메뉴 건너뛰기




Volumn 625, Issue , 2016, Pages 56-63

Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

Author keywords

Butyrate; Gut microbiome; Gut brain axis; High fiber diet; Neuroepigenetics

Indexed keywords

3 HYDROXYBUTYRIC ACID; BUTYRIC ACID; G PROTEIN COUPLED RECEPTOR; HISTONE DEACETYLASE INHIBITOR; BUTYRIC ACID DERIVATIVE;

EID: 84958279436     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2016.02.009     Document Type: Review
Times cited : (425)

References (102)
  • 2
    • 84891628557 scopus 로고    scopus 로고
    • Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis
    • Stilling R.M., Dinan T.G., Cryan J.F. Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis. Genes Brain Behav. 2014, 13:69-86.
    • (2014) Genes Brain Behav. , vol.13 , pp. 69-86
    • Stilling, R.M.1    Dinan, T.G.2    Cryan, J.F.3
  • 3
    • 4043161248 scopus 로고    scopus 로고
    • Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice
    • Sudo N., Chida Y., Aiba Y., Sonoda J., Oyama N., Yu X.-N., et al. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J. Physiol. 2004, 558:263-275.
    • (2004) J. Physiol. , vol.558 , pp. 263-275
    • Sudo, N.1    Chida, Y.2    Aiba, Y.3    Sonoda, J.4    Oyama, N.5    Yu, X.-N.6
  • 4
    • 84873932325 scopus 로고    scopus 로고
    • Short chain fatty acids and their receptors: new metabolic targets
    • Layden B.T., Angueira A.R., Brodsky M., Durai V., Lowe W.L. Short chain fatty acids and their receptors: new metabolic targets. Transl. Res. 2013, 161:131-140.
    • (2013) Transl. Res. , vol.161 , pp. 131-140
    • Layden, B.T.1    Angueira, A.R.2    Brodsky, M.3    Durai, V.4    Lowe, W.L.5
  • 5
    • 84901392235 scopus 로고    scopus 로고
    • Metabolic tinkering by the gut microbiome: implications for brain development and function
    • Selkrig J., Wong P., Zhang X., Pettersson S. Metabolic tinkering by the gut microbiome: implications for brain development and function. Gut Microbes 2014, 5:369-380.
    • (2014) Gut Microbes , vol.5 , pp. 369-380
    • Selkrig, J.1    Wong, P.2    Zhang, X.3    Pettersson, S.4
  • 10
    • 0034959553 scopus 로고    scopus 로고
    • Short-Chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides
    • Topping D.L., Clifton P.M. Short-Chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol. Rev. 2001, 81:1031-1064.
    • (2001) Physiol. Rev. , vol.81 , pp. 1031-1064
    • Topping, D.L.1    Clifton, P.M.2
  • 11
    • 0032720399 scopus 로고    scopus 로고
    • Prolonged intake of fructo-oligosaccharides induces a short-term elevation of lactic acid-producing bacteria and a persistent increase in cecal butyrate in rats
    • Le Blay G., Michel C., Blottiere H.M., Cherbut C. Prolonged intake of fructo-oligosaccharides induces a short-term elevation of lactic acid-producing bacteria and a persistent increase in cecal butyrate in rats. J. Nutr. 1999, 129:2231-2235.
    • (1999) J. Nutr. , vol.129 , pp. 2231-2235
    • Le Blay, G.1    Michel, C.2    Blottiere, H.M.3    Cherbut, C.4
  • 12
    • 0035172422 scopus 로고    scopus 로고
    • Only fibres promoting a stable butyrate producing colonic ecosystem decrease the rate of aberrant crypt foci in rats
    • Perrin P. Only fibres promoting a stable butyrate producing colonic ecosystem decrease the rate of aberrant crypt foci in rats. Gut 2001, 48:53-61.
    • (2001) Gut , vol.48 , pp. 53-61
    • Perrin, P.1
  • 13
    • 0038185227 scopus 로고    scopus 로고
    • Production rates and metabolism of short-chain fatty acids in the colon and whole body using stable isotopes
    • Pouteau E., Nguyen P., Ballèvre O., Krempf M. Production rates and metabolism of short-chain fatty acids in the colon and whole body using stable isotopes. Proc. Nutr. Soc. 2003, 62:87-93.
    • (2003) Proc. Nutr. Soc. , vol.62 , pp. 87-93
    • Pouteau, E.1    Nguyen, P.2    Ballèvre, O.3    Krempf, M.4
  • 14
    • 0030764592 scopus 로고    scopus 로고
    • Time of day and glucose tolerance status affect serum short-chain fatty concentrations in humans
    • Wolever T.M.S., Josse R.G., Leiter L.A., Chiasson J.-L. Time of day and glucose tolerance status affect serum short-chain fatty concentrations in humans. Metabolism 1997, 46:805-811.
    • (1997) Metabolism , vol.46 , pp. 805-811
    • Wolever, T.M.S.1    Josse, R.G.2    Leiter, L.A.3    Chiasson, J.-L.4
  • 15
    • 0028260120 scopus 로고
    • Butyrate as a differentiating agent: pharmacokinetics, analogues and current status
    • Newmark H.L., Lupton J.R., Young C.W. Butyrate as a differentiating agent: pharmacokinetics, analogues and current status. Cancer Lett. 1994, 78:1-5.
    • (1994) Cancer Lett. , vol.78 , pp. 1-5
    • Newmark, H.L.1    Lupton, J.R.2    Young, C.W.3
  • 16
    • 0033144060 scopus 로고    scopus 로고
    • Conjugated linoleic acid and other anticarcinogenic agents of bovine milk fat
    • Parodi P.W. Conjugated linoleic acid and other anticarcinogenic agents of bovine milk fat. J. Dairy Sci. 1999, 82:1339-1349.
    • (1999) J. Dairy Sci. , vol.82 , pp. 1339-1349
    • Parodi, P.W.1
  • 18
    • 79953036634 scopus 로고    scopus 로고
    • Oral administration of tributyrin increases concentration of butyrate in the portal vein and prevents lipopolysaccharide-induced liver injury in rats
    • Miyoshi M., Sakaki H., Usami M., Iizuka N., Shuno K., Aoyama M., et al. Oral administration of tributyrin increases concentration of butyrate in the portal vein and prevents lipopolysaccharide-induced liver injury in rats. Clin. Nutr. 2011, 30:252-258.
    • (2011) Clin. Nutr. , vol.30 , pp. 252-258
    • Miyoshi, M.1    Sakaki, H.2    Usami, M.3    Iizuka, N.4    Shuno, K.5    Aoyama, M.6
  • 19
    • 67649619244 scopus 로고    scopus 로고
    • Putting the HAT back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions
    • Sleiman S.F., Basso M., Mahishi L., Kozikowski A.P., Donohoe M.E., Langley B., et al. Putting the HAT back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions. Expert Opin. Invest. Drugs. 2009, 18:573-584.
    • (2009) Expert Opin. Invest. Drugs. , vol.18 , pp. 573-584
    • Sleiman, S.F.1    Basso, M.2    Mahishi, L.3    Kozikowski, A.P.4    Donohoe, M.E.5    Langley, B.6
  • 20
    • 0017864644 scopus 로고
    • The effect of sodium butyrate on histone modification
    • Sealy L. The effect of sodium butyrate on histone modification. Cell 1978, 14:115-121.
    • (1978) Cell , vol.14 , pp. 115-121
    • Sealy, L.1
  • 21
    • 0017886958 scopus 로고
    • Sodium butyrate inhibits histone deacetylation in cultured cells
    • Candido E. Sodium butyrate inhibits histone deacetylation in cultured cells. Cell 1978, 14:105-113.
    • (1978) Cell , vol.14 , pp. 105-113
    • Candido, E.1
  • 22
    • 0037386621 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway
    • Ryu H., Lee J., Olofsson B.A., Mwidau A., Dedeoglu A., Escudero M., et al. Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:4281-4286.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 4281-4286
    • Ryu, H.1    Lee, J.2    Olofsson, B.A.3    Mwidau, A.4    Dedeoglu, A.5    Escudero, M.6
  • 23
    • 0142157600 scopus 로고    scopus 로고
    • Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in huntington's disease mice
    • Ferrante R.J., Kubilus J.K., Lee J., Ryu H., Beesen A., Zucker B., et al. Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in huntington's disease mice. J. Neurosci. 2003, 23:9418-9427.
    • (2003) J. Neurosci. , vol.23 , pp. 9418-9427
    • Ferrante, R.J.1    Kubilus, J.K.2    Lee, J.3    Ryu, H.4    Beesen, A.5    Zucker, B.6
  • 24
    • 38149116286 scopus 로고    scopus 로고
    • Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection
    • Langley B., D'Annibale M.A., Suh K., Ayoub I., Tolhurst A., Bastan B., et al. Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection. J. Neurosci. 2008, 28:163-176.
    • (2008) J. Neurosci. , vol.28 , pp. 163-176
    • Langley, B.1    D'Annibale, M.A.2    Suh, K.3    Ayoub, I.4    Tolhurst, A.5    Bastan, B.6
  • 25
    • 20444446595 scopus 로고    scopus 로고
    • Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis
    • Camelo S., Iglesias A.H., Hwang D., Due B., Ryu H., Smith K., et al. Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2005, 164:10-21.
    • (2005) J. Neuroimmunol. , vol.164 , pp. 10-21
    • Camelo, S.1    Iglesias, A.H.2    Hwang, D.3    Due, B.4    Ryu, H.5    Smith, K.6
  • 26
    • 19944431703 scopus 로고    scopus 로고
    • Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease
    • Gardian G., Browne S.E., Choi D.-K., Klivenyi P., Gregorio J., Kubilus J.K., et al. Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease. J. Biol. Chem. 2005, 280:556-563.
    • (2005) J. Biol. Chem. , vol.280 , pp. 556-563
    • Gardian, G.1    Browne, S.E.2    Choi, D.-K.3    Klivenyi, P.4    Gregorio, J.5    Kubilus, J.K.6
  • 27
    • 84930935446 scopus 로고    scopus 로고
    • Beneficial effects of sodium butyrate in 6-OHDA induced neurotoxicity and behavioral abnormalities: modulation of histone deacetylase activity
    • Sharma S., Taliyan R., Singh S. Beneficial effects of sodium butyrate in 6-OHDA induced neurotoxicity and behavioral abnormalities: modulation of histone deacetylase activity. Behav. Brain Res. 2015, 291:306-314.
    • (2015) Behav. Brain Res. , vol.291 , pp. 306-314
    • Sharma, S.1    Taliyan, R.2    Singh, S.3
  • 28
    • 77956414742 scopus 로고    scopus 로고
    • Protection of dopaminergic cells from MPP+-mediated toxicity by histone deacetylase inhibition
    • Kidd S.K., Schneider J.S. Protection of dopaminergic cells from MPP+-mediated toxicity by histone deacetylase inhibition. Brain Res. 2010, 1354:172-178.
    • (2010) Brain Res. , vol.1354 , pp. 172-178
    • Kidd, S.K.1    Schneider, J.S.2
  • 29
    • 84879420897 scopus 로고    scopus 로고
    • Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson's disease
    • St Laurent R., O'Brien L.M., Ahmad S.T. Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson's disease. Neuroscience 2013, 246:382-390.
    • (2013) Neuroscience , vol.246 , pp. 382-390
    • St Laurent, R.1    O'Brien, L.M.2    Ahmad, S.T.3
  • 30
    • 33645775773 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor sodium butyrate protects against cisplatin-induced hearing loss in guinea pigs
    • Drottar M., Liberman M.C., Ratan R.R., Roberson D.W. The histone deacetylase inhibitor sodium butyrate protects against cisplatin-induced hearing loss in guinea pigs. Laryngoscope 2006, 116:292-296.
    • (2006) Laryngoscope , vol.116 , pp. 292-296
    • Drottar, M.1    Liberman, M.C.2    Ratan, R.R.3    Roberson, D.W.4
  • 31
    • 84901001266 scopus 로고    scopus 로고
    • HDAC inhibitors mitigate ischemia-induced oligodendrocyte damage: potential roles of oligodendrogenesis, VEGF, and anti-inflammation
    • Kim H.J., Chuang D.-M. HDAC inhibitors mitigate ischemia-induced oligodendrocyte damage: potential roles of oligodendrogenesis, VEGF, and anti-inflammation. Am. J. Transl. Res. 2014, 6:206-223.
    • (2014) Am. J. Transl. Res. , vol.6 , pp. 206-223
    • Kim, H.J.1    Chuang, D.-M.2
  • 32
    • 78650919356 scopus 로고    scopus 로고
    • Valproic acid attenuates blood-brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition
    • Wang Z., Leng Y., Tsai L.-K., Leeds P., Chuang D.-M. Valproic acid attenuates blood-brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition. J. Cereb. Blood Flow Metab. 2011, 31:52-57.
    • (2011) J. Cereb. Blood Flow Metab. , vol.31 , pp. 52-57
    • Wang, Z.1    Leng, Y.2    Tsai, L.-K.3    Leeds, P.4    Chuang, D.-M.5
  • 33
    • 34248530339 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action
    • Kim H.J., Rowe M., Ren M., Hong J.-S., Chen P.-S., Chuang D.-M. Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J. Pharmacol. Exp. Ther. 2007, 321:892-901.
    • (2007) J. Pharmacol. Exp. Ther. , vol.321 , pp. 892-901
    • Kim, H.J.1    Rowe, M.2    Ren, M.3    Hong, J.-S.4    Chen, P.-S.5    Chuang, D.-M.6
  • 34
    • 80052224793 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and mithramycin a impact a similar neuroprotective pathway at a crossroad between cancer and neurodegeneration
    • Sleiman S.F., Berlin J., Basso M., Karuppagounder S.S., Rohr J., Ratan R.R. Histone deacetylase inhibitors and mithramycin a impact a similar neuroprotective pathway at a crossroad between cancer and neurodegeneration. Pharmaceuticals (Basel) 2011, 4:1183-1195.
    • (2011) Pharmaceuticals (Basel) , vol.4 , pp. 1183-1195
    • Sleiman, S.F.1    Berlin, J.2    Basso, M.3    Karuppagounder, S.S.4    Rohr, J.5    Ratan, R.R.6
  • 35
    • 80051984937 scopus 로고    scopus 로고
    • Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression
    • Govindarajan N., Agis-Balboa R.C., Walter J., Sananbenesi F., Fischer A. Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression. J. Alzheimers Dis. 2011, 26:187-197.
    • (2011) J. Alzheimers Dis. , vol.26 , pp. 187-197
    • Govindarajan, N.1    Agis-Balboa, R.C.2    Walter, J.3    Sananbenesi, F.4    Fischer, A.5
  • 36
    • 76749091005 scopus 로고    scopus 로고
    • Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease
    • Kilgore M., Miller C.A., Fass D.M., Hennig K.M., Haggarty S.J., Sweatt J.D., et al. Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2010, 35:870-880.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 870-880
    • Kilgore, M.1    Miller, C.A.2    Fass, D.M.3    Hennig, K.M.4    Haggarty, S.J.5    Sweatt, J.D.6
  • 37
    • 84884706358 scopus 로고    scopus 로고
    • Arsenic toxicity induced endothelial dysfunction and dementia: pharmacological interdiction by histone deacetylase and inducible nitric oxide synthase inhibitors
    • Sharma B., Sharma P.M. Arsenic toxicity induced endothelial dysfunction and dementia: pharmacological interdiction by histone deacetylase and inducible nitric oxide synthase inhibitors. Toxicol. Appl. Pharmacol. 2013, 273:180-188.
    • (2013) Toxicol. Appl. Pharmacol. , vol.273 , pp. 180-188
    • Sharma, B.1    Sharma, P.M.2
  • 38
    • 84855207460 scopus 로고    scopus 로고
    • Memory impairment induced by brain iron overload is accompanied by reduced H3K9 acetylation and ameliorated by sodium butyrate
    • da Silva P.F., Garcia V.A., da A., Dornelles S., da Silva V.K., Maurmann N., Portal B.C.D., et al. Memory impairment induced by brain iron overload is accompanied by reduced H3K9 acetylation and ameliorated by sodium butyrate. Neuroscience 2012, 200:42-49.
    • (2012) Neuroscience , vol.200 , pp. 42-49
    • da Silva, P.F.1    Garcia, V.A.2    da, A.3    Dornelles, S.4    da Silva, V.K.5    Maurmann, N.6    Portal, B.C.D.7
  • 39
    • 68349152772 scopus 로고    scopus 로고
    • Histone deactylase inhibition combined with behavioral therapy enhances learning and memory following traumatic brain injury
    • Dash P.K., Orsi S.A., Moore A.N. Histone deactylase inhibition combined with behavioral therapy enhances learning and memory following traumatic brain injury. Neuroscience 2009, 163:1-8.
    • (2009) Neuroscience , vol.163 , pp. 1-8
    • Dash, P.K.1    Orsi, S.A.2    Moore, A.N.3
  • 41
    • 84937972383 scopus 로고    scopus 로고
    • Sodium butyrate prevents memory impairment by Re-establishing BDNF and GDNF expression in experimental pneumococcal meningitis
    • Barichello T., Generoso J.S., Simões L.R., Faller C.J., Ceretta R.A., Petronilho F., et al. Sodium butyrate prevents memory impairment by Re-establishing BDNF and GDNF expression in experimental pneumococcal meningitis. Mol. Neurobiol. 2015, 52:734-740.
    • (2015) Mol. Neurobiol. , vol.52 , pp. 734-740
    • Barichello, T.1    Generoso, J.S.2    Simões, L.R.3    Faller, C.J.4    Ceretta, R.A.5    Petronilho, F.6
  • 42
    • 0037019896 scopus 로고    scopus 로고
    • Enhancement of NGF- and cholera toxin-induced neurite outgrowth by butyrate in PC12 cells
    • Suzuki-Mizushima Y., Gohda E., Okamura T., Kanasaki K., Yamamoto I. Enhancement of NGF- and cholera toxin-induced neurite outgrowth by butyrate in PC12 cells. Brain Res. 2002, 951:209-217.
    • (2002) Brain Res. , vol.951 , pp. 209-217
    • Suzuki-Mizushima, Y.1    Gohda, E.2    Okamura, T.3    Kanasaki, K.4    Yamamoto, I.5
  • 43
    • 55549129648 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons
    • Wu X., Chen P.S., Dallas S., Wilson B., Block M.L., Wang C.-C., et al. Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons. Int. J. Neuropsychopharmacol. 2008, 11:1123-1134.
    • (2008) Int. J. Neuropsychopharmacol. , vol.11 , pp. 1123-1134
    • Wu, X.1    Chen, P.S.2    Dallas, S.3    Wilson, B.4    Block, M.L.5    Wang, C.-C.6
  • 44
    • 84859044408 scopus 로고    scopus 로고
    • Epigenetic modulation of Homer1a transcription regulation in amygdala and hippocampus with pavlovian fear conditioning
    • Mahan A.L., Mou L., Shah N., Hu J.-H., Worley P.F., Ressler K.J. Epigenetic modulation of Homer1a transcription regulation in amygdala and hippocampus with pavlovian fear conditioning. J. Neurosci. 2012, 32:4651-4659.
    • (2012) J. Neurosci. , vol.32 , pp. 4651-4659
    • Mahan, A.L.1    Mou, L.2    Shah, N.3    Hu, J.-H.4    Worley, P.F.5    Ressler, K.J.6
  • 45
    • 84931261861 scopus 로고    scopus 로고
    • Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene
    • Wei Y., Melas P.A., Wegener G., Mathé A.A., Lavebratt C. Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene. Int. J. Neuropsychopharmacol. 2015, 18:1-10.
    • (2015) Int. J. Neuropsychopharmacol. , vol.18 , pp. 1-10
    • Wei, Y.1    Melas, P.A.2    Wegener, G.3    Mathé, A.A.4    Lavebratt, C.5
  • 46
    • 84921612145 scopus 로고    scopus 로고
    • Sodium butyrate and mood stabilizers block ouabain-induced hyperlocomotion and increase BDNF, NGF and GDNF levels in brain of Wistar rats
    • Varela R.B., Valvassori S.S., Lopes-Borges J., Mariot E., Dal-Pont G.C., Amboni R.T., et al. Sodium butyrate and mood stabilizers block ouabain-induced hyperlocomotion and increase BDNF, NGF and GDNF levels in brain of Wistar rats. J. Psychiatry Res. 2015, 61:114-121.
    • (2015) J. Psychiatry Res. , vol.61 , pp. 114-121
    • Varela, R.B.1    Valvassori, S.S.2    Lopes-Borges, J.3    Mariot, E.4    Dal-Pont, G.C.5    Amboni, R.T.6
  • 47
    • 84924759788 scopus 로고    scopus 로고
    • Sodium butyrate functions as an antidepressant and improves cognition with enhanced neurotrophic expression in models of maternal deprivation and chronic mild stress
    • Valvassori S.S., Varela R.B., Arent C.O., Dal-Pont G.C., Bobsin T.S., Budni J., et al. Sodium butyrate functions as an antidepressant and improves cognition with enhanced neurotrophic expression in models of maternal deprivation and chronic mild stress. Curr. Neurovasc. Res. 2014, 11:359-366.
    • (2014) Curr. Neurovasc. Res. , vol.11 , pp. 359-366
    • Valvassori, S.S.1    Varela, R.B.2    Arent, C.O.3    Dal-Pont, G.C.4    Bobsin, T.S.5    Budni, J.6
  • 48
    • 84882452653 scopus 로고    scopus 로고
    • Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism
    • Intlekofer K.A., Berchtold N.C., Malvaez M., Carlos A.J., McQuown S.C., Cunningham M.J., et al. Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. Neuropsychopharmacology 2013, 38:2027-2034.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 2027-2034
    • Intlekofer, K.A.1    Berchtold, N.C.2    Malvaez, M.3    Carlos, A.J.4    McQuown, S.C.5    Cunningham, M.J.6
  • 49
    • 26944474790 scopus 로고    scopus 로고
    • Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum
    • Kumar A., Choi K.-H., Renthal W., Tsankova N.M., Theobald D.E.H., Truong H.-T., et al. Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 2005, 48:303-314.
    • (2005) Neuron , vol.48 , pp. 303-314
    • Kumar, A.1    Choi, K.-H.2    Renthal, W.3    Tsankova, N.M.4    Theobald, D.E.H.5    Truong, H.-T.6
  • 50
    • 84859108475 scopus 로고    scopus 로고
    • Changes in histone acetylation in the prefrontal cortex of ethanol-exposed adolescent rats are associated with ethanol-induced place conditioning
    • Pascual M., Do Couto B.R., Alfonso-Loeches S., Aguilar M.A., Rodriguez-Arias M., Guerri C. Changes in histone acetylation in the prefrontal cortex of ethanol-exposed adolescent rats are associated with ethanol-induced place conditioning. Neuropharmacology 2012, 62:2309-2319.
    • (2012) Neuropharmacology , vol.62 , pp. 2309-2319
    • Pascual, M.1    Do Couto, B.R.2    Alfonso-Loeches, S.3    Aguilar, M.A.4    Rodriguez-Arias, M.5    Guerri, C.6
  • 51
    • 84893845880 scopus 로고    scopus 로고
    • Epigenetic enhancement of brain-derived neurotrophic factor signaling pathway improves cognitive impairments induced by isoflurane exposure in aged rats
    • Ji M., Dong L., Jia M., Liu W., Zhang M., Ju L., et al. Epigenetic enhancement of brain-derived neurotrophic factor signaling pathway improves cognitive impairments induced by isoflurane exposure in aged rats. Mol. Neurobiol. 2014, 50:937-944.
    • (2014) Mol. Neurobiol. , vol.50 , pp. 937-944
    • Ji, M.1    Dong, L.2    Jia, M.3    Liu, W.4    Zhang, M.5    Ju, L.6
  • 52
    • 84908618854 scopus 로고    scopus 로고
    • Repression of contexual fear memory induced by isoflurane is accompanied by reduction in histone acetylation and rescued by sodium butyrate
    • Zhong T., Qing Q.J., Yang Y., Zou W.Y., Ye Z., Yan J.Q., et al. Repression of contexual fear memory induced by isoflurane is accompanied by reduction in histone acetylation and rescued by sodium butyrate. Br. J. Anaesth. 2014, 113:634-643.
    • (2014) Br. J. Anaesth. , vol.113 , pp. 634-643
    • Zhong, T.1    Qing, Q.J.2    Yang, Y.3    Zou, W.Y.4    Ye, Z.5    Yan, J.Q.6
  • 53
    • 68949212379 scopus 로고    scopus 로고
    • Lysine acetylation targets protein complexes and co-regulates major cellular functions
    • Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009, 325:834-840.
    • (2009) Science , vol.325 , pp. 834-840
    • Choudhary, C.1    Kumar, C.2    Gnad, F.3    Nielsen, M.L.4    Rehman, M.5    Walther, T.C.6
  • 54
    • 34248582299 scopus 로고    scopus 로고
    • C.D.81, a cell cycle regulator, is a novel target for histone deacetylase inhibition in glioma cells
    • Gensert J.M., Baranova O.V., Weinstein D.E., Ratan R.R. C.D.81, a cell cycle regulator, is a novel target for histone deacetylase inhibition in glioma cells. Neurobiol. Dis. 2007, 26:671-680.
    • (2007) Neurobiol. Dis. , vol.26 , pp. 671-680
    • Gensert, J.M.1    Baranova, O.V.2    Weinstein, D.E.3    Ratan, R.R.4
  • 55
    • 0019128183 scopus 로고
    • Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man
    • Roediger W.E. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 1980, 21:793-798.
    • (1980) Gut , vol.21 , pp. 793-798
    • Roediger, W.E.1
  • 56
    • 79955579989 scopus 로고    scopus 로고
    • The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
    • Donohoe D.R., Garge N., Zhang X., Sun W., O'Connell T.M., Bunger M.K., et al. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab. 2011, 13:517-526.
    • (2011) Cell Metab. , vol.13 , pp. 517-526
    • Donohoe, D.R.1    Garge, N.2    Zhang, X.3    Sun, W.4    O'Connell, T.M.5    Bunger, M.K.6
  • 57
    • 84870389262 scopus 로고    scopus 로고
    • The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation
    • Donohoe D.R., Collins L.B., Wali A., Bigler R., Sun W., Bultman S.J. The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Mol. Cell. 2012, 48:612-626.
    • (2012) Mol. Cell. , vol.48 , pp. 612-626
    • Donohoe, D.R.1    Collins, L.B.2    Wali, A.3    Bigler, R.4    Sun, W.5    Bultman, S.J.6
  • 58
    • 0020594056 scopus 로고
    • Regional cerebral metabolic alterations in dementia of the Alzheimer type: positron emission tomography with [18F]fluorodeoxyglucose
    • Friedland R.P., Budinger T.F., Ganz E., Yano Y., Mathis C.A., Koss B., et al. Regional cerebral metabolic alterations in dementia of the Alzheimer type: positron emission tomography with [18F]fluorodeoxyglucose. J. Comput. Assisted Tomogr. 1983, 7:590-598.
    • (1983) J. Comput. Assisted Tomogr. , vol.7 , pp. 590-598
    • Friedland, R.P.1    Budinger, T.F.2    Ganz, E.3    Yano, Y.4    Mathis, C.A.5    Koss, B.6
  • 59
    • 57649187117 scopus 로고    scopus 로고
    • Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease
    • Mosconi L., Pupi A., De Leon M.J. Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease. Ann. N. Y. Acad. Sci. 2008, 1147:180-195.
    • (2008) Ann. N. Y. Acad. Sci. , vol.1147 , pp. 180-195
    • Mosconi, L.1    Pupi, A.2    De Leon, M.J.3
  • 60
    • 69449085062 scopus 로고    scopus 로고
    • Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized double-blind, placebo-controlled, multicenter trial
    • Henderson S., Vogel J., Barr L. Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized double-blind, placebo-controlled, multicenter trial. Nutr. Metab. 2009, 6:1-25.
    • (2009) Nutr. Metab. , vol.6 , pp. 1-25
    • Henderson, S.1    Vogel, J.2    Barr, L.3
  • 61
    • 77149148756 scopus 로고    scopus 로고
    • Regulation of cellular metabolism by protein lysine acetylation
    • Zhao S., Xu W., Jiang W., Yu W., Lin Y., Zhang T., et al. Regulation of cellular metabolism by protein lysine acetylation. Science 2010, 327:1000-1004.
    • (2010) Science , vol.327 , pp. 1000-1004
    • Zhao, S.1    Xu, W.2    Jiang, W.3    Yu, W.4    Lin, Y.5    Zhang, T.6
  • 62
    • 84890547743 scopus 로고    scopus 로고
    • Sodium butyrate reverses the inhibition of Krebs cycle enzymes induced by amphetamine in the rat brain
    • Valvassori S.S., Calixto K.V., Budni J., Resende W.R., Varela R.B., de Freitas K.V., et al. Sodium butyrate reverses the inhibition of Krebs cycle enzymes induced by amphetamine in the rat brain. J. Neural Transm. 2013, 120:1737-1742.
    • (2013) J. Neural Transm. , vol.120 , pp. 1737-1742
    • Valvassori, S.S.1    Calixto, K.V.2    Budni, J.3    Resende, W.R.4    Varela, R.B.5    de Freitas, K.V.6
  • 64
    • 84915811448 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors reverse manic-like behaviors and protect the rat brain from energetic metabolic alterations induced by ouabain
    • Lopes-Borges J., Valvassori S.S., Varela R.B., Tonin P.T., Vieira J.S., Gonçalves C.L., et al. Histone deacetylase inhibitors reverse manic-like behaviors and protect the rat brain from energetic metabolic alterations induced by ouabain. Pharmacol. Biochem. Behav. 2015, 128:89-95.
    • (2015) Pharmacol. Biochem. Behav. , vol.128 , pp. 89-95
    • Lopes-Borges, J.1    Valvassori, S.S.2    Varela, R.B.3    Tonin, P.T.4    Vieira, J.S.5    Gonçalves, C.L.6
  • 65
    • 79957562543 scopus 로고    scopus 로고
    • G protein-coupled receptors: mutations and endocrine diseases
    • Vassart G., Costagliola S. G protein-coupled receptors: mutations and endocrine diseases. Nat. Rev. Endocrinol. 2011, 7:362-372.
    • (2011) Nat. Rev. Endocrinol. , vol.7 , pp. 362-372
    • Vassart, G.1    Costagliola, S.2
  • 66
    • 0038363378 scopus 로고    scopus 로고
    • The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
    • Brown A.J., Goldsworthy S.M., Barnes A.A., Eilert M.M., Tcheang L., Daniels D., et al. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J. Biol. Chem. 2003, 278:11312-11319.
    • (2003) J. Biol. Chem. , vol.278 , pp. 11312-11319
    • Brown, A.J.1    Goldsworthy, S.M.2    Barnes, A.A.3    Eilert, M.M.4    Tcheang, L.5    Daniels, D.6
  • 67
    • 79956348319 scopus 로고    scopus 로고
    • Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)
    • Kimura I., Inoue D., Maeda T., Hara T., Ichimura A., Miyauchi S., et al. Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proc. Natl. Acad. Sci. U. S. A. 2011, 108:8030-8035.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 8030-8035
    • Kimura, I.1    Inoue, D.2    Maeda, T.3    Hara, T.4    Ichimura, A.5    Miyauchi, S.6
  • 68
    • 84892814749 scopus 로고    scopus 로고
    • Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits
    • De Vadder F., Kovatcheva-Datchary P., Goncalves D., Vinera J., Zitoun C., Duchampt A., et al. Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell 2014, 156:84-96.
    • (2014) Cell , vol.156 , pp. 84-96
    • De Vadder, F.1    Kovatcheva-Datchary, P.2    Goncalves, D.3    Vinera, J.4    Zitoun, C.5    Duchampt, A.6
  • 69
    • 66149084058 scopus 로고    scopus 로고
    • GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon
    • Thangaraju M., Cresci G.A., Liu K., Ananth S., Gnanaprakasam J.P., Browning D.D., et al. GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon. Cancer Res. 2009, 69:2826-2832.
    • (2009) Cancer Res. , vol.69 , pp. 2826-2832
    • Thangaraju, M.1    Cresci, G.A.2    Liu, K.3    Ananth, S.4    Gnanaprakasam, J.P.5    Browning, D.D.6
  • 72
    • 84924862058 scopus 로고    scopus 로고
    • Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson's disease models are mediated by GPR109A-dependent mechanisms
    • Fu S.-P., Wang J.-F., Xue W.-J., Liu H.-M., Liu B., Zeng Y.-L., et al. Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson's disease models are mediated by GPR109A-dependent mechanisms. J. Neuroinflammation 2015, 12:1-14.
    • (2015) J. Neuroinflammation , vol.12 , pp. 1-14
    • Fu, S.-P.1    Wang, J.-F.2    Xue, W.-J.3    Liu, H.-M.4    Liu, B.5    Zeng, Y.-L.6
  • 73
    • 84889078129 scopus 로고    scopus 로고
    • β-Hydroxybutyrate modulates N-type calcium channels in rat sympathetic neurons by acting as an agonist for the G-protein-coupled receptor FFA3
    • Won Y.-J., Lu V.B., Puhl H.L., Ikeda S.R. β-Hydroxybutyrate modulates N-type calcium channels in rat sympathetic neurons by acting as an agonist for the G-protein-coupled receptor FFA3. J. Neurosci. 2013, 33:19314-19325.
    • (2013) J. Neurosci. , vol.33 , pp. 19314-19325
    • Won, Y.-J.1    Lu, V.B.2    Puhl, H.L.3    Ikeda, S.R.4
  • 74
    • 77951214977 scopus 로고    scopus 로고
    • The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects
    • Tarini J., Wolever T.M.S. The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects. Appl. Physiol. Nutr. Metab. 2010, 35:9-16.
    • (2010) Appl. Physiol. Nutr. Metab. , vol.35 , pp. 9-16
    • Tarini, J.1    Wolever, T.M.S.2
  • 75
    • 0033852616 scopus 로고    scopus 로고
    • Acarbose raises serum butyrate in human subjects withimpaired glucose tolerance
    • Wolever T.M.S., Chiasson J.-L. Acarbose raises serum butyrate in human subjects withimpaired glucose tolerance. Br. J. Nutr. 2000, 84:57-61.
    • (2000) Br. J. Nutr. , vol.84 , pp. 57-61
    • Wolever, T.M.S.1    Chiasson, J.-L.2
  • 76
    • 74049163780 scopus 로고    scopus 로고
    • Factors related to colonic fermentation of nondigestible carbohydrates of a previous evening meal increase tissue glucose uptake and moderate glucose-associated inflammation
    • Priebe M.G., Wang H., Weening D., Schepers M., Preston T., Vonk R.J. Factors related to colonic fermentation of nondigestible carbohydrates of a previous evening meal increase tissue glucose uptake and moderate glucose-associated inflammation. Am. J. Clin. Nutr. 2010, 91:90-97.
    • (2010) Am. J. Clin. Nutr. , vol.91 , pp. 90-97
    • Priebe, M.G.1    Wang, H.2    Weening, D.3    Schepers, M.4    Preston, T.5    Vonk, R.J.6
  • 77
    • 27244434038 scopus 로고    scopus 로고
    • Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism
    • Robertson M.D., Bickerton A.S., Dennis A.L., Vidal H., Frayn K.N. Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Am. J. Clin. Nutr. 2005, 82:559-567.
    • (2005) Am. J. Clin. Nutr. , vol.82 , pp. 559-567
    • Robertson, M.D.1    Bickerton, A.S.2    Dennis, A.L.3    Vidal, H.4    Frayn, K.N.5
  • 79
    • 77951878716 scopus 로고    scopus 로고
    • Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber pectin, through up-regulation of IL-4 and Th2 polarization
    • Sherry C.L., Kim S.S., Dilger R.N., Bauer L.L., Moon M.L., Tapping R.I., et al. Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber pectin, through up-regulation of IL-4 and Th2 polarization. Brain. Behav. Immun. 2010, 24:631-640.
    • (2010) Brain. Behav. Immun. , vol.24 , pp. 631-640
    • Sherry, C.L.1    Kim, S.S.2    Dilger, R.N.3    Bauer, L.L.4    Moon, M.L.5    Tapping, R.I.6
  • 80
    • 84919742335 scopus 로고    scopus 로고
    • Dietary fiber is positively associated with cognitive control among prepubertal children
    • Khan N.A., Raine L.B., Drollette E.S., Scudder M.R., Kramer A.F., Hillman C.H. Dietary fiber is positively associated with cognitive control among prepubertal children. J. Nutr. 2015, 145:143-149.
    • (2015) J. Nutr. , vol.145 , pp. 143-149
    • Khan, N.A.1    Raine, L.B.2    Drollette, E.S.3    Scudder, M.R.4    Kramer, A.F.5    Hillman, C.H.6
  • 81
    • 79953160733 scopus 로고    scopus 로고
    • Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects
    • Messaoudi M., Lalonde R., Violle N., Javelot H., Desor D., Nejdi A., et al. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br. J. Nutr. 2010, 105:755-764.
    • (2010) Br. J. Nutr. , vol.105 , pp. 755-764
    • Messaoudi, M.1    Lalonde, R.2    Violle, N.3    Javelot, H.4    Desor, D.5    Nejdi, A.6
  • 82
    • 72449188746 scopus 로고    scopus 로고
    • A randomized double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome
    • Rao A.V., Bested A.C., Beaulne T.M., Katzman M.A., Iorio C., Berardi J.M., et al. A randomized double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog. 2009, 1:1-6.
    • (2009) Gut Pathog. , vol.1 , pp. 1-6
    • Rao, A.V.1    Bested, A.C.2    Beaulne, T.M.3    Katzman, M.A.4    Iorio, C.5    Berardi, J.M.6
  • 83
    • 84878287270 scopus 로고    scopus 로고
    • Consumption of fermented milk product with probiotic modulates brain activity
    • Tillisch K., Labus J., Kilpatrick L., Jiang Z., Stains J., Ebrat B., et al. Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology 2013, 144:1394-1401.
    • (2013) Gastroenterology , vol.144 , pp. 1394-1401
    • Tillisch, K.1    Labus, J.2    Kilpatrick, L.3    Jiang, Z.4    Stains, J.5    Ebrat, B.6
  • 84
    • 79952582127 scopus 로고    scopus 로고
    • Gastrointestinal flora and gastrointestinal status in children with autism-comparisons to typical children and correlation with autism severity
    • Adams J.B., Johansen L.J., Powell L.D., Quig D., Rubin R.A. Gastrointestinal flora and gastrointestinal status in children with autism-comparisons to typical children and correlation with autism severity. BMC Gastroenterol. 2011, 11:1-13.
    • (2011) BMC Gastroenterol. , vol.11 , pp. 1-13
    • Adams, J.B.1    Johansen, L.J.2    Powell, L.D.3    Quig, D.4    Rubin, R.A.5
  • 85
    • 84879760435 scopus 로고    scopus 로고
    • Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children
    • Kang D.-W., Park J.G., Ilhan Z.E., Wallstrom G., Labaer J., Adams J.B., et al. Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children. PLoS One 2013, 8:e68322.
    • (2013) PLoS One , vol.8 , pp. e68322
    • Kang, D.-W.1    Park, J.G.2    Ilhan, Z.E.3    Wallstrom, G.4    Labaer, J.5    Adams, J.B.6
  • 87
    • 84857874680 scopus 로고    scopus 로고
    • Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances
    • Williams B.L., Hornig M., Parekh T., Lipkin W.I. Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. MBio 2012, 3:e00261-11.
    • (2012) MBio , vol.3 , pp. e00261-e00211
    • Williams, B.L.1    Hornig, M.2    Parekh, T.3    Lipkin, W.I.4
  • 89
    • 84866417257 scopus 로고    scopus 로고
    • Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder
    • Wang L., Christophersen C.T., Sorich M.J., Gerber J.P., Angley M.T., Conlon M.A. Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder. Dig. Dis. Sci. 2012, 57:2096-2102.
    • (2012) Dig. Dis. Sci. , vol.57 , pp. 2096-2102
    • Wang, L.1    Christophersen, C.T.2    Sorich, M.J.3    Gerber, J.P.4    Angley, M.T.5    Conlon, M.A.6
  • 90
    • 33845391588 scopus 로고    scopus 로고
    • Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders
    • MacFabe D.F., Cain D.P., Rodriguez-Capote K., Franklin A.E., Hoffman J.E., Boon F., et al. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behav. Brain Res. 2007, 176:149-169.
    • (2007) Behav. Brain Res. , vol.176 , pp. 149-169
    • MacFabe, D.F.1    Cain, D.P.2    Rodriguez-Capote, K.3    Franklin, A.E.4    Hoffman, J.E.5    Boon, F.6
  • 91
    • 78049463483 scopus 로고    scopus 로고
    • Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: relevance to autism spectrum disorder
    • MacFabe D.F., Cain N.E., Boon F., Ossenkopp K.-P., Cain D.P. Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: relevance to autism spectrum disorder. Behav. Brain Res. 2011, 217:47-54.
    • (2011) Behav. Brain Res. , vol.217 , pp. 47-54
    • MacFabe, D.F.1    Cain, N.E.2    Boon, F.3    Ossenkopp, K.-P.4    Cain, D.P.5
  • 92
    • 77949667960 scopus 로고    scopus 로고
    • Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders
    • Thomas R.H., Foley K.A., Mepham J.R., Tichenoff L.J., Possmayer F., MacFabe D.F. Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders. J. Neurochem. 2010, 113:515-529.
    • (2010) J. Neurochem. , vol.113 , pp. 515-529
    • Thomas, R.H.1    Foley, K.A.2    Mepham, J.R.3    Tichenoff, L.J.4    Possmayer, F.5    MacFabe, D.F.6
  • 93
    • 84859930091 scopus 로고    scopus 로고
    • Etiology of autistic features: the persisting neurotoxic effects of propionic acid
    • El-Ansary A.K., Ben Bacha A., Kotb M. Etiology of autistic features: the persisting neurotoxic effects of propionic acid. J. Neuroinflammation 2012, 9:1-14.
    • (2012) J. Neuroinflammation , vol.9 , pp. 1-14
    • El-Ansary, A.K.1    Ben Bacha, A.2    Kotb, M.3
  • 95
    • 41949122332 scopus 로고    scopus 로고
    • A novel rodent model of autism: intraventricular infusions of propionic acid increase locomotor activity and induce neuroinflammation and oxidative stress in discrete regions of adult rat brain
    • MacFabe D.F., Rodriguez- K., Hoffman J.E., Franklin A.E., Mohammad-A Y., Taylor A.R., et al. A novel rodent model of autism: intraventricular infusions of propionic acid increase locomotor activity and induce neuroinflammation and oxidative stress in discrete regions of adult rat brain. Am. J. Biochem. Biotechnol 2008, 4:146-166.
    • (2008) Am. J. Biochem. Biotechnol , vol.4 , pp. 146-166
    • MacFabe, D.F.1    Rodriguez-, K.2    Hoffman, J.E.3    Franklin, A.E.4    Mohammad-A, Y.5    Taylor, A.R.6
  • 96
    • 62649112890 scopus 로고    scopus 로고
    • Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the long-Evans rat: further development of a rodent model of autism
    • Shultz S.R., MacFabe D.F., Martin S., Jackson J., Taylor R., Boon F., et al. Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the long-Evans rat: further development of a rodent model of autism. Behav. Brain Res. 2009, 200:33-41.
    • (2009) Behav. Brain Res. , vol.200 , pp. 33-41
    • Shultz, S.R.1    MacFabe, D.F.2    Martin, S.3    Jackson, J.4    Taylor, R.5    Boon, F.6
  • 97
    • 11144259318 scopus 로고    scopus 로고
    • Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism
    • Schneider T., Przewłocki R. Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism. Neuropsychopharmacology 2005, 30:80-89.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 80-89
    • Schneider, T.1    Przewłocki, R.2
  • 98
    • 0034612151 scopus 로고    scopus 로고
    • Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism
    • Ingram J.L., Peckham S.M., Tisdale B., Rodier P.M. Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism. Neurotoxicol. Teratol. 2000, 22:319-324.
    • (2000) Neurotoxicol. Teratol. , vol.22 , pp. 319-324
    • Ingram, J.L.1    Peckham, S.M.2    Tisdale, B.3    Rodier, P.M.4
  • 99
  • 100
    • 84885761570 scopus 로고    scopus 로고
    • Acute prenatal exposure to a moderate Dose of valproic acid increases social behavior and alters gene expression in rats
    • Cohen O.S., Varlinskaya E.I., Wilson C.A., Glatt S.J., Mooney S.M. Acute prenatal exposure to a moderate Dose of valproic acid increases social behavior and alters gene expression in rats. Int. J. Dev. Neurosci. 2013, 31:740-750.
    • (2013) Int. J. Dev. Neurosci. , vol.31 , pp. 740-750
    • Cohen, O.S.1    Varlinskaya, E.I.2    Wilson, C.A.3    Glatt, S.J.4    Mooney, S.M.5
  • 102
    • 0032067472 scopus 로고    scopus 로고
    • Butyric acid from the diet: actions at the level of gene expression
    • Smith J.G., Yokoyama W.H., German J.B. Butyric acid from the diet: actions at the level of gene expression. Crit. Rev. Food Sci. Nutr. 1998, 38:259-297.
    • (1998) Crit. Rev. Food Sci. Nutr. , vol.38 , pp. 259-297
    • Smith, J.G.1    Yokoyama, W.H.2    German, J.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.