Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice

Biological Psychiatry

Volumn 82, Issue 7, 2017, Pages 472-487

  Burokas, Aurelijus ^a   Arboleya, Silvia ^a,c   Moloney, Rachel D ^a   Peterson, Veronica L ^a,b   Murphy, Kiera ^c   Clarke, Gerard ^a   Stanton, Catherine ^a,c   Dinan, Timothy G ^a   Cryan, John F ^a,b  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c TEAGASC FOOD RESEARCH CENTRE   (Ireland)

Author keywords

Animal behavior; Anxiety; Microbiota gut brain axis; Prebiotics; SCFAs; Stress

Indexed keywords

ACETIC ACID; BRAIN MONOAMINE; CORTICOSTERONE; FRUCTOSE OLIGOSACCHARIDE; GALACTOSE OLIGOSACCHARIDE; ISOBUTYRIC ACID; NEUROTRANSMITTER; PROPIONIC ACID; SHORT CHAIN FATTY ACID; TRYPTOPHAN; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; OLIGOSACCHARIDE; PREBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BEHAVIOR CHANGE; BIOINFORMATICS; BRAIN; BRAIN REGION; CHEMICAL COMPOSITION; CHRONIC STRESS; COGNITION; CONTROLLED STUDY; CORTICOSTERONE RELEASE; DEPRESSION; GENE EXPRESSION; HIPPOCAMPUS; HORMONE RELEASE; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE SYSTEM; INTESTINE FLORA; LOCOMOTION; MALE; MENTAL STRESS; MICROFLORA; MOUSE; NOCICEPTION; NONHUMAN; PARAMETERS; PRIORITY JOURNAL; QUALITY CONTROL; REAL TIME POLYMERASE CHAIN REACTION; SOCIAL BEHAVIOR; SPLEEN; STRESS; TRANQUILIZING ACTIVITY; TREATMENT DURATION; TRYPTOPHAN METABOLISM; ANIMAL; ANXIETY; BLOOD; C57BL MOUSE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GASTROINTESTINAL TRACT; METABOLISM;

ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; ANXIETY; BRAIN; CORTICOSTERONE; DEPRESSION; DISEASE MODELS, ANIMAL; GASTROINTESTINAL MICROBIOME; GASTROINTESTINAL TRACT; GENE EXPRESSION; LOCOMOTION; MALE; MICE; MICE, INBRED C57BL; NEUROTRANSMITTER AGENTS; NOCICEPTION; OLIGOSACCHARIDES; PREBIOTICS; STRESS, PSYCHOLOGICAL; TRYPTOPHAN;

EID: 85013756511     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2016.12.031     Document Type: Article

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