Persistent microbiome alterations modulate the rate of post-dieting weight regain

Nature

Volumn 540, Issue 7634, 2016, Pages 544-551

  Thaiss, Christoph A ^a   Itav, Shlomik ^a   Rothschild, Daphna ^a   Meijer, Mariska T ^a   Levy, Maayan ^a   Moresi, Claudia ^a   Dohnalová, Lenka ^a   Braverman, Sofia ^a   Rozin, Shachar ^a   Malitsky, Sergey ^a   Dori Bachash, Mally ^a   Kuperman, Yael ^a   Biton, Inbal ^a   Gertler, Arieh ^b   Harmelin, Alon ^a   Shapiro, Hagit ^a   Halpern, Zamir ^c,d   Aharoni, Asaph ^a   Segal, Eran ^a   Elinav, Eran ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

^d TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

FLAVONOID;

ALGORITHM; EXPERIMENTAL STUDY; MACHINE LEARNING; OBESITY; PHENOTYPE; RODENT; WEIGHT;

ACCELERATION; ALGORITHM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET; DIET INDUCED OBESITY; FEMALE; GERMFREE MOUSE; INTESTINE FLORA; MACHINE LEARNING; MALE; MOUSE; NONHUMAN; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; WEIGHT GAIN;

MUS;

EID: 85016260961     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature20796     Document Type: Article

References (34)

1. Stevens, J., Oakkar, E. E., Cui, Z., Cai, J., Truesdale, K. P. US adults recommended for weight reduction by 1998 and 2013 obesity guidelines, NHANES 2007-2012. Obesity (Silver Spring) 23, 527-531 (2015).
2. Anastasiou, C. A., Karfopoulou, E., Yannakoulia, M. Weight regaining: From statistics and behaviors to physiology and metabolism. Metabolism 64, 1395-1407 (2015).
3. Pietilaïnen, K. H., Saarni, S. E., Kaprio, J., Rissanen, A. Does dieting make you fat A twin study. Int. J. Obes. 36, 456-464 (2012).
4. Neumark-Sztainer, D., et al. Obesity, disordered eating, eating disorders in a longitudinal study of adolescents: How do dieters fare 5 years later J. Am. Diet. Assoc. 106, 559-568 (2006).
5. Saarni, S. E., Rissanen, A., Sarna, S., Koskenvuo, M., Kaprio, J. Weight cycling of athletes and subsequent weight gain in middleage. Int. J. Obes. 30, 1639-1644 (2006).
6. Dulloo, A. G., Montani, J. P. Pathways from dieting to weight regain, to obesity and to the metabolic syndrome: An overview. Obes. Rev. 16 (Suppl 1), 1-6 (2015).
7. Mehta, T., Smith, D. L., Jr, Muhammad, J., Casazza, K. Impact of weight cycling on risk of morbidity and mortality. Obes. Rev. 15, 870-881 (2014).
8. Turnbaugh, P. J., et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031 (2006).
9. Ridaura, V. K., et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341, 1241214 (2013).
10. Korem, T., et al. Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples. Science 349, 1101-1106 (2015).
11. David, L. A., et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 505, 559-563 (2014).
12. Liu, J., Lee, J., Salazar Hernandez, M. A., Mazitschek, R., Ozcan, U. Treatment of obesity with celastrol. Cell 161, 999-1011 (2015).
13. Elinav, E., et al. Pegylated leptin antagonist is a potent orexigenic agent: Preparation and mechanism of activity. Endocrinology 150, 3083-3091 (2009).
14. Shpilman, M., et al. Development and characterization of high affinity leptins and leptin antagonists. J. Biol. Chem. 286, 4429-4442 (2011).
15. Braune, A., Blaut, M. Bacterial species involved in the conversion of dietary flavonoids in the human gut. Gut Microbes 7, 216-234 (2016).
16. Myoung, H. J., Kim, G., Nam, K. W. Apigenin isolated from the seeds of Perilla frutescens britton var crispa (Benth.) inhibits food intake in C57BL/6J mice. Arch. Pharm. Res. 33, 1741-1746 (2010).
17. Guo, X., Liu, J., Cai, S., Wang, O., Ji, B. Synergistic interactions of apigenin, naringin, quercetin and emodin on inhibition of 3T3-L1 preadipocyte differentiation and pancreas lipase activity. Obes. Res. Clin. Pract. 10, 327-339 (2016).
18. Assini, J. M., et al. Naringenin prevents obesity, hepatic steatosis, glucose intolerance in male mice independent of fibroblast growth factor 21. Endocrinology 156, 2087-2102 (2015).
19. Hoek-van den Hil, E. F., et al. Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice. Genes Nutr. 10, 469 (2015).
20. Goldwasser, J., et al. Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: Role of PPAR, PPAR and LXR. PLoS One 5, e12399 (2010).
21. Kudo, N., et al. A single oral administration of theaflavins increases energy expenditure and the expression of metabolic genes. PLoS One 10, e0137809 (2015).
22. Choi, J. H., Yun, J. W. Chrysin induces brown fat-like phenotype and enhances lipid metabolism in 3T3-L1 adipocytes. Nutrition 32, 1002-1010 (2016).
23. Suárez-Zamorano, N., et al. Microbiota depletion promotes browning of white adipose tissue and reduces obesity. Nat. Med. 21, 1497-1501 (2015).
24. Carmody, R. N., et al. Diet dominates host genotype in shaping the murine gut microbiota. Cell Host Microbe 17, 72-84 (2015).
25. Sonnenburg, E. D., et al. Diet-induced extinctions in the gut microbiota compound over generations. Nature 529, 212-215 (2016).
26. Montani, J. P., Schutz, Y., Dulloo, A. G. Dieting and weight cycling as risk factors for cardiometabolic diseases: Who is really at risk Obes. Rev. 16 (Suppl 1), 7-18 (2015).
27. Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., Medzhitov, R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241 (2004).
28. Caporaso, J. G., et al. QIIME allows analysis of high-throughput community sequencing data. Nat. Methods 7, 335-336 (2010).
29. Thaiss, C. A., et al. Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell 159, 514-529 (2014).
30. Levy, M., et al. Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling. Cell 163, 1428-1443 (2015).
31. Li, J., et al. An integrated catalog of reference genes in the human gut microbiome. Nat. Biotechnol. 32, 834-841 (2014).
32. Kanehisa, M., Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27-30 (2000).
33. Bolger, A. M., Lohse, M., Usadel, B. Trimmomatic: A flexible trimmer for Illumina sequence data. Bioinformatics 30, 2114-2120 (2014).
34. Marco-Sola, S., Sammeth, M., Guigó, R., Ribeca, P. The GEM mapper: Fast, accurate and versatile alignment by filtration. Nat. Methods 9, 1185-1188 (2012).