In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit

Antiviral Research

Volumn 160, Issue , 2018, Pages 109-117

  Noshi, Takeshi ^a   Kitano, Mitsutaka ^a   Taniguchi, Keiichi ^a,b   Yamamoto, Atsuko ^a   Omoto, Shinya ^a   Baba, Keiko ^a   Hashimoto, Takashi ^a   Ishida, Kayo ^a   Kushima, Yukihiro ^a   Hattori, Kazunari ^a   Kawai, Makoto ^a   Yoshida, Ryu ^a   Kobayashi, Masanori ^a,d   Yoshinaga, Tomokazu ^a   Sato, Akihiko ^a,c   Okamatsu, Masatoshi ^b   Sakoda, Yoshihiro ^b   Kida, Hiroshi ^c   Shishido, Takao ^a   Naito, Akira ^a  

^a SHIONOGI AND CO LTD   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

^d GIFU UNIVERSITY   (Japan)

Author keywords

Baloxavir acid; Baloxavir marboxil; Cap dependent endonuclease; Influenza virus

Indexed keywords

BALOXAVIR; BALOXAVIR MARBOXIL; CAPPED RNA; FAVIPIRAVIR; LANINAMIVIR; MESSENGER RNA; OSELTAMIVIR; RNA POLYMERASE; SURAMIN; VIRUS RNA; ZANAMIVIR; ANTIVIRUS AGENT; ENDONUCLEASE; OXAZINE DERIVATIVE; PA PROTEIN, INFLUENZA VIRUSES; PYRIDINE DERIVATIVE; RNA DIRECTED RNA POLYMERASE; THIEPIN DERIVATIVE; TRIAZINE DERIVATIVE; VIRAL PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ANTIVIRAL SUSCEPTIBILITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL VIABILITY; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; EC50; ENZYMATIC ASSAY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; IC50; IN VITRO STUDY; INFLUENZA A VIRUS (H1N2); INFLUENZA A VIRUS (H5N1); INFLUENZA A VIRUS (H5N2); INFLUENZA A VIRUS (H5N6); INFLUENZA A VIRUS (H7N9); INFLUENZA A VIRUS (H9N2); INFLUENZA VIRUS; MDCK CELL LINE; NONHUMAN; PRIORITY JOURNAL; REVERSE GENETICS; RNA TRANSCRIPTION; SANGER SEQUENCING; SELECTIVITY INDEX; VIRUS ISOLATION; VIRUS PARTICLE; VIRUS REPLICATION; ANTIVIRAL RESISTANCE; DNA MUTATIONAL ANALYSIS; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; INFLUENZA A VIRUS; INFLUENZA B VIRUS; MICROBIAL SENSITIVITY TEST; MISSENSE MUTATION; VIRUS CULTURE;

ANTIVIRAL AGENTS; CYTOPATHOGENIC EFFECT, VIRAL; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE, VIRAL; ENDONUCLEASES; INFLUENZA A VIRUS; INFLUENZA B VIRUS; MICROBIAL SENSITIVITY TESTS; MUTATION, MISSENSE; OXAZINES; PYRIDINES; REVERSE GENETICS; RNA REPLICASE; SERIAL PASSAGE; THIEPINS; TRANSCRIPTION, GENETIC; TRIAZINES; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 85055754733     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2018.10.008     Document Type: Article

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