Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 50, 2008, Pages 19944-19949

  Becker, Michelle M ^a   Graham, Rachel L ^b   Donaldson, Eric F ^b   Rockx, Barry ^b   Sims, Amy C ^b,c   Sheahan, Timothy ^b   Pickles, Raymond J ^d   Corti, Davide ^e   Johnston, Robert E ^c   Baric, Ralph S ^b,c,d   Denison, Mark R ^a,f  

^a VANDERBILT UNIVERSITY   (United States)

^b IL   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

Author keywords

Emerging pathogens; Synthetic biology; Vaccine development; Zoonoses

Indexed keywords

COMPLEMENTARY DNA; NEUTRALIZING ANTIBODY; RNA DIRECTED RNA POLYMERASE; MEMBRANE PROTEIN; RECOMBINANT PROTEIN; SPIKE GLYCOPROTEIN, CORONAVIRUS; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; EPIDEMIC; FEMALE; GENE ISOLATION; GENE SEQUENCE; GENOME; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PUBLIC HEALTH; RECEPTOR BINDING; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIROGENESIS; VIRUS CULTURE; VIRUS RECOMBINANT; VIRUS REPLICATION; ZOONOSIS; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; BAT; CERCOPITHECUS; DISEASE TRANSMISSION; GENETIC RECOMBINATION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; MOLECULAR GENETICS; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA; VERO CELL; VIROLOGY;

ANIMALIA; CORONAVIRUS; MUS; SARS CORONAVIRUS;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CHIROPTERA; FEMALE; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC; RESPIRATORY MUCOSA; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VERO CELLS; VIRAL ENVELOPE PROTEINS; VIRUS REPLICATION; ZOONOSES;

EID: 58149398620     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808116105     Document Type: Article

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