Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

Journal of Medicinal Chemistry

Volumn 60, Issue 5, 2017, Pages 1648-1661

  Siegel, Dustin ^a   Hui, Hon C ^a   Doerffler, Edward ^a   Clarke, Michael O ^a   Chun, Kwon ^a   Zhang, Lijun ^a   Neville, Sean ^a   Carra, Ernest ^a   Lew, Willard ^a   Ross, Bruce ^a   Wang, Queenie ^a   Wolfe, Lydia ^a   Jordan, Robert ^a   Soloveva, Veronica ^b   Knox, John ^a   Perry, Jason ^a   Perron, Michel ^a   Stray, Kirsten M ^a   Barauskas, Ona ^a   Feng, Joy Y ^a   Xu, Yili ^a   Lee, Gary ^a   Rheingold, Arnold L ^c   Ray, Adrian S ^a   Bannister, Roy ^a   Strickley, Robert ^a   Swaminathan, Swami ^a   Lee, William A ^a   Bavari, Sina ^b   Cihlar, Tomas ^a   Lo, Michael K ^d   Warren, Travis K ^b   Mackman, Richard L ^a   more..

^a GILEAD SCIENCES   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; NUCLEIC ACID BASE; NUCLEOSIDE DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; PYRROLO[2,1 F][TRIAZIN 4 AMINO] ADENINE C NUCLEOSIDE; UNCLASSIFIED DRUG; ALANINE; AMIDE; GS-5734; PHOSPHORAMIDIC ACID; PHOSPHORIC ACID; RIBONUCLEOTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DIASTEREOISOMER; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; EBOLA HEMORRHAGIC FEVER; HUMAN; HUMAN CELL; MACROPHAGE; MORTALITY; NONHUMAN; SINGLE DRUG DOSE; STEREOSELECTIVITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VIREMIA; VIRUS SHEDDING; ANALOGS AND DERIVATIVES; CELL LINE; CHEMISTRY; DRUG DEVELOPMENT; HEMORRHAGIC FEVER, EBOLA; MICROBIAL SENSITIVITY TEST; VIRUS DISEASES;

ALANINE; AMIDES; CELL LINE; DRUG DISCOVERY; HEMORRHAGIC FEVER, EBOLA; HUMANS; MICROBIAL SENSITIVITY TESTS; PHOSPHORIC ACIDS; PRODRUGS; RIBONUCLEOTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS DISEASES;

EID: 85015071018     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b01594     Document Type: Article

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