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK-ERK pathway. J Biol Chem 290:5 (2015), 2902–2918.
    • (2015) J Biol Chem , vol.290 , Issue.5 , pp. 2902-2918
    • Miyamoto, J.1    Mizukure, T.2    Park, S.B.3
  • 50
    • 34047257009 scopus 로고    scopus 로고
    • Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese
    • Gaullier, J.M., Halse, J., Hoivik, H.O., et al. Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese. Br J Nutr 97:3 (2007), 550–560.
    • (2007) Br J Nutr , vol.97 , Issue.3 , pp. 550-560
    • Gaullier, J.M.1    Halse, J.2    Hoivik, H.O.3
  • 51
    • 0034804625 scopus 로고    scopus 로고
    • Conjugated linoleic acid supplementation in humans—metabolic effects
    • Smedman, A., Vessby, B., Conjugated linoleic acid supplementation in humans—metabolic effects. Lipids 36:8 (2001), 773–781.
    • (2001) Lipids , vol.36 , Issue.8 , pp. 773-781
    • Smedman, A.1    Vessby, B.2
  • 52
    • 74049148835 scopus 로고    scopus 로고
    • Dietary supplementation with cis-9,trans-11 conjugated linoleic acid and aortic stiffness in overweight and obese adults
    • Sluijs, I., Plantinga, Y., de Roos, B., Mennen, L.I., Bots, M.L., Dietary supplementation with cis-9,trans-11 conjugated linoleic acid and aortic stiffness in overweight and obese adults. Am J Clin Nutr 91:1 (2010), 175–183.
    • (2010) Am J Clin Nutr , vol.91 , Issue.1 , pp. 175-183
    • Sluijs, I.1    Plantinga, Y.2    de Roos, B.3    Mennen, L.I.4    Bots, M.L.5
  • 53
    • 20144389026 scopus 로고    scopus 로고
    • An oral supplement enriched with fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis: a randomized, controlled trial
    • Seidner, D.L., Lashner, B.A., Brzezinski, A., et al. An oral supplement enriched with fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis: a randomized, controlled trial. Clin Gastroenterol Hepatol 3:4 (2005), 358–369.
    • (2005) Clin Gastroenterol Hepatol , vol.3 , Issue.4 , pp. 358-369
    • Seidner, D.L.1    Lashner, B.A.2    Brzezinski, A.3
  • 54
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • Hsiao, E.Y., McBride, S.W., Hsien, S., et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155:7 (2013), 1451–1463.
    • (2013) Cell , vol.155 , Issue.7 , pp. 1451-1463
    • Hsiao, E.Y.1    McBride, S.W.2    Hsien, S.3
  • 55
    • 84923359335 scopus 로고    scopus 로고
    • Prediction and quantification of bioactive microbiota metabolites in the mouse gut
    • Sridharan, G.V., Choi, K., Klemashevich, C., et al. Prediction and quantification of bioactive microbiota metabolites in the mouse gut. Nat Commun, 5, 2014, 5492.
    • (2014) Nat Commun , vol.5 , pp. 5492
    • Sridharan, G.V.1    Choi, K.2    Klemashevich, C.3
  • 56
    • 85006117379 scopus 로고    scopus 로고
    • Modulation of a circulating uremic solute via rational genetic manipulation of the gut microbiota
    • Devlin, A.S., Marcobal, A., Dodd, D., et al. Modulation of a circulating uremic solute via rational genetic manipulation of the gut microbiota. Cell Host Microbe 20:6 (2016), 709–715.
    • (2016) Cell Host Microbe , vol.20 , Issue.6 , pp. 709-715
    • Devlin, A.S.1    Marcobal, A.2    Dodd, D.3
  • 57
    • 85061192204 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease
    • Rothhammer, V., Quintana, F.J., The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease. Nat Rev Immunol 19:3 (2019), 184–197.
    • (2019) Nat Rev Immunol , vol.19 , Issue.3 , pp. 184-197
    • Rothhammer, V.1    Quintana, F.J.2
  • 58
    • 85053900152 scopus 로고    scopus 로고
    • The environmental sensor AHR protects from inflammatory damage by maintaining intestinal stem cell homeostasis and barrier integrity
    • Metidji, A., Omenetti, S., Crotta, S., et al. The environmental sensor AHR protects from inflammatory damage by maintaining intestinal stem cell homeostasis and barrier integrity. Immunity 49:2 (2018), 353–62 e5.
    • (2018) Immunity , vol.49 , Issue.2 , pp. 353-62 e5
    • Metidji, A.1    Omenetti, S.2    Crotta, S.3
  • 59
    • 85027063083 scopus 로고    scopus 로고
    • Lactobacillus reuteri induces gut intraepithelial CD4(+)CD8alphaalpha(+) T cells
    • Cervantes-Barragan, L., Chai, J.N., Tianero, M.D., et al. Lactobacillus reuteri induces gut intraepithelial CD4(+)CD8alphaalpha(+) T cells. Science 357:6353 (2017), 806–810.
    • (2017) Science , vol.357 , Issue.6353 , pp. 806-810
    • Cervantes-Barragan, L.1    Chai, J.N.2    Tianero, M.D.3
  • 60
    • 84882664672 scopus 로고    scopus 로고
    • Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
    • Zelante, T., Iannitti, R.G., Cunha, C., et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity 39:2 (2013), 372–385.
    • (2013) Immunity , vol.39 , Issue.2 , pp. 372-385
    • Zelante, T.1    Iannitti, R.G.2    Cunha, C.3
  • 61
    • 84966526506 scopus 로고    scopus 로고
    • CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands
    • Lamas, B., Richard, M.L., Leducq, V., et al. CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands. Nat Med 22:6 (2016), 598–605.
    • (2016) Nat Med , vol.22 , Issue.6 , pp. 598-605
    • Lamas, B.1    Richard, M.L.2    Leducq, V.3
  • 62
    • 85055470325 scopus 로고    scopus 로고
    • The gut microbiota metabolite indole alleviates liver inflammation in mice
    • (fj201800544)
    • Beaumont, M., Neyrinck, A.M., Olivares, M., et al. The gut microbiota metabolite indole alleviates liver inflammation in mice. FASEB J 32 (2018), 6681–6693 (fj201800544).
    • (2018) FASEB J , vol.32 , pp. 6681-6693
    • Beaumont, M.1    Neyrinck, A.M.2    Olivares, M.3
  • 63
    • 84966658995 scopus 로고    scopus 로고
    • Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
    • Rothhammer, V., Mascanfroni, I.D., Bunse, L., et al. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat Med 22:6 (2016), 586–597.
    • (2016) Nat Med , vol.22 , Issue.6 , pp. 586-597
    • Rothhammer, V.1    Mascanfroni, I.D.2    Bunse, L.3
  • 64
    • 85047764155 scopus 로고    scopus 로고
    • Microglial control of astrocytes in response to microbial metabolites
    • Rothhammer, V., Borucki, D.M., Tjon, E.C., et al. Microglial control of astrocytes in response to microbial metabolites. Nature 557:7707 (2018), 724–728.
    • (2018) Nature , vol.557 , Issue.7707 , pp. 724-728
    • Rothhammer, V.1    Borucki, D.M.2    Tjon, E.C.3
  • 65
    • 77955903212 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    • Apetoh, L., Quintana, F.J., Pot, C., et al. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol 11:9 (2010), 854–861.
    • (2010) Nat Immunol , vol.11 , Issue.9 , pp. 854-861
    • Apetoh, L.1    Quintana, F.J.2    Pot, C.3
  • 66
    • 84863528247 scopus 로고    scopus 로고
    • Normal and pathologic concentrations of uremic toxins
    • Duranton, F., Cohen, G., De Smet, R., et al. Normal and pathologic concentrations of uremic toxins. J Am Soc Nephrol 23:7 (2012), 1258–1270.
    • (2012) J Am Soc Nephrol , vol.23 , Issue.7 , pp. 1258-1270
    • Duranton, F.1    Cohen, G.2    De Smet, R.3
  • 67
    • 85056078765 scopus 로고    scopus 로고
    • Uremic toxin Indoxyl Sulfate promotes Proinflammatory macrophage activation via the interplay of OATP2B1 and Dll4-notch Signaling
    • Nakano, T., Katsuki, S., Chen, M., et al. Uremic toxin Indoxyl Sulfate promotes Proinflammatory macrophage activation via the interplay of OATP2B1 and Dll4-notch Signaling. Circulation 139:1 (2019), 78–96.
    • (2019) Circulation , vol.139 , Issue.1 , pp. 78-96
    • Nakano, T.1    Katsuki, S.2    Chen, M.3
  • 68
    • 85051808351 scopus 로고    scopus 로고
    • Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme
    • Triplett, T.A., Garrison, K.C., Marshall, N., et al. Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme. Nat Biotechnol 36:8 (2018), 758–764.
    • (2018) Nat Biotechnol , vol.36 , Issue.8 , pp. 758-764
    • Triplett, T.A.1    Garrison, K.C.2    Marshall, N.3
  • 70
    • 70350031206 scopus 로고    scopus 로고
    • The uremic retention solute p-cresyl sulfate and markers of endothelial damage
    • Meijers, B.K., Van Kerckhoven, S., Verbeke, K., et al. The uremic retention solute p-cresyl sulfate and markers of endothelial damage. Am J Kidney Dis 54:5 (2009), 891–901.
    • (2009) Am J Kidney Dis , vol.54 , Issue.5 , pp. 891-901
    • Meijers, B.K.1    Van Kerckhoven, S.2    Verbeke, K.3
  • 71
    • 85065508932 scopus 로고    scopus 로고
    • Indoxyl Sulfate and p-Cresyl Sulfate promote vascular calcification and associate with glucose intolerance
    • Opdebeeck, B., Maudsley, S., Azmi, A., et al. Indoxyl Sulfate and p-Cresyl Sulfate promote vascular calcification and associate with glucose intolerance. J Am Soc Nephrol 30:5 (2019), 751–766.
    • (2019) J Am Soc Nephrol , vol.30 , Issue.5 , pp. 751-766
    • Opdebeeck, B.1    Maudsley, S.2    Azmi, A.3
  • 72
    • 33644872268 scopus 로고    scopus 로고
    • Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients
    • Bammens, B., Evenepoel, P., Keuleers, H., Verbeke, K., Vanrenterghem, Y., Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients. Kidney Int 69:6 (2006), 1081–1087.
    • (2006) Kidney Int , vol.69 , Issue.6 , pp. 1081-1087
    • Bammens, B.1    Evenepoel, P.2    Keuleers, H.3    Verbeke, K.4    Vanrenterghem, Y.5
  • 73
    • 85064347405 scopus 로고    scopus 로고
    • Faecal volatile biomarkers of Clostridium difficile infection
    • Patel, M., Fowler, D., Sizer, J., Walton, C., Faecal volatile biomarkers of Clostridium difficile infection. PLoS One, 14(4), 2019, e0215256.
    • (2019) PLoS One , vol.14 , Issue.4
    • Patel, M.1    Fowler, D.2    Sizer, J.3    Walton, C.4
  • 74
    • 85061906892 scopus 로고    scopus 로고
    • Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: A 6-month randomised controlled-feeding trial
    • Wan, Y., Wang, F., Yuan, J., et al. Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: A 6-month randomised controlled-feeding trial. Gut, 2019, 1–31.
    • (2019) Gut , pp. 1-31
    • Wan, Y.1    Wang, F.2    Yuan, J.3
  • 75
    • 78649820558 scopus 로고    scopus 로고
    • The prebiotic, oligofructose-enriched inulin modulates the faecal metabolite profile: an in vitro analysis
    • De Preter, V., Falony, G., Windey, K., Hamer, H.M., De Vuyst, L., Verbeke, K., The prebiotic, oligofructose-enriched inulin modulates the faecal metabolite profile: an in vitro analysis. Mol Nutr Food Res 54:12 (2010), 1791–1801.
    • (2010) Mol Nutr Food Res , vol.54 , Issue.12 , pp. 1791-1801
    • De Preter, V.1    Falony, G.2    Windey, K.3    Hamer, H.M.4    De Vuyst, L.5    Verbeke, K.6
  • 76
    • 84870021440 scopus 로고    scopus 로고
    • Xylo-oligosaccharide (XOS) in combination with inulin modulates both the intestinal environment and immune status in healthy subjects, while XOS alone only shows prebiotic properties
    • Lecerf, J.M., Depeint, F., Clerc, E., et al. Xylo-oligosaccharide (XOS) in combination with inulin modulates both the intestinal environment and immune status in healthy subjects, while XOS alone only shows prebiotic properties. Br J Nutr 108:10 (2012), 1847–1858.
    • (2012) Br J Nutr , vol.108 , Issue.10 , pp. 1847-1858
    • Lecerf, J.M.1    Depeint, F.2    Clerc, E.3
  • 77
    • 77949512191 scopus 로고    scopus 로고
    • Tolerance of arabinoxylan-oligosaccharides and their prebiotic activity in healthy subjects: a randomised, placebo-controlled cross-over study
    • Cloetens, L., Broekaert, W.F., Delaedt, Y., et al. Tolerance of arabinoxylan-oligosaccharides and their prebiotic activity in healthy subjects: a randomised, placebo-controlled cross-over study. Br J Nutr 103:5 (2010), 703–713.
    • (2010) Br J Nutr , vol.103 , Issue.5 , pp. 703-713
    • Cloetens, L.1    Broekaert, W.F.2    Delaedt, Y.3
  • 78
    • 84991053856 scopus 로고    scopus 로고
    • Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism
    • Wahlstrom, A., Sayin, S.I., Marschall, H.U., Backhed, F., Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab 24:1 (2016), 41–50.
    • (2016) Cell Metab , vol.24 , Issue.1 , pp. 41-50
    • Wahlstrom, A.1    Sayin, S.I.2    Marschall, H.U.3    Backhed, F.4
  • 79
    • 85052074956 scopus 로고    scopus 로고
    • A selective gut bacterial bile salt hydrolase alters host metabolism
    • Yao, L., Seaton, S.C., Ndousse-Fetter, S., et al. A selective gut bacterial bile salt hydrolase alters host metabolism. Elife, 7, 2018.
    • (2018) Elife , vol.7
    • Yao, L.1    Seaton, S.C.2    Ndousse-Fetter, S.3
  • 80
    • 84949255269 scopus 로고    scopus 로고
    • Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling
    • Levy, M., Thaiss, C.A., Zeevi, D., et al. Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling. Cell 163:6 (2015), 1428–1443.
    • (2015) Cell , vol.163 , Issue.6 , pp. 1428-1443
    • Levy, M.1    Thaiss, C.A.2    Zeevi, D.3
  • 81
    • 85013354757 scopus 로고    scopus 로고
    • Race-dependent association of sulfidogenic bacteria with colorectal cancer
    • Yazici, C., Wolf, P.G., Kim, H., et al. Race-dependent association of sulfidogenic bacteria with colorectal cancer. Gut 66:11 (2017), 1983–1994.
    • (2017) Gut , vol.66 , Issue.11 , pp. 1983-1994
    • Yazici, C.1    Wolf, P.G.2    Kim, H.3
  • 82
    • 85049305193 scopus 로고    scopus 로고
    • The gut microbiota mediates the anti-seizure effects of the Ketogenic diet
    • Olson, C.A., Vuong, H.E., Yano, J.M., Liang, Q.Y., Nusbaum, D.J., Hsiao, E.Y., The gut microbiota mediates the anti-seizure effects of the Ketogenic diet. Cell, 174(2), 2018, 497.
    • (2018) Cell , vol.174 , Issue.2 , pp. 497
    • Olson, C.A.1    Vuong, H.E.2    Yano, J.M.3    Liang, Q.Y.4    Nusbaum, D.J.5    Hsiao, E.Y.6
  • 83
    • 85026755340 scopus 로고    scopus 로고
    • The microbial metabolite desaminotyrosine protects from influenza through type I interferon
    • Steed, A.L., Christophi, G.P., Kaiko, G.E., et al. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science 357:6350 (2017), 498–502.
    • (2017) Science , vol.357 , Issue.6350 , pp. 498-502
    • Steed, A.L.1    Christophi, G.P.2    Kaiko, G.E.3
  • 84
    • 85055083712 scopus 로고    scopus 로고
    • Microbially produced imidazole propionate impairs insulin Signaling through mTORC1
    • Koh, A., Molinaro, A., Stahlman, M., et al. Microbially produced imidazole propionate impairs insulin Signaling through mTORC1. Cell 175:4 (2018), 947–61 e17.
    • (2018) Cell , vol.175 , Issue.4 , pp. 947-61 e17
    • Koh, A.1    Molinaro, A.2    Stahlman, M.3
  • 86
    • 4644293594 scopus 로고    scopus 로고
    • Intracellular polyamine levels of intestinal epithelial cells in inflammatory bowel disease
    • Weiss, T.S., Herfarth, H., Obermeier, F., et al. Intracellular polyamine levels of intestinal epithelial cells in inflammatory bowel disease. Inflamm Bowel Dis 10:5 (2004), 529–535.
    • (2004) Inflamm Bowel Dis , vol.10 , Issue.5 , pp. 529-535
    • Weiss, T.S.1    Herfarth, H.2    Obermeier, F.3
  • 87
    • 85012907304 scopus 로고    scopus 로고
    • NLRP6: a multifaceted innate immune sensor
    • Levy, M., Shapiro, H., Thaiss, C.A., Elinav, E., NLRP6: a multifaceted innate immune sensor. Trends Immunol 38:4 (2017), 248–260.
    • (2017) Trends Immunol , vol.38 , Issue.4 , pp. 248-260
    • Levy, M.1    Shapiro, H.2    Thaiss, C.A.3    Elinav, E.4
  • 88
    • 85000363137 scopus 로고    scopus 로고
    • Microbiota diurnal rhythmicity programs host Transcriptome oscillations
    • Thaiss, C.A., Levy, M., Korem, T., et al. Microbiota diurnal rhythmicity programs host Transcriptome oscillations. Cell 167:6 (2016), 1495–510 e12.
    • (2016) Cell , vol.167 , Issue.6 , pp. 1495-510 e12
    • Thaiss, C.A.1    Levy, M.2    Korem, T.3
  • 89
    • 84928156472 scopus 로고    scopus 로고
    • A day in the life of the meta-organism: diurnal rhythms of the intestinal microbiome and its host
    • Thaiss, C.A., Zeevi, D., Levy, M., Segal, E., Elinav, E., A day in the life of the meta-organism: diurnal rhythms of the intestinal microbiome and its host. Gut Microbes 6:2 (2015), 137–142.
    • (2015) Gut Microbes , vol.6 , Issue.2 , pp. 137-142
    • Thaiss, C.A.1    Zeevi, D.2    Levy, M.3    Segal, E.4    Elinav, E.5
  • 90
    • 84908302963 scopus 로고    scopus 로고
    • Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis
    • Thaiss, C.A., Zeevi, D., Levy, M., et al. Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell 159:3 (2014), 514–529.
    • (2014) Cell , vol.159 , Issue.3 , pp. 514-529
    • Thaiss, C.A.1    Zeevi, D.2    Levy, M.3
  • 91
    • 84946082842 scopus 로고    scopus 로고
    • Chronobiomics: the biological clock as a new principle in host-microbial interactions
    • Thaiss, C.A., Levy, M., Elinav, E., Chronobiomics: the biological clock as a new principle in host-microbial interactions. PLoS Pathog, 11(10), 2015, e1005113.
    • (2015) PLoS Pathog , vol.11 , Issue.10
    • Thaiss, C.A.1    Levy, M.2    Elinav, E.3
  • 92
    • 84948436225 scopus 로고    scopus 로고
    • Circadian clock control by polyamine levels through a mechanism that declines with age
    • Zwighaft, Z., Aviram, R., Shalev, M., et al. Circadian clock control by polyamine levels through a mechanism that declines with age. Cell Metab 22:5 (2015), 874–885.
    • (2015) Cell Metab , vol.22 , Issue.5 , pp. 874-885
    • Zwighaft, Z.1    Aviram, R.2    Shalev, M.3
  • 93
    • 85057741316 scopus 로고    scopus 로고
    • Commensals suppress intestinal epithelial cell retinoic acid synthesis to regulate interleukin-22 activity and prevent microbial dysbiosis
    • Grizotte-Lake, M., Zhong, G., Duncan, K., et al. Commensals suppress intestinal epithelial cell retinoic acid synthesis to regulate interleukin-22 activity and prevent microbial dysbiosis. Immunity 49:6 (2018), 1103–15 e6.
    • (2018) Immunity , vol.49 , Issue.6 , pp. 1103-15 e6
    • Grizotte-Lake, M.1    Zhong, G.2    Duncan, K.3
  • 94
    • 85040458973 scopus 로고    scopus 로고
    • The role of the gut microbiome in systemic inflammatory disease
    • Clemente, J.C., Manasson, J., Scher, J.U., The role of the gut microbiome in systemic inflammatory disease. BMJ, 360, 2018, j5145.
    • (2018) BMJ , vol.360
    • Clemente, J.C.1    Manasson, J.2    Scher, J.U.3
  • 95
    • 70450164341 scopus 로고    scopus 로고
    • Retinoic acid contributes to the induction of IL-12-hypoproducing dendritic cells
    • Wada, Y., Hisamatsu, T., Kamada, N., Okamoto, S., Hibi, T., Retinoic acid contributes to the induction of IL-12-hypoproducing dendritic cells. Inflamm Bowel Dis 15:10 (2009), 1548–1556.
    • (2009) Inflamm Bowel Dis , vol.15 , Issue.10 , pp. 1548-1556
    • Wada, Y.1    Hisamatsu, T.2    Kamada, N.3    Okamoto, S.4    Hibi, T.5
  • 96
    • 85029208152 scopus 로고    scopus 로고
    • Oral all-trans retinoic acid plus danazol versus danazol as second-line treatment in adults with primary immune thrombocytopenia: a multicentre, randomised, open-label, phase 2 trial
    • (e487-e96)
    • Feng, F.E., Feng, R., Wang, M., et al. Oral all-trans retinoic acid plus danazol versus danazol as second-line treatment in adults with primary immune thrombocytopenia: a multicentre, randomised, open-label, phase 2 trial. Lancet Haematol, 4(10), 2017 (e487-e96).
    • (2017) Lancet Haematol , vol.4 , Issue.10
    • Feng, F.E.1    Feng, R.2    Wang, M.3
  • 97
    • 33745069350 scopus 로고    scopus 로고
    • All-trans-retinoic acid suppresses interferon-gamma and tumor necrosis factor-alpha; a possible therapeutic agent for rheumatoid arthritis
    • Nozaki, Y., Tamaki, C., Yamagata, T., et al. All-trans-retinoic acid suppresses interferon-gamma and tumor necrosis factor-alpha; a possible therapeutic agent for rheumatoid arthritis. Rheumatol Int 26:9 (2006), 810–817.
    • (2006) Rheumatol Int , vol.26 , Issue.9 , pp. 810-817
    • Nozaki, Y.1    Tamaki, C.2    Yamagata, T.3
  • 98
    • 0027081810 scopus 로고
    • Phase I and pharmacokinetic evaluation of all-trans-retinoic acid in pediatric patients with cancer
    • Smith, M.A., Adamson, P.C., Balis, F.M., et al. Phase I and pharmacokinetic evaluation of all-trans-retinoic acid in pediatric patients with cancer. J Clin Oncol 10:11 (1992), 1666–1673.
    • (1992) J Clin Oncol , vol.10 , Issue.11 , pp. 1666-1673
    • Smith, M.A.1    Adamson, P.C.2    Balis, F.M.3
  • 99
    • 85051295681 scopus 로고    scopus 로고
    • Retinoic acid, leaky gut, and autoimmune diseases
    • Abdelhamid, L., Luo, X.M., Retinoic acid, leaky gut, and autoimmune diseases. Nutrients, 10(8), 2018.
    • (2018) Nutrients , vol.10 , Issue.8
    • Abdelhamid, L.1    Luo, X.M.2
  • 100
    • 85047752879 scopus 로고    scopus 로고
    • Interactions between bacteria and bile salts in the gastrointestinal and hepatobiliary tracts
    • Urdaneta, V., Casadesus, J., Interactions between bacteria and bile salts in the gastrointestinal and hepatobiliary tracts. Front Med (Lausanne), 4, 2017, 163.
    • (2017) Front Med (Lausanne) , vol.4 , pp. 163
    • Urdaneta, V.1    Casadesus, J.2
  • 101
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • Ridlon, J.M., Kang, D.J., Hylemon, P.B., Bile salt biotransformations by human intestinal bacteria. J Lipid Res 47:2 (2006), 241–259.
    • (2006) J Lipid Res , vol.47 , Issue.2 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.J.2    Hylemon, P.B.3
  • 102
    • 84873342775 scopus 로고    scopus 로고
    • Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
    • Sayin, S.I., Wahlstrom, A., Felin, J., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab 17:2 (2013), 225–235.
    • (2013) Cell Metab , vol.17 , Issue.2 , pp. 225-235
    • Sayin, S.I.1    Wahlstrom, A.2    Felin, J.3
  • 103
    • 84946217802 scopus 로고    scopus 로고
    • Importance of large intestine in regulating bile acids and glucagon-like Peptide-1 in germ-free mice
    • Selwyn, F.P., Csanaky, I.L., Zhang, Y., Klaassen, C.D., Importance of large intestine in regulating bile acids and glucagon-like Peptide-1 in germ-free mice. Drug Metab Dispos 43:10 (2015), 1544–1556.
    • (2015) Drug Metab Dispos , vol.43 , Issue.10 , pp. 1544-1556
    • Selwyn, F.P.1    Csanaky, I.L.2    Zhang, Y.3    Klaassen, C.D.4
  • 104
    • 85023645434 scopus 로고    scopus 로고
    • Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis
    • Worthmann, A., John, C., Ruhlemann, M.C., et al. Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis. Nat Med 23:7 (2017), 839–849.
    • (2017) Nat Med , vol.23 , Issue.7 , pp. 839-849
    • Worthmann, A.1    John, C.2    Ruhlemann, M.C.3
  • 105
    • 84944754899 scopus 로고    scopus 로고
    • Ursodeoxycholic acid inhibits Clostridium difficile spore germination and vegetative growth, and prevents the recurrence of Ileal Pouchitis associated with the infection
    • Weingarden, A.R., Chen, C., Zhang, N., et al. Ursodeoxycholic acid inhibits Clostridium difficile spore germination and vegetative growth, and prevents the recurrence of Ileal Pouchitis associated with the infection. J Clin Gastroenterol 50:8 (2016), 624–630.
    • (2016) J Clin Gastroenterol , vol.50 , Issue.8 , pp. 624-630
    • Weingarden, A.R.1    Chen, C.2    Zhang, N.3
  • 106
    • 85052980329 scopus 로고    scopus 로고
    • Temporal regulation of the bacterial metabolite Deoxycholate during colonic repair is critical for crypt regeneration
    • Jain, U., Lai, C.W., Xiong, S., et al. Temporal regulation of the bacterial metabolite Deoxycholate during colonic repair is critical for crypt regeneration. Cell Host Microbe 24:3 (2018), 353–63 e5.
    • (2018) Cell Host Microbe , vol.24 , Issue.3 , pp. 353-63 e5
    • Jain, U.1    Lai, C.W.2    Xiong, S.3
  • 107
    • 85047415625 scopus 로고    scopus 로고
    • Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells
    • Ma, C., Han, M., Heinrich, B., et al. Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells. Science, 360(6391), 2018.
    • (2018) Science , vol.360 , Issue.6391
    • Ma, C.1    Han, M.2    Heinrich, B.3
  • 108
    • 0028831047 scopus 로고
    • Unconjugated secondary bile acids in the serum of patients with colorectal adenomas
    • Bayerdorffer, E., Mannes, G.A., Ochsenkuhn, T., Dirschedl, P., Wiebecke, B., Paumgartner, G., Unconjugated secondary bile acids in the serum of patients with colorectal adenomas. Gut 36:2 (1995), 268–273.
    • (1995) Gut , vol.36 , Issue.2 , pp. 268-273
    • Bayerdorffer, E.1    Mannes, G.A.2    Ochsenkuhn, T.3    Dirschedl, P.4    Wiebecke, B.5    Paumgartner, G.6
  • 109
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • Yoshimoto, S., Loo, T.M., Atarashi, K., et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 499:7456 (2013), 97–101.
    • (2013) Nature , vol.499 , Issue.7456 , pp. 97-101
    • Yoshimoto, S.1    Loo, T.M.2    Atarashi, K.3
  • 110
    • 84962374550 scopus 로고    scopus 로고
    • Bacterial species involved in the conversion of dietary flavonoids in the human gut
    • Braune, A., Blaut, M., Bacterial species involved in the conversion of dietary flavonoids in the human gut. Gut Microbes 7:3 (2016), 216–234.
    • (2016) Gut Microbes , vol.7 , Issue.3 , pp. 216-234
    • Braune, A.1    Blaut, M.2
  • 111
    • 85008440879 scopus 로고    scopus 로고
    • The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids
    • Cassidy, A., Minihane, A.M., The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids. Am J Clin Nutr 105:1 (2017), 10–22.
    • (2017) Am J Clin Nutr , vol.105 , Issue.1 , pp. 10-22
    • Cassidy, A.1    Minihane, A.M.2
  • 112
    • 85016260961 scopus 로고    scopus 로고
    • Persistent microbiome alterations modulate the rate of post-dieting weight regain
    • Thaiss, C.A., Itav, S., Rothschild, D., et al. Persistent microbiome alterations modulate the rate of post-dieting weight regain. Nature 540:7634 (2016), 544–551.
    • (2016) Nature , vol.540 , Issue.7634 , pp. 544-551
    • Thaiss, C.A.1    Itav, S.2    Rothschild, D.3
  • 113
    • 58149197040 scopus 로고    scopus 로고
    • Growth parameter and viability modifications of Escherichia coli by phenolic compounds and argentine wine extracts
    • Rodriguez Vaquero, M.J., Manca de Nadra, M.C., Growth parameter and viability modifications of Escherichia coli by phenolic compounds and argentine wine extracts. Appl Biochem Biotechnol 151:2–3 (2008), 342–352.
    • (2008) Appl Biochem Biotechnol , vol.151 , Issue.2-3 , pp. 342-352
    • Rodriguez Vaquero, M.J.1    Manca de Nadra, M.C.2
  • 114
    • 85029159345 scopus 로고    scopus 로고
    • Flavonoid-rich extract of Paulownia fortunei flowers attenuates diet-induced Hyperlipidemia, hepatic Steatosis and insulin resistance in obesity mice by AMPK pathway
    • Liu, C., Ma, J., Sun, J., et al. Flavonoid-rich extract of Paulownia fortunei flowers attenuates diet-induced Hyperlipidemia, hepatic Steatosis and insulin resistance in obesity mice by AMPK pathway. Nutrients, 9(9), 2017.
    • (2017) Nutrients , vol.9 , Issue.9
    • Liu, C.1    Ma, J.2    Sun, J.3
  • 115
    • 85022205350 scopus 로고    scopus 로고
    • Post-dieting weight gain: the role of persistent microbiome changes
    • Thaiss, C.A., Shapiro, H., Elinav, E., Post-dieting weight gain: the role of persistent microbiome changes. Future Microbiol 12 (2017), 555–559.
    • (2017) Future Microbiol , vol.12 , pp. 555-559
    • Thaiss, C.A.1    Shapiro, H.2    Elinav, E.3
  • 116
    • 84926244926 scopus 로고    scopus 로고
    • The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells
    • Weng, Z., Patel, A.B., Panagiotidou, S., Theoharides, T.C., The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. J Allergy Clin Immunol 135:4 (2015), 1044–52 e5.
    • (2015) J Allergy Clin Immunol , vol.135 , Issue.4 , pp. 1044-52 e5
    • Weng, Z.1    Patel, A.B.2    Panagiotidou, S.3    Theoharides, T.C.4
  • 117
    • 70449643365 scopus 로고    scopus 로고
    • Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism
    • Parker-Athill, E., Luo, D., Bailey, A., et al. Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism. J Neuroimmunol 217:1–2 (2009), 20–27.
    • (2009) J Neuroimmunol , vol.217 , Issue.1-2 , pp. 20-27
    • Parker-Athill, E.1    Luo, D.2    Bailey, A.3
  • 118
    • 84977763636 scopus 로고    scopus 로고
    • Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6
    • Tsilioni, I., Taliou, A., Francis, K., Theoharides, T.C., Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6. Transl Psychiatry, 5, 2015, e647.
    • (2015) Transl Psychiatry , vol.5 , pp. e647
    • Tsilioni, I.1    Taliou, A.2    Francis, K.3    Theoharides, T.C.4
  • 119
    • 46749123053 scopus 로고    scopus 로고
    • Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease
    • Wang, J., Ho, L., Zhao, W., et al. Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease. J Neurosci 28:25 (2008), 6388–6392.
    • (2008) J Neurosci , vol.28 , Issue.25 , pp. 6388-6392
    • Wang, J.1    Ho, L.2    Zhao, W.3
  • 120
    • 84940999696 scopus 로고    scopus 로고
    • Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist
    • Cohen, L.J., Kang, H.S., Chu, J., et al. Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist. Proc Natl Acad Sci U S A 112:35 (2015), E4825–E4834.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.35 , pp. E4825-E4834
    • Cohen, L.J.1    Kang, H.S.2    Chu, J.3
  • 121
    • 85029128985 scopus 로고    scopus 로고
    • Commensal bacteria make GPCR ligands that mimic human signalling molecules
    • Cohen, L.J., Esterhazy, D., Kim, S.H., et al. Commensal bacteria make GPCR ligands that mimic human signalling molecules. Nature 549:7670 (2017), 48–53.
    • (2017) Nature , vol.549 , Issue.7670 , pp. 48-53
    • Cohen, L.J.1    Esterhazy, D.2    Kim, S.H.3
  • 122
    • 85057081688 scopus 로고    scopus 로고
    • Microbiome dynamics in obesity
    • Thaiss, C.A., Microbiome dynamics in obesity. Science 362:6417 (2018), 903–904.
    • (2018) Science , vol.362 , Issue.6417 , pp. 903-904
    • Thaiss, C.A.1
  • 123
    • 85065866008 scopus 로고    scopus 로고
    • The dimension of time in host-microbiome interactions
    • Uhr, G.T., Dohnalova, L., Thaiss, C.A., The dimension of time in host-microbiome interactions. mSystems, 4(1), 2019.
    • (2019) mSystems , vol.4 , Issue.1
    • Uhr, G.T.1    Dohnalova, L.2    Thaiss, C.A.3
  • 124
    • 77955472405 scopus 로고    scopus 로고
    • Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission
    • Hamer, H.M., Jonkers, D.M., Vanhoutvin, S.A., et al. Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission. Clin Nutr 29:6 (2010), 738–744.
    • (2010) Clin Nutr , vol.29 , Issue.6 , pp. 738-744
    • Hamer, H.M.1    Jonkers, D.M.2    Vanhoutvin, S.A.3
  • 125
    • 85044987701 scopus 로고    scopus 로고
    • Sodium butyrate inhibits inflammation and maintains epithelium barrier integrity in a TNBS-induced inflammatory bowel disease mice model
    • Chen, G., Ran, X., Li, B., et al. Sodium butyrate inhibits inflammation and maintains epithelium barrier integrity in a TNBS-induced inflammatory bowel disease mice model. EBioMedicine 30 (2018), 317–325.
    • (2018) EBioMedicine , vol.30 , pp. 317-325
    • Chen, G.1    Ran, X.2    Li, B.3
  • 126
    • 0000642926 scopus 로고    scopus 로고
    • Sulfasalazine or enteral diets containing fish oil or oligosaccharides attenuate chronic colitis in rats
    • Grisham, M.B., Demichele, S.J., Garleb, K.A., Specian, R.D., Sulfasalazine or enteral diets containing fish oil or oligosaccharides attenuate chronic colitis in rats. Inflamm Bowel Dis 2:3 (1996), 178–188.
    • (1996) Inflamm Bowel Dis , vol.2 , Issue.3 , pp. 178-188
    • Grisham, M.B.1    Demichele, S.J.2    Garleb, K.A.3    Specian, R.D.4
  • 127
    • 85054538042 scopus 로고    scopus 로고
    • Immunoregulatory effects of indole-3-carbinol on monocyte-derived macrophages in systemic lupus erythematosus: a crucial role for aryl hydrocarbon receptor
    • Mohammadi, S., Memarian, A., Sedighi, S., Behnampour, N., Yazdani, Y., Immunoregulatory effects of indole-3-carbinol on monocyte-derived macrophages in systemic lupus erythematosus: a crucial role for aryl hydrocarbon receptor. Autoimmunity 51:5 (2018), 199–209.
    • (2018) Autoimmunity , vol.51 , Issue.5 , pp. 199-209
    • Mohammadi, S.1    Memarian, A.2    Sedighi, S.3    Behnampour, N.4    Yazdani, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.