Backbone NMR reveals allosteric signal transduction networks in the β 1-adrenergic receptor

Nature

Volumn 530, Issue 7589, 2016, Pages 237-241

  Isogai, Shin ^a   Deupi, Xavier ^b   Opitz, Christian ^a   Heydenreich, Franziska M ^b   Tsai, Ching Ju ^b   Brueckner, Florian ^b   Schertler, Gebhard F X ^b,c   Veprintsev, Dmitry B ^b,c   Grzesiek, Stephan ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b PAUL SCHERRER INSTITUTE   (Switzerland)

^c ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EUKARYOTA;

APOPROTEIN; BETA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND;

ALLOSTERISM; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; MOVEMENT (PHYSIOLOGY); NUCLEAR MAGNETIC RESONANCE; PARTIAL AGONISM; POINT MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TURKEY (BIRD); X RAY CRYSTALLOGRAPHY;

ADRENERGIC BETA-1 RECEPTOR AGONISTS; ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ALLOSTERIC REGULATION; ANIMALS; APOPROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG PARTIAL AGONISM; HETEROTRIMERIC GTP-BINDING PROTEINS; LIGANDS; MODELS, MOLECULAR; MOVEMENT; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; POINT MUTATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, ADRENERGIC, BETA-1; SIGNAL TRANSDUCTION; TURKEYS;

EID: 84958063978     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature16577     Document Type: Article

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