Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis

Nature Medicine

Volumn 23, Issue 7, 2017, Pages 839-849

  Worthmann, Anna ^a   John, Clara ^a   Rühlemann, Malte C ^b   Baguhl, Miriam ^a   Heinsen, Femke Anouska ^b   Schaltenberg, Nicola ^a   Heine, Markus ^a   Schlein, Christian ^a   Evangelakos, Ioannis ^a   Mineo, Chieko ^c   Fischer, Markus ^d   Dandri, Maura ^a   Kremoser, Claus ^e   Scheja, Ludger ^a   Franke, Andre ^b   Shaul, Philip W ^c   Heeren, Joerg ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF HAMBURG   (Germany)

^e PHENEX PHARMACEUTICALS AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; BILE ACID CONJUGATE; CHOLESTEROL; CYTOCHROME P450 7B1; CYTOCHROME P450 FAMILY 7; LIPOPROTEIN; UNCLASSIFIED DRUG; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYP7B1 PROTEIN, MOUSE; LOW DENSITY LIPOPROTEIN RECEPTOR; MULTIDRUG RESISTANCE PROTEIN; P-GLYCOPROTEIN 2; RNA 16S; STEROID MONOOXYGENASE;

ANIMAL EXPERIMENT; ARTICLE; BILE ACID SYNTHESIS; BILIARY EXCRETION; BLOOD LEVEL; BROWN ADIPOSE TISSUE; CHOLESTEROL METABOLISM; COLD EXPOSURE; CONTROLLED STUDY; ENERGY METABOLISM; FECES; HOMEOSTASIS; INTESTINE FLORA; MOUSE; NONHUMAN; PRIORITY JOURNAL; THERMOGENESIS; ANIMAL; CASE CONTROL STUDY; COLD; GENE EXPRESSION PROFILING; GENETICS; HUMAN; INDIRECT CALORIMETRY; KNOCKOUT MOUSE; LIVER; METABOLISM; OBESITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADIPOSE TISSUE, BROWN; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILE ACIDS AND SALTS; BLOTTING, WESTERN; CALORIMETRY, INDIRECT; CASE-CONTROL STUDIES; CHOLESTEROL; COLD TEMPERATURE; CYTOCHROME P450 FAMILY 7; GASTROINTESTINAL MICROBIOME; GENE EXPRESSION PROFILING; HUMANS; LIVER; MICE; MICE, KNOCKOUT; OBESITY; P-GLYCOPROTEINS; RECEPTORS, LDL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, RIBOSOMAL, 16S; STEROID HYDROXYLASES; THERMOGENESIS;

EID: 85023645434     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4357     Document Type: Article

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