The prebiotic, oligofructose-enriched inulin modulates the faecal metabolite profile: An in vitro analysis

Molecular Nutrition and Food Research

Volumn 54, Issue 12, 2010, Pages 1791-1801

  De Preter, Vicky ^a   Falony, Gwen ^b   Windey, Karen ^a   Hamer, Henrike M ^a   De Vuyst, Luc ^b   Verbeke, Kristin ^a  

^a LEUVEN FOOD SCIENCE AND NUTRITION RESEARCH CENTRE LFORCE   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Metabolomics; Prebiotic; Protein fermentation; SCFA

Indexed keywords

FRUCTOSE OLIGOSACCHARIDE; INULIN; OLIGOSACCHARIDE; PREBIOTIC AGENT; VOLATILE FATTY ACID; VOLATILE ORGANIC COMPOUND;

ADOLESCENT; ADULT; ARTICLE; BIFIDOBACTERIUM; CHEMISTRY; COLON; FECES; FEMALE; FERMENTATION; HUMAN; ISOLATION AND PURIFICATION; MALE; METABOLISM; MICROBIOLOGY; MULTIVARIATE ANALYSIS;

ADOLESCENT; ADULT; BIFIDOBACTERIUM; COLON; FATTY ACIDS, VOLATILE; FECES; FEMALE; FERMENTATION; HUMANS; INULIN; MALE; MULTIVARIATE ANALYSIS; OLIGOSACCHARIDES; PREBIOTICS; VOLATILE ORGANIC COMPOUNDS; YOUNG ADULT;

EID: 78649820558     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201000136     Document Type: Article

References (45)

1. Falony, G., De Vuyst, L., in: Charalampopoulos, D., Rastall, R. A. (Eds.), Ecological Interactions of Bacteria in the Human Gut - Prebiotics and Probiotics Science and Technology, Springer Verlag, Heidelberg, Germany 2009, pp. 641-682.
2. Delzenne, N. M., Williams, C. M., Prebiotics and lipid metabolism. Curr. Opin. Lipidol. 2002, 13, 61-67.
3. Nyman, M., Fermentation and bulking capacity of indigestible carbohydrates: the case of inulin and oligofructose. Br. J. Nutr. 2002, 87, S163-S168.
4. Roberfroid, M. B., Introducing inulin-type fructans. Br. J. Nutr. 2006, 93, S13-S25.
5. De Preter, V., Vanhoutte, T., Huys, G., Swings, J. et al., Baseline microbiota activity and influence responses to prebiotic initial bifidobacteria counts dosing in healthy subjects. Aliment. Pharmacol. Ther. 2008, 27, 504-513.
6. Gibson, G. R., Probert, H. M., Van Loo, J., Rastall, R. A., Roberfroid, M. B., Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr. Res. Rev. 2004, 17, 259-275.
7. Kolida, S., Tuohy, K., Gibson, G. R., Prebiotic effects of inulin and oligofructose. Br. J. Nutr. 2002, 87, S193-S197.
8. Roberfroid, M. B., Van Loo, J. A., Gibson, G. R., The bifidogenic nature of chicory inulin and its hydrolysis products. J. Nutr. 1998, 128, 11-19.
9. Guarner, F., Inulin and oligofructose: impact on intestinal diseases and disorders. Br. J. Nutr. 2006, 93, S61-S65.
10. Wang, X., Gibson, G. R., Effects of the in-vitro fermentation of oligofructose and inulin by bacteria growing in the human large-intestine. J. Appl. Bacteriol. 1993, 75, 373-380.
11. Roediger, W. E. W., Role of anaerobic-bacteria in the metabolic welfare of the colonic mucosa in man. Gut 1980, 21, 793-798.
12. Hughes, R., Magee, E. A., Bingham, S., Protein degradation in the large intestine: relevance to colorectal cancer. Curr. Issues Intest. Microbiol. 2000, 1, 51-58.
13. Bammens, B., Evenepoel, P., Keuleers, H., Verbeke, K., Vanrenterghem, Y., Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients. Kidney Int. 2006, 69, 1081-1087.
14. Muir, J. G., Walker, K. Z., Kaimakamis, M. A., Cameron, M.-A. et al., Modulation of fecal markers relevant to colon cancer risk: a high-starch Chinese diet did not generate expected beneficial changes relative to a western-type diet. Am. J. Clin. Nutr. 1998, 68, 372-379.
15. Bone, E., Tamm, A., Hill, M., Production of urinary phenols by gut bacteria and their possible role in causation of large bowel cancer. Am. J. Clin. Nutr. 1976, 29, 1448-1454.
16. Meijers, B. K., De Preter, V., Verbeke, K., Vanrenterghem, Y., Evenepoel, P., p-Cresyl sulfate serum concentrations in haemodialysis patients are reduced by the prebiotic oligofructose-enriched inulin. Nephrol. Dial. Transplant. 2009, 25, 219-224.
17. Roediger, W. E. W., Duncan, A., Kapaniris, O., Millard, S., Reducing sulfur-compounds of the colon impair colonocyte nutrition - implications for ulcerative-colitis. Gastroenterology 1993, 104, 802-809.
18. De Preter, V., Van Staeyen, G., Esser, D., Rutgeerts, P., Verbeke, K., Development of a screening method to determine the pattern of fermentation metabolites in faecal samples using on-line purge-and-trap gas chromatographic-mass spectrometric analysis. J. Chromatogr. A 2009, 1216, 1476-1483.
19. Pedreschi, R., Vanstreels, E., Carpentier, S., Hertog, M. et al., Proteomic analysis of core breakdown disorder in Conference pears (Pyrus communis L.). Proteomics 2007, 7, 2083-2099.
20. Geypens, B., Claus, D., Evenepoel, P., Hiele, M. et al., Influence of dietary protein supplements on the formation of bacterial metabolites in the colon. Gut 1997, 41, 70-76.
21. Garner, C. E., Smith, S., Costello, B. D., White, P. et al., Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease. FASEB J. 2007, 21, 1675-1688.
22. Probert, C. S. J., Jones, P. R. H., Ratcliffe, N. M., A novel method for rapidly diagnosing the causes of diarrhoea. Gut 2004, 53, 58-61.
23. Morrison, D. J., Mackay, W. G., Edwards, C. A., Preston, T. et al., Butyrate production from oligofructose fermentation by the human faecal flora: what is the contribution of extracellular acetate and lactate? Br. J. Nutr. 2006, 96, 570-577.
24. Pompei, A., Cordisco, L., Raimondi, S., Amaretti, A. et al., In vitro comparison of the prebiotic effects of two inulin-type fructans. Anaerobe 2008, 14, 280-286.
25. Rycroft, C. E., Jones, M. R., Gibson, G. R., Rastall, R. A., A comparative in vitro evaluation of the fermentation properties of prebiotic oligosaccharides. J. Appl. Microbiol. 2001, 91, 878-887.
26. Stewart, M. L., Timm, D. A., Slavin, J. L., Fructooligosaccharides exhibit more rapid fermentation than long-chain inulin in an in vitro fermentation system. Nutr. Res. 2008, 28, 329-334.
27. Van de Wiele, T., Boon, N., Possemiers, S., Jacobs, H., Verstraete, W., Inulin-type fructans of longer degree of polymerization exert more pronounced in vitro prebiotic effects. J. Appl. Microbiol. 2007, 102, 452-460.
28. Cherbut, C., Aube, A. C., Blottiere, H. M., Galmiche, J. P. et al., Effects of short-chain fatty acids on gastrointestinal motility. Scand. J. Gastroenterol. 1997, 32, 58-61.
29. Duncan, S. H., Louis, P., Thomson, J. M., Flint, H. J. et al., The role of pH in determining the species composition of the human colonic microbiota. Environ. Microbiol. 2009, 11, 2112-2122.
30. Louis, P., Flint, H. J., Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. FEMS Microbiol. Lett. 2009, 294, 1-8.
31. Falony, G., Verschaeren, A., De Bruycker, F., De Preter, V. et al., In vitro kinetics of prebiotic inulin-type fructan fermentation by butyrate-producing colon bacteria: implementation of online gas chromatography for quantitative analysis of carbon dioxide and hydrogen gas production. Appl. Environ. Microbiol. 2009, 75, 5884-5892.
32. Scheppach, W., Luehrs, H., Menzel, T., Beneficial health effects of low-digestible carbohydrate consumption. Br. J. Nutr. 2001, 85, S23-S30.
33. Topping, D. L., Fukushima, M., Bird, A. R., Resistant starch as a prebiotic and synbiotic: state of the art. Proc. Nutr. Soc. 2003, 62, 171-176.
34. Gibson, G. R., Macfarlane, G. T., Cummings, J. H., Sulfate reducing bacteria and hydrogen metabolism in the human large-intestine. Gut 1993, 34, 437-439.
35. Roediger, W. E. W., Duncan, A., Kapaniris, O., Millard, S., Sulfide impairment of substrate oxidation in rat colonocytes - a biochemical basis for ulcerative-colitis. Clin. Sci. 1993, 85, 623-627.
36. Levine, J., Ellis, C. J., Furne, J. K., Springfield, J., Levitt, M. D., Fecal hydrogen sulfide production in ulcerative colitis. Am. J. Gastroenterol. 1998, 93, 83-87.
37. Pitcher, M. C. L., Cummings, J. H., Hydrogen sulphide: a bacterial toxin in ulcerative colitis? Gut 1996, 39, 1-4.
38. Ramasamy, S., Singh, S., Taniere, P., Langmann, M. J. S., Eggo, M. C., Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation. Am. J. Physiol. Gastrintest. Liver Physiol. 2006, 291, G288-G296.
39. Suarez, F. L., Springfield, J., Levitt, M. D., Identification of gases responsible for the odour of human flatus and evaluation of a device purported to reduce this odour. Gut 1998, 43, 100-104.
40. Macfarlane, G. T., Allison, C., Gibson, G. R., Effect of Ph on protease activities in the large-intestine. Lett. Appl. Microbiol. 1988, 7, 161-164.
41. Vince, A. J., Burridge, S. M., Ammonia production by intestinal bacteria: the effects of lactose, lactulose and glucose. J. Med. Microbiol. 1980, 13, 177-191.
42. Lewis, S., Brazier, J., Beard, D., Nazem, N., Proctor, D., Effects of metronidazole and oligofructose on faecal concentrations of sulphate-reducing bacteria and their activity in human volunteers. Scand. J. Gastroenterol. 2005, 40, 1296-1303.
43. Swanson, K. S., Grieshop, C. M., Flickinger, E. A., Bauer, L. L. et al., Fructooligosaccharides and Lactobacillus acidophilus modify bowel function and protein catabolites excreted by healthy humans. J. Nutr. 2002, 132, 3042-3050.
44. Marquet, P., Duncan, S. H., Chassard, C., Bernalier-Donadille, A., Flint, H. J., Lactate has the potential to promote hydrogen sulphide formation in the human colon. FEMS Microbiol. Lett. 2009, 299, 128-134.
45. Macfarlane, G. T., Cummings, J. H., Allison, C., Protein-degradation by human intestinal bacteria. J. Gen. Microbiol. 1986, 132, 1647-1656.