-
1
-
-
84894196760
-
Inflammasomes and metabolic disease
-
1 Henao-Mejia, J., et al. Inflammasomes and metabolic disease. Annu. Rev. Physiol. 76 (2014), 57–78.
-
(2014)
Annu. Rev. Physiol.
, vol.76
, pp. 57-78
-
-
Henao-Mejia, J.1
-
2
-
-
84949091051
-
Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion
-
2 He, W.T., et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion. Cell Res. 25 (2015), 1285–1298.
-
(2015)
Cell Res.
, vol.25
, pp. 1285-1298
-
-
He, W.T.1
-
3
-
-
84942856523
-
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
-
3 Kayagaki, N., et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526 (2015), 666–671.
-
(2015)
Nature
, vol.526
, pp. 666-671
-
-
Kayagaki, N.1
-
4
-
-
84978374487
-
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
-
4 Liu, X., et al. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 535 (2016), 153–158.
-
(2016)
Nature
, vol.535
, pp. 153-158
-
-
Liu, X.1
-
5
-
-
84942892037
-
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
-
5 Shi, J., et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526 (2015), 660–665.
-
(2015)
Nature
, vol.526
, pp. 660-665
-
-
Shi, J.1
-
6
-
-
84967309806
-
Integration of innate immune signaling
-
6 Thaiss, C.A., et al. Integration of innate immune signaling. Trends Immunol. 37 (2016), 84–101.
-
(2016)
Trends Immunol.
, vol.37
, pp. 84-101
-
-
Thaiss, C.A.1
-
7
-
-
84881627553
-
The expanding role of NLRs in antiviral immunity
-
7 Lupfer, C., Kanneganti, T.D., The expanding role of NLRs in antiviral immunity. Immunol. Rev. 255 (2013), 13–24.
-
(2013)
Immunol. Rev.
, vol.255
, pp. 13-24
-
-
Lupfer, C.1
Kanneganti, T.D.2
-
8
-
-
18644368579
-
Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1
-
8 Grenier, J.M., et al. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. FEBS Lett. 530 (2002), 73–78.
-
(2002)
FEBS Lett.
, vol.530
, pp. 73-78
-
-
Grenier, J.M.1
-
9
-
-
79957576718
-
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
-
9 Elinav, E., et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145 (2011), 745–757.
-
(2011)
Cell
, vol.145
, pp. 745-757
-
-
Elinav, E.1
-
10
-
-
79959369355
-
Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury
-
10 Normand, S., et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 9601–9606.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 9601-9606
-
-
Normand, S.1
-
11
-
-
79959540809
-
A functional role for Nlrp6 in intestinal inflammation and tumorigenesis
-
11 Chen, G.Y., et al. A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J. Immunol. 186 (2011), 7187–7194.
-
(2011)
J. Immunol.
, vol.186
, pp. 7187-7194
-
-
Chen, G.Y.1
-
12
-
-
84924299302
-
The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling
-
12 Gremel, G., et al. The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling. J. Gastroenterol. 50 (2015), 46–57.
-
(2015)
J. Gastroenterol.
, vol.50
, pp. 46-57
-
-
Gremel, G.1
-
13
-
-
84896691062
-
NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion
-
13 Wlodarska, M., et al. NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell 156 (2014), 1045–1059.
-
(2014)
Cell
, vol.156
, pp. 1045-1059
-
-
Wlodarska, M.1
-
14
-
-
84949255269
-
Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling
-
14 Levy, M., et al. Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling. Cell 163 (2015), 1428–1443.
-
(2015)
Cell
, vol.163
, pp. 1428-1443
-
-
Levy, M.1
-
15
-
-
79251558406
-
Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine
-
15 Kempster, S.L., et al. Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 300 (2011), G253–G263.
-
(2011)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.300
, pp. G253-G263
-
-
Kempster, S.L.1
-
16
-
-
84990846993
-
Host-protozoan interactions protect from mucosal infections through activation of the inflammasome
-
16 Chudnovskiy, A., et al. Host-protozoan interactions protect from mucosal infections through activation of the inflammasome. Cell 167 (2016), 444–456.
-
(2016)
Cell
, vol.167
, pp. 444-456
-
-
Chudnovskiy, A.1
-
17
-
-
84876713274
-
Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice
-
17 Sun, Y., et al. Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice. Gastroenterology 144 (2013), 1478–1487.
-
(2013)
Gastroenterology
, vol.144
, pp. 1478-1487
-
-
Sun, Y.1
-
18
-
-
54449083567
-
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
-
18 Johansson, M.E., et al. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc. Natl. Acad. Sci. U. S. A. 105 (2008), 15064–15069.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 15064-15069
-
-
Johansson, M.E.1
-
19
-
-
84963611503
-
Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia
-
19 Okumura, R., et al. Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. Nature 532 (2016), 117–121.
-
(2016)
Nature
, vol.532
, pp. 117-121
-
-
Okumura, R.1
-
20
-
-
80054122238
-
The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine
-
20 Vaishnava, S., et al. The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science 334 (2011), 255–258.
-
(2011)
Science
, vol.334
, pp. 255-258
-
-
Vaishnava, S.1
-
21
-
-
79954919685
-
Roadblocks in the gut: barriers to enteric infection
-
21 Gill, N., et al. Roadblocks in the gut: barriers to enteric infection. Cell Microbiol. 13 (2011), 660–669.
-
(2011)
Cell Microbiol.
, vol.13
, pp. 660-669
-
-
Gill, N.1
-
22
-
-
0027946483
-
Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin
-
22 Tytgat, K.M., et al. Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin. Gastroenterology 107 (1994), 1352–1363.
-
(1994)
Gastroenterology
, vol.107
, pp. 1352-1363
-
-
Tytgat, K.M.1
-
23
-
-
0036500996
-
Colorectal cancer in mice genetically deficient in the mucin Muc2
-
23 Velcich, A., et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 295 (2002), 1726–1729.
-
(2002)
Science
, vol.295
, pp. 1726-1729
-
-
Velcich, A.1
-
24
-
-
84976310851
-
A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion
-
24 Birchenough, G.M., A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science 352 (2016), 1535–1542.
-
(2016)
Science
, vol.352
, pp. 1535-1542
-
-
Birchenough, G.M.1
-
25
-
-
0037340434
-
Angiogenins: a new class of microbicidal proteins involved in innate immunity
-
25 Hooper, L.V., et al. Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat. Immunol. 4 (2003), 269–273.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 269-273
-
-
Hooper, L.V.1
-
26
-
-
74049122536
-
Enteric defensins are essential regulators of intestinal microbial ecology
-
26 Salzman, N.H., et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat. Immunol. 11 (2010), 76–83.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 76-83
-
-
Salzman, N.H.1
-
27
-
-
84868615556
-
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
-
27 Huber, S., et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 491 (2012), 259–263.
-
(2012)
Nature
, vol.491
, pp. 259-263
-
-
Huber, S.1
-
28
-
-
84923107393
-
Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection
-
28 Munoz, M., et al. Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection. Immunity 42 (2015), 321–331.
-
(2015)
Immunity
, vol.42
, pp. 321-331
-
-
Munoz, M.1
-
29
-
-
84946922380
-
Nlrp6 regulates intestinal antiviral innate immunity
-
29 Wang, P., et al. Nlrp6 regulates intestinal antiviral innate immunity. Science 350 (2015), 826–830.
-
(2015)
Science
, vol.350
, pp. 826-830
-
-
Wang, P.1
-
30
-
-
84880474099
-
Analysis of microbiota alterations in inflammasome-deficient mice
-
30 Elinav, E., et al. Analysis of microbiota alterations in inflammasome-deficient mice. Methods Mol. Biol. 1040 (2013), 185–194.
-
(2013)
Methods Mol. Biol.
, vol.1040
, pp. 185-194
-
-
Elinav, E.1
-
31
-
-
84907300008
-
Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease
-
31 Palm, N.W., et al. Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell 158 (2014), 1000–1010.
-
(2014)
Cell
, vol.158
, pp. 1000-1010
-
-
Palm, N.W.1
-
32
-
-
84920072880
-
Inflammasomes and the microbiota–partners in the preservation of mucosal homeostasis
-
32 Levy, M., et al. Inflammasomes and the microbiota–partners in the preservation of mucosal homeostasis. Semin. Immunopathol. 37 (2015), 39–46.
-
(2015)
Semin. Immunopathol.
, vol.37
, pp. 39-46
-
-
Levy, M.1
-
33
-
-
84878971321
-
Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer
-
33 Hu, B., et al. Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 9862–9867.
-
(2013)
Proc. Natl. Acad. Sci. U. S. A.
, vol.110
, pp. 9862-9867
-
-
Hu, B.1
-
34
-
-
84856957894
-
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
-
34 Henao-Mejia, J., et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482 (2012), 179–185.
-
(2012)
Nature
, vol.482
, pp. 179-185
-
-
Henao-Mejia, J.1
-
35
-
-
84930788424
-
Nonalcoholic fatty liver disease: a systematic review
-
35 Rinella, M.E., Nonalcoholic fatty liver disease: a systematic review. J. Am. Med. Assoc. 313 (2015), 2263–2273.
-
(2015)
J. Am. Med. Assoc.
, vol.313
, pp. 2263-2273
-
-
Rinella, M.E.1
-
36
-
-
84948972849
-
Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease
-
36 Lee, H.J., et al. Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease. World J. Gastroenterol. 21 (2015), 12787–12799.
-
(2015)
World J. Gastroenterol.
, vol.21
, pp. 12787-12799
-
-
Lee, H.J.1
-
37
-
-
85011597134
-
NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury
-
37 Seregin, S.S., et al. NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury. Mucosal Immunol., 196(1 Suppl), 2016, 126.14.
-
(2016)
Mucosal Immunol.
, vol.196
, Issue.1
, pp. 126.14
-
-
Seregin, S.S.1
-
38
-
-
84865130689
-
NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens
-
38 Anand, P.K., et al. NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature 488 (2012), 389–393.
-
(2012)
Nature
, vol.488
, pp. 389-393
-
-
Anand, P.K.1
-
39
-
-
84964312935
-
Expression of NALPs in adipose and the fibrotic progression of non-alcoholic fatty liver disease in obese subjects
-
39 Mehta, R., et al. Expression of NALPs in adipose and the fibrotic progression of non-alcoholic fatty liver disease in obese subjects. BMC Gastroenterol., 14, 2014, 208.
-
(2014)
BMC Gastroenterol.
, vol.14
, pp. 208
-
-
Mehta, R.1
-
40
-
-
84946020929
-
Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components
-
40 Liu, R., et al. Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components. Oncotarget 6 (2015), 33456–33469.
-
(2015)
Oncotarget
, vol.6
, pp. 33456-33469
-
-
Liu, R.1
-
41
-
-
84965035996
-
Analysis of inflammasomes and antiviral sensing components reveals decreased expression of NLRX1 in HIV-positive patients assuming efficient antiretroviral therapy
-
41 Nasi, M., et al. Analysis of inflammasomes and antiviral sensing components reveals decreased expression of NLRX1 in HIV-positive patients assuming efficient antiretroviral therapy. AIDS 29 (2015), 1937–1941.
-
(2015)
AIDS
, vol.29
, pp. 1937-1941
-
-
Nasi, M.1
-
42
-
-
83055161438
-
New gene functions in megakaryopoiesis and platelet formation
-
42 Gieger, C., et al. New gene functions in megakaryopoiesis and platelet formation. Nature 480 (2011), 201–208.
-
(2011)
Nature
, vol.480
, pp. 201-208
-
-
Gieger, C.1
-
43
-
-
84938573130
-
Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes
-
43 Ydens, E., et al. Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes. J. Neuroinflammation, 12, 2015, 143.
-
(2015)
J. Neuroinflammation
, vol.12
, pp. 143
-
-
Ydens, E.1
-
44
-
-
0037434890
-
Identification of mammalian orthologs associates PYPAF5 with distinct functional roles
-
44 Albrecht, M., et al. Identification of mammalian orthologs associates PYPAF5 with distinct functional roles. FEBS Lett. 538 (2003), 173–177.
-
(2003)
FEBS Lett.
, vol.538
, pp. 173-177
-
-
Albrecht, M.1
-
45
-
-
84974845506
-
Nuclear Retention of mRNA in Mammalian Tissues
-
45 Bahar Halpern, K., Nuclear Retention of mRNA in Mammalian Tissues. Cell Rep. 13 (2015), 2653–2662.
-
(2015)
Cell Rep.
, vol.13
, pp. 2653-2662
-
-
Bahar Halpern, K.1
-
46
-
-
84973663855
-
Accounting for reciprocal host-microbiome interactions in experimental science
-
46 Stappenbeck, T.S., Virgin, H.W., Accounting for reciprocal host-microbiome interactions in experimental science. Nature 534 (2016), 191–199.
-
(2016)
Nature
, vol.534
, pp. 191-199
-
-
Stappenbeck, T.S.1
Virgin, H.W.2
-
47
-
-
84866461477
-
Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice
-
47 Ubeda, C., et al. Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice. J. Exp. Med. 209 (2012), 1445–1456.
-
(2012)
J. Exp. Med.
, vol.209
, pp. 1445-1456
-
-
Ubeda, C.1
|