Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease

Journal of Virology

Volumn 87, Issue 19, 2013, Pages 10524-10538

  Stevaert, Annelies ^a   Dallocchio, Roberto ^b   Dessì, Alessandro ^b   Pala, Nicolino ^c   Rogolino, Dominga ^d   Sechi, Mario ^c   Naesens, Lieve ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b CNR   (Italy)

^c UNIVERSITY OF SASSARI   (Italy)

^d UNIVERSITY OF PARMA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE; ENZYME INHIBITOR; L 742 001; RIBAVIRIN; RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ANTIVIRAL SUSCEPTIBILITY; ARTICLE; BINDING SITE; CELL CULTURE; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROPHOBICITY; INFLUENZA VIRUS; MOLECULAR DOCKING; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; ANTIVIRAL AGENTS; CATALYTIC DOMAIN; CELLS, CULTURED; COMPUTATIONAL BIOLOGY; DOGS; DRUG RESISTANCE, VIRAL; ENZYME INHIBITORS; HUMANS; HYDROXYBUTYRATES; MOLECULAR STRUCTURE; MUTATION; ORTHOMYXOVIRIDAE; ORTHOMYXOVIRIDAE INFECTIONS; PIPERIDINES; PROTEIN CONFORMATION; RNA REPLICASE; VIRAL PROTEINS; VIRUS INTERNALIZATION; VIRUS REPLICATION;

EID: 84884683675     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00832-13     Document Type: Article

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