-
1
-
-
61349189727
-
Estimates of US influenza-associated deaths made using four different methods
-
Thompson, W. W. et al. Estimates of US influenza-associated deaths made using four different methods. Influenza and other respiratory viruses 3, 37-49, https://doi.org/10.1111/j.1750-2659.2009.00073.x (2009).
-
(2009)
Influenza and Other Respiratory Viruses
, vol.3
, pp. 37-49
-
-
Thompson, W.W.1
-
2
-
-
78549241668
-
Influenza vaccines for the future
-
Lambert, L. C. & Fauci, A. S. Influenza vaccines for the future. The New England journal of medicine 363, 2036-2044, https://doi.org/10.1056/NEJMra1002842 (2010).
-
(2010)
The New England Journal of Medicine
, vol.363
, pp. 2036-2044
-
-
Lambert, L.C.1
Fauci, A.S.2
-
3
-
-
84929492511
-
Adamantane-resistant influenza a viruses in the world (1902-2013): Frequency and distribution of M2 gene mutations
-
Dong, G. et al. Adamantane-resistant influenza a viruses in the world (1902-2013): frequency and distribution of M2 gene mutations. PloS one 10, e0119115, https://doi.org/10.1371/journal.pone.0119115 (2015).
-
(2015)
PloS One
, vol.10
, pp. e0119115
-
-
Dong, G.1
-
4
-
-
17744412173
-
Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: A randomized controlled trial. US Oral Neuraminidase Study Group
-
Treanor, J. J. et al. Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. US Oral Neuraminidase Study Group. Jama 283, 1016-1024 (2000).
-
(2000)
Jama
, vol.283
, pp. 1016-1024
-
-
Treanor, J.J.1
-
5
-
-
0034720503
-
Efficacy and safety of oseltamivir in treatment of acute influenza: A randomised controlled trial. Neuraminidase Inhibitor Flu Treatment Investigator Group
-
Nicholson, K. G. et al. Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial. Neuraminidase Inhibitor Flu Treatment Investigator Group. Lancet 355, 1845-1850 (2000).
-
(2000)
Lancet
, vol.355
, pp. 1845-1850
-
-
Nicholson, K.G.1
-
6
-
-
69149095237
-
Viral loads and duration of viral shedding in adult patients hospitalized with influenza
-
Lee, N. et al. Viral loads and duration of viral shedding in adult patients hospitalized with influenza. The Journal of infectious diseases 200, 492-500, https://doi.org/10.1086/600383 (2009).
-
(2009)
The Journal of Infectious Diseases
, vol.200
, pp. 492-500
-
-
Lee, N.1
-
7
-
-
79953230465
-
Viral clearance and inflammatory response patterns in adults hospitalized for pandemic 2009 influenza A(H1N1) virus pneumonia
-
Lee, N. et al. Viral clearance and inflammatory response patterns in adults hospitalized for pandemic 2009 influenza A(H1N1) virus pneumonia. Antiviral therapy 16, 237-247, https://doi.org/10.3851/IMP1722 (2011).
-
(2011)
Antiviral Therapy
, vol.16
, pp. 237-247
-
-
Lee, N.1
-
8
-
-
84919471395
-
Overview of the 3rd isirv-Antiviral Group Conference-advances in clinical management
-
Hurt, A. C., Hui, D. S., Hay, A. & Hayden, F. G. Overview of the 3rd isirv-Antiviral Group Conference-advances in clinical management. Influenza and other respiratory viruses 9, 20-31, https://doi.org/10.1111/irv.12293 (2015).
-
(2015)
Influenza and Other Respiratory Viruses
, vol.9
, pp. 20-31
-
-
Hurt, A.C.1
Hui, D.S.2
Hay, A.3
Hayden, F.G.4
-
9
-
-
85011796730
-
Structural insights into RNA synthesis by the influenza virus transcription-replication machine
-
Pflug, A., Lukarska, M., Resa-Infante, P., Reich, S. & Cusack, S. Structural insights into RNA synthesis by the influenza virus transcription-replication machine. Virus research 234, 103-117, https://doi.org/10.1016/j.virusres.2017.01.013 (2017).
-
(2017)
Virus Research
, vol.234
, pp. 103-117
-
-
Pflug, A.1
Lukarska, M.2
Resa-Infante, P.3
Reich, S.4
Cusack, S.5
-
10
-
-
84978162055
-
Influenza virus RNA polymerase: Insights into the mechanisms of viral RNA synthesis
-
Te Velthuis, A. J. & Fodor, E. Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis. Nature reviews. Microbiology 14, 479-493, https://doi.org/10.1038/nrmicro.2016.87 (2016).
-
(2016)
Nature Reviews. Microbiology
, vol.14
, pp. 479-493
-
-
Te Velthuis, A.J.1
Fodor, E.2
-
11
-
-
17444430403
-
Association of the influenza a virus RNA-dependent RNA polymerase with cellular RNA polymerase II
-
Engelhardt, O. G., Smith, M. & Fodor, E. Association of the influenza a virus RNA-dependent RNA polymerase with cellular RNA polymerase II. Journal of Virology 79, 5812-5818, https://doi.org/10.1128/jvi.79.9.5812-5818.2005 (2005).
-
(2005)
Journal of Virology
, vol.79
, pp. 5812-5818
-
-
Engelhardt, O.G.1
Smith, M.2
Fodor, E.3
-
12
-
-
85016158967
-
Structural basis of an essential interaction between influenza polymerase and Pol II CTD
-
Lukarska, M. et al. Structural basis of an essential interaction between influenza polymerase and Pol II CTD. Nature 541, 117-121, https://doi.org/10.1038/nature20594 (2017).
-
(2017)
Nature
, vol.541
, pp. 117-121
-
-
Lukarska, M.1
-
13
-
-
43249128376
-
The structural basis for cap binding by influenza virus polymerase subunit PB2
-
Guilligay, D. et al. The structural basis for cap binding by influenza virus polymerase subunit PB2. Nat Struct Mol Biol 15, 500-506 (2008).
-
(2008)
Nat Struct Mol Biol
, vol.15
, pp. 500-506
-
-
Guilligay, D.1
-
14
-
-
67249130012
-
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
-
Dias, A. et al. The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit. Nature 458, 914-918 (2009).
-
(2009)
Nature
, vol.458
, pp. 914-918
-
-
Dias, A.1
-
15
-
-
67249100913
-
Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site
-
Yuan, P. et al. Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature 458, 909-913 (2009).
-
(2009)
Nature
, vol.458
, pp. 909-913
-
-
Yuan, P.1
-
16
-
-
84922245983
-
Structural insight into cap-snatching and RNA synthesis by influenza polymerase
-
Reich, S. et al. Structural insight into cap-snatching and RNA synthesis by influenza polymerase. Nature 516, 361-366, https://doi.org/10.1038/nature14009 (2014).
-
(2014)
Nature
, vol.516
, pp. 361-366
-
-
Reich, S.1
-
17
-
-
85049212019
-
Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors
-
Pflug, A., Gaudon, S., Resa-Infante, P., Reich, S. & Cusack, S. Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res In revision. (2017).
-
(2017)
Nucleic Acids Res in Revision.
-
-
Pflug, A.1
Gaudon, S.2
Resa-Infante, P.3
Reich, S.4
Cusack, S.5
-
18
-
-
0033015827
-
Direct evidence that the poly(A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA template
-
Poon, L. L., Pritlove, D. C., Fodor, E. & Brownlee, G. G. Direct evidence that the poly(A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA template. J Virol 73, 3473-3476 (1999).
-
(1999)
J Virol
, vol.73
, pp. 3473-3476
-
-
Poon, L.L.1
Pritlove, D.C.2
Fodor, E.3
Brownlee, G.G.4
-
19
-
-
84887926053
-
New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain
-
Pautus, S. et al. New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain. Journal of medicinal chemistry 56, 8915-8930, https://doi.org/10.1021/jm401369y (2013).
-
(2013)
Journal of Medicinal Chemistry
, vol.56
, pp. 8915-8930
-
-
Pautus, S.1
-
20
-
-
84866146827
-
Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease
-
DuBois, R. M. et al. Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease. PLoS pathogens 8, e1002830, https://doi.org/10.1371/journal.ppat.1002830 (2012).
-
(2012)
PLoS Pathogens
, vol.8
, pp. e1002830
-
-
DuBois, R.M.1
-
21
-
-
84866177810
-
Structural analysis of specific metal chelating inhibitor binding to the endonuclease domain of influenza pH1N1 (2009) polymerase
-
Kowalinski, E. et al. Structural analysis of specific metal chelating inhibitor binding to the endonuclease domain of influenza pH1N1 (2009) polymerase. PLoS pathogens 8, e1002831, https://doi.org/10.1371/journal.ppat.1002831 (2012).
-
(2012)
PLoS Pathogens
, vol.8
, pp. e1002831
-
-
Kowalinski, E.1
-
22
-
-
84991769513
-
The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design
-
Stevaert, A. & Naesens, L. The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design. Medicinal research reviews 36, 1127-1173, https://doi.org/10.1002/med.21401 (2016).
-
(2016)
Medicinal Research Reviews
, vol.36
, pp. 1127-1173
-
-
Stevaert, A.1
Naesens, L.2
-
23
-
-
85035785809
-
Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference
-
McKimm-Breschkin, J. L. et al. Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference. Antiviral research 149, 118-142, https://doi.org/10.1016/j.antiviral.2017.11.013 (2018).
-
(2018)
Antiviral Research
, vol.149
, pp. 118-142
-
-
McKimm-Breschkin, J.L.1
-
24
-
-
0036211719
-
In vitro and in vivo activities of anti-influenza virus compound T-705
-
Furuta, Y. et al. In vitro and in vivo activities of anti-influenza virus compound T-705. Antimicrobial agents and chemotherapy 46, 977-981 (2002).
-
(2002)
Antimicrobial Agents and Chemotherapy
, vol.46
, pp. 977-981
-
-
Furuta, Y.1
-
25
-
-
84923234062
-
Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit
-
Byrn, R. A. et al. Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit. Antimicrobial agents and chemotherapy 59, 1569-1582, https://doi.org/10.1128/AAC.04623-14 (2015).
-
(2015)
Antimicrobial Agents and Chemotherapy
, vol.59
, pp. 1569-1582
-
-
Byrn, R.A.1
-
26
-
-
84906089131
-
Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2
-
Clark, M. P. et al. Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2. Journal of medicinal chemistry 57, 6668-6678, https://doi.org/10.1021/jm5007275 (2014).
-
(2014)
Journal of Medicinal Chemistry
, vol.57
, pp. 6668-6678
-
-
Clark, M.P.1
-
27
-
-
84880861322
-
Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744)
-
Johns, B. A. et al. Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744). Journal of medicinal chemistry 56, 5901-5916, https://doi.org/10.1021/jm400645w (2013).
-
(2013)
Journal of Medicinal Chemistry
, vol.56
, pp. 5901-5916
-
-
Johns, B.A.1
-
28
-
-
85049201017
-
S-033188, a small molecule inhibitor of Cap-dependent endonuclease of influenza A and Bvirus, leads to rapid and profound viral load reduction
-
Uehara, T., Shishido, T. & Ishibashi, T. S-033188, a small molecule inhibitor of Cap-dependent endonuclease of influenza A and Bvirus, leads to rapid and profound viral load reduction. Options IX for the Control of Influenza (2016).
-
(2016)
Options IX for the Control of Influenza
-
-
Uehara, T.1
Shishido, T.2
Ishibashi, T.3
-
29
-
-
0037770271
-
Overexpression of the alpha-2,6-sialyltransferase in MDCK cells increases influenza virus sensitivity to neuraminidase inhibitors
-
Matrosovich, M., Matrosovich, T., Carr, J., Roberts, N. A. & Klenk, H. D. Overexpression of the alpha-2,6-sialyltransferase in MDCK cells increases influenza virus sensitivity to neuraminidase inhibitors. J Virol 77, 8418-8425 (2003).
-
(2003)
J Virol
, vol.77
, pp. 8418-8425
-
-
Matrosovich, M.1
Matrosovich, T.2
Carr, J.3
Roberts, N.A.4
Klenk, H.D.5
-
30
-
-
84999837845
-
ViroSpot microneutralization assay for antigenic characterization of human influenza viruses
-
van Baalen, C. A. et al. ViroSpot microneutralization assay for antigenic characterization of human influenza viruses. Vaccine 35, 46-52, https://doi.org/10.1016/j.vaccine.2016.11.060 (2017).
-
(2017)
Vaccine
, vol.35
, pp. 46-52
-
-
Van Baalen, C.A.1
-
31
-
-
84962106718
-
Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor
-
Song, M. S. et al. Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proceedings of the National Academy of Sciences of the United States of America 113, 3669-3674, https://doi.org/10.1073/pnas.1519772113 (2016).
-
(2016)
Proceedings of the National Academy of Sciences of the United States of America
, vol.113
, pp. 3669-3674
-
-
Song, M.S.1
-
32
-
-
84953403658
-
Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains
-
Thierry, E. et al. Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains. Molecular cell 61, 125-137, https://doi.org/10.1016/j.molcel.2015.11.016 (2016).
-
(2016)
Molecular Cell
, vol.61
, pp. 125-137
-
-
Thierry, E.1
-
33
-
-
33748929006
-
Thermofluor-based high-throughput stability optimization of proteins for structural studies
-
Ericsson, U. B., Hallberg, B. M., Detitta, G. T., Dekker, N. & Nordlund, P. Thermofluor-based high-throughput stability optimization of proteins for structural studies. Analytical biochemistry 357, 289-298, https://doi.org/10.1016/j.ab.2006.07.027 (2006).
-
(2006)
Analytical Biochemistry
, vol.357
, pp. 289-298
-
-
Ericsson, U.B.1
Hallberg, B.M.2
Detitta, G.T.3
Dekker, N.4
Nordlund, P.5
-
34
-
-
77956030336
-
Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunit
-
Crepin, T. et al. Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunit. J Virol 84, 9096-9104, https://doi.org/10.1128/JVI.00995-10 (2010).
-
(2010)
J Virol
, vol.84
, pp. 9096-9104
-
-
Crepin, T.1
-
35
-
-
84905643808
-
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013
-
Meijer, A. et al. Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013. Antiviral research 110, 31-41, https://doi.org/10.1016/j.antiviral.2014.07.001 (2014).
-
(2014)
Antiviral Research
, vol.110
, pp. 31-41
-
-
Meijer, A.1
-
36
-
-
84892467702
-
Impact of potential permissive neuraminidase mutations on viral fitness of the H275Y oseltamivir-resistant influenza A(H1N1)pdm09 virus in vitro, in mice and in ferrets
-
Abed, Y., Pizzorno, A., Bouhy, X., Rheaume, C. & Boivin, G. Impact of potential permissive neuraminidase mutations on viral fitness of the H275Y oseltamivir-resistant influenza A(H1N1)pdm09 virus in vitro, in mice and in ferrets. J Virol 88, 1652-1658, https://doi.org/10.1128/JVI.02681-13 (2014).
-
(2014)
J Virol
, vol.88
, pp. 1652-1658
-
-
Abed, Y.1
Pizzorno, A.2
Bouhy, X.3
Rheaume, C.4
Boivin, G.5
-
37
-
-
84871965903
-
Systematic identification of H274Y compensatory mutations in influenza A virus neuraminidase by high-throughput screening
-
Wu, N. C. et al. Systematic identification of H274Y compensatory mutations in influenza A virus neuraminidase by high-throughput screening. J Virol 87, 1193-1199, https://doi.org/10.1128/JVI.01658-12 (2013).
-
(2013)
J Virol
, vol.87
, pp. 1193-1199
-
-
Wu, N.C.1
-
38
-
-
0034705225
-
A DNA transfection system for generation of influenza A virus from eight plasmids
-
Hoffmann, E., Neumann, G., Kawaoka, Y., Hobom, G. & Webster, R. G. A DNA transfection system for generation of influenza A virus from eight plasmids. Proceedings of the National Academy of Sciences of the United States of America 97, 6108-6113, https://doi.org/10.1073/pnas.100133697 (2000).
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 6108-6113
-
-
Hoffmann, E.1
Neumann, G.2
Kawaoka, Y.3
Hobom, G.4
Webster, R.G.5
-
39
-
-
84934444398
-
Estimation of crystallization likelihood through a fluorimetric thermal stability assay
-
Mariaule, V., Dupeux, F. & Marquez, J. A. Estimation of crystallization likelihood through a fluorimetric thermal stability assay. Methods in molecular biology 1091, 189-195, https://doi.org/10.1007/978-1-62703-691-7-13 (2014).
-
(2014)
Methods in Molecular Biology
, vol.1091
, pp. 189-195
-
-
Mariaule, V.1
Dupeux, F.2
Marquez, J.A.3
-
41
-
-
0028103275
-
TheCCP4 suite: Programs for protein crystallography. Acta crystallographica. Section D
-
Collaborative Computational Project, N. TheCCP4 suite: programs for protein crystallography. Acta crystallographica. Section D, Biological crystallography 50, 760-763, https://doi.org/10.1107/S0907444994003112 (1994).
-
(1994)
Biological Crystallography
, vol.50
, pp. 760-763
-
-
-
42
-
-
34447508216
-
Phaser crystallographic software
-
McCoy, A. J. et al. Phaser crystallographic software. Journal of applied crystallography 40, 658-674, https://doi.org/10.1107/S0021889807021206 (2007).
-
(2007)
Journal of Applied Crystallography
, vol.40
, pp. 658-674
-
-
McCoy, A.J.1
-
43
-
-
84860273177
-
Towards automated crystallographic structure refinement with phenix.refine
-
Afonine, P. V. et al. Towards automated crystallographic structure refinement with phenix.refine. Acta crystallographica. Section D, Biological crystallography 68, 352-367, https://doi.org/10.1107/S0907444912001308 (2012).
-
(2012)
Acta Crystallographica. Section D, Biological Crystallography
, vol.68
, pp. 352-367
-
-
Afonine, P.V.1
-
44
-
-
0030924992
-
Refinement of macromolecular structures by the maximum-likelihood method
-
Murshudov, G. N., Vagin, A. A. & Dodson, E. J. Refinement of macromolecular structures by the maximum-likelihood method. Acta crystallographica. Section D, Biological crystallography 53, 240-255, https://doi.org/10.1107/S0907444996012255 (1997).
-
(1997)
Acta Crystallographica. Section D, Biological Crystallography
, vol.53
, pp. 240-255
-
-
Murshudov, G.N.1
Vagin, A.A.2
Dodson, E.J.3
-
45
-
-
77949535720
-
Features and development of Coot
-
Emsley, P., Lohkamp, B., Scott, W. G. & Cowtan, K. Features and development of Coot. Acta crystallographica. Section D, Biological crystallography 66, 486-501, https://doi.org/10.1107/S0907444910007493 (2010).
-
(2010)
Acta Crystallographica. Section D, Biological Crystallography
, vol.66
, pp. 486-501
-
-
Emsley, P.1
Lohkamp, B.2
Scott, W.G.3
Cowtan, K.4
-
46
-
-
74549178560
-
MolProbity: All-atom structure validation for macromolecular crystallography
-
Chen, V. B. et al. MolProbity: all-atom structure validation for macromolecular crystallography. Acta crystallographica. Section D, Biological crystallography 66, 12-21, https://doi.org/10.1107/S0907444909042073 (2010).
-
(2010)
Acta Crystallographica. Section D, Biological Crystallography
, vol.66
, pp. 12-21
-
-
Chen, V.B.1
-
47
-
-
80054078285
-
A new generation of crystallographic validation tools for the protein data bank
-
Read, R. J. et al. A new generation of crystallographic validation tools for the protein data bank. Structure 19, 1395-1412, https://doi.org/10.1016/j.str.2011.08.006 (2011).
-
(2011)
Structure
, vol.19
, pp. 1395-1412
-
-
Read, R.J.1
|