메뉴 건너뛰기




Volumn 167, Issue , 2019, Pages 45-67

Advances in respiratory virus therapeutics – A meeting report from the 6th isirv Antiviral Group conference

Author keywords

Antiviral therapy; Coronavirus; Host directed therapeutics; Influenza; Respiratory syncytial virus

Indexed keywords

1,4 DIHYDRO 2,4,6 TRIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID METHYL 2 PHENYLTHIOETHYL ESTER; AK 0529; ANTIVIRUS AGENT; ARBIDOL; BALOXAVIR; BALOXAVIR MARBOXIL; CC 42344; DF 2162; DILTIAZEM; DOXYCYCLINE; EDP 938; EIDD 1931; EIDD 2801; ERITORAN; FAVIPIRAVIR; GEDIVUMAB; IMMUNOGLOBULIN; INFLUENZA VIRUS HEMAGGLUTININ; JNJ 53718678; LUMICITABINE; MONOCLONAL ANTIBODY; NITAZOXANIDE; OSELTAMIVIR; PEPTIDE CONJUGATE VACCINE; PIMODIVIR; PRESATOVIR; PROTEIN M2 1; REMDESIVIR; SIALIDASE INHIBITOR; UMIFENOVIR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VH 244; VIS 410; ZIRESOVIR; ADENOSINE PHOSPHATE; ALANINE;

EID: 85064122575     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2019.04.006     Document Type: Review
Times cited : (140)

References (145)
  • 2
    • 84963813156 scopus 로고    scopus 로고
    • Treatment outcomes for patients with middle eastern respiratory syndrome coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia
    • Al Ghamdi, M., Alghamdi, K.M., Ghandoora, Y., Alzahrani, A., Salah, F., Alsulami, A., Bawayan, M.F., Vaidya, D., Perl, T.M., Sood, G., Treatment outcomes for patients with middle eastern respiratory syndrome coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia. BMC Infect. Dis., 16, 2016, 174.
    • (2016) BMC Infect. Dis. , vol.16 , pp. 174
    • Al Ghamdi, M.1    Alghamdi, K.M.2    Ghandoora, Y.3    Alzahrani, A.4    Salah, F.5    Alsulami, A.6    Bawayan, M.F.7    Vaidya, D.8    Perl, T.M.9    Sood, G.10
  • 3
    • 84896695450 scopus 로고    scopus 로고
    • Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study
    • Al-Tawfiq, J.A., Momattin, H., Dib, J., Memish, Z.A., Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study. Int. J. Infect. Dis. 20 (2014), 42–46.
    • (2014) Int. J. Infect. Dis. , vol.20 , pp. 42-46
    • Al-Tawfiq, J.A.1    Momattin, H.2    Dib, J.3    Memish, Z.A.4
  • 4
    • 0025275762 scopus 로고
    • Association between respiratory syncytial virus outbreaks and lower respiratory tract deaths of infants and young children
    • Anderson, L.J., Parker, R.A., Strikas, R.L., Association between respiratory syncytial virus outbreaks and lower respiratory tract deaths of infants and young children. J. Infect. Dis. 161 (1990), 640–646.
    • (1990) J. Infect. Dis. , vol.161 , pp. 640-646
    • Anderson, L.J.1    Parker, R.A.2    Strikas, R.L.3
  • 8
    • 84978216553 scopus 로고    scopus 로고
    • Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physicians
    • Arabi, Y.M., Al-Enezi, F., Longuere, K.S., Balkhy, H.H., Al-Sultan, M., Al-Omari, A., Al-Hameed, F.M., Carson, G., Shindo, N., Fowler, R., Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physicians. BMC Anesthesiol., 16, 2016, 36.
    • (2016) BMC Anesthesiol. , vol.16 , pp. 36
    • Arabi, Y.M.1    Al-Enezi, F.2    Longuere, K.S.3    Balkhy, H.H.4    Al-Sultan, M.5    Al-Omari, A.6    Al-Hameed, F.M.7    Carson, G.8    Shindo, N.9    Fowler, R.10
  • 16
    • 85040575647 scopus 로고    scopus 로고
    • Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study
    • Beigel, J.H., Voell, J., Kumar, P., Raviprakash, K., Wu, H., Jiao, J.A., Sullivan, E., Luke, T., Davey, R.T. Jr., Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study. Lancet Infect. Dis. 18 (2018), 410–418.
    • (2018) Lancet Infect. Dis. , vol.18 , pp. 410-418
    • Beigel, J.H.1    Voell, J.2    Kumar, P.3    Raviprakash, K.4    Wu, H.5    Jiao, J.A.6    Sullivan, E.7    Luke, T.8    Davey, R.T.9
  • 19
    • 84901011755 scopus 로고    scopus 로고
    • Arbidol as a broad-spectrum antiviral: an update
    • Blaising, J., Polyak, S.J., Pecheur, E.I., Arbidol as a broad-spectrum antiviral: an update. Antivir. Res. 107 (2014), 84–94.
    • (2014) Antivir. Res. , vol.107 , pp. 84-94
    • Blaising, J.1    Polyak, S.J.2    Pecheur, E.I.3
  • 20
    • 85052974420 scopus 로고    scopus 로고
    • Inhaled therapy in respiratory disease: the complex interplay of pulmonary kinetic processes
    • Borghardt, J.M., Kloft, C., Sharma, A., Inhaled therapy in respiratory disease: the complex interplay of pulmonary kinetic processes. Can. Respir. J., 2018, 2018, 2732017.
    • (2018) Can. Respir. J. , vol.2018
    • Borghardt, J.M.1    Kloft, C.2    Sharma, A.3
  • 21
    • 25844438380 scopus 로고    scopus 로고
    • Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern
    • Bright, R.A., Medina, M.J., Xu, X., Perez-Oronoz, G., Wallis, T.R., Davis, X.M., Povinelli, L., Cox, N.J., Klimov, A.I., Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern. Lancet 366 (2005), 1175–1181.
    • (2005) Lancet , vol.366 , pp. 1175-1181
    • Bright, R.A.1    Medina, M.J.2    Xu, X.3    Perez-Oronoz, G.4    Wallis, T.R.5    Davis, X.M.6    Povinelli, L.7    Cox, N.J.8    Klimov, A.I.9
  • 23
    • 85064111661 scopus 로고    scopus 로고
    • Short period incidence sTudy of severe acute respiratory infection (SPRINT-SARI) initial data from a global observational study to better describe SARI epidemiology in critically ill patients
    • Carson, G.L., Castle, L., George, M., Horby, P., Longuere, K.S., Merson, L., Murthy, S., O'neill, G., Pardinaz-Solis, R., Webb, S., Short period incidence sTudy of severe acute respiratory infection (SPRINT-SARI) initial data from a global observational study to better describe SARI epidemiology in critically ill patients. Int. J. Infect. Dis., 53, 2016, 101.
    • (2016) Int. J. Infect. Dis. , vol.53 , pp. 101
    • Carson, G.L.1    Castle, L.2    George, M.3    Horby, P.4    Longuere, K.S.5    Merson, L.6    Murthy, S.7    O'neill, G.8    Pardinaz-Solis, R.9    Webb, S.10
  • 24
    • 64749089192 scopus 로고    scopus 로고
    • Update: influenza activity--United States, September 28, 2008-April 4, 2009, and composition of the 2009-10 influenza vaccine
    • Centers for Disease, C., Prevention, Update: influenza activity--United States, September 28, 2008-April 4, 2009, and composition of the 2009-10 influenza vaccine. MMWR Morb. Mortal. Wkly. Rep. 58 (2009), 369–374.
    • (2009) MMWR Morb. Mortal. Wkly. Rep. , vol.58 , pp. 369-374
    • Centers for Disease, C., Prevention,1
  • 31
    • 77956607815 scopus 로고    scopus 로고
    • Lopinavir/Ritonavir: a review of its use in the management of HIV-1 infection
    • Croxtall, J.D., Perry, C.M., Lopinavir/Ritonavir: a review of its use in the management of HIV-1 infection. Drugs 70 (2010), 1885–1915.
    • (2010) Drugs , vol.70 , pp. 1885-1915
    • Croxtall, J.D.1    Perry, C.M.2
  • 35
    • 18944399906 scopus 로고    scopus 로고
    • Respiratory syncytial virus load predicts disease severity in previously healthy infants
    • DeVincenzo, J.P., El Saleeby, C.M., Bush, A.J., Respiratory syncytial virus load predicts disease severity in previously healthy infants. J. Infect. Dis. 191 (2005), 1861–1868.
    • (2005) J. Infect. Dis. , vol.191 , pp. 1861-1868
    • DeVincenzo, J.P.1    El Saleeby, C.M.2    Bush, A.J.3
  • 40
    • 50149084678 scopus 로고    scopus 로고
    • Influenza virus protecting RNA: an effective prophylactic and therapeutic antiviral
    • Dimmock, N.J., Rainsford, E.W., Scott, P.D., Marriott, A.C., Influenza virus protecting RNA: an effective prophylactic and therapeutic antiviral. J. Virol. 82 (2008), 8570–8578.
    • (2008) J. Virol. , vol.82 , pp. 8570-8578
    • Dimmock, N.J.1    Rainsford, E.W.2    Scott, P.D.3    Marriott, A.C.4
  • 41
    • 84929029181 scopus 로고    scopus 로고
    • Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials
    • Dobson, J., Whitley, R.J., Pocock, S., Monto, A.S., Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials. Lancet 385 (2015), 1729–1737.
    • (2015) Lancet , vol.385 , pp. 1729-1737
    • Dobson, J.1    Whitley, R.J.2    Pocock, S.3    Monto, A.S.4
  • 42
    • 85048282659 scopus 로고    scopus 로고
    • Recent developments in interferon-based therapies for multiple sclerosis
    • Dumitrescu, L., Constantinescu, C.S., Tanasescu, R., Recent developments in interferon-based therapies for multiple sclerosis. Expert Opin. Biol. Ther. 18 (2018), 665–680.
    • (2018) Expert Opin. Biol. Ther. , vol.18 , pp. 665-680
    • Dumitrescu, L.1    Constantinescu, C.S.2    Tanasescu, R.3
  • 43
    • 80052422367 scopus 로고    scopus 로고
    • Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children
    • El Saleeby, C.M., Bush, A.J., Harrison, L.M., Aitken, J.A., Devincenzo, J.P., Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children. J. Infect. Dis. 204 (2011), 996–1002.
    • (2011) J. Infect. Dis. , vol.204 , pp. 996-1002
    • El Saleeby, C.M.1    Bush, A.J.2    Harrison, L.M.3    Aitken, J.A.4    Devincenzo, J.P.5
  • 45
    • 17644392071 scopus 로고    scopus 로고
    • Respiratory syncytial virus infection in elderly and high-risk adults
    • Falsey, A.R., Hennessey, P.A., Formica, M.A., Cox, C., Walsh, E.E., Respiratory syncytial virus infection in elderly and high-risk adults. N. Engl. J. Med. 352 (2005), 1749–1759.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 1749-1759
    • Falsey, A.R.1    Hennessey, P.A.2    Formica, M.A.3    Cox, C.4    Walsh, E.E.5
  • 48
    • 85063008890 scopus 로고    scopus 로고
    • Phase 2b study of pimodivir (JNJ-63623872) as monotherapy or in combination with oseltamivir for treatment of acute uncomplicated seasonal influenza A: TOPAZ trial
    • Finberg, R.W., Lanno, R., Anderson, D., Fleischhackl, R., van Duijnhoven, W., Kauffman, R.S., Kosoglou, T., Vingerhoets, J., Leopold, L., Phase 2b study of pimodivir (JNJ-63623872) as monotherapy or in combination with oseltamivir for treatment of acute uncomplicated seasonal influenza A: TOPAZ trial. J. Infect. Dis. 219:7 (2019 Mar 15), 1026–1034.
    • (2019) J. Infect. Dis. , vol.219 , Issue.7 , pp. 1026-1034
    • Finberg, R.W.1    Lanno, R.2    Anderson, D.3    Fleischhackl, R.4    van Duijnhoven, W.5    Kauffman, R.S.6    Kosoglou, T.7    Vingerhoets, J.8    Leopold, L.9
  • 52
    • 45949089501 scopus 로고    scopus 로고
    • A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation
    • Gaggar, A., Jackson, P.L., Noerager, B.D., O'Reilly, P.J., McQuaid, D.B., Rowe, S.M., Clancy, J.P., Blalock, J.E., A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation. J. Immunol. 180 (2008), 5662–5669.
    • (2008) J. Immunol. , vol.180 , pp. 5662-5669
    • Gaggar, A.1    Jackson, P.L.2    Noerager, B.D.3    O'Reilly, P.J.4    McQuaid, D.B.5    Rowe, S.M.6    Clancy, J.P.7    Blalock, J.E.8
  • 54
    • 85056226781 scopus 로고    scopus 로고
    • Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
    • Global Burden of Disease Collaborators, Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Infect. Dis. 18 (2018), 1191–1210.
    • (2018) Lancet Infect. Dis. , vol.18 , pp. 1191-1210
    • Global Burden of Disease Collaborators1
  • 58
    • 84966460100 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A
    • Gupta, P., Kamath, A.V., Park, S., Chiu, H., Lutman, J., Maia, M., Tan, M.-W., Xu, M., Swem, L., Deng, R., Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A. mAbs 8 (2016), 991–997.
    • (2016) mAbs , vol.8 , pp. 991-997
    • Gupta, P.1    Kamath, A.V.2    Park, S.3    Chiu, H.4    Lutman, J.5    Maia, M.6    Tan, M.-W.7    Xu, M.8    Swem, L.9    Deng, R.10
  • 59
    • 84904740878 scopus 로고    scopus 로고
    • Effect of nitazoxanide in adults and adolescents with acute uncomplicated influenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial
    • Haffizulla, J., Hartman, A., Hoppers, M., Resnick, H., Samudrala, S., Ginocchio, C., Bardin, M., Rossignol, J.F., Group, U.S.N.I.C.S. Effect of nitazoxanide in adults and adolescents with acute uncomplicated influenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial. Lancet Infect. Dis. 14 (2014), 609–618.
    • (2014) Lancet Infect. Dis. , vol.14 , pp. 609-618
    • Haffizulla, J.1    Hartman, A.2    Hoppers, M.3    Resnick, H.4    Samudrala, S.5    Ginocchio, C.6    Bardin, M.7    Rossignol, J.F.8
  • 63
    • 85059640945 scopus 로고    scopus 로고
    • Safety and efficacy of monoclonal antibody VIS410 in adults with uncomplicated influenza A infection: results from a randomized, double-blind, phase-2, placebo-controlled study
    • Hershberger, E., Sloan, S., Narayan, K., Hay, C.A., Smith, P., Engler, F., Jeeninga, R., Smits, S., Trevejo, J., Shriver, Z., Oldach, D., Safety and efficacy of monoclonal antibody VIS410 in adults with uncomplicated influenza A infection: results from a randomized, double-blind, phase-2, placebo-controlled study. EBioMedicine 40 (2019 Feb), 574–582.
    • (2019) EBioMedicine , vol.40 , pp. 574-582
    • Hershberger, E.1    Sloan, S.2    Narayan, K.3    Hay, C.A.4    Smith, P.5    Engler, F.6    Jeeninga, R.7    Smits, S.8    Trevejo, J.9    Shriver, Z.10    Oldach, D.11
  • 64
    • 85044290633 scopus 로고    scopus 로고
    • The role of adjuvant immunomodulatory agents for treatment of severe influenza
    • Hui, D.S., Lee, N., Chan, P.K., Beigel, J.H., The role of adjuvant immunomodulatory agents for treatment of severe influenza. Antivir. Res. 150 (2018), 202–216.
    • (2018) Antivir. Res. , vol.150 , pp. 202-216
    • Hui, D.S.1    Lee, N.2    Chan, P.K.3    Beigel, J.H.4
  • 68
    • 85064132385 scopus 로고    scopus 로고
    • Options IX
    • Chicago. Abstract LBP-17
    • Ison, M., Options IX. Chicago. Abstract LBP-17, 2016.
    • (2016)
    • Ison, M.1
  • 69
    • 85044182212 scopus 로고    scopus 로고
    • Improving delivery of early treatment to influenza-infected patients
    • Ison, M.G., Improving delivery of early treatment to influenza-infected patients. Clin. Infect. Dis. 66 (2017), 1042–1044.
    • (2017) Clin. Infect. Dis. , vol.66 , pp. 1042-1044
    • Ison, M.G.1
  • 70
    • 77951887472 scopus 로고    scopus 로고
    • End points for testing influenza antiviral treatments for patients at high risk of severe and life-threatening disease
    • Ison, M.G., de Jong, M.D., Gilligan, K.J., Higgs, E.S., Pavia, A.T., Pierson, J., Hayden, F.G., End points for testing influenza antiviral treatments for patients at high risk of severe and life-threatening disease. J. Infect. Dis. 201 (2010), 1654–1662.
    • (2010) J. Infect. Dis. , vol.201 , pp. 1654-1662
    • Ison, M.G.1    de Jong, M.D.2    Gilligan, K.J.3    Higgs, E.S.4    Pavia, A.T.5    Pierson, J.6    Hayden, F.G.7
  • 71
    • 85063009815 scopus 로고    scopus 로고
    • LB16. Phase 3 trial of baloxavir marboxil in high-risk influenza patients (CAPSTONE-2 study)
    • Ison, M.G., Portsmouth, S., Yoshida, Y., Shishido, T., Hayden, F., Uehara, T., LB16. Phase 3 trial of baloxavir marboxil in high-risk influenza patients (CAPSTONE-2 study). Open Forum Infect. Dis. 5 (2018), S764–S765.
    • (2018) Open Forum Infect. Dis. , vol.5 , pp. S764-S765
    • Ison, M.G.1    Portsmouth, S.2    Yoshida, Y.3    Shishido, T.4    Hayden, F.5    Uehara, T.6
  • 72
    • 85046436614 scopus 로고    scopus 로고
    • Identification of the I38T PA substitution as a resistance marker for next-generation influenza virus endonuclease inhibitors
    • Jones, J.C., Kumar, G., Barman, S., Najera, I., White, S.W., Webby, R.J., Govorkova, E.A., Identification of the I38T PA substitution as a resistance marker for next-generation influenza virus endonuclease inhibitors. mBio, 9, 2018.
    • (2018) mBio , vol.9
    • Jones, J.C.1    Kumar, G.2    Barman, S.3    Najera, I.4    White, S.W.5    Webby, R.J.6    Govorkova, E.A.7
  • 74
    • 85018868773 scopus 로고    scopus 로고
    • Inhibitors of influenza virus polymerase acidic (PA) endonuclease: contemporary developments and perspectives
    • Ju, H., Zhang, J., Huang, B., Kang, D., Huang, B., Liu, X., Zhan, P., Inhibitors of influenza virus polymerase acidic (PA) endonuclease: contemporary developments and perspectives. J. Med. Chem. 60 (2017), 3533–3551.
    • (2017) J. Med. Chem. , vol.60 , pp. 3533-3551
    • Ju, H.1    Zhang, J.2    Huang, B.3    Kang, D.4    Huang, B.5    Liu, X.6    Zhan, P.7
  • 75
    • 85009380300 scopus 로고    scopus 로고
    • Structural basis of influenza virus fusion inhibition by the antiviral drug arbidol
    • Kadam, R.U., Wilson, I.A., Structural basis of influenza virus fusion inhibition by the antiviral drug arbidol. Proc. Natl. Acad. Sci. U. S. A. 114 (2017), 206–214.
    • (2017) Proc. Natl. Acad. Sci. U. S. A. , vol.114 , pp. 206-214
    • Kadam, R.U.1    Wilson, I.A.2
  • 76
    • 72049128868 scopus 로고    scopus 로고
    • Clinical effectiveness of oseltamivir and zanamivir for treatment of influenza A virus subtype H1N1 with the H274Y mutation: a Japanese, multicenter study of the 2007-2008 and 2008-2009 influenza seasons
    • Kawai, N., Ikematsu, H., Hirotsu, N., Maeda, T., Kawashima, T., Tanaka, O., Yamauchi, S., Kawamura, K., Matsuura, S., Nishimura, M., Iwaki, N., Kashiwagi, S., Clinical effectiveness of oseltamivir and zanamivir for treatment of influenza A virus subtype H1N1 with the H274Y mutation: a Japanese, multicenter study of the 2007-2008 and 2008-2009 influenza seasons. Clin. Infect. Dis. 49 (2009), 1828–1835.
    • (2009) Clin. Infect. Dis. , vol.49 , pp. 1828-1835
    • Kawai, N.1    Ikematsu, H.2    Hirotsu, N.3    Maeda, T.4    Kawashima, T.5    Tanaka, O.6    Yamauchi, S.7    Kawamura, K.8    Matsuura, S.9    Nishimura, M.10    Iwaki, N.11    Kashiwagi, S.12
  • 77
    • 84913590251 scopus 로고    scopus 로고
    • Respiratory syncytial virus human experimental infection model: provenance, production, and sequence of low-passaged memphis-37 challenge virus
    • Kim, Y.I., DeVincenzo, J.P., Jones, B.G., Rudraraju, R., Harrison, L., Meyers, R., Cehelsky, J., Alvarez, R., Hurwitz, J.L., Respiratory syncytial virus human experimental infection model: provenance, production, and sequence of low-passaged memphis-37 challenge virus. PLoS One, 9, 2014, e113100.
    • (2014) PLoS One , vol.9
    • Kim, Y.I.1    DeVincenzo, J.P.2    Jones, B.G.3    Rudraraju, R.4    Harrison, L.5    Meyers, R.6    Cehelsky, J.7    Alvarez, R.8    Hurwitz, J.L.9
  • 78
    • 85033230992 scopus 로고    scopus 로고
    • The antiviral effects of RSV fusion inhibitor, MDT-637, on clinical isolates, vs its achievable concentrations in the human respiratory tract and comparison to ribavirin
    • Kim, Y.I., Pareek, R., Murphy, R., Harrison, L., Farrell, E., Cook, R., DeVincenzo, J., The antiviral effects of RSV fusion inhibitor, MDT-637, on clinical isolates, vs its achievable concentrations in the human respiratory tract and comparison to ribavirin. Influenza Other Respir Viruses 11 (2017), 525–530.
    • (2017) Influenza Other Respir Viruses , vol.11 , pp. 525-530
    • Kim, Y.I.1    Pareek, R.2    Murphy, R.3    Harrison, L.4    Farrell, E.5    Cook, R.6    DeVincenzo, J.7
  • 79
    • 85064116849 scopus 로고    scopus 로고
    • IDWeek 2016
    • New Orleans. Abstract 638
    • King, J., IDWeek 2016. New Orleans. Abstract 638, 2016.
    • (2016)
    • King, J.1
  • 83
    • 85058602387 scopus 로고    scopus 로고
    • Type I interferons: distinct biological activities and current applications for viral infection
    • Li, S.F., Gong, M.J., Zhao, F.R., Shao, J.J., Xie, Y.L., Zhang, Y.G., Chang, H.Y., Type I interferons: distinct biological activities and current applications for viral infection. Cell. Physiol. Biochem. 51 (2018), 2377–2396.
    • (2018) Cell. Physiol. Biochem. , vol.51 , pp. 2377-2396
    • Li, S.F.1    Gong, M.J.2    Zhao, F.R.3    Shao, J.J.4    Xie, Y.L.5    Zhang, Y.G.6    Chang, H.Y.7
  • 84
    • 85040699532 scopus 로고    scopus 로고
    • Five years of monitoring for the emergence of oseltamivir resistance in patients with influenza A infections in the influenza resistance information study
    • Lina, B., Boucher, C., Osterhaus, A., Monto, A.S., Schutten, M., Whitley, R.J., Nguyen-Van-Tam, J.S., Five years of monitoring for the emergence of oseltamivir resistance in patients with influenza A infections in the influenza resistance information study. Influenza Other Respir Viruses 12 (2018), 267–278.
    • (2018) Influenza Other Respir Viruses , vol.12 , pp. 267-278
    • Lina, B.1    Boucher, C.2    Osterhaus, A.3    Monto, A.S.4    Schutten, M.5    Whitley, R.J.6    Nguyen-Van-Tam, J.S.7
  • 85
    • 0029958486 scopus 로고    scopus 로고
    • Pharmacokinetics of inhaled drugs
    • Lipworth, B.J., Pharmacokinetics of inhaled drugs. Br. J. Clin. Pharmacol. 42 (1996), 697–705.
    • (1996) Br. J. Clin. Pharmacol. , vol.42 , pp. 697-705
    • Lipworth, B.J.1
  • 88
    • 33750721332 scopus 로고    scopus 로고
    • Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment?
    • Luke, T.C., Kilbane, E.M., Jackson, J.L., Hoffman, S.L., Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment?. Ann. Intern. Med. 145 (2006), 599–609.
    • (2006) Ann. Intern. Med. , vol.145 , pp. 599-609
    • Luke, T.C.1    Kilbane, E.M.2    Jackson, J.L.3    Hoffman, S.L.4
  • 92
    • 85035785809 scopus 로고    scopus 로고
    • Prevention and treatment of respiratory viral infections: presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference
    • McKimm-Breschkin, J.L., Jiang, S., Hui, D.S., Beigel, J.H., Govorkova, E.A., Lee, N., Prevention and treatment of respiratory viral infections: presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference. Antivir. Res. 149 (2018), 118–142.
    • (2018) Antivir. Res. , vol.149 , pp. 118-142
    • McKimm-Breschkin, J.L.1    Jiang, S.2    Hui, D.S.3    Beigel, J.H.4    Govorkova, E.A.5    Lee, N.6
  • 96
    • 85050799094 scopus 로고    scopus 로고
    • A review of therapeutics in clinical development for respiratory syncytial virus and influenza in children
    • Nicholson, E.G., Munoz, F.M., A review of therapeutics in clinical development for respiratory syncytial virus and influenza in children. Clin. Ther. 40 (2018), 1268–1281.
    • (2018) Clin. Ther. , vol.40 , pp. 1268-1281
    • Nicholson, E.G.1    Munoz, F.M.2
  • 102
    • 85046417699 scopus 로고    scopus 로고
    • Serum high-mobility-group box 1 as a biomarker and a therapeutic target during respiratory virus infections
    • Patel, M.C., Shirey, K.A., Boukhvalova, M.S., Vogel, S.N., Blanco, J.C.G., Serum high-mobility-group box 1 as a biomarker and a therapeutic target during respiratory virus infections. mBio, 9, 2018.
    • (2018) mBio , vol.9
    • Patel, M.C.1    Shirey, K.A.2    Boukhvalova, M.S.3    Vogel, S.N.4    Blanco, J.C.G.5
  • 103
    • 18544379485 scopus 로고    scopus 로고
    • Comparison of a real-time reverse transcriptase PCR assay and a culture technique for quantitative assessment of viral load in children naturally infected with respiratory syncytial virus
    • Perkins, S.M., Webb, D.L., Torrance, S.A., El Saleeby, C., Harrison, L.M., Aitken, J.A., Patel, A., DeVincenzo, J.P., Comparison of a real-time reverse transcriptase PCR assay and a culture technique for quantitative assessment of viral load in children naturally infected with respiratory syncytial virus. J. Clin. Microbiol. 43 (2005), 2356–2362.
    • (2005) J. Clin. Microbiol. , vol.43 , pp. 2356-2362
    • Perkins, S.M.1    Webb, D.L.2    Torrance, S.A.3    El Saleeby, C.4    Harrison, L.M.5    Aitken, J.A.6    Patel, A.7    DeVincenzo, J.P.8
  • 104
    • 85010028170 scopus 로고    scopus 로고
    • TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells, and protects mice from lethal influenza infection
    • Perrin-Cocon, L., Aublin-Gex, A., Sestito, S.E., Shirey, K.A., Patel, M.C., Andre, P., Blanco, J.C., Vogel, S.N., Peri, F., Lotteau, V., TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells, and protects mice from lethal influenza infection. Sci. Rep., 7, 2017, 40791.
    • (2017) Sci. Rep. , vol.7 , pp. 40791
    • Perrin-Cocon, L.1    Aublin-Gex, A.2    Sestito, S.E.3    Shirey, K.A.4    Patel, M.C.5    Andre, P.6    Blanco, J.C.7    Vogel, S.N.8    Peri, F.9    Lotteau, V.10
  • 108
    • 85049772079 scopus 로고    scopus 로고
    • Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: role of glycoprotein-specific thiol oxidoreductase ERp57
    • Piacentini, S., La Frazia, S., Riccio, A., Pedersen, J.Z., Topai, A., Nicolotti, O., Rossignol, J.F., Santoro, M.G., Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: role of glycoprotein-specific thiol oxidoreductase ERp57. Sci. Rep., 8, 2018, 10425.
    • (2018) Sci. Rep. , vol.8 , pp. 10425
    • Piacentini, S.1    La Frazia, S.2    Riccio, A.3    Pedersen, J.Z.4    Topai, A.5    Nicolotti, O.6    Rossignol, J.F.7    Santoro, M.G.8
  • 112
    • 41149091133 scopus 로고    scopus 로고
    • Structural basis for potent cross-neutralizing human monoclonal antibody protection against lethal human and zoonotic severe acute respiratory syndrome coronavirus challenge
    • Rockx, B., Corti, D., Donaldson, E., Sheahan, T., Stadler, K., Lanzavecchia, A., Baric, R., Structural basis for potent cross-neutralizing human monoclonal antibody protection against lethal human and zoonotic severe acute respiratory syndrome coronavirus challenge. J. Virol. 82 (2008), 3220–3235.
    • (2008) J. Virol. , vol.82 , pp. 3220-3235
    • Rockx, B.1    Corti, D.2    Donaldson, E.3    Sheahan, T.4    Stadler, K.5    Lanzavecchia, A.6    Baric, R.7
  • 113
    • 34447273596 scopus 로고    scopus 로고
    • Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice
    • Rockx, B., Sheahan, T., Donaldson, E., Harkema, J., Sims, A., Heise, M., Pickles, R., Cameron, M., Kelvin, D., Baric, R., Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice. J. Virol. 81 (2007), 7410–7423.
    • (2007) J. Virol. , vol.81 , pp. 7410-7423
    • Rockx, B.1    Sheahan, T.2    Donaldson, E.3    Harkema, J.4    Sims, A.5    Heise, M.6    Pickles, R.7    Cameron, M.8    Kelvin, D.9    Baric, R.10
  • 116
    • 84906669535 scopus 로고    scopus 로고
    • Nitazoxanide: a first-in-class broad-spectrum antiviral agent
    • Rossignol, J.F., Nitazoxanide: a first-in-class broad-spectrum antiviral agent. Antivir. Res. 110 (2014), 94–103.
    • (2014) Antivir. Res. , vol.110 , pp. 94-103
    • Rossignol, J.F.1
  • 118
    • 85064131362 scopus 로고    scopus 로고
    • 1062: compassionate use of intravenous (IV) zanamivir during the 2013-2014 influenza season: case series of three patients
    • S311-S311
    • Shah, P., Grein, J., Vakil, N., Hirai-Yang, A., Murthy, R., 1062: compassionate use of intravenous (IV) zanamivir during the 2013-2014 influenza season: case series of three patients. Open Forum Infect. Dis., 1, 2014 S311-S311.
    • (2014) Open Forum Infect. Dis. , vol.1
    • Shah, P.1    Grein, J.2    Vakil, N.3    Hirai-Yang, A.4    Murthy, R.5
  • 119
    • 85049589477 scopus 로고    scopus 로고
    • Update on nitazoxanide: a multifunctional chemotherapeutic agent
    • Shakya, A., Bhat, H.R., Ghosh, S.K., Update on nitazoxanide: a multifunctional chemotherapeutic agent. Curr. Drug Discov. Technol. 15 (2018), 201–213.
    • (2018) Curr. Drug Discov. Technol. , vol.15 , pp. 201-213
    • Shakya, A.1    Bhat, H.R.2    Ghosh, S.K.3
  • 121
    • 50149120731 scopus 로고    scopus 로고
    • Pathways of cross-species transmission of synthetically reconstructed zoonotic severe acute respiratory syndrome coronavirus
    • Sheahan, T., Rockx, B., Donaldson, E., Corti, D., Baric, R., Pathways of cross-species transmission of synthetically reconstructed zoonotic severe acute respiratory syndrome coronavirus. J. Virol. 82 (2008), 8721–8732.
    • (2008) J. Virol. , vol.82 , pp. 8721-8732
    • Sheahan, T.1    Rockx, B.2    Donaldson, E.3    Corti, D.4    Baric, R.5
  • 122
    • 39749177748 scopus 로고    scopus 로고
    • Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium
    • Sheahan, T., Rockx, B., Donaldson, E., Sims, A., Pickles, R., Corti, D., Baric, R., Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium. J. Virol. 82 (2008), 2274–2285.
    • (2008) J. Virol. , vol.82 , pp. 2274-2285
    • Sheahan, T.1    Rockx, B.2    Donaldson, E.3    Sims, A.4    Pickles, R.5    Corti, D.6    Baric, R.7
  • 128
    • 84884683675 scopus 로고    scopus 로고
    • Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease
    • Stevaert, A., Dallocchio, R., Dessi, A., Pala, N., Rogolino, D., Sechi, M., Naesens, L., Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease. J. Virol. 87 (2013), 10524–10538.
    • (2013) J. Virol. , vol.87 , pp. 10524-10538
    • Stevaert, A.1    Dallocchio, R.2    Dessi, A.3    Pala, N.4    Rogolino, D.5    Sechi, M.6    Naesens, L.7
  • 131
    • 0003077113 scopus 로고
    • A Regulatory Authority's Opinion about Surrogate Endpoints
    • J. Wiley New York
    • Temple, R.J., A Regulatory Authority's Opinion about Surrogate Endpoints. 1995, J. Wiley, New York.
    • (1995)
    • Temple, R.J.1
  • 133
    • 85053161710 scopus 로고    scopus 로고
    • Pimodivir treatment in adult volunteers experimentally inoculated with live influenza virus: a Phase IIa, randomized, double-blind, placebo-controlled study
    • Trevejo, J.M., Asmal, M., Vingerhoets, J., Polo, R., Robertson, S., Jiang, Y., Kieffer, T.L., Leopold, L., Pimodivir treatment in adult volunteers experimentally inoculated with live influenza virus: a Phase IIa, randomized, double-blind, placebo-controlled study. Antivir. Ther. 23 (2018), 335–344.
    • (2018) Antivir. Ther. , vol.23 , pp. 335-344
    • Trevejo, J.M.1    Asmal, M.2    Vingerhoets, J.3    Polo, R.4    Robertson, S.5    Jiang, Y.6    Kieffer, T.L.7    Leopold, L.8
  • 134
    • 33746261692 scopus 로고    scopus 로고
    • Guidance for Industry - Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims
    • U.S. Food & Drug Administration, Guidance for Industry - Patient-Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims. 2009.
    • (2009)
  • 135
    • 84872501381 scopus 로고    scopus 로고
    • Guidance for Industry - Influenza: Developing Drugs for Treatment And/or Prophylaxis
    • U.S. Food & Drug Administration, Guidance for Industry - Influenza: Developing Drugs for Treatment And/or Prophylaxis. 2011.
    • (2011)
  • 136
    • 84921730324 scopus 로고    scopus 로고
    • Guidance for Industry - Immunogenicity Assessment for Therapeutic Protein Products
    • U.S. Food & Drug Administration, Guidance for Industry - Immunogenicity Assessment for Therapeutic Protein Products. 2014.
    • (2014)
  • 137
    • 85064140617 scopus 로고    scopus 로고
    • Respiratory Syncytial Virus Infection: Developing Antiviral Drugs for Prophylaxis and Treatment
    • Guidance for Industry
    • U.S. Food & Drug Administration, Respiratory Syncytial Virus Infection: Developing Antiviral Drugs for Prophylaxis and Treatment. 2017, Guidance for Industry.
    • (2017)
  • 138
    • 85064121714 scopus 로고    scopus 로고
    • Critical Path Innovation Meetings (CPIM)
    • U.S. Food & Drug Administration. Critical Path Innovation Meetings (CPIM). 2018.
    • (2018)
  • 139
    • 84893289257 scopus 로고    scopus 로고
    • Adjuvant treatment with a mammalian target of rapamycin inhibitor, sirolimus, and steroids improves outcomes in patients with severe H1N1 pneumonia and acute respiratory failure
    • Wang, C.H., Chung, F.T., Lin, S.M., Huang, S.Y., Chou, C.L., Lee, K.Y., Lin, T.Y., Kuo, H.P., Adjuvant treatment with a mammalian target of rapamycin inhibitor, sirolimus, and steroids improves outcomes in patients with severe H1N1 pneumonia and acute respiratory failure. Crit. Care Med. 42 (2014), 313–321.
    • (2014) Crit. Care Med. , vol.42 , pp. 313-321
    • Wang, C.H.1    Chung, F.T.2    Lin, S.M.3    Huang, S.Y.4    Chou, C.L.5    Lee, K.Y.6    Lin, T.Y.7    Kuo, H.P.8
  • 141
    • 12244295453 scopus 로고    scopus 로고
    • Evaluation of neuraminidase enzyme assays using different substrates to measure susceptibility of influenza virus clinical isolates to neuraminidase inhibitors: report of the neuraminidase inhibitor susceptibility network
    • Wetherall, N.T., Trivedi, T., Zeller, J., Hodges-Savola, C., McKimm-Breschkin, J.L., Zambon, M., Hayden, F.G., Evaluation of neuraminidase enzyme assays using different substrates to measure susceptibility of influenza virus clinical isolates to neuraminidase inhibitors: report of the neuraminidase inhibitor susceptibility network. J. Clin. Microbiol. 41 (2003), 742–750.
    • (2003) J. Clin. Microbiol. , vol.41 , pp. 742-750
    • Wetherall, N.T.1    Trivedi, T.2    Zeller, J.3    Hodges-Savola, C.4    McKimm-Breschkin, J.L.5    Zambon, M.6    Hayden, F.G.7
  • 142
    • 85051995485 scopus 로고    scopus 로고
    • Highlights of Prescribing Information
    • Xofluza, Highlights of Prescribing Information. 2018.
    • (2018)
    • Xofluza1
  • 145
    • 85006821348 scopus 로고    scopus 로고
    • Investigational hemagglutinin-targeted influenza virus inhibitors
    • Zeng, L.Y., Yang, J., Liu, S., Investigational hemagglutinin-targeted influenza virus inhibitors. Expert Opin. Investig. Drugs 26 (2017), 63–73.
    • (2017) Expert Opin. Investig. Drugs , vol.26 , pp. 63-73
    • Zeng, L.Y.1    Yang, J.2    Liu, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.